ライフサイエンスコーパス: radiation-induced

1 ression suppresses the formation of ionizing radiation-induced 53BP1 and BRCA1 but not RNF168 foci, s

2 Finally, both PARP inhibition and radiation induced a similar metabolic responses in BRCA-

3 ontrary to published data in other models of radiation-induced acute and chronic toxicity, dose rates

4 inhibition of apoptotic caspases can augment radiation-induced antitumor immunity, independent of typ

5 apy synergizes with immunotherapy, promoting radiation-induced antitumor immunity.

6 phase cells, less susceptible to DNA damage, radiation-induced apoptosis and acquired enhanced migrat

7 In addition, anti-Ang2 enhanced radiation-induced apoptosis in cultured endothelial cell

8 MG132 treatment greatly reduced radiation-induced apoptosis in cultured osteoblastic cel

9 or, we previously reported a strategy termed radiation-induced apoptosis-targeted chemotherapy (RIATC

10 nctional absorption linked to alleviation of radiation-induced apoptotic death of intestinal crypt pr

11 in preirradiated cells, independent of their radiation-induced arrest in the G2/M phase.

12 5-desaturase, then UVR accelerates ionizing radiation-induced BCC carcinogenesis.

13 topical application of D3 inhibits ionizing radiation-induced BCC tumorigenesis.

14 ree Raman spectroscopic mapping to elucidate radiation-induced biomolecular changes in tumors and unc

15 However, radiation-induced bleeding was completely ameliorated in

16 MRI of irradiated spines detected radiation-induced BM vascular damage, measured by the si

17 1-34 and anti-sclerostin antibody attenuates radiation-induced bone damage by accelerating DNA repair

18 mented with dried plum powder (DP) prevented radiation-induced bone loss in mice.

19 n these mice, they recover more rapidly from radiation-induced bone marrow ablation and are more resi

20 of screening mammography; and the number of radiation-induced breast cancer cases and deaths associa

21 Life-years lost from radiation-induced breast cancer could not be estimated.

22 Estimates of risk for radiation-induced breast cancer from mammography screeni

23 Radiation-induced breast cancer incidence and mortality

24 breast cancer deaths averted (benefits) and radiation-induced breast cancer incidence and mortality

25 ntile were projected to develop 246 cases of radiation-induced breast cancer leading to 32 deaths per

26 f population) were projected to have greater radiation-induced breast cancer risk (266 cancer cases a

27 th large breasts may have a greater risk for radiation-induced breast cancer.

28 caffolding protein is exceptionally prone to radiation-induced bubbling.

29 The radiation-induced bystander effect (RIBE) refers to a un

30 However, the underlying mechanism(s) of radiation-induced bystander effect is still unclear.

31 The role of radiation-induced bystander effects in radiation therapy

32 translocation may occur as an early event in radiation-induced bystander responses and mediate TNFalp

33 d that the proportion of ultraviolet B (UVB) radiation-induced C>T transitions differed significantly

34 unique opportunity to study the mechanism of radiation-induced cachexia and will aid in efficacy stud

35 Here, we propose a non-human primate (NHP) radiation-induced cachexia model based on clinical and m

36 ng starting at age 50 years reduced risk for radiation-induced cancer 5-fold.

37 odes et al, as well as lifetime estimates of radiation-induced cancer mortality for mammography and B

38 imated 2 to 11 screening-related deaths from radiation-induced cancer per 100,000 women using digital

39 ation, arrhythmias, pericardial disease, and radiation-induced cardiotoxicity.

40 reatment outcomes and contribute to risk for radiation-induced cardiovascular disease and carcinogene

41 that protracted radiation exposure increases radiation-induced cataract risk: cumulative doses of rad

42 e current understanding of the mechanisms of radiation-induced cataracts.

43 ed prostasphere formation with resistance to radiation induced cell death.

44 data suggest that IL-18 plays a key role in radiation-induced cell and tissue damage and dysfunction

45 Captopril treatment did not affect radiation-induced cell cycle arrest genes or the immedia

46 HDAC4 knockdown and HDAC inhibitor enhanced radiation-induced cell death and reduced homologous reco

47 use adipocytes and protects fibroblasts from radiation-induced cell death, myofibroblast formation, a

48 delayed cell-death) as a means of modelling radiation-induced cell death.

