ライフサイエンスコーパス: radiosensitive

1 ozygotes in the human population may also be radiosensitive.

2 l that assumes all tumor cells are uniformly radiosensitive.

3 growth defects and are generally considered radiosensitive.

4 n the LD numbers and, by consequence, became radiosensitive.

5 r human papillomavirus (HPV) are exquisitely radiosensitive.

6 her response and lower dose were labelled as radiosensitive.

7 radioresistant, while Lgr5(+) stem cells are radiosensitive.

8 ere unable to resolve DNA damage, and became radiosensitive.

9 tributions, and the mutants were only mildly radiosensitive.

10 Lgr5(-) reserve stem cells are surprisingly radiosensitive.

11 l lines lacking functional ATM are extremely radiosensitive.

12 s, we conclude that CLL and non-CLL are both radiosensitive.

13 radiation therapy, as hypoxic cells are less radiosensitive.

14 tradicts this model, in that they are highly radiosensitive.

15 ssion of ATG5 and Beclin-1 made the WT cells radiosensitive.

16 (cs) and, like Atm(-/-) mice, are viable and radiosensitive [4-8].

17 uring the G2 delay when compared to the more radiosensitive A2780 cell line.

18 mary malignant brain tumor in children, is a radiosensitive and chemosensitive tumor.

19 In addition, Artemis mutants are radiosensitive and chromosomally unstable, which has bee

20 gene that encodes nibrin, and NBS cells are radiosensitive and defective in S-phase checkpoint activ

21 Tumor growth inhibition was relatively radiosensitive and dependent on host-derived CD8+ T cell

22 ermal Langerin(+) dendritic cells (DCs) were radiosensitive and displayed a distinct cell surface phe

23 The kidneys are radiosensitive and dose-limiting organs for radiotherapy

24 that NHEJ-deficient 2BN cells derived from a radiosensitive and immune-deficient patient lack XLF due

25 stigating in order to make cancer cells more radiosensitive and improve the efficacy of radiation tre

26 atterns, however, discriminated well between radiosensitive and more resistant lines, possibly being

27 Female BALB/c mice are unusually radiosensitive and more susceptible than C57BL/6 and oth

28 tion was of indeterminate origin, being both radiosensitive and not replenished by donor bone marrow.

29 We observed that radiosensitive and radioresistant cells played distinct

30 aH2AX focus formation or immunoreactivity in radiosensitive and radioresistant human tumor cell lines

31 ed in a human cell line-derived model and in radiosensitive and radioresistant patient-derived models

32 Extramedullary plasmacytomas are highly radiosensitive and radiotherapy is therefore used as a t

33 One subset was radiosensitive and rapidly replaced from hematogenous pr

34 even at very high levels, remained as chemo/radiosensitive and repair deficient as the parental cell

35 ATM-deficient cells are radiosensitive and show impaired cell cycle arrest and i

36 ost markedly in mammary tissue, and are both radiosensitive and susceptible to radiogenic mammary can

37 ta argue that Lgr5(-) reserve stem cells are radiosensitive and that Lgr5(+) cells are crucial for ro

38 Mutant rhp6-788 is slightly HU sensitive, radiosensitive, and exhibits normal checkpoint responses

39 against either class I or class II Ags, was radiosensitive, and required cell-cell contact.

40 and clinical features, F96-224 cells are as radiosensitive as Artemis null cell lines.

41 However, in contrast to radiosensitive Atm-/- fibroblasts and radioresistant Atm

42 In contrast, TCR revision is radiosensitive, B cell, CD28, and inducible costimulator

43 potential protective effect of receptors on radiosensitive, bone marrow-derived cells.

44 that these DNA-PKcs null mutants were highly radiosensitive but also that upon IR treatment, p53 accu

45 that has the interesting phenotype of being radiosensitive, but having only a modest defect in VDJ r

46 Malignant plasma cells are very radiosensitive, but the potential role of radioimmunothe

47 ataxia telangiectasia gene are indeed highly radiosensitive, but their numbers are very small.

