ライフサイエンスコーパス: rDNA

1 rDNA genes are arranged in large stretches of tandem rep

2 rDNA linkages are coated by the transcription factor UBF

3 rDNA, the genes encoding the RNA components of ribosomes

4 16S rDNA PCR analysis reveals the presence of bacterial DNA

5 16S rDNA sequencing was conducted as a readout for changes i

6 16S rDNA-the backbone of microbiome analyses-allows us to as

7 We also analysed 16S rDNA tag amplicon libraries of the biofilms associated w

8 entified using the ratio of 16S rRNA and 16S rDNA (rRNA/rDNA) for individual populations, but this ap

9 s, we performed nutritional analysis and 16S rDNA microbiome sequencing, which showed that high-fat d

10 ditionally, we analyzed the 23S rDNA and 16S rDNA regions for the presence of possible mutations lead

11 Culture of internal organs and 16S rDNA sequencing revealed TLR7-dependent translocation of

12 on cohort, the correlation between blood 16S rDNA concentration and LF, whereas we did not confirm th

13 microbiome composition, assessed by both 16S rDNA and metagenomic DNA sequencing, of TB cases during

14 ystem, the Mahomet Aquifer, USA, by both 16S rDNA and rRNA amplicon deep sequencing.

15 ollected and microbiota were analyzed by 16S rDNA sequencing.

16 ial metabolic interactions (MMinte) from 16S rDNA data.

17 icrobiome composition data obtained from 16S rDNA sequencing of 90 cirrhotic patients with and withou

18 rial DNA sequences of four genetic loci (16S rDNA, 28S rDNA, Cytochrome oxidase I and Cytochrome b).

19 h biofilm microbiota from Illumina MiSeq 16S rDNA (V3-V4) sequencing and culturing were analysed.

20 q((R)) platform, targets a mitochondrial 16S rDNA region recently found to be suitable for the differ

21 Unweighted Unifrac distances of 16S rDNA (ribosomal DNA) sequences confirmed the introductio

22 stigated using network analysis based on 16S rDNA and internal transcribed spacer deep sequencing.

23 ty assembly and activity based on paired 16S rDNA and 16S rRNA sequencing.

24 The 16S rDNA concentration was significantly higher in patients

25 The 16S rDNA gene was evaluated by the amplified ribosomal DNA r

26 cell sorting and deep sequencing of the 16S rDNA gene was used to characterize the bacterial recogni

27 The 16S rDNA sequencing and the phylogenetic analysis revealed t

28 cted to Illumina MiSeq sequencing of the 16S rDNA V4 region.

29 ncing targeting the V3-V4 regions of the 16S rDNA.

30 Though 16S rDNA sequencing showed the similarity between Ixodes spp

31 lex melt curve signatures as compared to 16S rDNA amplicons with enhanced interspecies discrimination

32 Universal bacterial qPCR of total 16S rDNA revealed a bacterial load exceeding that of backgro

33 tool microbiota were characterized using 16S rDNA amplicon sequencing.

34 skin microbiome was determined by using 16S rDNA sequencing.

35 eruleoalba and Phocoena phocoena), using 16S rDNA-amplicon metabarcoding.

36 he microbial community was examined with 16S rDNA MiSeq sequencing and quantitative polymerase chain

37 16S-rDNA-encoding sequence analysis in feces identified a si

38 amples were (1) microscopy positive; (2) 18S rDNA PCR positive; (3) positive for merozoite surface pr

39 Copy numbers of 5S and 18S rDNA are reduced moderately in the pprtel1 mutant, and s

40 um falciparum infection was confirmed by 18S rDNA polymerase chain reaction (PCR), and pfhrp2/3 genes

41 -based immunoassay and for P. falciparum 18S rDNA by photo-induced electron transfer polymerase chain

42 river that are genetically identical for 18S rDNA.

43 Two 18S rDNA hypervariable sites, the V4 and V8-V9 regions, were

44 AMF diversity was determined using 18S rDNA pyrosequencing analysis of 360 soil samples taken a

45 Additionally, we analyzed the 23S rDNA and 16S rDNA regions for the presence of possible m

46 lexed HyCCAPP was applied to four genes (25S rDNA, ARX1, CTT1, and RPL30) in S. cerevisiae under norm

47 equences of four genetic loci (16S rDNA, 28S rDNA, Cytochrome oxidase I and Cytochrome b).

