ライフサイエンスコーパス: radial glia

1 poptosis of neurons, and to a lesser extent, radial glia.

2 dual-labeled glial cells were tanycytes and radial glia.

3 ts of Notch signaling in human but not mouse radial glia.

4 locity of nuclear movement of FMRP-deficient radial glia.

5 cerebral cortex begins with the formation of radial glia.

6 genitors and the increased number of Sox2(+) radial glia.

7 correlated with an increasing quiescence of radial glia.

8 etion and reporter activation in a subset of radial glia.

9 g to irreversible changes in aging zebrafish radial glia.

10 tectum that gives rise to neurons and other radial glia.

11 elating to neuroepithelial cells rather than radial glia.

12 ed role in inhibiting the differentiation of radial glia.

13 ivide asymmetrically to generate neurons and radial glia.

14 al cell development or is already present in radial glia.

15 bellar granule neuron precursors (CGNPs) and radial glia.

16 lls are born prenatally and are derived from radial glia.

17 ociation is essential for MARCKS function in radial glia.

18 eterminant of apicobasal polarity in retinal radial glia.

19 e from neuroepithelial cells to neuronogenic radial glia.

20 basement membrane, Cajal-Retzius cells, and radial glia.

21 e they are needed, two critical functions of radial glia.

22 monstrates that these cells are derived from radial glia.

23 alian target of rapamycin signaling in outer radial glia.

24 enitors, including neuroepithelial cells and radial glia.

25 hic factor (BDNF) and vimentin, a marker for radial glia.

26 s are produced from neural stem cells termed radial glia [1, 2].

27 We also identified a mitotic defect in outer radial glia, a progenitor subtype that is largely absent

28 xhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression res

29 ted by ablation of other CNS cell types, and radial glia ablation also compromises the subsequent for

30 We found that radial glia ablation in zebrafish embryos leads to exces

31 early up-regulation of markers of gliogenic radial glia after injury either at E11 or E15.

32 n of the apical ventricular zone and loss of radial glia alignment.

33 ecent in vivo fate mapping experiments, that radial glia also generate neurons during embryonic devel

34 heir derived basal progenitors, to gliogenic radial glia and adult-like neural progenitors, together

35 ruption to the morphology and positioning of radial glia and an accumulation of olfactory axon debris

36 ruct, we identified Sox2-expressing cells as radial glia and as a component of the progenitor pool of

37 We found that NFIB is strongly expressed in radial glia and corticofugal neurons throughout cortical

38 adial glia progenitors produce self-renewing radial glia and differentiating cells simultaneously in

39 The overgrown radial glia and emigrated neurons disrupted the overlyin

40 of neurogenic transcription factors in early radial glia and enriched activation of mammalian target

41 In the adult optic tract and tectum, radial glia and free astroglia coexist.

42 vely isolate distinct, viable populations of radial glia and intermediate cells for in vitro analysis

43 distinct populations of neural progenitors, radial glia and intermediate progenitor cells, are respo

44 Principal neurons originate locally from radial glia and intermediate progenitors (IPCs), whereas

45 nts predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex

46 s that does not require altered signaling in radial glia and is accompanied by changes in layer-speci

47 tivity inhibits this process in hypothalamic radial glia and is not required for their self-renewal.

48 The GLAST promoter is active in both radial glia and many astrocytes in the developing CNS bu

49 re;Erbb3(F/F) mice, which lack Erbb3 in both radial glia and neurons, exhibit impairments in balance

50 progenitors and is specifically required in radial glia and newly born pyramidal neurons migrating t

51 ebellar size due to reduced proliferation of radial glia and other glial precursors in late embryonic

52 During development, SC1 localizes to radial glia and pial-derived structures, including the v

53 (Sema6D) and Nr-CAM are expressed on midline radial glia and Plexin-A1 on chiasm neurons, and Plexin-

54 expressed in a region-specific manner in the radial glia and stem cells of transient embryonic zones

55 ry progenitors, from early and midneurogenic radial glia and their derived basal progenitors, to glio

56 Lineage analysis of individual radial glia and their progeny demonstrated that less tha

57 cess initially organized by primary cilia in radial glia and then refined by motile cilia in ependyma

58 epression favored in less lineage-restricted radial glia and transcriptional activation favored in mo

59 mulates two parallel events: detachment from radial glia and translocation of the cell soma to the to

60 They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisio

61 The apical domain of embryonic (radial glia) and adult (B1 cells) neural stem cells (NSC

62 r pool and generate basal progenitors, outer radial glia, and cortical neurons.

