ライフサイエンスコーパス: quinoline

1 d by a 5, 6, or 7 membered carbocycle to the quinoline.

2 cantly greater than those of quinolino[7,8-h]quinoline.

3 d selectively the E-isomer of pyrimido[1,6-a]quinoline.

4 (26) is more superbasic than quinolino[7,8-h]quinoline.

5 ygen atom from N-oxide to the C3 position of quinolines.

6 emoselectivity for the synthesis of 8-benzyl quinolines.

7 oration and hydrosilylation of pyridines and quinolines.

8 tetrahydroquinolines into the corresponding quinolines.

9 y the synthesis of pharmaceutically relevant quinolines.

10 ecently published results focused on related quinolines.

11 ng this amidated product into functionalized quinolines.

12 indole derivatives, tyrosine analogues, and quinolines.

13 alkyl quinolines as well as more common aryl quinolines.

14 ing closure to yield hydroxynaphthalenes and quinolines.

15 rogenation of tetrahydroquinolines to afford quinolines.

16 2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]-quinoline ((+/-)-(11)C-YJH08), a radioligand for PET tha

17 uted carbazole (6), benzothiophene (10), and quinoline (14) derivatives can be synthesized.

18 ogen derivatives 4,9-dichloroquinolino[7,8-h]quinoline (16) and 4,9-dibromoquinolino[7,8-h]quinoline

19 uinoline (16) and 4,9-dibromoquinolino[7,8-h]quinoline (17) as precursors has granted the formation o

20 od involves the Ugi-4CR of 2-chloro-3-formyl quinolines 1a-h, amines 2a-d, 2-chloroacetic acid 3, and

21 Starting from quinoline 2 with weak ATR inhibitory activity, lead opti

22 d atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biom

23 Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were syn

24 design led to the identification of 3-pentyl-quinoline-2-amine as a novel, human TLR8-specific agonis

25 phenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide, 1).

26 the kynurenic acid analog 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid (7-chlorokynurenic acid; 7-C

27 calculation, and the N-heterocyclic carbene quinoline-2-ylidene is not formed as a tautomer.

28 hthalene ("proton sponge") 1 and quino[7,8-h]quinoline 2a have been examined.

29 n-3-yl]-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline -3-carboxamide; MQC) dose-dependently suppress

30 In the case of 2-substituted quinolines, 3-hydroxyquinoline was observed as the main

31 we show the synthesis of the tetrazolo[1,5-a]quinoline-3-carbaldehyde and tetrazolo[1,5-a]quinoline-3

32 -activity relationships, and binding mode of quinoline-3-carbohydrazide derivatives as allosteric mod

33 (4-methyl-1,4-diazepan-1- yl)sulfonyl)phenyl)quinoline-3-carbonitrile (NEU-924, 83) for T. cruzi and

34 1S)-1-(1-methyl-1H-pyrazol-3-yl)e thyl]amino}quinoline-3-carboxamide (74) as potent and highly select

35 quinoline-3-carbaldehyde and tetrazolo[1,5-a]quinoline-3-dimethyl acetal at room temperature in metha

36 rmacokinetic profile of 2,3,4-trisubstituted quinoline, 4, led to the discovery of two potent, select

37 (4),N(4),N(9),N(9)-tetraethylquinolino[7,8-h]quinoline-4,9-diamine (26) is more superbasic than quino

38 ion of a phenotypic screening hit based on a quinoline-4-carboxamide derivative resulted in the highl

39 amoyl)-phenyl)-6,8-dimethyl-2-(pyridin-2- yl)quinoline-4-carboxamide], a selective GPR55 antagonist.

40 DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described.

41 l 8-bromo-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline-4-carboxylate via a conjugate addition/intramo

42 any prefunctionalization and N-protection of quinoline-4-ones.