48 hly efficient I-PpoI-induced DSBs in the 28S rDNA gene, we observed a hierarchy of recruitment for ea

49 d (L-type) and separated (S-type) 5S and 35S rDNA units, chromosome number, genome size and ploidy le

50 ot seem to be influenced by homoeologous 35S rDNA ratios and developmental stage.

51 , expression and epigenetic landscape of 35S rDNA in an allotetraploid grass that exhibits ND, Brachy

52 A non-terminal position of 35S rDNA was found in about 25% of single-locus karyotypes,

53 sists of the reversible silencing of 35S/45S rDNA loci inherited from one of the ancestors of an allo

54 opsis thaliana), we demonstrate that all 45S rDNA arrays become transcriptionally active and are recr

55 ts of k-mers associated with centromere, 45S rDNA, knob, and retrotransposons were found among groups

56 upancy, including the 45S ribosomal DNA (45S rDNA) loci, where loss of ATRX results in altered expres

57 iption of 18S, 5.8S, and 18S rRNA genes (45S rDNA), cotranscriptional processing of pre-rRNA, and ass

58 While reductions in 45S rDNA copy numbers observed in pprtel1 and pprad51-1-2 pl

59 revealed two massively large variants of 45S rDNA and their corresponding nucleolus organizer regions

60 to examine allele-specific expression of 45S rDNA in the hybrids.

61 wledge of the functional organization of 45S rDNA, pre-rRNA transcription, rRNA processing activities

62 r than B73, equivalent levels of overall 45S rDNA expression indicates that transcriptional or post-t

63 esults in altered expression of specific 45S rDNA sequence variants.

64 Genotype specific 45S rDNA sequences were discovered.

65 al regulation mechanisms operate for the 45S rDNA in the hybrids.

66 chromosome number and characterized the 45S rDNA structural organization.

67 tel1 and pprad51-1-2 plants apply also to 5S rDNA, changes in transcript levels are different for 45S

68 three regions, and the lost ability of 5.8S rDNA sequence to fold into a conserved secondary structu

69 by molecular PCR assay based on the ITS-5.8S rDNA.

70 Here we use a rDNA barcoding approach to reveal how microbial communit

71 egions of ribosomal DNA (rDNA) and activates rDNA transcription, transformed cell growth, and tumor f

72 zation of transcriptionally competent active rDNA chromatin at size scales well below the diffraction

73 We identify active rDNA chromatin units exhibiting uniformly ring-shaped co

74 ey features of the 3D organization of active rDNA chromatin units and their nucleolar clusters provid

75 The active rDNA chromatin units are clearly separated from each oth

76 s occurring between transcriptionally active rDNA loci spatially colocated in the same nucleolar comp

77 cerevisiae caused R-loop accumulation along rDNA.

78 the distribution of RNase H1 and Top1 along rDNA coincided at sites where R-loops accumulated in mam

79 neurodegeneration in childhood with altered rDNA chromatin status and rRNA metabolism.

80 A bridges, rDNA damage, and aneuploidy of an rDNA-containing acrocentric chromosome.

81 molecular mechanisms by which one ancestral rDNA set is selected for silencing remain unclear.

82 synthesis, ribonucleotide pool balance, and rDNA stability.

83 mmunity in a subtropical estuary by rRNA and rDNA-based high throughput sequencing of 97 samples coll

84 DNA damage, the maintenance of telomeres and rDNA, and repair of double-stranded breaks (DSBs) induce

85 encing defect at centromeres, telomeres, and rDNA loci.

86 ci and X chromosome inactivation, as well as rDNA contact maps that anchor and position the rDNA rela

87 x epistatic and allelic interactions between rDNA haplotypes that apparently regulate the entire rRNA

88 was exploited to study relationships between rDNA locus number, distribution, the occurrence of linke

89 Defective resolution leads to rDNA bridges, rDNA damage, and aneuploidy of an rDNA-containing acroce

90 The ribosomal gene cluster (rDNA) on synXII was left intact during the assembly proc

91 ization of the multicopy rRNA gene clusters (rDNA) in the nucleolus is less well understood.

92 -KAT7 complexes with transcription-competent rDNA loci but not to transcriptionally silent rDNA loci,

93 ines derived from T. mirus with a dominant d-rDNA homeolog transmitted this expression pattern over g

94 t2 phosphorylation stimulates Ect2-dependent rDNA transcription.

95 iated transformation requires Ect2-dependent rDNA transcription.

96 acts with c-Myc and enhances c-Myc-dependent rDNA transcription key for ribosomal biogenesis.

97 from normal human donors have no detectable rDNA.