49 translocations are hallmark of cancer and of radiation-induced cell killing, reflecting joining of in

50 with antibody-mediated pharmacokinetics and radiation-induced cell killing.

51 tment with the NOX inhibitor, GKT, decreased radiation-induced cellular injury and restored SMPDL3b b

52 radioresistance in a manner associated with radiation-induced centrosome overduplication and mitotic

53 Radiation-induced changes in the dermis and epidermis we

54 th CT and (18)F-FDG PET/CT is low because of radiation-induced changes.

55 We found no evidence that patients with radiation-induced chronic gastrointestinal symptoms, inc

56 (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) partakes in triple

57 Furthermore, exposure to high-LET radiation induced clonal expansion of a subset of progen

58 glia through CSF1R inhibition can ameliorate radiation-induced cognitive deficits in mice.

59 mals receiving the PLX5622 diet exhibited no radiation-induced cognitive deficits, and exhibited near

60 pocampal transplantation of hNSC ameliorated radiation-induced cognitive deficits.

61 Radiation-induced cognitive dysfunction (RICD) is a prog

62 These radiation-induced cognitive impairments are accompanied

63 c deletion of CNS complement C1q ameliorates radiation-induced cognitive impairments, synaptic loss,

64 PA) and its analog, Radioprotein-1, on gamma-radiation-induced colonic epithelial barrier dysfunction

65 Symptomatic radiation-induced complication was encountered in 8 pati

66 We observed that radiation-induced CS-GRP78 stimulates the nuclear accumu

67 t an increased susceptibility to ultraviolet radiation-induced cutaneous squamous cell carcinoma (cuS

68 Captopril reduced radiation-induced cytokines EPO, G-CSF, and SAA in the p

69 overexpressing podocytes were protected from radiation-induced cytoskeletal remodeling.

70 Blockage of autophagy upregulated radiation-induced cytotoxicity but only modestly affecte

71 eloped after radiation and protected against radiation-induced damage and death in both germ-free and

72 ster model to study the molecular effects of radiation-induced damage and repair.

73 enescence is a fundamental mechanism driving radiation-induced damage in the salivary gland and sugge

74 o produce a proliferative response following radiation-induced damage indicating a fundamental requir

75 myelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes.

76 space pharmaceutical drug molecules from the radiation-induced damage to help extend or at least pres

77 pedient model system to study the effects of radiation-induced damage to the intestine in adults and

78 d, although involved in protecting ISCs from radiation-induced damage, it is non-essential in tissue

79 o protected skin cells and rat skins against radiation-induced damage.

80 e materials with unprecedented resistance to radiation-induced damage.

81 ts into heterogeneous characteristics of the radiation-induced-damage zone.

82 we show that KD of E6AP sensitizes cells to radiation-induced death.

83 ect colorectal or prostate cancer cells from radiation-induced death.

84 quencing revealed that Ang2 blocking rescued radiation-induced decreases in T cells and cells of the

85 uses conducting polymer tattoos to detect UV radiation-induced deep tissue damage in living organisms

86 eling (RBS-C) spectra show that the range of radiation-induced defect clusters far exceed the theoret

87 s can absorb and eliminate a large number of radiation-induced defect clusters.

88 rfaces capable of absorbing and annihilating radiation-induced defects.

89 dalities, we showed that FLASH did not cause radiation-induced deficits in learning and memory in mic

90 , our mouse model can be used for studies on radiation-induced development of GBM and therapeutic str

91 chromatids in G-2 arrested cells of random, radiation-induced 'dirty' DSBs.

92 al cardiologists are increasingly exposed to radiation-induced diseases like cataract and the stochas

93 Ionising radiation induced DNA damage and subsequent biological r

94 Radiation induced DNA damage repair is an attractive the

95 Following radiation induced DNA damage, several repair pathways ar

96 y protect in multiple ways normal cells from radiation-induced DNA damage but also make cancer cells

97 Failure in repairing ultraviolet radiation-induced DNA damage can lead to mutations and c

98 ent detection of repair proteins at ionizing radiation-induced DNA damage foci that Wwox expression s

99 sicles, and iii) ability to resolve ionizing radiation-induced DNA damage foci.