63 fab/Vegfr2 signaling: vegfab is expressed by radial glia, and genetic or pharmacological inhibition o

64 critically modulates the functional state of radial glia, and induction of ErbB2 in distinct adult as

65 Polarized radial glia are crucial to the formation of the cerebral

66 In these mutants, radial glia are depleted due to an increased transition

67 Radial glia are highly polarized cells that serve as neu

68 We conclude that beta1 integrins in radial glia are required for the proper development of t

69 These data indicate that radial glia are the source of both neurons and astrocyte

70 progenitors derived from ventricular apical radial glia (aRG) that selectively lose their apical pro

71 ating heterogeneity in cell potential before radial glia arise.

72 Our results identify these radial glia as a previously unreported Sox1/Sox2/Sox9 po

73 ollowing birth, neurons use the processes of radial glia as scaffolding for oriented migration.

74 SVZ cells with long basal processes, and in radial glia at early postnatal times.

75 cell-specifically expressed in PAX3-negative radial glia at the midline of the neural tube during ear

76 brain of adult fish, in neurons and also in radial glia, behaving as neural stem cells.

77 Neocortical basal radial glia (bRG) and cerebellar Bergmann glia (BG) are

78 especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IP

79 nriched expression in excitatory neurons and radial glias but depleted expression in inhibitory neuro

80 We sought to fate map dorsal radial glia by codelivering an adenovirus expressing Cre

81 as, modest transcriptional differences among radial glia cascade into robust typological distinctions

82 nd, notably, a distinct human-specific outer radial glia cell layer.

83 ctivity is robustly enhanced in mutant outer radial glia cells (oRGs), a subtype of NPCs barely detec

84 LncND expression is enriched in radial glia cells (RGCs) in the ventricular and subventr

85 onic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis into

86 een demonstrated to promote the formation of radial glia cells and Notch signaling is one such signal

87 tical progenitors, resulting in an excess of radial glia cells at the expense of intermediate progeni

88 tor EphB1, which interacts with ephrin-B2 on radial glia cells at the optic chiasm to repulse VT axon

89 ly, LOC646329 is a lncRNA enriched in single radial glia cells but is detected at low abundance in ti

90 Ependymal cells are generated from radial glia cells during embryonic brain development and

91 Radial glia cells function as guide cells for neuronal m

92 rotonin receptor HTR2A selectively activates radial glia cells in the developing human, but not mouse

93 further show late-emerging shh-GFP positive radial glia cells in the medial zone of the dorsal telen

94 Radial glia cells in the VZ primarily divide with a vert

95 using real-time imaging of cohorts of mouse radial glia cells, we show that the radial glial scaffol

96 to a prolonged cell cycle and maintenance of radial glia cells.

97 ts absence, ependymal cells fail to suppress radial glia characteristics, resulting in a defective la

98 These include radial glia comparable to Type E and Type B cells, and a

99 Interestingly, radial glia continued to transition into postnatal NSCs

100 we provide evidence that beta1 integrins in radial glia control the morphological differentiation of

101 Mechanistically, we find that radial glia control these processes via Vegfab/Vegfr2 si

102 Mechanistically, we determined that radial glia control this process via the Vegf decoy rece

103 r features to distinctive behaviors of outer radial glia, demonstrate the necessity of STAT3 signalin

104 ncreased activation of this pathway in human radial glia, dependent on two receptors upregulated spec

105 born neurons, indicating CCM3 involvement in radial glia-dependent locomotion and possible interactio

106 poration, we expressed MrgA1 in slow cycling radial glia-derived B1 cells, i.e., NPCs.