43 no-4-(4-fluorophenylamino)-1H-pyrazolo[4,3-c]quinoline (42) combined with chemotherapeutic CPT-11 tre

44 of pore-size in a coordination network, [Cu(quinoline-5-carboxyate)2 ]n (Qc-5-Cu) ena+bles ultra-hig

45 ime, 10-dimethylamino derivatives of benzo[h]quinoline 6 and benzo[h]quinazoline 7a-e as mixed analog

46 l)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide monohydrate]] (galunisertib) (IC

47 cation of the screening hit 11H-indolo[3,2-c]quinoline-6-carboxylic acid revealed structure-activity

48 ture determination of three 11H-indolo[3,2-c]quinoline-6-carboxylic acids cocrystallized with DYRK1A

49 yl-3',4'-dihydro-1'H-spiro[cyclopropane-1,2'-quinoline] (6) and 6'-chloro-1'-methyl-3',4'-dihydro-1'H

50 yl-3',4'-dihydro-1'H-spiro[cyclopropane-1,2'-quinoline] (7) are 3.5 x 10(2) s(-1) and 4.1 x 10(2) s(-

51 nding pharmacophores, 8-(methylsulfonylamino)quinoline (8-MSQ) was identified as a hit.

52 o-2,3-dihydro-1,4-dioxino[2,3-g]thieno[2,3-b]quinoline-8 -carboxamide (8), inhibited this interaction

53 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8- sulfonamide) have the combined properties o

54 henyl)-3a,4,5,9b-te-trahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (2,3,5,6TMP-TQS), previously pub

55 p-tolyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4MP-TQS), together with all oth

56 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (GAT107) and 3-(3,4-difluorophen

57 trahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide (TQS) and the alpha7 ago-PAM 4BP

58 trahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide were also linear and showed no c

59 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide), consistent with AA site involv

60 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, is a strong positive allosteric

61 henyl)-3a,4,5,9b-te-trahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, originally reported to lack act

62 effect a three-component reaction between a quinoline, a terminal alkyne, and ethyl chloroformate.

63 ion of a variety of N-heteroarenes including quinolines, acridines, benzo[h], and 1,5-naphthyridine a

64 , we report on the effects of pyrazolo[4,3-c]quinolines acting as a new class of bacterial betaG-spec

65 Quinolines also form various complexes with soluble hema

66 ect remote C-H carboxylation of naphthyl and quinoline amides was developed using CBr(4) and alcohol.

67 The NPAHs 1,4-dihydro(iso)quinoline and (iso)quinoline can be synthesized through

68 ded to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline derivatives.

69 Lower rim amide linked 8-amino quinoline and 8-amino naphthalene moiety 1,3,5-trideriva

70 By studying the 10-hydroxybenzo[h]quinoline and 8-hydroxyquinoline molecules using anion p

71 licenes were synthesized utilizing versatile quinoline and 9-(2-ethylhexyl)-2,7-dimethoxycarbazole-3-

72 ogen bond catalysts bind to the electrophile quinoline and activate it by lowering its LUMO energy, w

73 Potency was enhanced by methylation of the quinoline and by introduction of simple chiral moieties,

74 ew styryl dyes derived from 4-pyridine and 4-quinoline and having an ammonioalkyl N-substituent and b

75 s, revealing that high quantum yields of the quinoline and isoquinoline derivatives are a result of t

76 the results obtained for previously reported quinoline and isoquinoline derivatives.

77 Structure-activity relationships in both the quinoline and naphthyridine series leading to the identi

78 tolerates a variety of functional groups on quinoline and olefin moieties.

79 portant determinant of resistance to several quinoline and quinoline-like antimalarial drugs.

80 ulates the responsiveness to a wide range of quinoline and quinoline-like compounds.

81 thesis of two important heterocycles such as quinoline and quinoxaline.

82 (last on August 21, 2017) for studies of the quinoline and structurally related antimalarials for mal

83 ular study revealed the necessity of hydroxy quinoline and the amine group for La(3+) ion binding and

84 A total of 15 different quinolines and 14 different pyrimidines were synthesized

85 ch for the synthesis of 3-aryl-2-substituted quinolines and 4-arylacridines has been developed via th

86 c approach for the synthesis of indolo[2,3-b]quinolines and benzothieno[2,3-b]quinolines has been dev

87 ss to provide the corresponding indolo[2,3-b]quinolines and benzothieno[2,3-b]quinolines, respectivel

88 Bioactives such as indoles, quinolines and cis-(+)-12-oxophytodienoic acid, in syner

89 r exploitation in targeting more embellished quinolines and isoquinolines and complex platforms embod

90 organozinc nucleophiles to N-acyl activated quinolines and isoquinolines is described.

