ライフサイエンスコーパス: quality control mechanism

1 ucidates a conserved cotranslational protein quality control mechanism.

2 nd trafficking and is at the center of their quality control mechanism.

3 ter extent than wild-type Mot1, suggesting a quality control mechanism.

4 ciated degradation (ERAD) are the primary ER quality control mechanism.

5 suggesting a previously unrecognized kinetic quality control mechanism.

6 that Pma1-7 is a substrate for a Golgibased quality control mechanism.

7 pparent monomers by a putative Cx43-specific quality control mechanism.

8 this lipid as part of a possible homeostatic/quality control mechanism.

9 GFBP-3 alters mitophagy, a key mitochondrial quality control mechanism.

10 crucial component of the mRNA 5'-end capping quality control mechanism.

11 suppressed by inhibition of a competing RNA quality control mechanism.

12 oteasome pathway serves as a general protein quality-control mechanism.

13 ng to MHCI proteins are degraded by cellular quality control mechanisms.

14 bly due to undescribed endoplasmic reticulum quality control mechanisms.

15 ablishing a molecular link between these two quality control mechanisms.

16 mics, indicating compromise of mitochondrial quality control mechanisms.

17 occur after failure of the cellular protein quality control mechanisms.

18 associations are not required to satisfy ER quality control mechanisms.

19 es the surveillance of various mitochondrial quality control mechanisms.

20 estigated the impact of alphaSyn on cellular quality control mechanisms.

21 he levels of entire suites of chaperones and quality control mechanisms.

22 f all organisms and is overseen by intrinsic quality control mechanisms.

23 inate unstable or misfolded proteins through quality control mechanisms.

24 king removal of the transcript by native RNA quality control mechanisms.

25 out major energy input and without bypass of quality control mechanisms.

26 aggregates, cells are equipped with protein quality control mechanisms.

27 tants, seeking to identify relevant cellular quality control mechanisms.

28 misfolding, revealing in vivo limitations on quality control mechanisms.

29 degeneration and (2) activate mitochondrial quality control mechanisms.

30 omain, suggesting evolutionary divergence of quality-control mechanisms.

31 dity-eggs-would be subject to more stringent quality-control mechanisms.

32 ly arising from the action of possible mtDNA quality-control mechanisms.

33 most of the cellular ATP and requires strict quality-control mechanisms.

34 synthesize the most recent work exploring NE quality control mechanisms across eukaryotes.

35 of this protein to the endoplasmic reticulum quality control mechanisms, affecting its trafficking to

36 nal transduction pathways regulating protein quality control mechanisms aimed at restoring homeostasi

37 erged as an excellent system for identifying quality control mechanisms along the pathway.

38 ed with a different kinetics by different ER quality control mechanisms; although C300stop is rapidly

39 lective autophagy serves as an intracellular quality control mechanism and requires autophagy recepto

40 processing mutants that engage the cellular quality control mechanism and show a strong interaction

41 iants, we then reveal discrete steps in this quality control mechanism and the differential functiona

42 mulation is driven by impaired mitochondrial quality control mechanisms and contributes to the develo

43 the endoplasmic reticulum are identified by quality control mechanisms and dislocated to the cytosol

44 3T-alphaSyn in disrupting astrocytic protein quality control mechanisms and establish astrocytes as a

45 Development of quality control mechanisms and introduction of peer revi

46 ication-mediated regulation of intracellular quality control mechanisms and its known involvement in

47 ian hsf genes, but specifically hsf1, in the quality control mechanisms and maintenance of CNS homeos

48 wo genomes for protein biogenesis, efficient quality control mechanisms, and appropriate distribution

49 protein aggregation, and down-regulation of quality control mechanisms are all hallmarks of cellular

50 r understanding of how mitochondrial protein quality control mechanisms are coordinated across these

51 alled ribosome into subunits.Several protein quality control mechanisms are in place to trigger the r

52 Both quality control mechanisms are key to prevent proteotoxi

53 l insertion into a lipid bilayer, responsive quality control mechanisms are required to resolve aberr

54 e Clp proteolytic core, can confer a protein quality control mechanism at the envelope.

55 lasmic domains, the signal provides a common quality control mechanism at the Golgi for Kir channels.

