ライフサイエンスコーパス: quinolone

1 ine, thiazole, quinoxaline, benzoxazole, and quinolone.

2 ) to form the signal molecule 2-heptyl-4(1H)-quinolone.

3 pare patients treated with azithromycin vs a quinolone.

4 which makes this enzyme produce the diketide quinolone.

5 to pyridyl 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolones.

6 a promoter for the synthesis of substituted quinolones.

7 d tetrahydroquinolines to afford indoles and quinolones.

8 and parC recognized to confer resistance to quinolones.

9 addition, 13 (44.8%) of 29 patients received quinolones.

10 ins (four cases), cephalosporins (41 cases), quinolones (15 cases), and pristinamycin (seven cases) w

11 ent publications report in vitro activity of quinolone 3-esters against the bc1 protein complex of Pl

12 4-Quinolone-3-carboxamide derivatives have long been recog

13 roperties of previously reported 4-hydroxy-2-quinolone-3-carboxamides, a structural optimization prog

14 nt class of orally active antimalarial 4(1H)-quinolone-3-diarylethers.

15 The synthesis of the chromone- and quinolone-3-sulfonamide intermediates features formylati

16 nd in-house screening of a limited number of quinolones (50 compounds) identified approximately 100 h

17 d out to downselect the most promising 4(1H)-quinolones, 7, 62, 66, and 67, which possessed low-nanom

18 Carboxanilides 6a-c and quinolones 9a-c and 11a were evaluated for DNA binding p

19 d the divalent metal ions that could support quinolone activity.

20 olin: adjusted OR = 0.49; 95% CI, 0.34-0.71; quinolone: adjusted OR = 0.55; 95% CI, 0.35-0.87) for co

21 a potential route to enhance the activity of quinolones against E. coli persisters.

22 A novel quinolone alkaloid, vitiquinolone (5) together with eigh

23 elos that is involved in the biosynthesis of quinolone alkaloid.

24 Quinolone alkaloids, found abundantly in the roots of ba

25 Use of azithromycin alone or a quinolone alone for treatment of Legionella pneumonia wa

26 Quinolones alone were used in 28.8%, azithromycin alone

27 Drugs in known classes such as new quinolones, aminoglycosides, tetracyclines, and beta-lac

28 r the anthranilate-derived production of the quinolone and acridone alkaloid by type III polyketide s

29 thaliana and that the plant is sensitive to quinolone and aminocoumarin antibiotics, compounds that

30 her that enzyme is indeed the target for the quinolone and aminocoumarin antibiotics.

31 ions is a two-point hydrogen bonding between quinolone and catalyst enabling efficient energy transfe

32 Quinolone and fluoroquinolone antibiotics are potent, br

33 ruginosa PAO1-based 2-heptyl-3-hydroxy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone r

34 ing (QS) molecules, 2-heptyl-3-hydroxy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone,

35 d to compare the rate of perforation between quinolone and neomycin plus hydrocortisone ear drop-expo

36 iptions was used to compare TMP risk between quinolone and neomycin-exposed patients.

37 this ParE toxin, PaParE, against effects of quinolone and other antibiotics.

38 Isolates were screened for cephalosporin, quinolone and tetracycline resistance genes using PCR.

39 ated with resistance to isoniazid, rifampin, quinolones and injectable drugs in Mycobacterium tubercu

40 vel class of N-linked aminopiperidinyl alkyl quinolones and naphthyridones that kills Mtb by inhibiti

41 s at the aliphatic C3-substituent of various quinolones and pyridones.

42 racis topoisomerase IV, their sensitivity to quinolones and related drugs and their use of metal ions

43 l molecules including Pseudomonas-associated quinolones and rhamnolipids in feces, setting the stage

44 t-off values of beta-lactams, tetracyclines, quinolones and sulfonamides were determined to be 8 ng/m

45 ansport-kinetics of antimicrobial drug ions (quinolones and sulfonamides) at a water/oil interface.

46 of antibiotics (beta-lactams, tetracyclines, quinolones and sulfonamides) in milk within 20 min.

47 for the quantification of 14 antimicrobials (quinolones and tetracyclines) in fish.