91 approach of general applicability to diverse quinolines and isoquinolines via a tactic that utilizes

92 , and sugar-derived ones, leading to desired quinolines and naphthydrines with good yields.

93 in that study the substrates were limited to quinolines and pyridines.

94 able, and practical synthesis of substituted quinolines and pyrimidines using combinations of 2-amino

95 alization of alcohols to various substituted quinolines and quinazolin-4(3H)-ones under relatively mi

96 A wide variety of substituted quinolines and quinazolin-4(3H)-ones were synthesized in

97 Tetrahydroquinoline, quinoline, and dihydroquinolinone are common core motifs

98 ng heteroaryl chlorides, including pyridine, quinoline, and isoquinoline derivatives.

99 lines in the presence of tert-butyl nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 degree

100 ylation of substituted tetrahydroquinolines, quinolines, and 3,4-dihydro-2-quinolinones at most posit

101 multifunctional naphthalenes, phenanthrenes, quinolines, and benzo[b]carbazoles via Knoevenagel conde

102 tron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbenzenes leading

103 soquinoline derivatives differ from those of quinolines, and the most pronounced differences are foun

104 activity of several isomeric protonated (iso)quinoline- and acridine-based biradicals was examined.

105 Several examples of the quinoline-annulated porphyrins were crystallographically

106 tion and inhibition by chloroquine, a common quinoline antimalarial drug.

107 d in situ surface observations and show that quinoline antimalarials inhibit beta-hematin crystal sur

108 tion, classical or nonclassical; and whether quinoline antimalarials inhibit crystallization by seque

109 Quinoline antimalarials target hemozoin formation causin

110 ed sensitivity to chloroquine and some other quinoline antimalarials, but exhibit no or minimal chang

111 l mode of hemozoin growth inhibition for the quinoline antimalarials.

112 Chiral acetyl-protected aminoalkyl quinoline (APAQ) ligands were recently discovered to aff

113 The 8-amino quinoline (AQ) directing group can easily be removed, al

114 ium carbonate modified with lead acetate and quinoline are widely employed industrially for the parti

115 Quinolines are common pharmacophores present in numerous

116 These quinolines are unethically used in beekeeping, and a zer

117 e yields of the target 2,4-bisphosphorylated quinolines are up to 77%.

118 o be facilitated by harnessing the substrate quinoline as an N-ligand, and evidence of the palladium-

119 lective three-component synthesis of 2-alkyl quinolines as well as more common aryl quinolines.

120 However, quinoline-based ALLINIs impose a low genetic barrier for

121 ilar pocket at the IN dimer interface as the quinoline-based ALLINIs, the lead compound, 5, inhibited

122 Recently discovered quinoline-based allosteric IN inhibitors (ALLINIs) poten

123 Quinoline-based analogues showed lower inhibitory activi

124 hibited IN mutants that confer resistance to quinoline-based compounds.

125 The quinoline-based FAP inhibitor (FAPI) PET tracer (68)Ga-F

126 The quinoline-based FAP-inhibitor PET tracer, (68)Ga-FAPI-04

127 Herein, we present our research toward novel quinoline-based hFP-R antagonists, including synthesis a

128 A quinoline-based ligand effectively promotes the palladiu

129 The use of a newly developed quinoline-based ligand is essential for the cross-coupli

130 A quinoline-based ligand was shown to promote palladium-ca

131 Three pyridine- and quinoline-based ligands are developed to match different

132 The recent development of quinoline-based ligands targeting cancer-associated fibr

133 c acid-derived amides was developed by using quinoline-based ligands.