107 the mechanism of the signaling hierarchy of radial glia developmental cascade promoted by Notch sign

108 gues demonstrated that zebrafish spinal cord radial glia differentiate into cells that are similar to

109 n cortical progenitors results in precocious radial glia differentiation and a temporal shift of cort

110 neural progenitors and negatively regulates radial glia differentiation.

111 Here we show that CNS-resident radial glia direct the vascularization of neighboring ti

112 Cerebral cortical neurons arise from radial glia (direct neurogenesis) or from intermediate p

113 These results suggest that outer radial glia directly support the subventricular niche th

114 tex, and inhibiting HTR2A receptors in human radial glia disrupts the radial glial scaffold.

115 in two radial glia, whereas the majority of radial glia divide asymmetrically to generate neurons an

116 ) cells adjacent to dorsal midline Nestin(+) radial glia (dmNes+RG) down-regulate apical polarity pro

117 eled cells increased 20%, as the fraction of radial glia dropped and the proportion of neuronal proge

118 teraction between migrating interneurons and radial glia during the switch from tangential to radial

119 o tissue preparation to mechanically isolate radial glia endfeet from the soma, and we use photoconve

120 revealed that early OL progenitor cells and radial glia expressed Olig1, whereas Olig2 was localized

121 However, in NfiB(-/-) cortices, radial glia failed to generate outer radial glia, subseq

122 eal a rich, regulated local transcriptome in radial glia, far from the soma, and establish a tractabl

123 In addition, the dorsal radial glia fate map to astrocytes lining the dorsal asp

124 nched leading processes are less parallel to radial glia fibers than those unbranched, suggesting som

125 cular zones of the pallium and migrate along radial glia fibers to reach the appropriate cortical lay

126 glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precurs

127 nbranched, suggesting some independence from radial glia fibers.

128 e show that Notch signaling promotes Xenopus radial glia formation and that the Notch activation is s

129 that the Notch activation is sufficient for radial glia formation prior to neural tube closure.

130 Notch1-induced erbB2 promoter activation and radial glia formation selectively, without affecting Su(

131 er, these results show that Notch1 regulates radial glia formation through two distinct transcription

132 d that Oct-1 is sufficient and necessary for radial glia formation.

133 ownstream effector of Notch signaling during radial glia formation.

134 superficial tectum, we find no evidence that radial glia function as a scaffold for neuronal migratio

135 Radial glia function during CNS development both as neur

136 Here we demonstrate that Notch1 effects on radial glia gene expression are mediated by two downstre

137 During forebrain development, radial glia generate neurons through the production of i

138 During embryogenesis, dorsal radial glia generate pyramidal cell neurons but not inte

139 To directly test whether radial glia give rise to ependymal cells, we used a Cre-

140 We found that dorsal radial glia give rise to gray and white matter astrocyte

141 d in the direct differentiation pathway from radial glia --> postmitotic projection neuron, in which

142 e used in vitro analysis to confirm that the radial glia had phagocytosed debris from olfactory axons

143 progenitors, and the subventricular (outer) radial glia, have been identified but the contribution o

144 These cells, later termed radial glia, have been studied primarily as migratory sc

145 After injuries, radial glia in aged brains are reactivated, and the perc

146 We show that radial glia in dorsomedial cortex retract their apical e

147 rogenesis has been observed, but the role of radial glia in generating these new neurons is unclear.

148 ns: a guidance for newly produced cells like radial glia in immature brain and/or a connection betwee

149 Radial glia in the developing brain extend motile filopo

150 h1 receptor is critical for the formation of radial glia in the developing nervous system.