48 for interactions between clinically relevant quinolones and topoisomerase IV and provide a likely mec

49 decreased development of new cephalosporin, quinolone, and macrolide drugs and reduced participation

50 d chromones, as well as a thiochromone and a quinolone, and the resulting vinylogous addition product

51 ng/mL for tetracyclines, 0.08-2.0 ng/mL for quinolones, and 0.1-3.98 ng/mL for sulfonamides, with li

52 ans, thiophenes, benzothiophenes, pyrazoles, quinolones, and chromones can be applied.

53 necrosis should be favored (eg, carbapenems, quinolones, and metronidazole).

54 -level susceptibility to most macrolides and quinolones, and moderate susceptibility to most tetracyc

55 cides to polar drugs, including penicillins, quinolones, and tetracyclines.

56 In contrast to the quinolone- and acridone-producing A. marmelos QNS, C. mi

57 and microbiological evaluation of chromone-, quinolone-, and benzoxazinone-3-sulfonamide derivatives

58 oval of nalidixic acid (NAL), a recalcitrant quinolone antibacterial agent.

59 Quinolone antibacterials represent one of medicine's mos

60 Guidelines recommend azithromycin or a quinolone antibiotic for treatment of Legionella pneumon

61 this study, the adsorption of a widely used quinolone antibiotic in aquaculture, Oxolinic acid (OA),

62 Oxolinic acid (OA) is a widely used quinolone antibiotic in aquaculture.

63 Here we show that the quinolone antibiotic trovafloxacin is a novel PANX1 inhi

64 that the reactive transport of a widely used quinolone antibiotic, pipemidic acid (PIP), in MnO(2)-co

65 ed a third-generation cephalosporin and/or a quinolone antibiotic.

66 Quinolone antibiotics have antiviral properties against

67 Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as bro

68 raphic method for the determination of seven quinolone antibiotics in tissue of Atlantic salmon (Salm

69 s the capacity of magnetite to bind not only quinolone antibiotics such as nalidixic acid (NA) and fl

70 Comparing different quinolone antibiotics suggests that certain structural f

71 ation of Escherichia coli persisters against quinolone antibiotics which target the GyrA subunit of D

72 use of growth phase-dependent persistence to quinolone antibiotics.

73 occus aureus, and Mycobacterium smegmatis to quinolone antibiotics.

74 nes were shown to sensitize P. aeruginosa to quinolones, antibiotics that elicit a strong SOS respons

75 Quinolones are antibiotics that are accredited in human

76 Quinolones are important antibiotics, partially because

77 Although quinolones are the most commonly prescribed antibacteria

78 Although quinolones are widely used to treat bacterial infections

79 ated mutations [MRMs]) and in parC and gyrA (quinolone-associated mutations) were detected by targete

80 To guide the development of new quinolone-based agents, it is critical to understand the

81 Accordingly, a variety of quinolone-based FAP inhibitors (FAPIs) coupled to chelat

82 llographic and biochemical studies show that quinolone binding involves a water/metal-ion bridge betw

83 structure of cleaved complexes, two modes of quinolone binding must exist.

84 raphy reveals that 34 occupies the classical quinolone binding site in the topoisomerase IV-DNA cleav

85 he data support the existence of a secondary quinolone-binding mode in which the quinolone C7 ring sy

86 ificities and produces not only acridone and quinolone but also chalcone, benzophenone, and phloroglu

87 nvolves a water/metal-ion bridge between the quinolone C3-C4 keto-acid and amino acids in helix-4 of

88 econdary quinolone-binding mode in which the quinolone C7 ring system interacts with GyrA; the data a

89 ether the infected strains were resistant to quinolone can be performed simultaneously on a single ch

90 completely restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12

91 Benzyl quinolone carboxylic acid (BQCA) is an unprecedented exa

92 ated the actions at an M(1) DREADD of benzyl quinolone carboxylic acid (BQCA), a positive allosteric

93 ently described allosteric modulator, benzyl quinolone carboxylic acid (BQCA), behaves according to a

94 sclosures of an independent discovery of the quinolone class of antibacterials have been almost entir

95 The quinolone class of antibiotics, which targets bacterial

96 ith antibiotics belonging to the widely used quinolone class.

97 cepts point to new approaches for developing quinolone-class compounds that have increased potency ag

98 up other than the commonly used pyridine and quinolone classes for Cp*Co(III) -catalyzed C(sp(3) )-H

99 ntiates antibiotics from the beta-lactam and quinolone classes.

100 Quinolones containing the amine-based side chain were se

101 led subtly by manipulation of the privileged quinolone core at the 2 or 3 position.