100 Low-dose radiation-induced DNA damage in the epithelial cells of

101 Mechanistically, we found that AIM2 senses radiation-induced DNA damage in the nucleus to mediate i

102 Because ATM is an apical kinase in the radiation-induced DNA damage response, we investigated t

103 the salivary gland long after initiation of radiation-induced DNA damage was required for both senes

104 over, our PARG inhibitor sensitizes cells to radiation-induced DNA damage, suppresses replication for

105 tes important apoptotic genes in response to radiation-induced DNA damage.

106 regulation and also influences the repair of radiation-induced DNA damage.

107 d to sustain stress-survival responses after radiation-induced DNA damage.

108 in preventing cutaneous cancer caused by UV radiation-induced DNA damage.

109 tumors while oxygen is essential to enhance radiation-induced DNA damages.

110 mal intermingling is an important driver for radiation-induced DNA mis-repair.

111 roteins and variably contributes to ionizing radiation-induced DSB repair in human and chicken cells.

112 ocalize with phosphorylated H2AX at ionizing radiation-induced DSBs but not with 53BP1.

113 Our results demonstrate that radiation-induced DSBs cooperate with preexisting tumor

114 tion; however, its contribution to repair of radiation-induced DSBs has not been characterized.

115 loped an application allowing simulations of radiation induced early DNA damage on a naked cell nucle

116 However, the molecular basis of such a radiation induced effect is not known.

117 While Hey2 silencing has no effect on radiation-induced EndoMT in vitro, Hey2 overexpression i

118 ted the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition

119 reached at 11 mo after nCRT, suggesting that radiation-induced esophagitis had mostly resolved by tha

120 beyond 3 mo after nCRT and to determine when radiation-induced esophagitis has resolved.

121 nCRT as soon as the esophagus recovers from radiation-induced esophagitis.

122 In the current study, we showed that gamma radiation-induced expression of p21(Waf1/Cip1) in Bmi1-C

123 al changes in heart function are produced by radiation-induced fibrosis and cardiomyocyte functional

124 Most of these symptoms are caused by radiation-induced fibrosis and reduce the quality of lif

125 served in animal models that the severity of radiation-induced fibrosis in normal tissue correlates t

126 r blockade or deletion of A2AR could prevent radiation-induced fibrosis.

127 NA damage, and RAD51 recruitment to ionizing radiation induced foci (IRIF), which requires end resect

128 The average number of radiation-induced foci (RIF) per cell increased over the

129 of histone-variant H2AX (gamma-H2AX) to mark radiation-induced foci (RIFs).

130 at specifically associates with the ionizing radiation-induced foci formation region of 53BP1.

131 tination as well as 53BP1 and BRCA1 ionizing radiation-induced foci formation.

132 exhibit reduced ATM activation and ionizing radiation-induced foci, they display apoptotic pannuclea

133 ics at the crystal-melt interface during the radiation induced formation of Se nano-crystallites in p

134 ees C, began transforming to alpha-SiC, with radiation-induced Frank dislocation loops serving as the

135 e S phase to the G2/M phase and functions in radiation-induced G2 checkpoint control.

136 y reducing untoward morbidity and death from radiation-induced gastrointestinal bleeding.

137 -approved medications that prevent or reduce radiation-induced gastrointestinal injury.

138 Radiation-induced gastrointestinal syndrome (RIGS) is a

139 of lymphopenia and assessed the severity of radiation-induced gastrointestinal toxicity triggered by

140 Radiation-induced gastrointestinal toxicity was more pro

141 ammatory enterocolitis, mesenteric ischemia, radiation-induced gastrointestinal toxicity, and Graft v

142 phosphodiesterase acid-like 3b (SMPDL3b) in radiation-induced GEnC damage.

143 NOX-derived reactive oxygen species (ROS) in radiation-induced GEnC damage.

144 RNA-sequencing studies revealed that most radiation-induced genes were strongly dependent on only

145 aneously inhibiting telomerase and promoting radiation-induced genomic DNA damage.

146 ding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS).

147 y patients with GBM confer susceptibility to radiation-induced glioma.

148 eous gliomas, but were highly susceptible to radiation-induced gliomagenesis.

