ライフサイエンスコーパス: rabies

1 long-lasting and efficient vaccines against rabies.

2 ndia, representing one-third of global human rabies.

3 the probability that a biting dog would have rabies.

4 bies is an effective means of reducing human rabies.

5 after being exposed to animals suspected of rabies.

6 ng the viruses that cause measles, Ebola and rabies.

7 nations for effective prevention of clinical rabies, a more rapidly protective vaccine is needed.

8 ough social contacts can control vampire bat rabies-a medically and economically important zoonosis i

9 ollow-up survey, one was deemed to be due to rabies after a probable rabies exposure.

10 o counsel animal-bite victims on the risk of rabies and appropriate treatment, as well as the Haiti A

11 a few well-studied wildlife systems such as rabies and bovine tuberculosis.

12 The rabies and Ebola viruses recruit the highly conserved ho

13 proven to be efficient dual vaccines against rabies and emergent infectious diseases such as Ebola vi

14 We observed a reduction in rabies antibody geometric mean titer in the chloroquine

15 We conclude that there is no reduction of rabies antibody response in subjects taking Malarone or

16 of HDCV was given to evaluate the anamnestic rabies antibody response.

17 ll subjects in both study groups possessed a rabies antibody titer >0.5 IU/mL on day 7 following the

18 except 1 (99.3%) in each study group, had a rabies antibody titer >0.5 IU/mL on day 7 following the

19 The pathogenic mechanisms for rabies are not well understood.

20 riven rabies transmission model fit to human rabies autopsy data and human rabies surveillance data f

21 logy to heat-stabilize FiloRab1 (inactivated rabies-based Ebola vaccine), a candidate Ebola vaccine,

22 efore critical for interpreting monosynaptic rabies-based tracing in the sensory system.

23 he circuitry of the target region and depict rabies-based transsynaptic tracing and LSFM as efficient

24 These results suggest that rabies-based unbiased screening of changes in input popu

25 the highest incidences of dog-mediated human rabies, but only deploys Catch-Neuter-Vaccinate-Release

26 ray dogs could cost-effectively reduce human rabies by almost 90%.

27 iding PEP administration in situations where rabies can be definitively ruled out.

28 g trend (p < 0.001 and tau = -0.88) of human rabies cases (Correlation coefficient: -0.82) have been

29 een found to be effective for reducing human rabies cases in Bangladesh.

30 Rabies, caused by rabies virus (RABV), is a fatal enceph

31 Rabies, caused by rabies virus (RABV), is an ancient zoo

32 ith serological and/or molecular evidence of rabies circulation, DrBHV infects 80-100% of bats, sugge

33 Rabies continues to present a public health threat in mo

34 Currently, rabies control in Tamil Nadu involves postexposure vacci

35 doses of either the RTS,S/AS01 vaccine or a rabies (control) vaccine.

36 We subjected 1327 clinically diagnosed human rabies death and mass dog vaccination (MDV) data during

37 bies incidence in Bangladesh and a subset of rabies death data (422) for clinico-epidemiological anal

38 We estimated that there would be four human rabies deaths among the 1478 people assessed by IBCM dur

39 ly, could very cost-effectively reduce human rabies deaths by 70% within 5 y, and a modest expansion

40 Over 20,000 rabies deaths occur annually in India, representing one-

41 mme, which would equate to a 65% decrease in rabies deaths.

42 ng to scale up MDV may help to prevent human rabies deaths.

43 Domestic dogs cause over 99% of human rabies deaths.

44 ity of microneedle patch vaccination using a rabies DNA vaccine in dogs.

45 nds of people in developing countries die of rabies each year due to the inability to control dog pop

46 s prophylaxis after exposure in a low-income rabies-endemic setting.

47 Rabies exposure represents a major concern for HCWs and

48 administered to all persons with a suspected rabies exposure, while avoiding PEP administration in si

49 deemed to be due to rabies after a probable rabies exposure.

50 ns of confirmed, probable, suspected, or non-rabies exposures.

51 13%) suspected exposures, and 1176 (80%) non-rabies exposures.