102 itution pattern on the benzenoid ring of the quinolone core significantly influenced reactivity with

103 s, the most promising of which contained the quinolone core.

104 give ring-fused indoles B, quinolines C, or quinolones D depending on the reaction conditions employ

105 Chemically distinct from other quinolones, delafloxacin exhibits enhanced potency, part

106 The 6-amino-7-[4-(2-pyridinyl)-1-piperazinyl]quinolone derivative 8 proved to be the best compound of

107 ty of vosaroxin, a first-in-class anticancer quinolone derivative, plus cytarabine in patients with r

108 Fused pyrimidinone and quinolone derivatives that are of potential interest to

109 Vosaroxin, a quinolone-derived intercalating agent has several proper

110 We evaluated two quinolone disks and five fluoroquinolone disks for their

111 Independent risk factors were quinolone dispensed to the mothers (odds ratio [OR], 1.5

112 Independent risk-factors were quinolone dispensed to the mothers [Odds Ratio (OR) 1.50

113 Data on quinolones dispensed to the mother, any antibiotics disp

114 Data on quinolones dispensed to the mother, any antibiotics disp

115 nt SIMS imaging at the same location detects quinolone distributions in excellent agreement with the

116 Macrolides, quinolones, doxycycline, nonaromatic antiepileptics, and

117 that an A. thaliana mutant resistant to the quinolone drug ciprofloxacin has a point mutation in ATG

118 argeted DNA gyrase that is the target of the quinolone drug ciprofloxacin; this has important consequ

119 sistance to a family of antibiotics known as quinolones due to single-point mutations.

120 Patients exposed to quinolone ear drops had a higher risk of perforation, wi

121 This study examined whether the use of quinolone ear drops increased the risk of perforation wi

122 Exposure of children with TT to quinolone ear drops is associated with increased risk of

123 Use of quinolone ear drops to treat AOE is associated with a pr

124 Use of quinolone ear drops was associated with increased risk f

125 This study investigated whether quinolone ear drops, with or without corticosteroids, in

126 tients/families accordingly when prescribing quinolone ear drops.

127 ification, resulting in metabolically stable quinolones effective against multi drug resistant (MDR)

128 its natural substrates and those of the Nor quinolone efflux pumps are unknown.

129 mice using a combination of an endochin-like quinolone (ELQ) prodrug and atovaquone.

130 Endochin-like quinolones (ELQ) were prepared by a novel chemical route

131 cs, beta-lactam (ampicillin and penicillin), quinolone (enoxacin), aminoglycoside (kanamycin and neom

132 g modes raises the possibility that multiple quinolone-enzyme-DNA complexes can form, a discovery tha

133 preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalaria

134 The sensor is based on a quinolone fluorophore incorporating a boronic acid recog

135 We evaluated 16 quinolone/fluoroquinolone disks for their ability to det

136 ructure-activity relationship study on 4(1H)-quinolones, focusing on the reduction of cross-resistanc

137 athogen Pseudomonas aeruginosa employs alkyl quinolones for cell-to-cell communication.

138 tween the lowest energy hydroxyquinoline and quinolone forms is 27 and 38 kJ mol(-1), for 5Me-HQE and

139 ence for the preparation of functionalized 4-quinolones from 2-iodoanilines and alkynes via two diffe

140 antibiotic efficacy in clinical isolates for quinolones from drug affinity (R2>0.9).

141 s described to synthesize highly substituted quinolones from pyridones.

142 tivity of some aryl propionic acids, (fluoro)quinolones, furocoumarins, metal coordination complexes,

143 The quinolone-fused lactam LP99 is now reported as the first

144 ns are novel fungal alkaloids that feature a quinolone-gamma-lactam hybrid, which is a potential phar

145 panding the paradigm for the biosynthesis of quinolone-gamma-lactam natural products via Dieckmann co

146 the enzymatic basis for the formation of the quinolone-gamma-lactam structure.

147 lowed by Dieckmann condensation, to form the quinolone-gamma-lactam.

148 losporin-related SCARs were able to tolerate quinolones, glycopeptides, and carbapenems.

149 isolates were found to be susceptible to the quinolone group of antibiotics (moxifloxacin followed by

150 rms and plays a functional role in mediating quinolone-gyrase interactions.