149 , there is considerable debate about whether radiation-induced green-up during the dry season is real

150 ation of the regenerative response following radiation-induced gut injury is needed to develop a prev

151 h for natural genetic variants that regulate radiation-induced gut permeability in adult D. melanogas

152 ically, most research on understanding space radiation-induced health risks has been performed using

153 possible survival benefit might be offset by radiation-induced heart disease.

154 allocated to no IMNI because of the risk of radiation-induced heart disease.

155 4 h to 28 d in nonhuman primates (NHPs) with radiation-induced hematopoietic syndrome (6.5 Gy exposur

156 apy delivered at 3 h or 30 h in ameliorating radiation-induced hematopoietic syndrome and show that p

157 The only available option to treat radiation-induced hematopoietic syndrome is allogeneic h

158 etry is particularly suitable for minimizing radiation-induced hepatotoxicity.

159 Mechanistically, DJ001 suppresses radiation-induced HSC apoptosis via activation of the Rh

160 be limited by the development of persistent radiation-induced immunosuppression.

161 Radiation-induced impairments in spatial, episodic and r

162 hat IL-18BP may protect multiple organs from radiation-induced inflammation and oxidative stress.

163 Radiation-induced inflammatory markers for bone marrow a

164 l the development of agents for ameliorating radiation-induced injuries.

165 intestinal stem cell regeneration following radiation-induced injury in vivo, and enhances recovery

166 ng-lived clones during homeostasis and after radiation-induced injury in vivo.

167 esponse for cell survival/self-renewal after radiation-induced injury is unclear.

168 hich emulates clinically relevant intestinal radiation-induced injury, can be used to assess radiopro

169 esophageal epithelial regeneration following radiation-induced injury.

170 le for restitution and function after severe radiation-induced injury.

171 scence and regenerative potential upon gamma radiation-induced injury.

172 ported that IL-18 plays an important role in radiation-induced injury.

173 se ATR can significantly potentiate ionizing radiation-induced innate immune responses.

174 l for studying the molecular determinants of radiation-induced intestinal damage and testing novel ra

175 Radiation-induced intestinal injury (RIII) constitutes a

176 ved agent for the prevention or treatment of radiation-induced intestinal injury.

177 eased survival after irradiation and rescued radiation-induced intestinal permeability.

178 During radiation-induced intestinal regeneration, LIG4 mainly e

179 SMPDL3b as a potential therapeutic target in radiation-induced kidney damage.

180 he cell cycle, is an impediment to repair of radiation-induced lesions in this organism, and that the

181 clin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice.

182 HDAC4 signaling blockade enhances radiation-induced lethality in HCC cells and xenografts.

183 blation and are more resistant to whole-body radiation-induced lethality.

184 ribed in salivary glands in conjunction with radiation-induced loss of salivary gland function as wel

185 ine in BALF and exhibited significantly less radiation-induced lung fibrosis (P < 0.010).

186 Radiation-induced lung fibrosis (RILF) is a common side

187 r findings demonstrate that CD73 potentiates radiation-induced lung fibrosis, suggesting that existin

188 nduced changes in the myeloid compartment in radiation-induced lung fibrosis.

189 r CD73 antibodies also significantly reduced radiation-induced lung fibrosis.

190 s unclear whether it plays a similar role in radiation-induced lung fibrosis.

191 Radiation-induced lung injury (RILI) is a delayed effect

192 Differences in the pathogenesis of radiation-induced lung injury among murine strains offer

193 monstrate that IL-13 is a major regulator of radiation-induced lung injury and demonstrates that stra

194 minimally invasive biomarkers for predicting radiation-induced lung injury before symptoms develop.

195 ave been proposed for predicting symptomatic radiation-induced lung injury in human.

196 Radiation-induced lung injury is a highly complex combin

197 tly labeled and injected into a rat model of radiation-induced lung injury via endotracheal (ET) or i

198 new therapeutic avenues for the treatment of radiation-induced lung injury.

199 ond can spare the immune system in models of radiation induced lymphopenia.

