ライフサイエンスコーパス: radioresistant

1 ports suggest that mast cells are relatively radioresistant.

2 ons in the Atm-/- central nervous system are radioresistant.

3 +) cells phagocytose, respond to LPS and are radioresistant.

4 to radiotherapy, whereas adjacent CSCs were radioresistant.

5 astoma stem-like cells (GSC) that are highly radioresistant.

6 ISCs in mice can cycle rapidly yet still be radioresistant.

7 Consequently, EGFRvIII-expressing tumors are radioresistant and continue to grow following whole-brai

8 Further, Krt15+ cells were radioresistant and contributed to esophageal epithelial

9 The critical FcgammaRII(+) cells are radioresistant and could not be reconstituted with splen

10 Thus, in vivo both radioresistant and hemopoietic cells play key nonredunda

11 Glioblastomas (GBM) are highly radioresistant and lethal brain tumors.

12 precursors, whereas the other was relatively radioresistant and long-lived.

13 Since cancer stem cells (CSCs) are radioresistant and metastasis-initiating cells, we exami

14 radioresistant cells and PAFR engagement on radioresistant and radiosensitive cells in the lung prom

15 The contribution of radioresistant and radiosensitive cells to Il-18bp produ

16 mice revealed that TLR and RLH signaling of radioresistant and radiosensitive cells was required for

17 demonstrated that Ifitm3 functioned in both radioresistant and radiosensitive cells, as higher level

18 genetic overexpression and knockdown yielded radioresistant and sensitive phenotypes, respectively, i

19 Deinococcus radiodurans, a highly radioresistant and stress-resistant bacterium, encodes t

20 Uveal melanomas are notoriously radioresistant and thus necessitate treatment with extre

21 in fraction of gingival gammadeltaT cells is radioresistant and tissue-resident, persisting locally i

22 In bone marrow chimeras, radioresistant and, likely, nonhematopoietic cells were

23 to encounter B27 in the thymus, and residual radioresistant and/or extrathymically derived host T cel

24 elative contributions of the nonhemopoietic (radioresistant) and the hemopoietic (radiosensitive) com

25 o a later onset of lymphoma development, are radioresistant, and lack serum Ig throughout life.

26 ompared with differentiated cells, GSCs were radioresistant, and this correlated with a higher mitoch

27 We found that radioresistant antigen-presenting cells and, specificall

28 ed both I-A glycoproteins and high levels of radioresistant APC activity.

29 ast to radiosensitive Atm-/- fibroblasts and radioresistant Atm-/- neurons, survival of Atm-/- astroc

30 cQ family member, the RecQ helicase from the radioresistant bacterium Deinococcus radiodurans encodes

31 moted by the RecA protein from the extremely radioresistant bacterium Deinococcus radiodurans is the

32 mM, and [DP1] = 3 mM, the ratio found in the radioresistant bacterium Deinococcus radiodurans, with [

33 ide the evidence that aggressive behavior of radioresistant BC is caused by CD47-mediated anti-phagoc

34 Radioresistant BCBM cell lines and specimens expressed h

35 We found that SPARC deficiency in the radioresistant BM stroma compartment impairs myelofibros

36 sis is concurrently upregulated with HER2 in radioresistant breast cancer (BC) cells and RT-treated m

37 HER2(+)/CD44(+)/CD24(-/low)) isolated from a radioresistant breast cancer cell population after long-

38 se proteins in two pairs of matched parental/radioresistant breast cancer cells (i.e., MDA-MB-231 and

39 human cancers, including chemoresistant and radioresistant breast cancer cells, but its functional c

40 to explore Rac1 as a therapeutic target for radioresistant breast cancer cells.

41 ere used as companion biomarkers to identify radioresistant breast cancer xenografts highly amenable

42 The radioresistant C33A and CaSki cell lines, but not the ra

43 -231 and MCF-7 cells and their corresponding radioresistant C5 and C6 clones), with the goal of asses

44 Copper ionophore treatment sensitizes radioresistant cancer cells and cell line- and patient-d

45 The selection of radioresistant cancer cells during fractionated radiatio

46 (RR) as well as the biological signatures of radioresistant cancer cells still need to be clarified.

