ライフサイエンスコーパス: queuine

1 NAs in their anticodon wobble positions with queuine.

2 bble position with the deazaguanine analogue queuine.

3 The modified RNA base queuine [7-(4,5-cis-dihydroxy-1-cyclopenten-3-ylaminomet

4 exposure is regulated by the availability of queuine, a micronutrient and essential precursor to the

5 Val161, evolved for increased recognition of queuine and a concomitantly decreased recognition of pre

6 ified bases such as deazaguanines related to queuine and archaeosine, pyrimidines comparable with lys

7 understanding of how intracellular levels of queuine and queuosine are regulated and how their defici

8 ber SLC35F2 as a unique transporter for both queuine and queuosine in Schizosaccharomyces pombe and T

9 many metabolites, including the well-studied queuine as substrate for host tRNA queuosine modificatio

10 le of Q synthesis and rely on salvage of the queuine base (q) as a Q precursor.

11 vely made by bacteria, and the corresponding queuine base is a micronutrient salvaged by eukaryotic s

12 Excess exogenous queuine can cause repletion of tRNA queuine levels in Ra

13 for bacterial TGTs is the anticodon loop of queuine-cognate tRNAs, the minimum recognition sequence

14 a UGU sequence in the anticodon loop of the queuine-cognate tRNAs.

15 RasC4 cells are hypomodified for queuine compared with C3H cells, despite increase tRNA-g

16 levels were stimulated by growth of cells in queuine-containing medium; in vitro Pmt1 activity was en

17 maintaining the anticodon identities of the queuine-containing tRNAs and suggests that TGT mutants c

18 rowth in horse serum, which contains no free queuine, eliminates Q from the cellular tRNA population

19 lines may be useful systems for the study of queuine function in normal cells and the causes and cons

20 ither on horse serum or calf serum with free queuine had no effect on frameshifting either.

21 cation in normal cells and the mechanisms of queuine hypomodification in tumors are unknown.

22 4) with respect to the causes and effects of queuine hypomodification.

23 st-transcriptional modification of tRNA with queuine in Escherichia coli is the exchange of the queui

24 n 34 of tRNA(Y,H,N,D) with the modified base queuine in eukaryotes or its precursor, preQ(1) base, in

25 ses and consequences of hypomodification for queuine in tumors.

26 Limiting queuine increased arsenite-induced cell death, altered t

27 ed by the absence of the enzyme that inserts queuine into tRNA, eukaryotic tRNA-guanine transglycosyl

28 Notably, queuine is a micronutrient that is scavenged by higher e

29 y studies suggested that cytosolic uptake of queuine is mediated by a selective transporter that is r

30 xogenous queuine can cause repletion of tRNA queuine levels in RasC4 cells.

31 The molecular role of queuine modification in normal cells and the mechanisms

32 Queuine modification is defective in many tumors and tra

33 Queuine modification of both C3H and RasC4 cells can be

34 nM) and a high-affinity transporter for the queuine nucleobase (K(m) 67 nM), with the additional pre

35 ermediate, but mammals import the free base, queuine, obtained from the diet or the intestinal flora.

36 ognize the guanine in tRNA and the free base queuine or preQ(1) to catalyze this exchange.

37 sglycosylase (TGT) catalyzes the exchange of queuine (or a precursor) for guanine 34 in tRNA.

38 e in Escherichia coli is the exchange of the queuine precursor, preQ1 into tRNA.

39 e exchange of guanine for the 7-deazaguanine queuine precursor, prequeuosine1 (preQ1).

40 ynthesize Q by the base-for-base exchange of queuine (Q base) for guanine in the unmodified tRNA, a r

41 The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronu

42 ed in the incorporation of the modified base queuine (Q) into the wobble position of certain tRNAs.

43 m intracellular metabolism, one exception is queuine (q)/queuosine (Q), which eukaryotes obtain from

44 ed in the incorporation of the modified base queuine [Q, 7-(4,5-cis-dihydroxy-2-cyclopenten-1-ylamino

45 nous benzodiazepine synthesis, production of queuine/queuosine, and excretion of dietary mercury.

46 Queuine reverses this effect by competing with preQ(1) t

47 tivity was enhanced on Q-containing RNA; and queuine-stimulated in vivo methylation was abrogated by

48 ription elongation factor (GreA), a possible queuine synthesis protein, and a possible chemotaxis pro

49 the substrate for Q-modification in tRNA is queuine, the catabolic product of the Q-base of gut bact

50 e additional presence of second low-affinity queuine transporter (K(m) 259 nM).

51 ubacterial TGTs to recognize preQ(1) but not queuine, whereas the eukaryal equivalent, Val161, evolve

52 ter reflect bioavailability of the precursor queuine, which eukaryotes scavenge from the tRNAs of bac