200 diation in our models of cardiac and splenic radiation-induced lymphopenia or gastrointestinal mucosa

201 Moreover, ionizing radiation induced macrophage morphological alterations a

202 rty eyes in 40 treatment-naive patients with radiation-induced macular edema and a resulting decrease

203 c, GaAs/AlGaAs 2D electron system, where the radiation-induced magnetoresistance oscillation frequenc

204 Radiation-induced magnetoresistance oscillations are exa

205 Such expectations for the radiation-induced magnetoresistance oscillations are pre

206 teristics of the microwave/mm-wave/terahertz radiation-induced magnetoresistance oscillations in mono

207 report that the oscillation frequency of the radiation-induced magnetoresistance oscillations in the

208 aphene, bilayer graphene is expected to show radiation-induced magnetoresistance oscillations more si

209 etoresistance effect even in the presence of radiation-induced magnetoresistance oscillations, the ma

210 or use as a chemopreventive strategy for UVB radiation-induced malignancies.

211 ism are hypothyroidism and a minimal risk of radiation-induced malignancies.

212 nts because of an increased lifetime risk of radiation-induced malignancies.

213 an anti-CCR2 antibody results in blockade of radiation-induced MDSC infiltration.

214 Although radiation-induced mesenteritis or peritonitis can potent

215 ur studies performed by means of synchrotron radiation induced micro- and submicro-X-ray fluorescence

216 UCY2C signaling exacerbated RIGS, amplifying radiation-induced mortality, weight loss, mucosal bleedi

217 activation and therefore may mitigate/treat radiation-induced multiple organ injuries and increase a

218 ell polyomavirus integration and ultraviolet-radiation-induced mutations, providing rationale for tre

219 TFP causes loss of radiation-induced Nanog mRNA expression, and activation

220 For radiation-induced nausea and vomiting, adjustments were

221 intracellular molecular pathways involved in radiation-induced nephropathy are still poorly understoo

222 Radiation-induced neurocognitive decrements in immunocom

223 ne at the Australian Synchrotron, we studied radiation-induced nontargeted effects in C57BL/6 mice.

224 ormed for potentially other reasons, such as radiation-induced optic neuropathy, or where visual outc

225 ral mucosa as a potential therapy to prevent radiation induced oral mucositis.

226 The primary and secondary endpoints were radiation-induced oral mucositis and neck dermatitis, re

227 el role of proteasome inhibitors in treating radiation-induced osteoporosis.

228 zomib is a novel therapeutic agent for focal radiation-induced osteoporosis.

229 ing NOX1 using NOX1-specific siRNA mitigated radiation-induced oxidative stress and cellular injury.

230 of skin injury common to these exposures is radiation-induced oxidative stress.

231 treatment strongly but reversibly inhibited radiation-induced p53 activation, which blocked p53-upre

232 d prior to irradiation significantly reduced radiation-induced pain after 3, 7, and 21days by 53+/-4%

233 oustic beam, as opposed to previous acoustic radiation induced particle concentration where objects t

234 nces the efficacy of RT in GBM by preventing radiation-induced phenotype conversion of radiosensitive

235 at sites of covalent DNA lesions such as UV radiation-induced photoproducts.

236 cate a potential role for SMPDL3b and RTX in radiation-induced podocytopathy.

237 dy investigates the role of sphingolipids in radiation-induced podocytopathy.

238 ust be considered in the safety assessments, radiation induced processes constitute a key-component.

239 Tracking primary radiation-induced processes in matter requires ultrafast

240 Radiation-induced proctitis (RIP) is the most common cli

241 Using a murine model of radiation-induced proctitis, the prophylactic delivery o

242 Radiation induced production of MCSF by PDA cells.

243 Radiation-induced pulmonary fibrosis (RIPF) is a debilit

244 Radiation-induced pulmonary fibrosis (RIPF) is a debilit

245 Radiation-induced pulmonary fibrosis (RTPF) is a progres

246 prominent modification in a murine model of radiation-induced pulmonary fibrosis and in idiopathic p

247 Radiation-induced pulmonary fibrosis is a severe side ef

248 othesis that IL-13 drives the progression of radiation-induced pulmonary fibrosis.

249 to unrecognized sequelae that contributes to radiation-induced pulmonary injury and IPF.