47 The up-regulation of the PrxII protein in radioresistant cancer cells suggested that human peroxir

48 sing the subpopulation of chemoresistant and radioresistant cancer stem cells (CSC).

49 s for tumoricidal treatment of traditionally radioresistant cancers while sparing critical adjacent s

50 n of TLR9/STAT3 signaling may help eliminate radioresistant cancers.

51 of allogeneic bone marrow was mediated by a radioresistant CD8(+)TCR-alphabeta(+)NK1.1(-) T cell pop

52 that MyD88 and the IL-18R were required in a radioresistant cell in the sensitization phase of the CH

53 MDA-MB-231 and MCF7, and their corresponding radioresistant cell lines.

54 een the presence of an active and relatively radioresistant cell population, demonstrable in vitro, a

55 In both tumorigenic and radioresistant cell populations, a phenotypic switch occ

56 ce using bone marrow chimeras and found that radioresistant cells (presumably LC) were able to cross-

57 cation of TLR3 signaling by nonhematopoietic radioresistant cells and enhanced mouse protection to ho

58 imeric mice revealed that CD36 engagement on radioresistant cells and PAFR engagement on radioresista

59 tained gammaH2AX for a greater duration than radioresistant cells and tumors.

60 e measured DC activation in a model in which radioresistant cells can or cannot respond to lipopolysa

61 migration induced by LPS is unimpaired when radioresistant cells cannot respond to the stimulus.

62 NLRP6 signalling in both haematopoietic and radioresistant cells contributed to increased susceptibi

63 spleen as opposed to a major contribution of radioresistant cells in the lung.

64 eleration mainly involved HVEM expression by radioresistant cells in the Rag(-/-) recipients interact

65 One method to make hypoxic, radioresistant cells more radiation sensitive has been t

66 TNF-alpha, IL-12, and IL-6 cytokines and the radioresistant cells most of the KC, IP-10, and MCP-1 cy

67 Together, our data show that VM-expressing radioresistant cells play a key role in the initiation o

68 We observed that radiosensitive and radioresistant cells played distinct roles in the innate

69 We identified lung endothelial cells as radioresistant cells that express STING.

70 e marrow-derived and non-bone marrow-derived radioresistant cells to induce hemagglutinin-specific an

71 a U251 cells and moderately sensitized these radioresistant cells to radiation.

72 -18bp expression in either radiosensitive or radioresistant cells using bone marrow transfer between

73 In bone marrow chimeras, synthesis of C3 by radioresistant cells was necessary and sufficient to con

74 ure IL-7 availability in vivo, we found that radioresistant cells were the source of IL-7 for both CD

75 Mice lacking IL-1R on radioresistant cells, but not hematopoietic cells, faile

76 Finally, disruption of IL-12p70 in radioresistant cells, such as LCs, but not in BMDCs resu

77 a STAT1 and IFN-gamma receptors expressed on radioresistant cells, suppresses fibrin deposition.

78 s absent or limited to radiosensitive versus radioresistant cells.

79 and altered cytokine secretion by surviving radioresistant cells.

80 Cysltr2 or when deficiency was restricted to radioresistant cells.

81 y in both donor hematopoietic cells and host radioresistant cells.

82 ersely correlated with expression of Chk1 in radioresistant cells.

83 notype is dependent on AHR in Tek-expressing radioresistant cells.

84 hematopoietic cells and the IL-1 receptor on radioresistant cells.

85 p90 interaction and HIF-1alpha expression in radioresistant cells.

86 We established three radioresistant cervical cancer cell lines by exposure of

87 blasts from IFN receptor 1 knockout mice are radioresistant compared with wild-type mouse embryonic f

88 We report that recognition of LPS by the radioresistant compartment is sufficient to induce local

89 l types, C/EBPdelta was required only in the radioresistant compartment to drive GN pathology.

90 uced by hematopoietic cells is sensed by the radioresistant compartment to promote bone disease.

91 (MTP), as well as deletion of HSP110 in the radioresistant compartment.

92 C is often resistant to radiotherapy, making radioresistant CRPC an incurable disease.

93 d ATM expression and mitigated the growth of radioresistant CRPC tumors.

94 tore the cytotoxic effects of irradiation in radioresistant CSC populations.