98 ngly, we found that all NORs with detectable rDNA are active, as defined by upstream binding factor l

99 In yeast, circular ribosomal DNA (rDNA) accumulates dramatically as cells age, however lit

100 1) on the promoter regions of ribosomal DNA (rDNA) and activates rDNA transcription, transformed cell

101 a species-specific region of ribosomal DNA (rDNA) and an established fluorescent in situ hybridizati

102 Hog1 is linked to a defect in ribosomal DNA (rDNA) and telomere segregation, and it ultimately delays

103 The multicopy ribosomal DNA (rDNA) array gives origin to the nucleolus, a large nonme

104 zer regions (NORs) comprising ribosomal DNA (rDNA) arrays.

105 icroscopy to demonstrate that ribosomal DNA (rDNA) can form linkages between chromosomes.

106 genes are found in two large ribosomal DNA (rDNA) clusters and little is known about the contributio

107 Ribosomal DNA (rDNA) consists of highly repeated sequences that are pro

108 CSB regulate transcription of ribosomal DNA (rDNA) genes and ribosome biogenesis.

109 , and noncoding RNAs from the ribosomal DNA (rDNA) intergenic spacers, consistent with its previously

110 The ribosomal DNA (rDNA) is the most evolutionarily conserved segment of th

111 cific upstream element in the ribosomal DNA (rDNA) promoter and interacts with two other Pol I initia

112 the BD Max platform targeting ribosomal DNA (rDNA) region nucleotide sequences to quickly and accurat

113 ouble-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repressio

114 transition, resolution of the ribosomal DNA (rDNA) repeats is delayed.

115 multicopy small-subunit (SSU) ribosomal DNA (rDNA) sequences were used as targets.

116 one deacetylase Sir2 controls ribosomal DNA (rDNA) silencing by inhibiting recombination and RNA poly

117 for SUMO-dependent control of ribosomal DNA (rDNA) silencing through the opposing actions of a STUbL

118 Deep sequencing of ribosomal DNA (rDNA) suggests thousands of different microbes may be pr

119 targeting of FGFR2, activate ribosomal DNA (rDNA) transcription and delay differentiation in osteopr

120 e oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription.

121 -GFP expression inserted into ribosomal DNA (rDNA) using time-lapse microscopy.

122 es, including centromere, 45S ribosomal DNA (rDNA), knob, and telomere repeats.

123 Here, nonnative rRNA gene [ribosomal DNA (rDNA)] copies were identified in a set of 16 diploid bar

124 lled via genetic interactions between entire rDNA cluster haplotypes (alleles).

125 underlying genetic variation and establishes rDNA as a genomic target of nutritional insults.

126 This work establishes rDNA as developmentally regulated loci that receive dire

127 tructure, and the high levels of euchromatic rDNA induced by the BBDS mutations direct nucleolar diso

128 lls and decreased number of cells expressing rDNA with insertions.

129 ly of transcription initiation complexes for rDNA.

130 on sites especially at K14 are important for rDNA silencing and aging.

131 mammalian cells, that PAF53 is necessary for rDNA transcription and cell growth, and that all three P

132 logue of yeast RPA49, PAF53, is required for rDNA transcription and mitotic growth.

133 C terminus that mediates its specificity for rDNA-associated proteins and show that this region binds

134 e protein biosynthetic pathway, leading from rDNA transcription and ribosome biogenesis to mRNA synth

135 lar chromatin remodeling complex (NoRC) from rDNA, together with recruitment of the EMT-driving trans

136 Ribosomal RNA (rRNA) is transcribed from rDNA by RNA polymerase I (Pol I) to produce the 45S prec

137 Telomeres and ribosomal RNA genes (rDNA) are essential for cell survival and particularly s

138 ould explain the shared ribosomal RNA genes (rDNA) phenotypes.

139 rase I transcription of ribosomal RNA genes (rDNA), induces replication stress and activates the DNA

140 olus, organized around arrays of rRNA genes (rDNA), dissolves during prophase of mitosis in metazoans

141 Uniparental silencing of 35S rRNA genes (rDNA), known as nucleolar dominance (ND), is common in i

142 minating non-essential protein coding genes, rDNA and LTRs.

143 HG contexts in the silencing of the S-genome rDNA loci was revealed.

144 rDNA units in addition to the native Hordeum rDNA copies.