134 eport design, synthesis, and validation of a quinoline-based novel class of topoisomerase 1 (Top1) in

135 We previously reported potent quinoline-based PDE5 inhibitors (PDE5Is) for the treatme

136 The recent development of quinoline-based PET tracers that act as FAP inhibitors (

137 The recent development of quinoline-based PET tracers that act as fibroblast-activ

138 Methods: Novel quinoline-based radiotracers were synthesized by organic

139 gas-phase reactivities of several protonated quinoline-based sigma-type (carbon-centered) mono-, bi-,

140 A complimentary catalyst system (quinoline-based silane ligand with [(COD)IrOMe](2) ) was

141 cascade delivering a series of pyrrolo[1,2-a]quinolines bearing phosphonate or phosphine oxide moieti

142 rido[1,2-a] benzimidazole, benzimidazo[1,2-a]quinolines, benzimidazo [1,2-a]pyrazine, benzo[4,5] imid

143 described for the synthesis of various fused quinoline, benzoquinoline, and naphthoquinoline derivati

144 o these FIT-PNAs, we have introduced the bis-quinoline (BisQ) cyanine dye that emits light in the red

145 etrazolyl)quinolines or 1,2,3-triazolo[1,5-a]quinoline by conventional flash vacuum pyrolysis (FVP) w

146 etitive Bronsted acid-catalyzed reduction of quinoline by Hantzsch ester.

147 The reduction of quinoline by SmI2 results in an instantaneous [2 + 3] cy

148 epared a number of di- and trifunctionalized quinolines by selective metalation of chloro-substituted

149 odies a quaterpyridine backbone but with the quinoline C8 providing an additional sp(2) center separa

150 The NPAHs 1,4-dihydro(iso)quinoline and (iso)quinoline can be synthesized through reaction of pyridyl

151 Starting from the micromolar 8-quinoline carboxamide high-throughput screening hit 1a,

152 A novel series of 3-quinoline carboxamides has been discovered and optimized

153 ze this intermediate to the pyrrolo[4,3,2-de]quinoline characteristic of the lymphostins resulted in

154 n in malaria parasites and the target of the quinoline class of antimalarials.

155 By contrast, quinoline-class antimalarials inhibit the formation of h

156 ivity in the regioselective hydrogenation of quinoline, compared with PtNPs of 5.3 nm, allowing the r

157 fungal metabolite brefeldin A (BFA) and the quinoline compound Golgicide A (GCA) inhibited HSV-1 ent

158 vities of up to 94:6 e.r. with 2-substituted quinolines containing C8-amino functionality.

159 sciplinary approaches, we identified a novel quinoline core ligand, BMPQ-1, which bound to human telo

160 Cyclic ether fused-quinolines could also be accessed using this fast, opera

161 Herein, we report a coumarin-quinoline (CQ) conjugate-based turn-on near-infrared (NI

162 The use of a quinoline derivative as a ligand also enables C(sp(3))-H

163 The reverse hydrogenation reaction of quinoline derivatives (H2 storage) was also optimized an

164 strategy, a library of 5-methyl-indolo[3,2-c]quinoline derivatives (IQc) with a range of alkyldiamine

165 This approach resulted in quinazoline-quinoline derivatives as potent inhibitors of DNMT3A and

166 e most potent ligand among the imidazo[1,5-a]quinoline derivatives described so far.

167 Moreover, due to the importance of quinoline derivatives for a variety of applications, the

168 A new approach to benzo[f]quinoline derivatives has been found by an effective for

169 In this study, a new series of more than 60 quinoline derivatives has been synthesized and evaluated

170 in the presence of KF gave 3-(2-hydroxyaryl)quinoline derivatives in good yields.

171 The use of AgSbF(6) as a catalyst led to quinoline derivatives in high yields.

172 in 2-(2-vinylstyryl)oxazoles to form benzo[f]quinoline derivatives proceeds on the S1 PES via a stepw

173 ly obtained pK(aH) values of quinolino[7,8-h]quinoline derivatives show that N(4),N(4),N(9),N(9)-tetr

174 strategies toward the synthesis of bioactive quinoline derivatives such as chloroquine analogues.