95 on profiling of prostate cancer cells, their radioresistant derivatives, ALDH(+) and ALDH(-) cell pop

96 Overall, this study identified a highly radioresistant dietary fungus, Aureobasidium pullulans,

97 s, these features may identify patients with radioresistant disease and provide an opportunity for ph

98 led to more residual chromosome aberrations, radioresistant DNA synthesis (a hallmark of genomic inst

99 ataxia telangiectasia-like disorder undergo radioresistant DNA synthesis (RDS), failing to suppress

100 n the intra S phase checkpoint, resulting in radioresistant DNA synthesis (RDS)-the failure to suppre

101 langiectasia mutated (ATM) kinase and elicit radioresistant DNA synthesis after gamma-irradiation(2).

102 Cells deficient in MLL showed radioresistant DNA synthesis and chromatid-type genomic

103 rexpression of wild-type ATR complements the radioresistant DNA synthesis phenotype of cells lacking

104 imics human t(11;16) leukaemia show a severe radioresistant DNA synthesis phenotype.

105 This 'radioresistant DNA synthesis' (RDS) is a phenotypic hall

106 nt of A549 cells with wortmannin resulted in radioresistant DNA synthesis, a characteristic abnormali

107 astoid cell lines, we used radiosensitivity, radioresistant DNA synthesis, and irradiation-induced au

108 cancer predisposition, radiosensitivity and radioresistant DNA synthesis-S phase checkpoint deficien

109 ation and p53 serine 18 phosphorylation, and radioresistant DNA synthesis.

110 itosis, and S-phase-irradiated cells exhibit radioresistant DNA synthesis.

111 tion-induced DNA damage, a phenomenon termed radioresistant DNA synthesis.

112 ective DNA-PKcs(-/-) tumor cell line and its radioresistant DNA-PKcs(+/+)-transfected counterpart wer

113 cytes and cognate self-antigens expressed by radioresistant elements in the thymus have been shown to

114 ed analyses of RNA sequencing (RNA-seq) from radioresistant esophageal cancer cells and single-cell R

115 Unexpectedly, radioresistant FcRgamma-expressing cells in an organ dis

116 d suggest that metabolically dismantling the radioresistant features of tumors may provide potential

117 rmore, this method could identify additional radioresistant fungi that protect the gut from radiation

118 ila model to test whether feeding two highly radioresistant fungi, Aureobasidium pullulans and Rhodot

119 is associated with CD47 anti-phagocytosis in radioresistant GBM cells and regrown GBM after radiation

120 small cell lung carcinoma 54A and the highly radioresistant glioblastoma multiforme U87, respectively

121 We found that these radioresistant glioma cells are susceptible to Fas-media

122 quely radiosensitive GM cell line but not in radioresistant GM cell lines.

123 nsitivity: radiosensitive, radio-normal, and radioresistant groups.

124 d glucose flux leads to glucose addiction in radioresistant HCC cells and a corresponding increase in

125 stant C33A and CaSki cell lines, but not the radioresistant HeLa cell line, exhibited significantly i

126 ating from nonhematopoietic tissues and from radioresistant hematopoietic cells are neither sufficien

127 lysis class, number of brain metastases, and radioresistant histology.

128 mda5 was required in both marrow-derived and radioresistant host cells for adaptive responses.

129 as generated by both bone marrow-derived and radioresistant host cells.

130 Specific targeting of radioresistant host NK cells allows for a significant re

131 Thus, radioresistant host T cells are a significant barrier to

132 Radioresistant host T cells significantly affect the abi

133 Radioresistant HT29 and OVCAR cells demonstrate BrdU foc

134 ically as experimental sensitizing agents in radioresistant human cancers, and there is a direct corr

135 Radioresistant human glioblastoma cells in which erbB re

136 n, ICP0, from the viral genome, rendered two radioresistant human glioblastoma multiforme cell lines

137 at 2-4 h after IR (450-600 cGy) in confluent radioresistant human malignant melanoma (U1-Mel) cells.

138 mRNA expression was consistently elevated in radioresistant human rectal cancers.

139 on or immunoreactivity in radiosensitive and radioresistant human tumor cell lines and xenografted tu

140 Two murine models of radioresistant hypoxic cancer were used to study the eff

141 eathing is potentially useful to reoxygenate radioresistant hypoxic cells and improve the radiotherap

142 ggests that CHL was especially pronounced in radioresistant hypoxic cells possessing a larger transme

143 n by BM-derived cells and TNFR expression by radioresistant IECs.