52 Sylvatic rabies has been eradicated from most of Central Europe,

53 Although rabies has been the subject of large-scale public health

54 Human rabies immunoglobulin (HRIG; Imogam(R) Rabies-HT), in a ratio of 1:1.

55 th Organization (WHO) international standard rabies immune globulins (SRIGs) allow the standardisatio

56 and miromavimab) or the reference arm, Human rabies immunoglobulin (HRIG; Imogam(R) Rabies-HT), in a

57 In order to diminish the requirements for rabies immunoglobulin (RIG) and multiple vaccinations fo

58 (PEP), which includes the administration of Rabies immunoglobulin (RIG).

59 erse effects observed with the blood derived rabies immunoglobulin products has led to search for alt

60 Candidate IRRSs IMORAB2, from human rabies immunoglobulin; and GCIRAB1, from pooled serum sa

61 The risk of rabies in a biting dog as assessed through Haiti's rabie

62 This model enables us to project the risk of rabies in biting dogs in Haiti shortly after the bite ev

63 Accurate and timely risk assessment of rabies in biting dogs is critical to ensure that rabies

64 model was developed to quantify the risk of rabies in biting dogs, using data from Haiti's animal ra

65 del were used to quantify the probability of rabies in biting dogs.

66 The mean incubation period of rabies in cases with exposure sites on the head & neck (

67 rdable vaccine to control canine-transmitted rabies in developing countries.

68 ealth" committee to address the challenge of rabies in dogs and humans.

69 other animals has virtually eliminated human rabies in industrialized countries.

70 theoretically appealing solution to managing rabies in its reservoir host.

71 2018 to quantify the impacts of MDV on human rabies incidence in Bangladesh and a subset of rabies de

72 We show that RavP and LC8 colocalize in rabies infected cells, and that LC8 interactions are ess

73 root ganglia neurons, display resistance to rabies infection.

74 development of a single-dose vaccine against rabies infections.

75 Rabies is a fatal viral disease typically transmitted th

76 orts RABV particles through axons.IMPORTANCE Rabies is a fatal zoonotic disease with a nearly 100% ca

77 Rabies is a viral zoonosis transmitted by vampire bats a

78 Vaccinating dogs against rabies is an effective means of reducing human rabies.

79 educe unnecessary PEP costs when the risk of rabies is determined as sufficiently low and the animal

80 Rabies is endemic in most parts of the world, and more e

81 he most efficient way to prevent and control rabies is to implement vaccination programs for domestic

82 ty globally include viral (for example, HIV, rabies, Japanese encephalitis virus, herpes simplex viru

83 Cocaine increased rabies-labelled inputs from the globus pallidus externus

84 However, the inherent cytotoxicity of the rabies largely prevents its implementation in long-term

85 nted negative strand (NNS) RNA viruses (e.g. rabies, measles, Ebola) contains five collinear sequence

86 S RNA viruses, including the human pathogens rabies, measles, respiratory syncytial virus, Nipah, and

87 projection-specific electrophysiological and rabies-mediated input mapping in mice to uncover adolesc

88 Rabies-mediated monosynaptic retrograde tracing identifi

89 We used rabies-mediated tract-tracing in transgenic Kiss1-Cre mi

90 h different envelopes (vesicular stomatitis, Rabies, Mokola and Ross River viral envelopes) and self-

91 u that were validated by real-time livestock rabies mortality data.

92 amuscular [IM], 2 vs 3 doses, and controls), rabies neutralizing antibody titers were measured to 1 y

93 reduce the probability, size and duration of rabies outbreaks, even at low but realistically achievab

94 accoon populations are highly susceptible to rabies outbreaks, that the risk of large outbreaks varie

95 rovide a means for future studies addressing rabies pathobiology.

96 d prevents G-mediated viral entry.IMPORTANCE Rabies PEP depends on anti-RABV IgG, which is expensive

97 es in biting dogs is critical to ensure that rabies PEP is administered to all persons with a suspect

98 fective replacement for the IgG component of rabies PEP, we developed and implemented a high-throughp

99 However, immunoglobulin (IgG)-based rabies postexposure prophylaxis (PEP) is expensive, rest

100 (PrEP and PEP) could substantially simplify rabies prevention and therefore increase compliance.