175 This method could also be applied to other quinoline derivatives using appropriate alkynes.

176 A wide scope of N-arylimine and quinoline derivatives was demonstrated and good efficien

177 A series of imidazo[1,5-a]quinoline derivatives was designed and synthesized as ce

178 rotective properties for these imidazo[1,5-a]quinoline derivatives.

179 lled C(sp(3))-H arylation using pyridine and quinoline derivatives: The former promotes exclusive mon

180 the generation of a variety of indolo[2,3-b]quinolines derivatives in good to moderate yields with a

181 amily of potential autophagy blockers is the quinoline-derived antimalarial family, including chloroq

182 trate scope, and mechanistic experiments for quinoline-directed alkene oxyacylation.

183 e intramolecular oxyacylation of alkenes via quinoline-directed C-O bond activation.

184 alkaloid core is efficiently prepared from a quinoline, employing a method which relies on a newly de

185 widely used antimalarial drugs belong to the quinoline family.

186 prised of an NHS-carbamate reactive group, a quinoline fluorophore, and a tertiary amine for enhancin

187 ibenzothiophene, fluorenones, xanthones, and quinoline fractions.

188 ort the first synthesis of 2,3-disubstituted quinolines from anilines and aromatic or aliphatic epoxi

189 gioselective synthesis of C-3-functionalized quinolines from azadienes (in situ generated from 2-amin

190 A concise synthesis of quinoline-fused eight-membered rings from simple startin

191 as (ii) the presence of the nitrogen on the quinoline group, and (iii) of a hydrophobic group on the

192 Ar reaction sequence in the same molecule of quinoline has been realized.

193 lithium reagents to non-activated imines and quinolines has been accomplished in green, biorenewable

194 ndolo[2,3-b]quinolines and benzothieno[2,3-b]quinolines has been developed by employing the freshly p

195 II) ion detection reagent, 10-hydroxybenzo[h]quinoline (HBQ), with an optical field enhanced silicon

196 containing benzannulated phenanthridine and quinoline heterocycles paired with amido donors.

197 f 10 3-imidazo[1,2-a]pyridin-tetrazolo[1,5-a]quinolines in 28-94% yields via a novel one-pot Groebke-

198 lkenyl iodides converted to multisubstituted quinolines in good to excellent yields.

199 good to excellent yields on the platform of quinolines in the presence of KOH in aqueous media at ro

200 ade sequence to access highly functionalized quinolines including the core structures of an antiproto

201 ding pyrimidines, N-substituted piperidines, quinolines, indoles, N-substituted imidazoles, triazoles

202 s an N-ligand, and evidence of the palladium-quinoline interaction is provided by (1)H-(15)N HMBC NMR

203 In contrast to quinolines, introduction of amine side chains did not le

204 -IQ) formed by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a highly mutagenic and carcinogenic hete

205 Quinolino[7,8-h]quinoline is a superbasic compound, with a pK(aH) in ace

206 trolled synthesis of very highly substituted quinolines is described.

207 ne, and quinoline, to prepare pyrimido[1,6-a]quinolines is reported.

208 e structure-based design and optimization of quinoline lead compounds to identify FT-2102, a potent,

209 The use of a tailor-made quinoline ligand is also crucial for this reaction to pr

210 covery of chiral acetyl-protected aminoethyl quinoline ligands that enable asymmetric palladium inser

211 f the readily available 8-hydroxy- or 8-thio-quinoline ligands, which are well known for their strong

212 catalyzed C(sp(3))-H bromination, enabled by quinoline ligands.

213 We report that binuclear benzo[h]quinoline-ligated Ni(II) complexes, upon oxidation, unde

214 inant of resistance to several quinoline and quinoline-like antimalarial drugs.

215 ponsiveness to a wide range of quinoline and quinoline-like compounds.

216 The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatibl

217 mine (HAA) 2-amino-3,4-dimethylimidazo(4,5-f)quinoline (MeIQ).