56 be expressed in JNCL patients since cellular quality control mechanisms at the RNA and protein levels

57 arity of translocation reveals an unforeseen quality-control mechanism at the origin.

58 These studies reveal a previously unknown quality control mechanism by which indole integrates DNA

59 Interfering with common protein quality control mechanisms by mutating and inhibiting th

60 Failures of the quality control mechanisms by the heat shock proteins (H

61 ernative pre-mRNA splicing (AS) and the mRNA quality control mechanism called nonsense-mediated decay

62 Our results reveal that the Tat quality control mechanism can be harnessed for molecular

63 Here we provide evidence that a peripheral quality control mechanism can contribute to development

64 ses due to age-related impairment of protein quality control mechanisms can promote the transcellular

65 and retrieval, suggest a difference in their quality control mechanism compared with that of misfolde

66 ed the PGC transcriptional program, a potent quality control mechanism detects and drives damaged PGC

67 r work documents that a sex-linked organelle quality control mechanism drives the uniparental organel

68 building of filaments may act as a stringent quality control mechanism during HR.

69 is BMP-gated cell-cycle checkpoint defines a quality control mechanism during mesenchymal collective

70 strate that GTPBP1 functions as an important quality control mechanism during translation elongation

71 al proteostasis depends on cytosolic protein quality control mechanisms during crises.

72 Quality control mechanisms during protein synthesis are

73 Protein quality control mechanisms eliminate defective polypepti

74 An important quality control mechanism eliminates meiocytes that have

75 ent proteins without interference of protein quality control mechanisms, enabling the selective clear

76 This quality control mechanism ensures that the bacteria can

77 Therefore, critical quality control mechanisms exist to protect mitochondria

78 e ability to perform a previously unexpected quality control mechanism for CCA synthesis.

79 ne where it possibly confers a novel protein quality control mechanism for chloroplast preprotein imp

80 face, and favor a role for p24 proteins in a quality control mechanism for endoplasmic reticulum-Golg

81 We recently described a non-canonical ER quality control mechanism for folding of thrombospondin

82 Thus, Kud acts as a quality control mechanism for LINC-mediated nucleocytosk

83 Mitophagy serves as an essential quality control mechanism for mitochondria in the heart

84 her, these modifications appear to provide a quality control mechanism for punctin-1 secretion.

85 it has been suggested that this represents a quality control mechanism for subunit functionality.

86 t this pathway also functions as an inherent quality control mechanism for the process of pre-mRNA sp

87 ons suggest that POFUT2 is involved in an ER quality control mechanism for TSR folding and that B3GLC

88 on and the importance of responsive ribosome quality control mechanisms for cell fitness and human he

89 contrast, very little is known about post-ER quality control mechanisms for damaged or misfolded inte

90 osomes and suggest the possible existence of quality control mechanisms for disposal of aggregated pr

91 ence of translation on mRNA decay provides a quality-control mechanism for minimizing the use of poor

92 the endoplasmic reticulum (ER), reflecting a quality control mechanism found in many complex multisub

93 rt and support a broader conservation of RNA quality control mechanisms from yeast to humans.

94 Although linked to translation and quality control mechanisms, GTPBP1 molecular functions r

95 We conclude that a quality control mechanism has been conserved from yeast

96 However, detailed knowledge of lysosomal quality control mechanisms has only emerged relatively r

97 confinement, which, together with biological quality control mechanisms, helps proteins remain solubl

98 mainly when interference with mitochondrial quality control mechanisms impedes their roles in mainte

99 cay (NMD) is a conserved translation-coupled quality control mechanism in all eukaryotes that regulat

100 liferation and the p53 pathway as a powerful quality control mechanism in erythropoiesis.

101 Our data reveal a pre-mRNA 5' end capping quality control mechanism in mammalian cells, indicating

102 e transport to the GA, thus overwhelming the quality control mechanism in the ER.