151 Indolo[3,2-c]quinolones have been efficiently synthesized via an acid

152 ely used to treat bacterial infections, some quinolones have unexplained side effects, including deat

153 ne known inhibitor, hydroxy-2-dodecyl-4-(1H)-quinolone (HDQ), and this was used along with a range of

154 rther demonstrated in synthesis of quinoline-quinolone hybrid as well as 6-aryl-benzofuro[3,2-c]quino

155 One such compound is 4(1H)-quinolone ICI 56,780, which is known to be a causal prop

156 Deciphering the complexity of quinolone IDHR seems mandatory.

157 Cefazolin sodium and quinolone in combination with an anaerobic agent were as

158 for assessment and prediction of the fate of quinolones in sediment-seawater interface systems.

159 otic and 1359 (3.2%) of the mothers received quinolones in the 6 months preceding bacteriuria.

160 tic and 1,359 (3.2%) of the mothers received quinolones in the 6 months preceding bacteriuria.

161 nfection among isolates usually sensitive to quinolones in the levofloxacin group vs placebo (14/24 [

162 use on gram-negative bacterial resistance to quinolones in their offspring.

163 +) concentration required to produce maximal quinolone-induced DNA cleavage and restricted the divale

164 Consequently, the mar locus reduces quinolone-induced DNA damage and the ability of tetracyc

165 A repair, thus reducing antibiotic entry and quinolone-induced DNA damage.

166 s are proposed to serve as a critical enzyme-quinolone interaction site by anchoring a water-metal io

167 water-metal ion bridge that is critical for quinolone interactions with other bacterial type II topo

168 mutation of both residues abrogated protein-quinolone interactions.

169 ermination of 2-amino-3-methyl imidazo[4-5-f]quinolone (IQ), 2-amino-3, 8-dimethlylimidazo[4, 5-f]qui

170 2-Amino-3-methylimidazo[4,5-f]quinolone (IQ), a heterocyclic amine found in cooked mea

171 quinolone signal (PQS; 2-heptyl-3-hydroxy-4-quinolone) is one of these signals, and it is known to b

172 sing resistance to multiple drugs, including quinolones, is associated with decreased susceptibility

173 tabolism is sufficient to sensitize cells to quinolone killing.

174 quent Mtb screening of the complete in-house quinolone library (350 compounds) identified a further a

175 e (IQ), 2-amino-3, 8-dimethlylimidazo[4, 5-f]quinolone (MeIQ), 2-amino-3,4- dimethylimidazo[4,5-f]qui

176 ity, and suggest that re-engineering certain quinolones might help develop newer antibacterials.

177 and it controls the production of 2-alkyl-4-quinolone molecules which are important for pathogenicit

178 Included ear drops were quinolones (ofloxacin, ciprofloxacin plus hydrocortisone

179 for isoniazid, 98.7% for rifampin, 97.6% for quinolones (ofloxacin, levofloxacin, or moxifloxacin), 9

180 n carboxylate or amide group of deprotonated quinolone or sulfonamide, respectively, may play a domin

181 Our findings link growth-dependent quinolone persistence to discrete impairments in respira

182 We show that the stimulation of quinolone persisters is due to indole pulse, rather than

183 m beta-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene q

184 l zinc ions detection was developed based on quinolone platform.

185 QS signal molecule 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS), a minimal medium containing PQS as the

186 Quinolone prescription to mothers was linked to increase

187 Quinolones prescription to mothers was linked to increas

188 nones with 2-formyl azaarenes (pyridines and quinolones) provides azaaryl (pyridyl and quinolyl) auro

189 The small molecule 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas Quinolone Signal [PQS]) is one of

190 izes the small molecule 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal [PQS]).

191 gen-containing heterocycles such as indoles, quinolones, pyrazoles, and others.

192 s related to an impaired production of alkyl quinolone QS signals, likely prompted by the reduced ava

193 anese oxides used as engineered geomedia for quinolone remediation and in developing transport models

194 olates from Nigeria for six plasmid-mediated quinolone resistance (PMQR) genes.

195 he topoisomerase genes, but plasmid-mediated quinolone resistance (PMQR) mechanisms have also been de

196 gyrB, parC, and parE and/or plasmid-mediated quinolone resistance (PMQR) mechanisms including qnr var

197 d for Escherichia coli with plasmid-mediated quinolone resistance (PMQR), extended-spectrum beta-lact

198 industrial region in India were analyzed for quinolone resistance (qnr) genes by quantitative PCR.