218 ly reported the therapeutic potential of the quinoline methanol Vacquinol-1 (1) that targets glioblas

219 pment of antileishmanial agents, a series of quinoline-metronidazole hybrid compounds was synthesized

220 hmanial lead and emphasize the importance of quinoline-metronidazole series as a suitable platform fo

221 state places significant spin density on the quinoline moiety of the 1-isocyTPQA ligand positioned tr

222 By incorporation of an indole or a quinoline moiety to the 9H-pyrimido[4,5-b]indole core, w

223 variety of functional groups on the 8-methyl quinoline moiety.

224 henyl group adjacent to the oxime, forming a quinoline moiety.

225 pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (MP-10) in rodents and in monkeys.

226 strated by gram scale synthesis of C-8 amide quinoline N-oxide and by converting this amidated produc

227 study revealed five-membered rhodacycle with quinoline N-oxide as a key intermediate for regioselecti

228 as an amidating reagent for C8-amidation of quinoline N-oxide for the first time.

229 II)-catalyzed C-8 selective C-H amidation of quinoline N-oxide using dioxazolone as an amidating reag

230 protocol for C8-bromination and amidation of quinoline N-oxide was developed.

231 o-triphenylmonoquinoline-annulated porphyrin quinoline N-oxide, possessing a slightly shifted and sha

232 Interestingly, 2-substituted quinoline N-oxides also afforded good yields of the corr

233 ynthesis of various 2-anilinoquinolines from quinoline N-oxides and aryldiazonium salts in acetonitri

234 A wide substrate scope with respect to quinoline N-oxides and olefins (activated acrylates and

235 bstrates and by converting the C8-olefinated quinoline N-oxides into various other useful molecules.

236 m-catalyzed distal C(sp(2))-H olefination of quinoline N-oxides is developed.

237 Reactions of various 2-substitued quinoline N-oxides with ortho-(trimethylsilyl)aryltrifla

238 a family of closely related pyrrolo[4,3,2-de]quinoline natural products produced by Streptomyces and

239 between the phenol oxygen (proton donor) and quinoline nitrogen (proton acceptor), dO...N, giving ris

240 ic features of the bridging motif as well as quinoline nucleus were explored.

241 with positions 4 and 5 of the imidazo[1,5-a]quinoline nucleus.

242 hibitors were added to P450 3A4 in 7-benzoyl quinoline O-debenzylation reactions, and similar pattern

243 The addition to pyridines and quinolines occurs under almost identical conditions and

244 The quinoline oligoamides were rationally functionalized by

245 icient preparation of selected pyrrolo[1,2-a]quinolines on multigram scale without any safety concern

246 f either a 2-oxo-1,2-dihydropyrrolo[4,3,2-de]quinoline or an unusual N,C-linked tetrahydropyrroloquin

247 ethylquinolines generated from (5-tetrazolyl)quinolines or 1,2,3-triazolo[1,5-a]quinoline by conventi

248 hydrocarbons (aza-(P)AHs; namely, pyridine, quinoline, phenanthridine, and benzo[d]thiazole) is repo

249 ts and C-substituents ranging from coumarin, quinoline, phthalimide to truxene.

250 A family of quinoline-platinum(II) complexes as efficient photocatal

251 rid-2'-yl)-8-(1'',10''-phenanthrolin-2''-yl)-quinoline (ppq) embodies a quaterpyridine backbone but w

252 (1'',10''-phenanthrol-2''-yl)-2-(pyrid-2'-yl)quinoline (ppq), has been prepared by two sequential Fri

253 rom Hantzsch ester, a weak Bronsted acid, to quinoline prior to hydride reduction was identified as t

254 scope of both heterocyclic arenes (pyridine, quinoline, pyrazole, imidazole, furan, thiophene, benzof

255 n-containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivati

256 bioactive heterocyclic backbones containing quinoline, pyrrolidone, and beta-lactam with high bond-f

257 logy is further demonstrated in synthesis of quinoline-quinolone hybrid as well as 6-aryl-benzofuro[3

258 iosynthesized by (18)F-introduction onto the quinoline rather than the pyrazole moiety of the MP-10 p

259 Quinolines react with acylacetylenes and secondary phosp

260 ndolo[2,3-b]quinolines and benzothieno[2,3-b]quinolines, respectively, in moderate to excellent yield

261 vealed that the geometric disposition of the quinoline ring at the C8 chiral carbon of cinchona-enami

262 AR) of the 4-, 6-, and 8-substituents of the quinoline ring resulted in the identification of approxi

263 e former originates from the presence of the quinoline ring, which slows the formation of the off-cyc

264 one hybrid as well as 6-aryl-benzofuro[3,2-c]quinoline scaffold.