144 to respond to alloantigens and deplete host radioresistant immune cells in GVHD recipients, alloreac

145 group composed of tumor cell lines that were radioresistant in culture (D0 > 2 Gy) and derived from k

146 ls are highly radiosensitive in the soma and radioresistant in the germline.

147 of p53 does not make these epithelial cells radioresistant in vivo to doses of 8 Gy and above.

148 Axl and Mer are expressed in radioresistant intestinal macrophages, and the loss of t

149 The role for FcgammaRIIb expression on radioresistant intrinsic renal cells in the protection f

150 We propose the name "sessile" for the radioresistant Kupffer cells that do not participate in

151 Sequential exposure of radioresistant LNCaP (wild-type (wt) p53), LNCaP/Bcl-2 (

152 lts indicate that HA14-1 potently sensitizes radioresistant LNCaP and PC3 cells to gamma radiation, r

153 vival and angiogenic activity in a subset of radioresistant lung cancer cell lines by elevating HIF-1

154 sed the survival and angiogenic potential of radioresistant lung cancer cells in vitro.

155 Likewise, siRNA silencing of TRAF2 in radioresistant lung cancer H1299 cells caused growth sup

156 First, before radiation exposure the radioresistant LYar cells expressed significantly greate

157 owing irradiation, which was not observed in radioresistant male NSCLC cell lines.

158 vealed the loss of chromosome Y (LOY) in the radioresistant male NSCLC cell lines.

159 the CNS in both Bax-/- and Atm-/- mice were radioresistant, mice nullizygous for both Bax and Atm sh

160 purpose was to examine whether targeting of radioresistant NK cells and/or T cells in the recipient

161 These data suggest that radioresistant non-LC present self-Ag in K14-OVAp mice a

162 lized OVA requires the expression of Jak3 in radioresistant nonhematopoietic cells.

163 ppears to be associated with a population of radioresistant nonlymphoid cells.

164 lignancy among women worldwide and is highly radioresistant, often resulting in local treatment failu

165 and Rickettsia prowazekii, and the extremely radioresistant organism Deinococcus radiodurans.

166 ointing to a critical role for VM-expressing radioresistant parenchymal and/or stromal cells in the r

167 line-derived model and in radiosensitive and radioresistant patient-derived models of glioblastoma th

168 ed to improve GBM control by eliminating the radioresistant phagocytosis-proofing tumor cells in GBM

169 from a neutral sphingomyelinase generates a radioresistant phenotype as measured by a marked decreas

170 lular GSH levels, and consequently induced a radioresistant phenotype in a HIF-1-dependent manner.

171 y the oncogenic small GTPase, Ras, display a radioresistant phenotype in response to ionizing radiati

172 -3 kinase (PI-3K) with LY294002 reverted the radioresistant phenotype in the immortalized astrocytes.

173 + intestinal stem cell population retain the radioresistant phenotype of normal colorectal PDOs, mali

174 The exact biological mechanism governing the radioresistant phenotype of prostate tumours at a high r

175 The radioresistant phenotype was reversed when the cells wer

176 Loss of H3K27me3 was associated with a radioresistant phenotype, high relapse rates, and poor o

177 st that cancer cells acquire antioxidant and radioresistant phenotypes through UCHL1-HIF-1-mediated m

178 ciated enrichment of CD44 subpopulations and radioresistant phenotypes.

179 PC-F vaccine can induce specific immunity to radioresistant populations of mammary tumor cells and, t

180 e increased to eradicate tumor residues with radioresistant properties due to other factors.

181 has been associated with the antioxidant and radioresistant properties of cancer cells, gene networks

182 ensitization, and hindered tumorigenicity of radioresistant prostate cancer cells.

183 hydrogenase (ALDH) activity is indicative of radioresistant prostate progenitor cells with an enhance

184 and that the marker-identified population is radioresistant relative to the marker-negative cells.

185 ired IRF-1 expression by both leukocytes and radioresistant renal cells, the latter identified as S3

186 CBCs are relatively radioresistant, repairing DNA by homologous recombinatio

187 ified into a radiosensitive (RS) group and a radioresistant (RR) group.