151 Radial glia in the developing optic tectum extend highly

152 Remarkably, radial glia in the embryo have a translational polarity

153 ox recombination strategy to genetically tag radial glia in the neonatal brain and follow their proge

154 strocytes reportedly arise from two sources: radial glia in the ventricular zone and progenitors in t

155 unctions of progenitors and the integrity of radial glia in the vMB, which leads to a severe reductio

156 Hypothalamic radial glia in the zebrafish larva thus exhibit several

157 zone at the EM and found a subpopulation of radial glia in various stages of transformation into epe

158 anipulating PKG1, Rac1, or RhoA signaling in radial glia in vivo to eliminate glial filopodia or impa

159 We find that genetic ablation of radial glia in zebrafish larvae leads to a complete loss

160 Ventral radial glia, in contrast, retract their processes to for

161 open chromatin peaks, and transcriptomes for radial glia, intermediate progenitor cells, excitatory n

162 generate 3D structures containing polarized radial glia, intermediate progenitors, and a spectrum of

163 ression, suggesting a delay in maturation of radial glia into intermediate progenitors.

164 hanisms controlling the timely transition of radial glia into IPCs during forebrain development.

165 ar zone (SVZ) involves the transformation of radial glia into neural stem cells, in addition to the m

166 aging revealed the direct differentiation of radial glia into neurons.

167 We also show that AXL expression in radial glia is conserved in developing mouse and ferret

168 Moreover, mosaic overexpression of Vegfab in radial glia is sufficient to partially rescue the VTA fo

169 These cells coexpress markers for radial glia like GFAPdelta, nestin, and vimentin.

170 Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human bra

171 Here, we have found that mouse hippocampal radial glia-like (RGL) neural stem cells express the syn

172 individual, quiescent, and nestin-expressing radial glia-like (RGL) precursors in the adult mouse den

173 The complex morphology of radial glia-like (RGL) stem cells suggests that these ce

174 signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in

175 gyrus that were in transition from stem-like radial glia-like cells (type 1) to immature transiently

176 human cell types, including five subtypes of radial glia-like cells and four progenitors.

177 Here we show that large numbers of radial glia-like cells and intermediate progenitor cells

178 We find that OSVZ radial glia-like cells have a long basal process but, su

179 These data show that GFAP-expressing radial glia-like cells in the dentate gyrus cradle newbo

180 hibit significant pathology in GFAP-positive radial glia-like cells in the dentate gyrus, and suffer

181 d doublecortin-positive immature neurons and radial glia-like cells in the hippocampal dentate gyrus

182 er, but the cell body of the GFAP-expressing radial glia-like cells is not as intimately associated w

183 The establishment of non-ventricular radial glia-like cells may have been a critical evolutio

184 e identified a pool of embryonically derived radial glia-like cells present in the meninges that migr

185 different stages of neurogenesis, including radial glia-like cells, intermediate progenitors, neurob

186 ntermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neur

187 In developing neural retina, radial glia-like Muller cells are generated late in neur

188 Each part's neurogenic potential, radial glia-like neural stem cells (NSCs) proliferation

189 Radial glia-like neural stem cells (RGLs) in the dentate

190 ive activity due to a reduced number of both radial glia-like neural stem cells (type-1 cells) and in

191 ere we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse de

192 90A, a RHO GTPase-activating protein, in the radial glia-like neural stem cells within the ventricula

193 e adult mouse hippocampus, nestin-expressing radial glia-like quiescent neural stem cells (RGLs) resp

194 on, defects of the self-renewal capacity and radial glia-like stem cell outgrowth of postnatal GD3S-K

195 Specifically, radial glia-like type 1 NSCs were shifted from a prolife

196 First, the radial glia-like, hypothalamic tanycytes show high DCL e

197 lly and spatially restricted trajectories of radial glia maturation and neurogenesis in developing hu

198 iquitin immunofluorescence was identified in radial glia, mature astrocytes, ependyma, and choroid pl

199 eas Pax2(+) optic nerve astroglia and Vim(+) radial glia may aid in early axonal guidance.

200 Although outer subventricular zone radial glia may generate the majority of human cortical

201 Although radial glia may guide axons as they navigate to the supe

202 we show that CNS progenitors, referred to as radial glia, modulate vascular patterning around the spi

203 ression, abnormal cell adhesion, and altered radial glia morphology.