103 These data implicate DNA repair as a key quality control mechanism in the female germ line and a

104 Thus, we define a novel lysosomal quality control mechanism in which lysosomal injury trig

105 we provide evidence for a previously unknown quality control mechanism in which the abundant ribosome

106 We investigated the role of protein quality control mechanisms in cell wall integrity and fo

107 The physiological necessity of these quality control mechanisms in different environments rem

108 ecific roles and regulation of mitochondrial quality control mechanisms in kidney resident and circul

109 l substrates to interrogate cellular protein quality control mechanisms in mammalian cells using a fo

110 studies highlight the importance of protein quality control mechanisms in regulating polyglutamine-i

111 ess on ER and inner nuclear membrane protein quality control mechanisms in Saccharomyces cerevisiae.

112 understanding of the organization of protein quality control mechanisms in the cytosol and nucleus.

113 Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibiti

114 lar senescence and implicates CHIP-dependent quality control mechanisms in the regulation of mammalia

115 Mitophagy is an important quality-control mechanism in eukaryotic cells, and defec

116 d, suggesting a Nonsense-Mediated Decay-like quality-control mechanism in prokaryotes.

117 oteomics further reveal a universal cellular quality-control mechanism in which cells adapt to proteo

118 detail the intimate crosstalk among the 3 ER quality-control mechanisms in the dynamic regulation of

119 hondrial homeostasis is mediated by multiple quality control mechanisms including mitophagy, a form o

120 Multiple quality control mechanisms, including antioxidant defenc

121 Here we review translation-coupled mRNA quality control mechanisms, including the non-stop and n

122 Selection and/or quality-control mechanisms, including DNA repair and apo

123 otein stability that is based on the folding quality control mechanism inherent to the twin-arginine

124 of O-fucosylation and how it participates in quality control mechanisms inside the ER.

125 Quality control mechanisms intervene appropriately when

126 e seemingly distinct mitochondrial-cytosolic quality control mechanisms into a single network, the mi

127 ase targeting mRNA, potentially as part of a quality control mechanism involved in translation termin

128 One of the most fascinating quality-control mechanisms involves tmRNA, also known as

129 stalled ribosomes are rescued by a conserved quality-control mechanism involving transfer-messenger R

130 We show that this quality control mechanism is specific to G interface mut

131 Tat translocator, indicating that a folding quality-control mechanism is intrinsic to the export pro

132 misfolded proteins that escape the cellular quality-control mechanisms is a common feature of a wide

133 As a quality control mechanism, KPAF3 binding ensures that mR

134 d intervention of the "endoplasmic reticulum quality control" mechanism leading to degradation of the

135 olding defect, in conjunction with normal ER quality control mechanisms, leads to defective Tg export

136 Yet protein quality control mechanisms may also deliberately cluster

137 We propose that different quality control mechanisms may assess discrete domains o

138 onset of diseases suggests that compensatory quality control mechanisms may be engaged to delay these

139 Endoplasmic reticulum (ER) quality control mechanisms monitor the folding of nascen

140 Three principal ER quality-control mechanisms, namely, the unfolded protein

141 ed that Saccharomyces cerevisiae possesses a quality control mechanism, nonfunctional rRNA decay (NRD

142 Thus, eukaryotes possess a quality-control mechanism, nonfunctional rRNA decay (NRD

143 Here, we provide an overview of three quality control mechanisms--nonsense-mediated mRNA decay

144 508 CFTR and associates with key elements in quality control mechanism of CFTR.

145 involve A chain unfolding in the ER and the quality control mechanism of ER-associated degradation (

146 s the cytosol by a process that involves the quality control mechanism of ER-associated degradation (

147 rigger its export to the cytosol through the quality control mechanism of ER-associated degradation (

148 to-cytosol translocation of CTA1 through the quality control mechanism of ER-associated degradation.

149 s the cytosol in a process that involves the quality control mechanism of ER-associated degradation.

150 of misfolded glycoproteins as a part of the quality control mechanism of the endoplasmic reticulum (

151 nexin, a component of what is considered the quality control mechanism of the ER.

152 ssociated degradation (ERAD) is an essential quality control mechanism of the folding state of protei

153 ed forms of hemagglutinin were bypassing the quality control mechanism of the secretory pathway.

154 -implicated proteins by using the endogenous quality control mechanisms of a cell.

155 PBPR in fulfilling a crucial function in the quality control mechanisms of antigen processing and pre

156 st comprehensive characterization of protein quality control mechanisms of K(V)11.1.