199 ffective therapy, but treatment failures and quinolone resistance are emerging.

200 The most common causes of quinolone resistance are mutations of a specific serine

201 the findings will inform the development of quinolone resistance assays needed to ensure optimal sel

202 t mutations at GyrA(A90) and GyrA(D94) cause quinolone resistance by disrupting the bridge-enzyme int

203 y by target-based mutations in the GyrA/ParC quinolone resistance determining region, have eroded the

204 rm significant contacts with residues in the quinolone resistance determining region.

205 pe SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7).

206 Quinolone resistance genes were detected in 42% of well

207 Quinolone resistance has been documented in the paediatr

208 Quinolone resistance has been documented in the pediatri

209 macrolide resistance as well as emergence of quinolone resistance has occurred.

210 Rising macrolide and quinolone resistance in Mycoplasma genitalium necessitat

211 talium (MG) exceeds 50% in many regions, and quinolone resistance is increasing.

212 re unlikely to exist in nature; nonetheless, quinolone resistance proteins have been identified.

213 The mechanism by which plasmid-borne quinolone resistance proteins promotes the selection of

214 Quinolone resistance was detected in 2,182 (5.3%) of uri

215 Quinolone resistance was detected in 2182 (5.3%) urine c

216 No mutations for macrolide/quinolone resistance was detected.

217 ent; 31% had parC mutations (all outside the quinolone resistance-determining region).

218 timicrobial resistance genes and mutation in quinolone resistance-determining regions (QRDR) in fecal

219 Mutations in the quinolone resistance-determining regions (QRDR) of gyrA

220 lmonella due to chromosomal mutations in the quinolone resistance-determining regions (QRDRs) of the

221 nolones that overcome existing GyrA-mediated quinolone resistance.

222 kely mechanism for the most common causes of quinolone resistance.

223 tibiotic prophylaxis in case of selection of quinolone resistance.

224 italium (MG) exceeds 50% in many regions and quinolone-resistance is increasing.

225 Here we outline the impacts of quinolone-resistance mutations in relation to the fitnes

226 years with community acquired, gram-negative quinolone resistant bacteriuria.

227 Expression/purification of the quinolone-resistant A. thaliana gyrase yields active enz

228 ked to increased risk of community-acquired, quinolone-resistant bacteria in their offspring, by abou

229 nked to increased risk of community-acquired quinolone-resistant bacteria in their offspring, by abou

230 years with community acquired, gram-negative quinolone-resistant bacteriuria.

231 er children had 1.33-1.43 increased odds for quinolone-resistant bacteriuria.

232 er children had 1.33-1.43 increased odds for quinolone-resistant bacteriuria.

233 istant gram-negative bacteria (P = .016), or quinolone-resistant gram-negative bacteria (QR-GNB) (P =

234 bacteriostatic activity for Cip-AcCl with a quinolone-resistant GyrA-G81C variant of Escherichia col

235 nother multivariate analysis performed among quinolone-resistant isolates, treatment failure was 3 ti

236 esistance proteins promotes the selection of quinolone-resistant mutants is unclear.

237 Quinolone-resistant N. gonorrhoeae and reduced cefixime

238 Quinolone-resistant N. gonorrhoeae has arisen multiple t

239 Acinetobacter baumannii [8], carbapenem- and quinolone-resistant Pseudomonas aeruginosa [26], and der

240 inst most Gram-positive pathogens, including quinolone-resistant strains, which is further enhanced a

241 highly effective in treating macrolide- and quinolone-resistant strains.

242 The quinolone ring is noted as participating in a pi-stackin

243 he general 6-chloro-7-methoxy-2-methyl-4(1H)-quinolone scaffold which were substituted at the 3-posit

244 ive antimalarial pharmacophores, such as the quinolone scaffold, to yield potent and highly efficacio

245 een appended to the C7 position of different quinolone scaffolds do not take advantage of specific co

246 e envisioned, and then created, novel 4-(1H)-quinolone scaffolds that target the cytochrome bc1 compl

247 Controls were similar children with quinolone sensitive bacteriuria.

248 Moreover we show that, as in bacteria, the quinolone-sensitive (wild-type) allele is dominant to th

249 Controls were similar children with quinolone-sensitive bacteriuria.

250 Extensive physicochemical evaluation of the quinolone series was carried out to downselect the most

251 by P. aeruginosa and whether the Pseudomonas quinolone signal (PQS) and the MucD periplasmic protease

252 The Pseudomonas quinolone signal (PQS) compound is a secreted P. aerugin

253 The Pseudomonas aeruginosa quinolone signal (PQS) is a quorum sensing molecule that

254 regulator) for its regulation of Pseudomonas quinolone signal (PQS) production and anthranilate metab

255 The Pseudomonas quinolone signal (PQS) regulates various virulence facto

256 nteracting with the iron-binding Pseudomonas quinolone signal (PQS), a cell-cell signalling compound.