48 Cells from radiosensitive, cancer-prone BALB/c mice showed ineffici

49 There was a significant association for radiosensitive cancers (OR, 1.85; 95% CI, 1.21-2.81) but

50 (all except leukemias and lymphomas), known radiosensitive cancers (thyroid, breast, leukemia, and b

51 Testing in other radiosensitive cancers is warranted.

52 es revealed that the IL-1R was required in a radiosensitive cell in the sensitization phase of the CH

53 180BR is a radiosensitive cell line defective in DSB repair, which

54 We show that a radiosensitive cell line, mutant for the RAD51 homolog X

55 In the third group, composed of radiosensitive cell lines derived from tumors associated

56 In addition, the radiosensitive cell populations (crypt or stem cells) ar

57 de the selective elimination of particularly radiosensitive cell types and consequent loss of specifi

58 cceptance is associated with the presence of radiosensitive cells in the donor liver that may interac

59 The simulated absorbed doses to radiosensitive cells in the GI tract for 99mTc and 123I

60 ls and PAFR engagement on radioresistant and radiosensitive cells in the lung promote allergic respon

61 organ examined, with a major contribution of radiosensitive cells in the spleen as opposed to a major

62 n the innate response to flagellin, with the radiosensitive cells producing the majority of the TNF-a

63 The contribution of radioresistant and radiosensitive cells to Il-18bp production varied marked

64 TLR and RLH signaling of radioresistant and radiosensitive cells was required for efficient protecti

65 ase of cytokines and danger signals by dying radiosensitive cells, and altered cytokine secretion by

66 IL-1beta blockade, IL-1beta deficiency in radiosensitive cells, and CCR2/CCR7 double deficiency bu

67 Ifitm3 functioned in both radioresistant and radiosensitive cells, as higher levels of WNV were obser

68 ined with a layer of endosteum that contains radiosensitive cells.

69 oietic (radioresistant) and the hemopoietic (radiosensitive) compartments, we measured both innate an

70 d higher levels of TGLI1, but not GLI1, than radiosensitive counterparts.

71 is directly required for the accumulation of radiosensitive dermal-derived langerin(+)CD103(+) DCs in

72 A radiosensitive DNA repair-deficient xrs-5 cell line was

73 rminal modification renders mice exquisitely radiosensitive due to defects in HSC/progenitor prolifer

74 ts suggest that there may be a donor-derived radiosensitive element that enhances allograft survival

75 Radiosensitive elements in kidney allograft may be respo

76 critical factors that impact the dose to the radiosensitive epidermis.

77 Although the disease is radiosensitive, external beam radiation leads to signifi

78 p53 or interfering RNA to inhibit p21 stayed radiosensitive for 24 hours after drug treatment.

79 are hyperproliferative and potentially more radiosensitive) for patients treated with previous chemo

80 red GDR as a new cause for development of a "radiosensitive" form of immune dysregulation in patients

81 inducing a protective autophagy response in radiosensitive gastrointestinal tissues.

82 , TRADD expression was induced in a uniquely radiosensitive GM cell line but not in radioresistant GM

83 The choice of therapeutic modality in this radiosensitive group of patients should be made on a cas

84 rmed cell lines from Ku703A/3A mice are more radiosensitive, have a significant decrease in DNA end r

85 However, NOD/LtSz-scid mice are highly radiosensitive, have short life spans, and a small numbe

86 ave not gained success in patients except in radiosensitive hematological neoplasms, or in settings i

87 , nitric oxide synthase 2 production by both radiosensitive hematopoietic and radioresistant stromal

88 licited in the absence of Ag presentation by radiosensitive host hematopoietic-derived APCs after all

89 e reported that in the absence of functional radiosensitive host hematopoietic-derived APCs, H-Y Ag p

90 r T cells will induce GVHD in the absence of radiosensitive host hematopoietic-derived APCs.

91 ld indeed represent a societally-significant radiosensitive human subpopulation.

92 of radioresistant stroma cells as well as of radiosensitive immune cells is needed to effectively pro

93 cond group, composed of cell lines that were radiosensitive in culture (D0 approximately 1 Gy) but de

94 al epithelial (SIE) cells are among the most radiosensitive in the body.

95 ponse to radiation; these animals are highly radiosensitive in the soma and radioresistant in the ger

96 ls expressing AS-IGF1R transcripts were more radiosensitive in vitro and in vivo than controls.