157 d enzymes are unable to efficiently pass the quality control mechanisms of the endoplasmic reticulum,

158 stence of polyadenylated rRNAs may reflect a quality-control mechanism of rRNA biogenesis.

159 Two distinct quality-control mechanisms operate together to combat th

160 to support these divisions, which lack many quality control mechanisms operating in somatic cells un

161 several levels and by multiple mitochondrial quality control mechanisms present in the intermembrane

162 the endoplasmic reticulum (ER) is one of the quality control mechanisms present in the protein secret

163 This quality control mechanism promotes tissue health by favo

164 genetic suppressors that inactivate the Tat quality-control mechanism provides direct evidence for t

165 g how proteases and E3s cooperate in protein quality control mechanisms remains minimal.

166 mitophagy, and lysosomal function affect the quality control mechanisms required for neuronal surviva

167 Nonsense-mediated mRNA decay (NMD) is a quality control mechanism responsible for "surveying" mR

168 -associated degradation (ERAD) is a critical quality control mechanism responsible for eliminating mi

169 modify several proteins involved in protein-quality control mechanisms, resulting in their lipoxidat

170 This finding suggests that quality control mechanisms sensitive to an absence of N-

171 is is an unexpected observation, as cellular quality control mechanisms should remove misfolded prote

172 However, whether RNA quality control mechanisms, such as nonsense-mediated mR

173 Endoplasmic reticulum (ER) quality control mechanisms target terminally misfolded p

174 This indicates that the cytoplasmic RNA quality control mechanism targets the TEs that are poorl

175 Mitophagy is a mitochondrial quality control mechanism that allows for the selective

176 s the best-characterized posttranscriptional quality control mechanism that cells have evolved in the

177 for monitoring tRNA stability in a cellular quality control mechanism that degrades structurally dam

178 tochondrial stress and activate mitophagy, a quality control mechanism that eliminates damaged mitoch

179 Cell competition is a quality control mechanism that eliminates unfit cells.

180 m-associated degradation (ERAD) is a protein quality control mechanism that eliminates unwanted prote

181 ng the unique involvement of the Tat folding quality control mechanism that ensures only native-like

182 of excess unassembled Alg13p is an important quality control mechanism that ensures proper protein co

183 st time that the translation-like cycle is a quality control mechanism that ensures the fidelity of t

184 No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with tran

185 t are components of a unified and integrated quality control mechanism that exerts different effects

186 A system is a highly conserved translational quality control mechanism that helps maintain the transl

187 pC suggests the presence of a CtpA-dependent quality control mechanism that may sense proper transloc

188 d decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm.

189 A postthymic quality control mechanism that purges these cells from t

190 orted from folded proteins and degraded by a quality control mechanism that requires ER-to-Golgi tran

191 oreover, we discovered a translation-coupled quality control mechanism that resolves covalent RNA-pro

192 our data identify STING-TFEB as a lysosomal quality control mechanism that responds to lysosomal dys

193 ly B cell development: SL chain is part of a quality control mechanism that tests a mu-chain for its

194 ochondrial fusion and fission are protective quality control mechanisms that can be dysregulated in H

195 Eukaryotic mRNAs are subject to quality control mechanisms that degrade defective mRNAs.

196 Ribosomes stalled on aberrant mRNAs engage quality control mechanisms that degrade the partially tr

197 Protein homeostasis is maintained by quality control mechanisms that detect and eliminate def

198 Therefore, cells evolved cotranslational quality control mechanisms that eliminate these transcri

199 The current report identifies quality control mechanisms that exclude the improper pol

200 rescued DeltaF508CFTR remains susceptible to quality control mechanisms that lead to accelerated endo

201 Quality control mechanisms that maintain the physical in

202 n function and implicate homeostatic protein quality control mechanisms that may go awry in NvAMD.