257 so promote the production of the Pseudomonas quinolone signal (PQS), a quorum sensing molecule that a

258 ced secreted small molecule, the Pseudomonas quinolone signal (PQS), has been shown to initiate OMV f

259 hich encodes the key synthase of Pseudomonas quinolone signal (PQS).

260 The Pseudomonas quinolone signal (PQS; 2-heptyl-3-hydroxy-4-quinolone) i

261 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas Quinolone Signal [PQS]) is one of these signals and its

262 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal [PQS]).

263 h as the quorum-sensing molecule Pseudomonas quinolone signal and the exopolysaccharide Psl, is regul

264 qsR acts as the receptor for the Pseudomonas quinolone signal, and it controls the production of 2-al

265 cteristic fatty acids (e.g., palmitic acid), quinolone signal, and riboflavin fragments were found to

266 timulation by denatonium or with Pseudomonas quinolone signaling molecules led to an increase in muco

267 ins, carbohydrates, and, for the first time, quinolone signaling molecules-in Pseudomonas-derived bio

268 nt agreement with the CRM, discerns multiple quinolone species which differ slightly in mass, resolve

269 The quinolone-specific aptamers bound to ofloxacin, one of t

270 The functionality of quinolone-specific aptamers in real water samples was de

271 nd, shifting from 4-quinolone to 4-hydroxy-2-quinolone structure enabled the discovery of a novel cla

272 ment or scaffold modification to 4-hydroxy-2-quinolone structure.

273 a further approximately 90 hits across three quinolone subtemplates.

274 drawbacks associated with the development of quinolones such as SMERs.

275 lones, macrolides, nitrofurans, penicillins, quinolones, sulfamides and tetracyclines) in Argentinean

276 actam, imidazole, macrolide, nitrofurantoin, quinolone, sulphonamide and trimethoprim, and tetracycli

277 For comparison, 3 control reference quinolone-susceptible strains were included.

278 Two novel type III polyketide synthases, quinolone synthase (QNS) and acridone synthase (ACS), we

279 ion of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. marmelos that is invol

280 identification of a characteristic FabH-like quinolone synthase from Pseudomonas aeruginosa with high

281 RhlR and MvfR, and genes of the Pseudomonas quinolone system.

282 tic elements and resistance determinants for quinolones, tetracyclines, and beta-lactamases are share

283 g-binding mode in which the other end of the quinolone, the C7 ring system, interacts with GyrA.

284 the critically important antimicrobials were quinolones, third- and fourth-generation cephalosporins,

285 On the other hand, shifting from 4-quinolone to 4-hydroxy-2-quinolone structure enabled the

286 raoxonase 2 (PON2) inhibitor (Triazolo[4,3-a]quinolone, TQ416) significantly affected recovering cell

287 The potent oral activity of 2-pyridyl quinolones underlines the potential of this template for

288 is study investigated the effect of maternal quinolone use on gram-negative bacterial resistance to q

289 Children with previous quinolone use were excluded.

290 S data and further show that the anti-cancer quinolone vosaroxin acts solely as an intercalating pois

291 95% confidence interval [CI], 5.0%-8.2%) for quinolones vs 6.4% (95% CI, 5.0%-7.9%) for azithromycin

292 dium berghei in mice showed that these 4(1H)-quinolones were efficacious for the reduction of parasit

293 The quinolones were eluted without interferences using mobil

294 These novel quinolones were explored to recognize nitroaromatic comp

295 Examined quinolones were isolated from salmon tissue by extractio

296 The quinolones were resolved in <22min using a mobile phase

297 Carboxanilides and quinolones were tested for the antiproliferative activit

298 dary metabolites, including rhamnolipids and quinolones, were detected and visualized on both macro-

299 The biological evaluation illustrated that 4-quinolones with a benzylamide function in position 3 and

300 lected aptamers were shown to detect various quinolones with high specificity, while specific binding