145 Here we show that resolution of human rDNA occurs in anaphase after the bulk of the genome, de

146 These observations imply rDNA looping and exclude potential formation of systemat

147 Bs generated by IR and site-specific DSBs in rDNA.

148 The MET3pr-GFP expression in rDNA is highly correlated in mother and daughter cells a

149 s essential and to determine its function in rDNA transcription.

150 eviously uncharacterized function of NuMA in rDNA transcription and p53-independent nucleolar stress

151 Overexpression of c-Myc increases rDNA transcription and the frequency of rDNA linkages, f

152 The caveolae-independent rDNA transcriptional role of PTRF not only explains the

153 g to uniformly high expression of individual rDNA in single cells.

154 We found that individual rDNA genes have high level of cell-to-cell heterogeneity

155 Despite this inherent instability, rDNA copy number is generally maintained within a partic

156 n of interrupted units and control of intact rDNA expression.

157 rDNA units and variable expression of intact rDNA.

158 hes discrimination of interrupted and intact rDNAs and removes cell-to-cell heterogeneity leading to

159 Utilizing ectopically integrated rDNA repeats, we validate our findings and demonstrate t

160 ired for efficient repression of interrupted rDNA units and variable expression of intact rDNA.

161 Insertion of heterologous sequences into rDNA leads to repression associated with reduced express

162 BRCA1/2-intact breast cancer cells involving rDNA transcription and ribosome biogenesis.

163 and fungal Internal Transcribed Spacer (ITS) rDNA sequences, samples contained high diversity at all

164 We also tested whether pairing ITS1 rDNA Illumina sequences generated taxonomic biases relat

165 ular test is a qPCR assay targeting the ITS1 rDNA region (ITS1) of Ac.

166 d specific species of Cladocopium spp. (ITS2 rDNA type-C) yet all experienced similar patterns of pho

167 f species-specific primers based on the ITS2 rDNA were developed for psocid identification.

168 encing by controlling the abundance of a key rDNA silencing protein, Tof2.

169 sites reduces DDX21 nucleolar localization, rDNA transcription, ribosome biogenesis, protein transla

170 to the presence of mechanisms that maintain rDNA copy number in a homeostatic range.

171 served Pir2/ARS2 protein, and also maintains rDNA integrity and silencing by promoting heterochromati

172 ing that nonhomologous end-joining maintains rDNA integrity during meiosis.

173 fas1xfas2 genetic background) showing major rDNA rearrangements.

174 t deficits in our understanding of mammalian rDNA transcription.

175 pproach with biochemistry to study mammalian rDNA transcription.

176 cess and subsequently replaced by a modified rDNA unit used to regenerate rDNA at three distinct chro

177 in in the nucleus and predicts that multiple rDNA loci will form a single nucleolus independent of th

178 re was no evidence that any of the nonnative rDNA units were transcribed; some showed indications of

179 We observed rDNA linkages in many different human cell types and dem

180 is required for serum-induced activation of rDNA transcription.

181 The ensuing derepression of rDNA transcription promotes cell proliferation.

182 rindividual variation in the distribution of rDNA.

183 nced accurately estimated alpha diversity of rDNA sequences from bacteria and fungi.

184 eloped a tool to estimate alpha diversity of rDNA sequences from microbes (and other sequences).

185 Delays or failure of rDNA double-strand break (DSB) repair are deleterious, a

186 ases rDNA transcription and the frequency of rDNA linkages, further suggesting that their formation d

187 howed a higher intragenomic heterogeneity of rDNA compared with B. distachyon.

188 ryotic genomes contain dozens to hundreds of rDNA genes, however, only a fraction of the rRNA genes s

189 re arranged in large arrays with hundreds of rDNA units in tandem.

190 crocentric p-arms can occur independently of rDNA content, suggesting that sequences elsewhere on the

191 ed by overexpression of PABPs, inhibition of rDNA transcription, or alterations in TRAMP activity.

192 ential for Orc1 to maintain the integrity of rDNA borders during meiosis, a process distinct and inde

193 Our knowledge of the mechanism of rDNA transcription has benefited from the combined appli

194 which are known to have a reduced number of rDNA copies, and plant lines with restored CAF-1 functio

195 Thus, temporal regulation of rDNA segregation is conserved between yeast and man and

196 te its potential importance in regulation of rDNA transcription and replication.

197 lar insight into ECT2-mediated regulation of rDNA transcription in cancer cells and offer a rationale

198 oisomerase I in the epigenetic regulation of rDNA, independent of its known catalytic activity.

199 its enzymatic activity are key regulators of rDNA transcription, which is a critical step in ribosome

200 (Hh) pathway, is required for the repair of rDNA DSBs.