101 Because humans get rabies primarily through dog bites, stray dog population

102 IBCM programme to promote best practices for rabies prophylaxis after exposure in a low-income rabies

103 NA viruses, among them the virus that causes rabies (RABV), include many deadly human pathogens.

104 reparation and qualification of two internal rabies reference standards (IRRSs), calibrated against W

105 Rabies remains a major public health threat around the w

106 Rabies remains a public health threat in most parts of t

107 Rabies remains a public health threat, with more than 55

108 In addition, identification of rabies-resistant neurons might provide a means for futur

109 are suitable for use as IRRS in the in-house rabies RFFIT.

110 A recent study employed a self-inactivating rabies (SiR) virus that enables recording or manipulatio

111 By contrast, for rabies, small hosts will be disproportionately more comp

112 e that elevation is associated with a slower rabies spread in a natural population.

113 l fit to human rabies autopsy data and human rabies surveillance data from Tamil Nadu.

114 riate treatment, as well as the Haiti Animal Rabies Surveillance Program (HARSP) to examine the anima

115 in a biting dog as assessed through Haiti's rabies surveillance program was highly elevated when the

116 biting dogs, using data from Haiti's animal rabies surveillance program.

117 ce of developing and deploying a large-scale rabies surveillance system based on mobile phones in sou

118 Although there are effective vaccines for rabies, this disease still takes the lives of about 50,0

119 Although transmission of rabies to HCWs has never been documented, high-risk expo

120 Rabies tracing from USV-responsive neurons reveals exten

121 Recent advances in connectomics and rabies tracing have yielded much higher estimates of ret

122 Monosynaptic transsynaptic rabies tracing indicated the pathway contacts multiple c

123 Rabies tracing of monosynaptic inputs to A1 L6 CT neuron

124 Monosynaptic rabies tracing of the presynaptic organization revealed

125 ell transcriptomic analyses and monosynaptic rabies tracing to compare mouse primary visual cortex CC

126 We used rabies tracing(1,12) to label and functionally image the

127 Using rabies tracing, calcium imaging, and patch-clamp recordi

128 Given the lack of human-to-human rabies transmission from our own experience and the lite

129 We developed a data-driven rabies transmission model fit to human rabies autopsy da

130 ment of direct antiviral small molecules for Rabies treatment.

131 We simulated three oral rabies vaccination (ORV) campaigns: (1) first generation

132 ve effectiveness of three components of oral rabies vaccination (ORV) programmes targeting raccoons-t

133 of this study suggest that efficacy of oral rabies vaccination by aerial delivery is associated with

134 assess methods for achieving effective anti-rabies vaccination coverage.

135 y titers of >=0.5 IU/mL following the second rabies vaccination dose and maintained this protection t

136 Effective and safe single-visit rabies vaccination for pre- and postexposure prophylaxis

137 ID rabies vaccination induces acceptable antibody titers at

138 Oral rabies vaccination of foxes is an effective method for c

139 The existing 4-week preexposure rabies vaccination schedule is costly and often not prac

140 nteers (aged 18-40 years) with no history of rabies vaccination were sequentially enrolled.

141 es for simple and potentially cost-effective rabies vaccination, and assess the safety and immunogeni

142 Lack of prior rabies vaccination, biting 2 or more people, and if the

143 hich can broaden humoral responses following rabies vaccination.

144 n impair the immune responses to intradermal rabies vaccination.

145 receive three doses of either RTS,S/AS01 or rabies vaccine (both 0.5 mL per dose by intramuscular in

146 emulsion (GLA-SE; 2.5 or 5 mug), or control rabies vaccine (Verorab) were administered intramuscular

147 0.1 mL ID of the human diploid cell culture rabies vaccine [HDCV] at days 0 and 7) vs a standard 3-v

148 ly a total of 81 (57.0%) tested positive for rabies vaccine antibodies, possibly, due to the delayed

149 ecommends intradermal (ID) administration of rabies vaccine for preexposure prophylaxis.

150 In this study, a novel rabies vaccine that expressed murine IL-7 was developed.

151 e to the delayed uptake of bait in which the rabies vaccine was already inactivated.

152 omising candidate vector for a transmissible rabies vaccine, and provide a framework to discover and

153 from healthy adults immunised with licensed rabies vaccine, were generated.

154 fluenced the prevalence of antibodies to the rabies vaccine.

155 99 to receive RTS,S/AS01 and 101 to receive rabies vaccine.