204 We found that GOF disrupts mitosis of radial-glia neural progenitors (RGCs), inside-out radial

205 scriptional regulator PRDM16 is expressed by radial glia, neural progenitors present in both regions;

206 rom the amplification of actively neurogenic radial glia of the embryonic telencephalon.

207 Radial glia of the mouse cerebral cortex emerge from neu

208 SARA is enriched at the apical endfeet of radial glia of the neocortex.

209 NA expression signatures resembling those of radial glia, oligoneuronal precursors, neuronal precurso

210 The resulting clones are derived from two radial glia on average, span cortical layers 2-6, and ar

211 Young neurons did not use radial glia or blood vessels as a migratory scaffold; in

212 progenitor cells merely expand the output of radial glia or instead generate distinct types of neuron

213 ogenitors in the mammalian brain derive from radial glia or specialized astrocytes.

214 hat partial genetic ablation of hypothalamic radial glia or their progeny causes a net increase in th

215 positions in the cortical plate along outer radial glia (oRG) cell fibers.

216 an invasive cell population similar to outer radial glia (oRG), a fetal cell type that expands the st

217 ut virtually absent in rodents, called outer radial glia (ORG), have been suggested to be crucial to

218 ral progenitor cells (NPCs), including outer radial glia (oRG).

219 g early development of the olfactory system, radial glia play an important role in removing overexten

220 tage of cell cycle entry is increased in the radial glia population.

221 sion across single cells, we find that outer radial glia preferentially express genes related to extr

222 edominantly on white matter cells, including radial glia, premyelinating oligodendrocytes, and subpla

223 premature infants (25-37 PCW), we found that radial glia, premyelinating oligodendrocytes, and subpla

224 ding axons closely followed the filaments of radial glia present in the olfactory bulb during embryon

225 ressed in the Bergmann glia, a population of radial glia present in the Purkinje cell layer.

226 eurons but also impairs RGC neurogenesis and radial glia processes.

227 The first type, radial glia, produce neurons and glia, divide at the ven

228 ermediate progenitor cells, are derived from radial glia, produce only neurons, and divide away from

229 We found that mutant radial glia produced abnormally large numbers of Cux1-po

230 Here, we use time-lapse imaging to track radial glia progenitor behavior in the developing zebraf

231 erative capacity of rescued apical and outer radial glia progenitor cells.

232 cal/ventricular surface and the ascending of radial glia/progenitor fibers toward the pial/basal surf

233 In the developing cerebral cortex, radial glia progenitors (RGPs) generate nearly all neoco

234 The mutation leads to eventual reduction in radial glia progenitors (RGPs).

235 of the RNA binding protein (RBP), Elavl4, in radial glia progenitors and early neurons depends on its

236 ion and demonstrate that its inactivation in radial glia progenitors and nascent neurons produces sev

237 Centrosome duplication in dividing radial glia progenitors generates a pair of centrosomes

238 mother centriole is required for maintaining radial glia progenitors in the developing mammalian neoc

239 The generation of neurons and glia from radial glia progenitors is critical to proper neocortica

240 Asymmetric divisions of radial glia progenitors produce self-renewing radial gli

241 to constitute the future neocortex, renewing radial glia progenitors stay in the VZ for subsequent di

242 tion of proliferation, phenotypic changes in radial glia progenitors, and neurogenesis to spinal cord

243 cting different gene expression gradients in radial glia progenitors, intermediate progenitors, and p

244 in the VZ and is preferentially inherited by radial glia progenitors, whereas the centrosome containi

245 randomizes the cleavage plane orientation of radial glia progenitors.

246 nged mitosis is sufficient to alter fates of radial glia progeny and define a new paradigm to underst

247 t the onset of neurogenesis, Rbm8a regulates radial glia proliferation and prevents premature neurona

248 cellular signalling mechanisms that regulate radial glia proliferation are not well understood, it ha

249 However, the relative number of basal radial glia-recently proposed to be important in gyrific

250 sion of the cell polarity regulator Cdc42 in radial glia regulates glial endfeet activities and inter

251 of the olfactory bulb, axons degenerated and radial glia responded by phagocytosing the resulting deb

252 We find that ablation of radial glia results in vessel regression, concomitant wi

253 for the first time, rapid mRNA transport in radial glia, revealing that the basal process is a highw

254 rive in the cortex via tangential migration, radial glia (RG) are the main cell type present.

