ライフサイエンスコーパス: radial glial cell

1 cell cycle coupling via Cyclin D in a single radial glial cell.

2 l phenotype, activates the erbB2 promoter in radial glial cells.

3 erts a critical role in the establishment of radial glial cells.

4 neocortex are generated by stem cells called radial glial cells.

5 begin to upregulate genes that characterise radial glial cells.

6 retinaldehyde dehydrogenase, is expressed by radial glial cells.

7 llary acidic protein (GFAP) in telencephalic radial glial cells.

8 ed with an abrupt termination of many of the radial glial cells.

9 ocytes by stimulating somal translocation of radial glial cells.

10 ut apparent surface-mediated guidance of the radial glial cells.

11 The radial glial cell, a transient embryonic cell type known

12 that this organization is conserved in basal radial glial cells, a related progenitor cell population

13 Thanks to the persistence of radial glial cells acting as neural stem cells, the brai

14 and that the basal fibre, inherited by outer radial glial cells after ventricular radial glial divisi

15 We resolved 24 clusters of radial glial cells along the neural tube and outlined di

16 dial glia results in the self-renewal of the radial glial cell and the birth of a neuron.

17 oliferation and premature differentiation of radial glial cells and aberrant positioning of newborn n

18 of VZ intermediate progenitors derived from radial glial cells and are distinct from the multipolar

19 Radial glial cells and astrocytes function to support th

20 tion between the two major progenitor types, radial glial cells and basal progenitors, was impaired.

21 monstrated by inactivating the Fgfr1 gene in radial glial cells and by RNAi knockdown of Fgfr1 in viv

22 eactivity is detected simultaneously in both radial glial cells and cells that have the positional an

23 receptor, Cxcr4, is expressed in cerebellar radial glial cells and conditional Cxcr4 ablation with N

24 lar to mammalian astrocytes that derive from radial glial cells and elaborate processes to establish

25 s of cortical neural progenitor cells (NPCs)-radial glial cells and intermediate progenitor cells-was

26 ity is detected in the transitional forms of radial glial cells and mature astrocytes, but not in neu

27 croscopy, we performed time-lapse imaging of radial glial cells and measured filopodial motility in t

28 f gene sets related to the cell cycle, basal radial glial cells and neural differentiation.

29 sent study examined the relationship between radial glial cells and newborn neurons in the adult dent

30 ent, nascent pyramidal neurons migrate along radial glial cells and overtake earlier-born neurons to

31 ventricular radial glial cells produce outer radial glial cells and seed formation of the outer subve

32 ted that both cycling and noncycling Sox2(+) radial glial cells and Tbr2(+) intermediate progenitors

33 expression to the nestin(+)/Pax6(+)/GLAST(+) radial glial cells and Tbr2(+) intermediate progenitors

34 suggesting that defective connection between radial glial cells and the pial surface mediated by LAMB

35 diate interactions of migrating neurons with radial glial cells and to function as a receptor for the

36 ntal defects by reducing the number of basal radial glial cells and upper-layer neurons.

37 cerebral cortex contains migrating neurons, radial glial cells, and a large population of cycling pr

38 cells, intermediate progenitor cells, outer radial glial cells, and neurons.

39 We report that the radial glial cell antigen RC2 identifies the majority of

40 However, the mechanisms that determine how radial glial cells are established, maintained, and tran

41 provide evidence that mouse Fezf2-expressing radial glial cells are multipotent progenitors that sequ

42 Together these results demonstrate that radial glial cells are neural progenitors in the develop

43 al and precursor cells by demonstrating that radial glial cells are themselves neuronal progenitor ce

44 These results identify Fezf2(+) radial glial cells as a multipotent neocortical progenit

45 LA8 altered the fate specification of apical radial glial cells, as reflected by the enrichment of ge

46 ry receptor AXL is highly expressed by human radial glial cells, astrocytes, endothelial cells, and m

47 embrane Dystroglycan and beta1-Integrin in a radial glial cell-autonomous manner.

48 We discovered that Hs-HARE5 modifies radial glial cell behaviour, with increased self-renewal

49 During cortical development, human basal radial glial cells (bRGCs) are highly capable of sustain

50 post-conception revealed high expression in radial glial cells, compatible with a role in neurogenes

51 ence for the cooperative role of neuron- and radial glial-cell-derived ECM molecules in cortical deve

52 NCAN binds to both radial glial-cell-derived tenascin-C (TNC) and hyalurona

53 lear migration (INM)--a hallmark of cortical radial glial cell development.