265 design of this series centered on morphing a quinoline series recently disclosed in the patent litera

266 nhibition with the model substrate 7-benzoyl quinoline showed lag phases in several cases, consistent

267 Pyridine- and quinoline-stabilized silyl cations have been prepared, a

268 oups with respect to both the alkyne and the quinoline starting materials and the products are easily

269 addition to the C4 position of 4-substituted quinoline substrates, with subsequent Hantzsch ester-pro

270 e, liberating water (and H(2) in the case of quinoline synthesis) as the sole byproduct.

271 first generation of fluoroalkyl-substituted quinoline tau binding ligands with suboptimal physicoche

272 as palladium-catalyzed coupling to generate quinolines that can be substituted at every position of

273 thereby completing S(N)(H)Ar reaction, with quinolines, the reaction stops at the formation of the a

274 partners, including pyridines, pyrimidines, quinolines, thiophenes, and piperidines.

275 it is preferable to lower the LUMO energy of quinoline through protonation by Hantzsch ester as a Bro

276 cyclopentenyl ring to the plane of the core quinoline to be a crucial determinate of PAM activity.

277 oaddition, using sulfonyl azide, alkyne, and quinoline, to prepare pyrimido[1,6-a]quinolines is repor

278 These reactions are exclusively enabled by quinoline-type ligands.

279 component Povarov reaction forms 2,3-dialkyl quinolines under the same green conditions that enable t

280 Quinolines undergo catalyst-free double CH-functionaliza

281 f [1,3,4]thiadiazolo[3',2':1,2]imidazo[4,5-c]quinolines using a Pictet-Spengler reaction.

282 hesis of alkoxy-substituted 3H-pyrrolo[3,4-b]quinolines using alcohols as nucleophiles.

283 reductive functionalization of pyridines and quinolines using catalytic iridium; thus, inexpensive an

284 he synthesis of densely substituted 4-alkoxy quinolines via an oxonium ion triggered alkyne carboamin

285 /imidazole-substituted 1,3-dihydrofuro[3,4-b]quinolines via C-O and C-N bond formation.

286 (4-(2,4-dinitrophenylsulfonyl)piperazin-1-yl)quinoline (VR23) as a small molecule that potently inhib

287 edlander and Combes syntheses of substituted quinolines were conducted in charged microdroplets produ

288 ing cholesterol derivatives, and substituted quinolines were obtained in good yields by using a minut

289 A wide variety of highly substituted quinolines were obtained with moderate to excellent yiel

290 A series of 18 3-tetrazolyl-tetrazolo[1,5-a]quinolines were synthesized in 21-90% yields via a novel

291 d N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity a

292 ble an important class of C-3-functionalized quinolines, which are difficult to access.

293 lyzed C(sp(3))-H bond alkylation of 8-methyl quinoline with maleimides is reported.

294 of unactivated C(sp(3))-H bonds of 8-methyl quinolines with arylboronic acids to synthesize diarylme

295 The reaction of quinolines with CF(3)-ynones resulted in the formation o

296 y selective metalation of chloro-substituted quinolines with metal amides followed by reaction with d

297 ielding dearomative C-4 functionalization of quinolines with organometallics with nearly absolute reg

298 For the quinophthalone type dye Quinoline Yellow (E104), the adsorption is also maximal

299 cluding Tartrazine (E102), Chrysoine (E103), Quinoline Yellow (E104), Yellow 2G (E107), Sunset Yellow

300 m reactions of pyridine-, isoquinoline-, and quinoline ynones, via 5-exo-dig cyclization.