156 recipients and 37 (36.6%, 27.3-46.8) of 101 rabies-vaccine recipients (relative risk 1.1, 95% CI 0.8

157 1 recipients and four (4.0%, 1.1-9.8) of 101 rabies-vaccine recipients died, but no deaths were deeme

158 1 recipients and 12 (11.9%, 6.3-19.8) of 101 rabies-vaccine recipients had at least one serious adver

159 case of Haemophilus influenza meningitis (1% rabies-vaccine recipients), and one case of tuberculosis

160 of pneumonia (1% RTS,S/AS01 recipients vs 3% rabies-vaccine recipients), five cases of gastroenteriti

161 troenteritis (3% RTS,S/AS01 recipients vs 2% rabies-vaccine recipients), five cases of malnutrition (

162 -vaccine recipients), one case of sepsis (1% rabies-vaccine recipients), one case of Haemophilus infl

163 malnutrition (2% RTS,S/AS01 recipients vs 3% rabies-vaccine recipients), one case of sepsis (1% rabie

164 el highlights the safety of third generation rabies vaccines and serves as a platform for standardize

165 While rabies vaccines are inactivated and thus have an excelle

166 need to develop single-dose and long-lasting rabies vaccines.

167 which may help in designing more-efficacious rabies vaccines.

168 r (GM-CSF) can enhance the immunogenicity of rabies vaccines.

169 hich will help in designing more efficacious rabies vaccines.

170 implications in the development of efficient rabies vaccines.

171 ase-based intersectional labeling method and rabies viral monosynaptic tracing, which enables subtype

172 Using rabies viral tracers, we demonstrate disynaptic projecti

173 trograde transsynaptic tracing with modified rabies viral vectors.

174 Understanding the interactions between rabies virus (RABV) and individual host cell proteins is

175 both survival from infection with attenuated rabies virus (RABV) and reduction of neurological sequel

176 Both canine distemper virus (CDV) and rabies virus (RABV) cause lethal disease in wild and dom

177 Rabies virus (RABV) causes a severe and fatal neurologic

178 Rabies virus (RABV) causes fatal encephalitis in more th

179 Our studies demonstrate that wild-type (wt) rabies virus (RABV) does not activate DCs.

180 letion variant of the SAD-B19 vaccine strain rabies virus (RABV) has been the reagent of choice in mo

181 al spread rate, persistence and incidence of rabies virus (RABV) in raccoons (Procyon lotor).

182 Rabies virus (RABV) P gene mRNA encodes five in-frame st

183 The rabies virus (RABV) phosphoprotein P is a multifunctiona

184 Rabies virus (RABV) postexposure prophylaxis (PEP) requi

185 dress this need, we developed an inactivated rabies virus (RABV) that contains the MERS-CoV spike (S)

186 In this study, a recombinant rabies virus (RABV) that expressed murine interleukin-7

187 l infections, we investigated the ability of rabies virus (RABV) to activate DCs.

188 ptive chimpanzees to test oral delivery of a rabies virus (RABV) vectored vaccine against Ebola virus

189 Its pathogen, rabies virus (RABV), can utilize its viral proteins, suc

190 ic and sometimes deadly viruses that include rabies virus (RABV), human respiratory syncytial virus (

191 Rabies, caused by rabies virus (RABV), is a fatal encephalitis in humans a

192 Rabies, caused by rabies virus (RABV), is an ancient zoonosis and still a

193 such as vesicular stomatitis virus (VSV) and rabies virus (RABV), possess an unconventional mRNA capp

194 Replication-deficient rabies virus (RABV)-based vaccines induce rapid and pote

195 loRab1 PBV vaccines and challenged them with rabies virus (RABV).

196 ted GL261 tumor-bearing mice with attenuated rabies virus (RABV).

197 r the RNA-dependent RNA polymerase (RdRP) of rabies virus (RABV).

198 inserted into the genome of the recombinant rabies virus (rRABV) strain LBNSE, and the effect of the

199 plementary targeting system for monosynaptic rabies virus (RV) tracing that identifies direct inputs

200 ion, we developed a self-inactivating DeltaG-rabies virus (SiR) that transcriptionally disappears fro

201 erlying geographic expansions of vampire bat rabies virus (VBRV) in Peru.