250 s, and may yield important insights into the radiation-induced reactive sites for corrosion and catal

251 Quantification of radiation-induced recovery caused by alpha-particles dur

252 nd m-IC(C12) cell monolayers, LPA attenuated radiation-induced redistribution of TJ proteins, which w

253 iation of GSCs in vitro, suggesting that the radiation-induced reduction in ITH was dependent on the

254 niques, crystallographic orientation and the radiation-induced relative strains were measured and fur

255 Here we report the current spikes due to radiation-induced resonant tunneling of fluctuation Coop

256 In summary, our findings uncovered a novel radiation-induced response, which may modify radiation t

257 n dose and may predict future development of radiation-induced retinal toxicity.

258 There was no clinical evidence (0%) of radiation-induced retinopathy, maculopathy, or optic neu

259 ric oxide synthases uncoupling and augmented radiation-induced ROS.

260 ls and nitric oxide production and decreased radiation-induced ROS.

261 ithin the murine submandibular gland rescued radiation-induced salivary gland dysfunction.

262 In this study, we used a mouse model of radiation-induced salivary hypofunction to investigate t

263 rium solute clusters formed and sustained by radiation induced segregation (RIS); or, (b) equilibrium

264 y characteristics are found to determine the radiation-induced segregation of Cr.

265 It is thus essential to understand the radiation-induced segregation of native defects and impu

266 howed that depletion of TAZ by RNAi promotes radiation-induced senescence and growth arrest.

267 gested that inhibition of TAZ is involved in radiation-induced senescence and might benefit GBM radio

268 utathione and increased their sensitivity to radiation-induced senescence.

269 tant risk factors for solar ultraviolet (UV) radiation-induced skin cancer.

270 targeted antioxidant prevents and mitigates radiation-induced skin damage characterized by clinical

271 Radiation-induced skin damage ranges from photoaging and

272 NF-E2-related factor 2/GCH1/BH4 axis during radiation-induced skin damage.

273 roves tissue perfusion and mitigates chronic radiation-induced skin fibrosis, highlighting a potentia

274 related factor 2-mediated protection against radiation-induced skin injury by inhibiting ROS producti

275 Radiation-induced skin injury is a common side effect of

276 e (50-500 bp) scale, obtained using ionizing radiation-induced spatially correlated cleavage of DNA w

277 We propose that radiation-induced STING activation is immunosuppressive

278 determine that a combination of surface and radiation-induced strains lead to an FCC to hexagonal cl

279 plantation and promotes HSPC expansion after radiation-induced stress.

280 at Li-layered cathodes are more resistant to radiation-induced structural transformations, such as am

281 he mevalonate pathway prevented fractionated-radiation-induced suppression of KLF2, TM, and eNOS expr

282 tenin destruction complex is able to promote radiation-induced TAZ inhibition and growth arrest in th

283 However, radiation-induced therapeutic effect in viable cells in

284 chymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice.

285 al-dependent apoptosis plays a major role in radiation-induced tissue damage.

286 rinapant inhibited tumor growth and enhanced radiation-induced TNFalpha, tumor responses, and host su

287 aid the understanding of dose dependence of radiation-induced toxicities after eye-preserving radiot

288 thout influencing acute DNA damage or a late radiation-induced toxicity (fibrosis) to normal mouse lu

289 ignificant proportion of patients experience radiation-induced toxicity due to damage to normal tissu

290 In this review, radiation-induced toxicity in the gastrointestinal (GI)

291 Conclusion: No apparent signs of radiation-induced toxicity or decreased tolerance to rel

292 ct several cellular compartments affected by radiation-induced toxicity.

293 his study, we determined if the frequency of radiation-induced transformation and cancer progression

294 ther, these results suggest that analysis of radiation-induced translatomes can provide new molecular

295 could more actively target to the ligands of radiation-induced tumor cells, which could accumulate mo

296 ted here whether Ang2 blocking could enhance radiation-induced tumor vascular damage.

297 Concerns on high-energy particle radiation-induced tumorigenic transformation of normal t

298 articles provided noninvasive information on radiation-induced vascular damage.

299 such as Takayasu arteritis, chemotherapy- or radiation-induced vascular inflammation, or foreign-body

300 e escalation clinical trial in patients with radiation-induced xerostomia.