54 C is not essential for the role of MARCKS in radial glial cell development.

55 Surprisingly, Dcx(ko/Y) radial glial cells displayed spindle orientation abnorma

56 Once formed, polarized radial glial cells divide either symmetrically or asymme

57 a two-step process in which Pax6-expressing radial glial cells divide in the VZ to produce Tbr2-expr

58 Numb expression suppress mPar3 regulation of radial glial cell division and daughter cell fate specif

59 investigation of spindle orientation during radial glial cell division, revealed that NFIX promotes

60 the beating of numerous cilia from ependymal radial glial cells (ERGs) generating flow in the central

61 How radial glial cells establish and maintain their morpholo

62 to reduced reelin signaling and disorganized radial glial cell fibers.

63 developing cerebral cortex, neurons regulate radial glial cell function and radial glial cells, in tu

64 Radial glial cells function during CNS development as ne

65 hin the first few days after labeling, these radial glial cells gave rise to neurons, oligodendrocyte

66 The mechanisms of human outer radial glial cell generation are unknown, but are propos

67 Radial glial cell generation is significantly impaired i

68 During embryonic development, radial glial cells give rise to neurons, then to astrocy

69 Q84Pfs protein promotes the radial glial cell identity and suppresses neuronal migra

70 sociated with specific tumor types including radial glial cells in ependymomas and oligodendrocyte pr

71 ynthetic needs and to produce abundant basal radial glial cells in human brain development.

72 The reduced number of basal radial glial cells in patient-derived cerebral organoids

73 Radial glial cells in the cerebellum were intensely labe

74 Radial glial cells in the cerebral cortex serve as proge

75 f interactions between migrating neurons and radial glial cells in the developing cerebral cortex.

76 of the switch from neuroepithelial cells to radial glial cells in the developing mammalian cerebral

77 cells, and it causes cell-cycle deficits of radial glial cells in the embryonic mouse cortex and hum

78 tributed to protracted neurogenesis by outer radial glial cells in the outer subventricular zone, a r

79 te here that calcium waves propagate through radial glial cells in the proliferative cortical ventric

80 aled that IH(30) increased the proportion of radial glial cells in the subgranular zone, yet decrease

81 oon cells and dysplastic neurons derive from radial glial cells in the telencephalic ventricular zone

82 Neurons arise directly from radial glial cells in the ventricular zone (VZ) and indi

83 During early postnatal periods, radial glial cells in various ventricular zones of the b

84 rons regulate radial glial cell function and radial glial cells, in turn, support neuronal cell migra

85 To study how migrating neurons and radial glial cells influence each others' function in th

86 types crucial during embryonic development: radial glial cells, intermediate progenitor cells, outer

87 Further, differentiation of radial glial cells into astrocytes was accelerated, sugg

88 ptor complex, leads to the transformation of radial glial cells into astrocytes.

89 In this study, we utilized radial glial cells (iRGCs), immature and mature astrocyt

90 CYFIP1 and WAVE signaling similarly affects radial glial cells, leading to their ectopic localizatio

91 In the absence of APC, radial glial cells lose their polarity and responsivenes

92 lar component of the postnatal SVZ, promotes radial glial cell maintenance and proliferation in an au

93 The organization and function of radial glial cells may thus be a unifying feature of the

94 We further find that outer radial glial cell mitotic behaviour is cell intrinsic, a

95 Radial glial cell modulation could thus affect neuron pr

96 proposed to involve division of ventricular radial glial cells; neural stem cells present in all dev

97 probe the development of neural stem cells, radial glial cells, neurons, and astrocytes.

98 Radial glial cells not only facilitate the generation, p

99 These results demonstrate that radial glial cells not only serve as progenitors for man

100 mitotic spindle orientation increased outer radial glial cell number, and ultimately neuronal number

101 Radial migration, apparently supported by radial glial cells, occurred within the proliferative zo

102 In addition to radial glial cells of neurohistogenesis, immature astroc

103 ) or double knock-out mice, respectively] in radial glial cells of the dorsal telencephalon.

104 cortex, neurons are generated directly from radial glial cells or indirectly via basal progenitors.

105 ressing "Pre-OPCs" that originate from outer radial glial cells (oRGs) and undergo mitotic somal tran

106 ic carnivore, focusing our analysis on outer radial glial cells (oRGs).

107 Radial glial cells play a critical role in the construct

108 In the ventricular zone, the radial glial cell population remains largely unaltered m

109 pathway but becomes minimal or absent where radial glial cell processes enter the marginal zone regi

110 reas the protein is exclusively expressed in radial glial cell processes that occupy the rhombomere b

111 ructure formed between migrating neurons and radial glial cell processes.