201 om spatial orientation of regular repeats of rDNA coding sequences within the nucleoli.

202 r unambiguously and use them as reporters of rDNA cluster-specific expression.

203 We discuss the role of rDNA and the nucleolus in nuclear organization and funct

204 After nucleosome deposition at each round of rDNA replication, the Pol I transcription machinery has

205 By contrast, LYAR has no effect on rDNA methylation or the binding of RNA polymerase I subu

206 ses presented summarise current knowledge on rDNA locus numbers and distribution in plants.

207 the mechanism by which ECT2 engages UBF1 on rDNA promoters.

208 n factor upstream binding factor 1 (UBF1) on rDNA promoters and recruiting Rac1 and its downstream ef

209 ication of pre-rRNA levels indicated ongoing rDNA transcription in yeast mitosis.

210 In contrast, lines derived from the p-rDNA dominant progenitor were meiotically unstable, freq

211 viduals harbor up to five different panicoid rDNA units in addition to the native Hordeum rDNA copies

212 ing we assign these variants to a particular rDNA cluster unambiguously and use them as reporters of

213 able epigenetic reprogramming of the partner rDNA arrays, harmonizing the expression of thousands of

214 case that localizes to nucleoli and promotes rDNA transcription when ADP-ribosylated.

215 of2 abundance, suggesting that Ulp2 promotes rDNA silencing by opposing STUbL-mediated degradation of

216 ith either Ulp2 or Tof2 dramatically reduces rDNA silencing and causes a marked drop in Tof2 abundanc

217 on and degradation, thereby further reducing rDNA transcription to save energy to overcome cell death

218 d by a modified rDNA unit used to regenerate rDNA at three distinct chromosomal locations.

219 egions of the genome and repetitive regions: rDNA and telomeric Y' regions.

220 lized SUMO isopeptidase and a STUbL regulate rDNA silencing by controlling the abundance of a key rDN

221 s to catalog NORs in terms of their relative rDNA content and activity status.

222 rring endonuclease that targets a repetitive rDNA sequence highly-conserved in a wide range of organi

223 or a conserved sequence within the ribosomal rDNA repeats, located in a single cluster on the Anophel

224 ing the ratio of 16S rRNA and 16S rDNA (rRNA/rDNA) for individual populations, but this approach fail

225 cal and biochemical characteristics and 16 S rDNA identification.

226 emonia viridis and Actinia equina using 16 S rDNA pyrosequencing.

227 DNA loci but not to transcriptionally silent rDNA loci, thereby increasing rRNA synthesis by altering

228 enetically activate transcriptionally silent rDNA.

229 lving acrocentric p-arms and observe silent, rDNA-containing NORs that are dissociated from nucleoli.

230 A single copy of a Panicum sp. rDNA unit present in H. bogdanii had been interrupted by

231 ucleoli with CDC14-GFP revealed that a split rDNA locus indeed forms a single nucleolus.

232 analyses of peritrichs that incorporated SSU rDNA sequences of samples collected from three continent

233 arcoding of a ~ 830 bp fragment from the SSU rDNA to identify the kleptoplasts and correlated transmi

234 eutic targeting of UBF1- and ECT2-stimulated rDNA transcription for the management of NSCLC.

235 These included truncations of subterminal rDNA sequences; acquisition of MoTeR insertions by 'plai

236 DNA methylation that silences supernumerary rDNA units and regulates nucleolar activity.

237 maintenance mechanisms and how they sustain rDNA copy number throughout populations.

238 haemulonii, and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C

239 age varies greatly among accessions and that rDNA cluster-specific expression and silencing is contro

240 We demonstrate that rDNA cluster-usage varies greatly among accessions and t

241 defects in RNA polymerase I, suggesting that rDNA transcription supports nucleolar segregation.

242 The rDNA is also a significant target of DNA methylation tha

243 The rDNA/nucleolus has been directly and mechanistically imp

244 The rDNA/nucleolus has emerged as a coordinating hub in whic

245 uneven local polymerase occupancy along the rDNA, indicating substantial variation in transcription

246 we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological

247 h bind the RNA polymerase I promoter and the rDNA binding barrier protein Fob1, but only about one-th

248 mation of lethal repair intermediates at the rDNA because of a barrier imposed by RNA polymerase I.