97 the ATM gene (ATM(+/-)) may be slightly more radiosensitive in vitro, it remained to be determined wh

98 We found that these stem cells are highly radiosensitive, in contrast to their isogenic differenti

99 In particular, the highly radiosensitive intestine limits the use of radiation for

100 date the performance of a biomarker panel of radiosensitive intracellular leukocyte proteins (ACTN1,

101 ased localization of radiopharmaceuticals in radiosensitive kidney subregions can potentially lead to

102 tor, but not other innate immune sensors, in radiosensitive leukocytes protects against tumour format

103 Another radiosensitive line, mutant for XRCC3 and defective in H

104 ken together, these data identify c-MYC as a radiosensitive locus, implicating this oncogenic transcr

105 rays to survey common CNVs in a cohort of 50 radiosensitive lymphoblastoid cell lines (RS-LCLs) deriv

106 immunosuppressive agent that acts by killing radiosensitive lymphocytes.

107 Radiosensitive male NSCLC cell lines demonstrated a dose

108 morphology defects in the gut, with the more radiosensitive males displaying increased midgut cellula

109 ance the oncolytic potency of MV-Edm against radiosensitive malignancies and to facilitate noninvasiv

110 eriments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphom

111 Multiple myeloma is a radiosensitive malignancy that is currently incurable.

112 On the other hand, a radiosensitive mutant (irs-20) of DNA-PKcs with a defect

113 DNA-PK-deficient cell lines are radiosensitive mutants lacking either the catalytic subu

114 protein carbonylation than is the much more radiosensitive nematode Caenorhabditis elegans.

115 antagonism, have sought to minimize dose to radiosensitive neurogenic regions while normalizing exci

116 the two kinetics and their positions define radiosensitive niches in zebrafish embryos.

117 ells have decreased apoptosis in contrast to radiosensitive non-cancerous A-T cells.

118 ng radiation-induced phenotype conversion of radiosensitive non-GICs into treatment-resistant, induce

119 tively depleted Il-18bp expression in either radiosensitive or radioresistant cells using bone marrow

120 e basis of the DNA repair strategies of more radiosensitive organisms.

121 determine normalized dose data for maternal radiosensitive organs and embryo/fetus from 256-slice CT

122 iminary tests of shielding other superficial radiosensitive organs frequently included at diagnostic

123 Mitochondrial p53 accumulation occurred in radiosensitive organs like thymus, spleen, testis, and b

124 Organ and surface dose to specific radiosensitive organs were estimated by using software f

125 rofile of the cumulative uptake over time of radiosensitive organs.

126 tion is associated with massive apoptosis in radiosensitive organs.

127 nce animal survival or crypt regeneration in radiosensitive p21 KO-recipient mice.

128 in a redistribution of the cells into a more radiosensitive phase of the cell cycle or in an increase

129 Tachpyridine arrested cells at G2, a radiosensitive phase of the cell cycle, and enhanced the

130 ortion of cells in G2-M (27% versus 5%), the radiosensitive phase of the cell cycle.

131 partial synchronisation of cells in the most radiosensitive phase of the cell-cycle.

132 e DNA glycosylases in mutant cells confers a radiosensitive phenotype and an increase in the number o

133 ns in the LRR can only partially reverse the radiosensitive phenotype and V(D)J recombination deficit

134 Initially this was because of the unusual radiosensitive phenotype of cells from A-T patients, and

135 isolated as a second-site suppressor of the radiosensitive phenotype of seeds defective in the repai

136 ulature in wild-type mice that resembled the radiosensitive phenotype of tumor vessels in SCID mice.

137 t mechanisms may be responsible for the more radiosensitive phenotype.

138 of multiple myeloma, an incurable but highly radiosensitive plasma cell malignancy.

139 myelination appears to be mediated by a CD8+ radiosensitive population, which is induced on infection

140 Interestingly, two radiosensitive primary fibroblast cell lines, derived fr

141 Indeed, exposure of radiosensitive prostatic cancer cells to low non-cytotox

142 three patient subgroups of radiosensitivity: radiosensitive, radio-normal, and radioresistant groups.