202 Using rabies virus -mediated monosynaptic retrograde tracing t

203 , West Nile virus [WNV], Sindbis virus [SV], rabies virus [RV], and influenza A virus [IAV]) remains

204 against heterologous CDV strains.IMPORTANCE Rabies virus and canine distemper virus (CDV) cause high

205 own that a Th1-biased seroconversion to both rabies virus and MARV glycoproteins (GPs) is beneficial

206 hysiological recording system, combined with rabies virus and optogenetic cell-type identification, t

207 cles of two recombinant rhabdoviral vectors, rabies virus and vesicular stomatitis virus (VSV), expre

208 accinated subjects developed protective anti-rabies virus antibody titers.

209 By using orthogonal tract tracing and rabies virus approaches in transgenic SVZ-lineage-tracin

210 We used a G-deleted rabies virus as a retrograde tracer to label CG neurons

211 Using rabies virus as a retrograde transneuronal tracer in mic

212 DFA) detection remains the gold standard for rabies virus diagnostics.

213 tion of pseudotyped and genetically modified rabies virus evidence was found for direct synaptic inpu

214 retrogradely labeled following injections of rabies virus expressing enhanced green fluorescent prote

215 Monosynaptically restricted rabies virus facilitates the anatomical investigation of

216 Incorporation of IFN-gamma into the rabies virus genome highly attenuated the virus.

217 ding to the first 19 nucleotides (nt) of the rabies virus genome, we demonstrate that L alone initiat

218 f a prophylactic mRNA-based vaccine encoding rabies virus glycoprotein (CV7201).

219 (VSV) to encode a fluorophore and either the rabies virus glycoprotein (RABV-G) or its own glycoprote

220 To this end, a SAM vaccine encoding the rabies virus glycoprotein (RVG) was used.

221 The neurotoxin-like region of the rabies virus glycoprotein inhibited acetylcholine respon

222 inding of this study is that a region in the rabies virus glycoprotein, with homologies to snake toxi

223 vitro, as did full length ectodomain of the rabies virus glycoprotein.

224 results can explain observed constraints on rabies virus host shifts, describe a previously unrecogn

225 complete labeling of neurons with a modified rabies virus identified these neurons as pyramidal cells

226 Using pseudotyped rabies virus in a transgenic Gpr151-Cre mouse line, mono

227 We used transneuronal transport of rabies virus in monkeys and rats to identify regions of

228 a set of gene sequences from an epidemic of rabies virus in North American raccoons.

229 performed retrograde injections of modified rabies virus in the visual cortex and pulvinar of the Lo

230 sceptible to infection with EnvA-pseudotyped rabies virus in tumor virus A receptor transgenic mice,

231 Rabies virus induces drastic behaviour modifications in

232 es involved in innate immune response during rabies virus infection and that the M protein of wild is

233 se neurotropic viruses in neuronal cells and rabies virus infection in mouse brains.

234 n and that the M protein of wild isolates of rabies virus is a viral immune-modulatory factor playing

235 Rabies virus is an important zoonotic pathogen.

236 rapid production of murine IFN-gamma by the rabies virus itself would induce a more robust antiviral

237 Using rabies virus monosynaptic tracing, we mapped cocaine-ind

238 luorescent-focus inhibition test (RFFIT) for rabies virus neutralising antibody measurement.

239 etermine the lowest dose of CV7201 to elicit rabies virus neutralising titres equal to or greater tha

240 wo arms assessed as percentage of those with rabies virus neutralizing antibodies titers >= 0.5 IU/mL

241 This insight into the architecture of the rabies virus nucleocapsid highlights the surprising stru

242 V is a negative strand RNA virus, similar to rabies virus or Ebola virus, that has a unique mechanism

243 Here we show that inactivated rabies virus particles containing the MERS-CoV S1 protei

244 ndidates based on recombinant vaccine strain rabies virus particles, which concurrently display the p

245 outs of the LC8 recognition motif within the rabies virus phosphoprotein (RavP) result in completely

246 tional significance of the components of the rabies virus replication machinery is incomplete.

247 Retrograde monosynaptic tracing with rabies virus reveals that this results in synaptic conta

248 Surprisingly, experiments using monosynaptic rabies virus showed that proopiomelanocortin (POMC) and

249 erstand the molecular machinery required for rabies virus spread in the nervous system.