249 mechanisms promoting genome stability at the rDNA locus and subtelomeric regions in the most common h

250 In contrast, at the rDNA, cohesin and condensin activity inhibit the repair

251 VSG117 expression from the rDNA was not adequate for functional complementation, an

252 polymerase II-catalyzed transcription in the rDNA of Saccharomyces cerevisiae Sir2 is recruited to no

253 ss of age-associated hypermethylation in the rDNA relative to other segments of the genome, and which

254 RNs to effect efficient DSB resection in the rDNA, demonstrating that the presence of three XRN enzym

255 merase I loading to the coding region of the rDNA and this is Ncl dependent.

256 ted to nontranscribed spacer 1 (NTS1) of the rDNA array by interaction between the RENT ( RE: gulatio

257 the genome, and which forms the basis of the rDNA clock.

258 Pol I occupancy of the coding region of the rDNA in THO mutants is decreased to ~50% of WT level.

259 ed a dramatic reduction in the number of the rDNA repeat units in Spirodela to fewer than 100, which

260 likely reflects the dynamic activity of the rDNA-specific RENT complex, as MET3pr-GFP expression in

261 NA contact maps that anchor and position the rDNA relative to the rest of the genome.

262 This shields the rDNA from acquiring canonical meiotic chromatin modifica

263 cts with Ulp2 and one of its substrates, the rDNA silencing protein Tof2, through adjacent conserved

264 was closer to microscopy estimates than the rDNA assay, which overestimated abundance across the ful

265 lidate our findings and demonstrate that the rDNA constitutes an HR-refractory genome environment.

266 a model whereby Top1p recruits Sir2p to the rDNA and clarifies a structural role of DNA topoisomeras

267 ing by markedly increased UBF binding to the rDNA promoter and to the 5'- external transcribed spacer

268 inding bromodomains and recruits BRD2 to the rDNA promoter and transcribed regions via association wi

269 result that CXXC-PHD recruits POLR1A to the rDNA promoter.

270 show that this region binds directly to the rDNA-associated protein Csm1.

271 omethylated chromatin is associated with the rDNA locus while telomeric regions are assembled into a

272 DNA lesions within the rDNA arrays are repaired in an RAD51-independent but LIG

273 exclusively with CpG methylation within the rDNA.

274 BRD2 also helps recruit BRD4 to rDNA.

275 t of the MYST-type acetyltransferase KAT7 to rDNA loci, resulting in enhanced local acetylation of hi

276 DSB) repair are deleterious, and can lead to rDNA transcriptional arrest, chromosomal translocations,

277 Defective resolution leads to rDNA bridges, rDNA damage, and aneuploidy of an rDNA-con

278 binds to 18S and 28S rRNAs and localizes to rDNA promoter regions.

279 to ionizing radiation (IR) and localizes to rDNA sequences in response to both global DSBs generated

280 and CSB both stimulate the binding of Ncl to rDNA and subsequent rRNA synthesis.

281 s downstream effector nucleophosmin (NPM) to rDNA.

282 of BRD4 and KAT7, which is then recruited to rDNA independently of the BRD2-KAT7 complex to accelerat

283 quired for UBF1-mediated ECT2 recruitment to rDNA, elevated rRNA synthesis, and transformed growth.

284 Here we show that the nucleolar response to rDNA breaks is dependent on both ATM and ATR activity.

285 sis and nucleolar segregation in response to rDNA breaks.

286 ion and nucleolar segregation in response to rDNA breaks.

287 remains into adulthood and is restricted to rDNA copies associated with a specific genetic variant w

288 ave disproportionally high ratios of rRNA to rDNA, an indication of higher protein synthesis, compare

289 Our findings tie Hh signaling to rDNA repair and this heretofore unknown function may be

290 the binding of RNA polymerase I subunits to rDNA. These data suggest that LYAR promotes the associat

291 117 were obtained from the Pol I-transcribed rDNA.

292 s necessary for manufacturing peptides using rDNA technology with tandem repeats.

293 ina MiSeq sequencing of the bacterial 16S V4 rDNA.

294 uring prophase of mitosis in metazoans, when rDNA transcription ceases, and reforms in telophase, whe

295 ption ceases, and reforms in telophase, when rDNA transcription resumes.

296 r DNA were lost after ~15 divisions, whereas rDNA circles underwent massive accumulation to >95% of c

297 chromatin remodeling complex associated with rDNA transcription.

298 170 nm in human fibroblasts, consistent with rDNA looping.

299 Inhibiting GLI1 interferes with rDNA DSB repair and impacts RNA polymerase I activity an

300 The signature sequences within rDNA, which can be used to determine species identity, w