112 Here we show that human ventricular radial glial cells produce outer radial glial cells and

113 s and contains Pax6(+)/Hopx(+) outer (basal) radial glial cells producing astrocytes and oligodendroc

114 larly, ZIKA-NS2A, but not DENV-NS2A, reduces radial glial cell proliferation and causes AJ deficits i

115 active in the cerebellar VZ and essential to radial glial cell proliferation and expansion of GABAerg

116 Dystroglycan also regulates perinatal radial glial cell proliferation and transition into inte

117 in the developing brain, it led to a halt in radial glial cell proliferation, disorganized radial fib

118 photoreceptor cells, associated neurons, and radial glial cells, rapamycin prevented nuclear and cell

119 nd adhesion interactions between neurons and radial glial cells regulate neuronal migration as well a

120 Recent work suggests that radial glial cells represent many, if not most, of the n

121 Aromatase expression was observed in radial glial cells, revealed by co-localization with the

122 Embryonically, proliferation of radial glial cells (RGC) and intermediate precursors (IP

123 11.5 (E11.5), the majority of Pax6-positive radial glial cells (RGCs) and Tbr2-positive intermediate

124 Radial glial cells (RGCs) are essential for the generati

125 There are indications that radial glial cells (RGCs) are involved in initiating mye

126 Radial glial cells (RGCs) are the most abundant macrogli

127 ne (VZ) challenges the widely held view that radial glial cells (RGCs) are the sole occupants of this

128 e generated in a temporal sequence, with all radial glial cells (RGCs) contributing to both lower and

129 mapping to demonstrate that Fezf2-expressing radial glial cells (RGCs) exist throughout cortical deve

130 evelopment of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtyp

131 ule precursors (CGPs) and differentiation of radial glial cells (RGCs) in the cerebellum.

132 Radial glial cells (RGCs) in the developing cerebral cor

133 Radial glial cells (RGCs) in the ventricular neuroepithe

134 While radial glial cells (RGCs) maintain basal and apical anch

135 During vertebrate cortical neurogenesis, radial glial cells (RGCs) serve as neural stem cells tha

136 ing, regularly spaced, tiled organization of radial glial cells (RGCs) serves as a framework to gener

137 t two types of dividing cells in the VZ: (1) radial glial cells (RGCs) that span the entire neocortic

138 e neocortical ventricular zone (VZ) contains radial glial cells (RGCs) with restricted fate potential

139 go transitions from neuroepithelial cells to radial glial cells (RGCs), and later, a subpopulation of

140 cells in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons,

141 noid modeling shows reduced proliferation of radial glial cells (RGCs), leading to smaller organoids

142 n response to DNA damage resulted in loss of radial glial cells (RGCs), underpinning microcephaly.

143 s seen to colabel subsets of Pax6-expressing radial glial cells (RGCs), whereas only cD2 colabeled wi

144 These features are especially prominent in radial glial cells (RGCs), which are neural and glial pr

145 The polarity and adhesion of radial glial cells (RGCs), which function as progenitors

146 The polarity and organization of radial glial cells (RGCs), which serve as both stem cell

147 nes such as Hmga2 and Ccnd1 when compared to radial glial cells (RGCs).

148 The radial glial cells serve as neural progenitors and as a

149 Because radial glial cells supply the brain with RA during the d

150 t antiadhesive signaling via SPARC-like 1 on radial glial cell surfaces may enable neurons to recogni

151 two types of macroglial cells, Muller cells, radial glial cells that are the principal macroglial cel

152 developing rodent cortex are generated from radial glial cells that function as neural stem cells.

153 Hypothalamic tanycytes, radial glial cells that share many features with neurona

154 During asymmetric divisions of radial glial cells, the basal cell may inherit the radia

155 sufficient to induce somal translocation of radial glial cells throughout the cortex; furthermore, t

156 iking: Zac1 delayed the transition of apical radial glial cells to basal intermediate neuronal progen

157 le exit, with a premature differentiation of radial glial cells to intermediate progenitors and neuro

158 uring embryonic brain development arise from radial glial cells which communicate, in part, via ATP m

159 o promotes the maintenance and elongation of radial glial cells, which are essential for guiding neur

160 t in part by suppressing Notch activation in radial glial cells, which leads to the increased express

161 ere more severely affected, especially outer radial glial cells, which mouse embryonic cortex lacks.

162 Radial glial cells within the scaffold constantly intera