188 ld be a useful approach for the treatment of radioresistant solid tumors such as glioblastomas.

189 inases (CDKs) to convert normal cells into a radioresistant state by inducing reversible cell cycle a

190 whereas concomitant TLR and RLH signaling of radioresistant stroma cells as well as of radiosensitive

191 B virus infection through its action within radioresistant stromal cells and not bone marrow-derived

192 ressing NK cell precursors and LT-responsive radioresistant stromal cells are necessary for NK cell d

193 sis function required expression of CD137 by radioresistant stromal cells as well as by bone marrow-d

194 est not in hematopoietic cells but rather in radioresistant stromal cells needed for the development

195 ion by both radiosensitive hematopoietic and radioresistant stromal cells prevented exacerbation of a

196 pressures on UPSs and suggest that targeting radioresistant subclonal populations could improve outco

197 -based vaccine that specifically targets the radioresistant subpopulation of tumor cells.

198 tes radiosensitivity and is downregulated in radioresistant subpopulations of breast cancer cells, an

199 ] are involved, we analyzed their profile in radioresistant (SW480) and radiosensitive (SW48) human c

200 CD62L(-) T cells were able to deplete host radioresistant T cells and facilitate hematopoietic engr

201 val assays that GSCs were significantly more radioresistant than paired tumor bulk populations.

202 s, but not fibroblasts, were moderately more radioresistant than their wild-type counterparts, sugges

203 ring mutant Nrf2E79Q were substantially more radioresistant than tumors with wild-type Nrf2 in immuno

204 t survive large radiation doses are not more radioresistant than unirradiated cells and tumors, and a

205 s postirradiation and are substantially more radioresistant than wild-type cells.

206 her doses of radiation are given to the more radioresistant tissue.

207 not induce elevations in Bax or apoptosis in radioresistant tissues such as heart, skeletal muscle, b

208 This suppression was radioresistant to 25 Gy.

209 ted stable myeloid leukemia HL60 cell clones radioresistant to either gamma-rays or alpha-particles t

210 high-risk group (nonresponse), which proved radioresistant to treatment.

211 (IR) treatment resulted in the selection of radioresistant tumor (nu61) that overexpresses the signa

212 ony-stimulating factor (GM-CSF) derived from radioresistant tumor cells following RT is necessary for

213 is promising for radioimmunotherapy against radioresistant tumor cells such as CSCs.

214 by IR and enhanced cell death in irradiated radioresistant tumor cells.

215 ion of effector T cells capable of targeting radioresistant tumor cells.

216 induction of apoptotic tumor cell death in a radioresistant tumor model both in vitro and in vivo.

217 Conversion into a radioresistant tumor phenotype when implanted in SCID(as

218 ingle high-grade epidural lesion caused by a radioresistant tumor who also have an estimated survival

219 preliminary data indicate their utility for radioresistant tumors adjacent to highly critical struct

220 d to salivary gland malignancies and certain radioresistant tumors such as sarcomas.

221 ating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatme

222 r proton radiotherapy for the same subset of radioresistant tumors where neutrons show a benefit over

223 ropriate for some subgroups of patients with radioresistant tumors, but routine avoidance of WBRT sho

224 Renal-cell carcinoma is considered to be a radioresistant tumour, but this notion might be wrong.

225 l treatment for malignant melanoma and other radioresistant tumours.

226 NA and reveal a new therapeutic strategy for radioresistant tumours.

227 Instead, we find radioresistant tyrosinase mRNA expression in lymphoid co

228 Radioresistant variants isolated from MCF-7 human carcin

229 Loss of Ly6e in Lyz2-expressing cells, radioresistant Vav1-expressing cells and non-haematopoie

230 Since hypoxic tumors are radioresistant, we posited that the aerobic state of a t

231 of autophagy rendered the Bak/Bax(-/-) cells radioresistant, whereas overexpression of ATG5 and Becli

232 receptor 2-positive tumors seemed to be most radioresistant, whereas triple-negative tumors had the l

233 s, Krt19(+) cancer-initiating cells are also radioresistant, while Lgr5(+) stem cells are radiosensit

234 tumor regression in 80% of the animals in a radioresistant xenograft model.