255 rofiles, characterizing them as a subtype of radial glia (RG) cells.

256 ew studies have shown that some glial cells--radial glia (RG) in development and specific subpopulati

257 types of proliferative astrocyte precursors: radial glia (RG) in the ventricular zone and a second ce

258 diverse repertoire of neuroepithelial cells, radial glia (RG), and intermediate neurogenic progenitor

259 aracterize because progenitors, particularly radial glia (RG), are rare and are defined by a combinat

260 Radial glia (RG), the progenitors of cortical neurons an

261 Folding of the cortex and the persistence of radial glia (RG)-like cells called Bergmann glia (BG) ar

262 ry neuronal progenitor pool that arises from radial glia (RG).

263 to the increased proliferative potential of radial glia (RG; neural stem cells) and their subventric

264 itors (IPs) are derived from the multipotent radial glia (RGs) and serve as the direct precursors for

265 radial glial activities within the evolving radial glia scaffold to coordinate the formation of cere

266 ired to maintain the overall polarity of the radial glia scaffold.

267 toskeletal organization of oRG cells and the radial glia scaffold.

268 rtices, radial glia failed to generate outer radial glia, subsequently resulting in a loss of late ba

269 hest GLAST promoter activity was observed in radial glia, such as those located in the subgranular la

270 se belonging to the recently described outer radial glia, suggesting a mechanism by which ferret neur

271 velopment such as the transcriptome of outer-radial glia, suggesting use of a human-derived model rem

272 dings reveal dynamism and interactions among radial glia that appear to be crucial contributors to th

273 In parallel, the radial glia that contact the ventricle develop distinct

274 developing mouse cortex from GFAP-expressing radial glia that generate neurons and oligodendrocytes.

275 vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neura

276 the store-operated response in Muller cells, radial glia that perform key structural, signaling, osmo

277 ating along a route outlined by a cascade of radial glia, the Dlx2-positive population appears to mig

278 Radial glia, the neural stem cells of the neocortex, are

279 Radial glia, the neuronal stem cells of the embryonic ce

280 Several progenitors, such as the ventricular radial glia, the subventricular intermediate progenitors

281 Radial glia therefore provide an instructive structural

282 lecular and morphological differentiation of radial glia through the transcriptional activation of at

283 ave an important role in the transition from radial glia to astrocytes by stimulating somal transloca

284 Here we show that the transition from radial glia to intermediate progenitor cell is associate

285 ults indicate that FGFs normally repress the radial glia to progenitor cell transition during cortico

286 grate along the rostral migratory stream and radial glia, to reach their final destinations in the ol

287 velopment-more specifically, the ventricular radial glia-to-intermediate progenitor cell transition a

288 Radial glia transform into astrocytes at the end of embr

289 gment epithelium, Kollicker's organ, and the radial glia triggers waves of intracellular Ca(2+) relea

290 r progeny demonstrated that less than 10% of radial glia undergo symmetric divisions resulting in two

291 ng to show that a population of hypothalamic radial glia undergoes self-renewal and generates multipl

292 Ablation of Nsdhl in radial glia using GFAP-cre resulted in live-born, normal

293 unit hypothesis, highlights the ventricular radial glia (vRG) scaffold as a key architectonic featur

294 tricular surface; in the retina, the Mueller radial glia were immunoreactive for Homer1, but not Home

295 atically improve the morphology of disrupted radial glia, whereas blockade of NRG1-erbB signaling pre

296 undergo symmetric divisions resulting in two radial glia, whereas the majority of radial glia divide

297 ExM enabled the tracing of fine processes of radial glia, which are not resolvable with diffraction-l

298 er successfully, owing to the recruitment of radial glia, which function as NSCs.

299 for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in mo

300 elimination of Kif3a from a subpopulation of radial glia, which resulted in ablation of primary cilia