250 The matrix (M) protein of wild isolates of rabies virus such as Tha (M-Tha) was previously shown to

251 We used a retrograde trans-synaptic rabies virus system to generate brain-wide maps of the i

252 We used the monosynaptic rabies virus system, in conjunction with mice expressing

253 We used a monosynaptic rabies virus to define the circuit's functional connecti

254 Here, we used transneuronal transport of rabies virus to identify the areas of the primate cerebr

255 e used retrograde transneuronal transport of rabies virus to identify the cortical areas that most di

256 Using monosynaptically-restricted rabies virus tracing of OPC afferents, we identified ext

257 n Tau(VLW) DGCs, and monosynaptic retrograde rabies virus tracing showed that these cells are disconn

258 We employed cell-type-specific monosynaptic rabies virus tracings to characterize afferent connectio

259 pulation lives in a country where the canine rabies virus variant is endemic and dog bites are common

260 s using homologous (inactivated Pitman Moore rabies virus) and heterologous (inactivated vesicular st

261 eported that a viral protein (G-protein from rabies virus) capable of interfering with protein-protei

262 virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane

263 4 experimental cross-species inoculations of rabies virus, a widespread zoonosis which in nature exhi

264 nd to be an important restriction factor for rabies virus, acting directly or indirectly against vira

265 members of NNS RNA viruses, such as measles, rabies virus, and Ebola virus.

266 s, including Ebola virus, Lassa virus, LCMV, rabies virus, and Marburg virus, which was substituted f

267 such as vesicular stomatitis virus (VSV) and rabies virus, catalyzes the transfer of 5'-phospho-RNA (

268 animals developed protective titers against rabies virus, illustrating that a bivalent rabies virus-

269 e order Mononegavirales, which also includes rabies virus, measles virus, and respiratory syncytial v

270 that multiple neurotropic viruses, including rabies virus, vesicular stomatitis virus, Semliki Forest

271 We used rabies virus-based circuit-mapping tools to reveal the i

272 LORAB1, a recombinant, bivalent, inactivated rabies virus-based EBOV vaccine, in rhesus and cynomolgu

273 Rabies virus-based monosynaptic tracing has been used to

274 Rabies virus-based retrograde tracing has developed into

275 sults demonstrate an important limitation of rabies virus-based retrograde tracing of sensory neurons

276 Using rabies virus-based transsynaptic tracing, we find that a

277 t rabies virus, illustrating that a bivalent rabies virus-based vaccine against CDV induces protectiv

278 Rabies virus-based vectors have been proven to be effici

279 In this study, we developed a modified rabies virus-mediated monosynaptic retrograde tracing me

280 Glycoprotein-deleted rabies virus-mediated monosynaptic tracing has become a

281 Here, we use G-deleted rabies virus-mediated monosynaptic tracing to identify i

282 rategy combining retroviral birthdating with rabies virus-mediated putative retrograde trans-synaptic

283 ce immunized with LBNSE-CXCL13 produced more rabies virus-neutralizing antibodies (VNAs) and develope

284 We have developed an inactivated rabies virus-vectored MARV vaccine (FILORAB3) to protect

285 the behavioural changes in hosts infected by rabies virus.

286 city, is an important restriction factor for rabies virus.

287 dangerous zoonotic pathogens, like Ebola or rabies virus.

288 , such as HSV, Zika virus, dengue virus, and rabies virus.

289 Combining rabies-virus tracing, optical clearing (CLARITY), and wh

290 Finally, using rabies-virus-assisted monosynaptic tracing, we show that

291 Attenuated rabies viruses (RABV) are unique tools to study CNS immu

292 hereas all animals that received recombinant rabies viruses carrying only the CDV attachment protein

293 ts immunized twice with a mix of recombinant rabies viruses carrying the CDV fusion and attachment gl

294 Although modified rabies viruses have emerged as a powerful tool for traci

295 ent study, it was found that the recombinant rabies viruses rB2c-K1685A and rB2c-K1829A, carrying mut

296 synaptic infection from the spinal cord with rabies viruses that carry glycoproteins in their envelop

297 Here we generated recombinant inactivated rabies viruses that carry one of the CDV glycoproteins o

298 ealed using Cre-conditional pseudorabies and rabies viruses.

299 been homogeneous, they would have eliminated rabies with high probability.

300 s may be inadequate to prevent the spread of rabies within these populations.