143 potentially leading to active uptake in the radiosensitive red marrow region where these cells are l

144 y signature, patients were classified into a radiosensitive (RS) group and a radioresistant (RR) grou

145 Artemis deficiency leads to congenital radiosensitive severe acquired immune deficiency (RS-SCI

146 g agents and absence of B and T lymphocytes (radiosensitive severe combined immune deficiency [RS-SCI

147 Radiosensitive severe combined immune deficiency in huma

148 oss of ARTEMIS function therefore results in radiosensitive severe combined immunodeficiency (RS-SCID

149 The Artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients

150 Human radiosensitive severe combined immunodeficiency results

151 tive in ataxia telangiectasia and a class of Radiosensitive-Severe Combined Immunodeficiency (RS-SCID

152 Multiple myeloma is a highly radiosensitive skeletal malignancy, but bone-seeking rad

153 on of PAX7 positive cells, we show that this radiosensitive skeletal muscle progenitor pool contribut

154 ase was 1.7- and 1.3-fold for the moderately radiosensitive small cell lung carcinoma 54A and the hig

155 More strikingly, we also can create a radiosensitive state when the select let-7 family of miR

156 um response was more pronounced for the more radiosensitive strain.

157 P, the bladder tumour cell line MGH-U1 and a radiosensitive subclone S40b.

158 population includes genetically predisposed radiosensitive subsets.

159 Skin is radiosensitive, suggesting it is well-oxygenated.

160 image but reduced the amount of radiation to radiosensitive superficial structures.

161 their profile in radioresistant (SW480) and radiosensitive (SW48) human colorectal cell lines.

162 discovered as the gene inactivated in human radiosensitive T(-)B(-) severe combined immunodeficiency

163 evelopment of adaptive immunity and leads to radiosensitive T- B- severe combined immunodeficiency (R

164 trating that children are not, in fact, more radiosensitive than adults in the radiologic imaging dos

165 ion, in particular for children who are more radiosensitive than adults.

166 e of the DNA-PKcs variants are slightly more radiosensitive than cells completely deficient in DNA-PK

167 or ataxia telangiectasia (A-T) are much more radiosensitive than cells from unaffected individuals.

168 od) and CFU-GM(blood) were considerably more radiosensitive than femoral progenitors, thereby providi

169 hree SCAN1 lines examined were slightly more radiosensitive than normal cells, but only for fractiona

170 ective in undergoing apoptosis but were more radiosensitive than the WT cells in autophagy.

171 heir DT, i.e. the faster cells grow the more radiosensitive they are.

172 compared with non-stem cells within several radiosensitive tissue niches and culture models.

173 rogeneity of radioactivity in this important radiosensitive tissue.

174 Active bone marrow is one of the more radiosensitive tissues in the human body and, hence, it

175 e potential for complications to nontargeted radiosensitive tissues might be reduced.

176 We find that radiosensitive tissues show prolonged p53 signaling afte

177 (177)Lu-DOTA-Bn), that leads to high TIs for radiosensitive tissues such as blood (TI = 73) and kidne

178 ietic rescue but by positive impact on other radiosensitive tissues, such as the intestinal mucosa.

179 tion (IR) induces p53-dependent apoptosis in radiosensitive tissues, suggesting that p53 is a determi

180 nt-related toxicities, based on high TIs for radiosensitive tissues.

181 rpin RNA renders the IR-resistant nu61 cells radiosensitive to IR.

182 However, radiosensitive tumor cells and xenografts retained gamma

183 umor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of pa

184 Although CTCL is a highly radiosensitive tumor, the complex topography of acral su

185 tended to persist longer in smaller or more radiosensitive tumors.

186 The loss in effectiveness is most severe for radiosensitive tumors.

187 Inclusion of the radiosensitive variable improved lasso logistic regressi

188 ass I MHC expression is absent or limited to radiosensitive versus radioresistant cells.

189 significant difference in expression between radiosensitive versus radiotolerant strains, suggesting

190 licular lymphoma has been shown to be highly radiosensitive with responses to doses as low as 4 Gy in

191 ic small round cell tumor (DSRCT) is a rare, radiosensitive, yet difficult-to-treat sarcoma subtype a