203 However, the quality control mechanisms that minimize the contributio

204 Mitochondrial fission and mitophagy are quality control mechanisms that normally help maintain a

205 The quality control mechanisms that oversee these processes

206 sembly on XPD and highlight the existence of quality control mechanisms that prevent the incorporatio

207 nd Mmr1p, which favors bulk inheritance; and quality control mechanisms that promote segregation of f

208 en avidly studied, little is known about the quality control mechanisms that resolve faulty transloca

209 Therefore, identifying quality control mechanisms that sustain the mitochondria

210 In addition, numerous quality control mechanisms that target aberrant RNAs hav

211 Cell competition is a fitness quality-control mechanism that contributes to this balan

212 se-mediated mRNA decay (NMD) is a eukaryotic quality-control mechanism that detects and degrades aber

213 Cell competition acts as a quality-control mechanism that eliminates cells less fit

214 Autophagy is a quality-control mechanism that helps to maintain cellula

215 ense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate

216 This response is thought to be a quality-control mechanism that protects cells from trunc

217 POFUT2 and B3GLCT mediate a noncanonical ER quality-control mechanism that recognizes folded TSRs an

218 I examine cell competition, a quality-control mechanism that removes less fit loser ce

219 Processing is subject to a quality-control mechanism that retains improperly proces

220 We suggest that the quality-control mechanism that retains receptors in post

221 Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNA

222 ole in DNA replication or replication-linked quality-control mechanisms that are especially important

223 rase II is built in the cytoplasm and reveal quality-control mechanisms that link HSP90 to the nuclea

224 n is essential for cellular homeostasis, but quality-control mechanisms that maintain healthy lysosom

225 These data show that a single quality-control mechanism, the editing of misacylated am

226 e volume of sample introduced to an in-built quality control mechanism through dynamic data capture.

227 The pathway maintains a quality control mechanism to assure that aberrantly proc

228 yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely

229 -associated degradation (ERAD) is a cellular quality control mechanism to dispose of misfolded protei

230 egradation of mature miRNAs and siRNAs, as a quality control mechanism to eliminate dysfunctional or

231 tazoan organisms, cell competition acts as a quality control mechanism to eliminate unfit cells in fa

232 ormally control S phase entry, possibly as a quality control mechanism to ensure adequate stem cell p

233 lta264 CFTR, binds to key elements in the ER quality control mechanism to increase the amounts of the

234 greement that proteolytic pathways provide a quality control mechanism to limit accumulation of damag

235 amine the contribution of the UGT1-regulated quality control mechanism to MHC I antigen presentation.

236 homotetramerization of apo-SiRHP serves as a quality control mechanism to prevent formation of inacti

237 long the aging process, suggesting a lack of quality control mechanism to remove defective mitochondr

238 rial cell and that FtsH acts as an important quality control mechanism to remove it.

239 We propose that nicalin/NRA-2 functions in a quality control mechanism to retain mutant channels in t

240 the FcepsilonRI alpha-chain activates the ER quality control mechanism to retain this subunit in the

241 gest that mitochondrial division serves as a quality control mechanism to suppress oxidative damage a

242 Eukaryotic cells have evolved sophisticated quality control mechanisms to eliminate aggregation-pron

243 There are multiple quality control mechanisms to ensure that nascent polype

244 ryotic cells have evolved numerous layers of quality control mechanisms to ensure that the tRNAs are

245 omyocytes rely on multilayered mitochondrial quality control mechanisms to maintain a healthy populat

246 ific interventions that target mitochondrial quality control mechanisms to preserve and restore mitoc

247 g-related modifications may require cellular quality control mechanisms to prevent deleterious effect

248 The use of quality control mechanisms to stall developmental pathwa

249 ing mRNA maturation and lacks the need for a quality-control mechanism to ensure its fidelity.

250 to the extensively studied tapasin-mediated quality control mechanism, UGT1 adds a new level of cont

251 Collectively, these data uncover a novel quality control mechanism used by the cell to maintain p

252 chondrial fission is thought to be part of a quality-control mechanism whereby damaged mitochondrial

253 In yeast, Cdc48-Ufd1-Npl4 is controlled by a quality control mechanism, whereby substrates must be co

254 folding sensor subunit enables a stochastic quality control mechanism, which marks with increasing p

255 rely on more advanced folding-assistance and quality control mechanisms, which include chaperonins.

256 ine supplementation induces distinct protein quality control mechanisms, which may allow therapeutic

257 alance between oxidative protein folding and quality control mechanisms, which together ensure high-c

258 afforded by the twin-arginine translocation quality control mechanism with a function-based screen,

259 ltransferase (GT), an essential regulator of quality control mechanisms within the endoplasmic reticu