ライフサイエンスコーパス: random sequence

1 red orange juice/d and 500 mL placebo/d in a random sequence.

2 se of a simple two-layer model to tones in a random sequence.

3 uscarinic cholinergic antagonist atropine in random sequence.

4 ich involved looking through the images in a random sequence.

5 1 and 130, allocated in a computer-generated random sequence.

6 d 10 mL was given rectally to 10 subjects in random sequence.

7 oligoribonucleotide of the same length and a random sequence.

8 mg twice daily or placebo for 1 week each in random sequence.

9 sing phage display of heptameric peptides of random sequence.

10 ughout and while asleep from 0000 to 0200 in random sequence.

11 ith the TFIID complex has been replaced by a random sequence.

12 construct that contains 26 nucleotides in a random sequence.

13 g(2+)-dependent self-cleaving ribozymes from random sequence.

14 ry 3 min) and post-TME (Bruce protocol) in a random sequence.

15 ) on the expected density of minimizers in a random sequence.

16 to dry cord care using a computer-generated random sequence.

17 f faces and houses were displayed rapidly in random sequence.

18 a wide range of odor gradients, presented in random sequence.

19 was achieved by using the computer-generated random sequence.

20 iae chromosome V, other genomic regions, and random sequences.

21 d performance for distinguishing ncRNAs from random sequences.

22 rokaryotes, 16 unicellular eukaryotes, and 2 random sequences.

23 initiate R-loops much more efficiently than random sequences.

24 populations or even in unselected samples of random sequences.

25 antly (p < 0.05) greater palindromicity than random sequences.

26 sis' conclusion that coding DNA behaves like random sequences.

27 s is added to differentiate coding exons and random sequences.

28 on CTS-containing DNA substrates compared to random sequences.

29 intensive reminders using computer-generated random sequences.

30 00-fold decrease in abundance in a sample of random sequences.

31 oles (<1 attomole) of predominantly inactive random sequences.

32 ion from RNA libraries containing completely random sequences.

33 ven folded, proteins occur in collections of random sequences.

34 g mRNA, to sample a large number of distinct random sequences.

35 ribozymes (RNA enzymes) from large pools of random sequences.

36 dary structures no more stable than those of random sequences.

37 c (first-order) structure and the entropy of random sequences.

38 e effective at relieving PLN inhibition than random sequences.

39 f-the-pairs scoring system, which will align random sequences.

40 cted for the first time from a large pool of random sequences.

41 ns can be achieved with improved modeling of random sequences.

42 t not about objects or temporal positions in random sequences.

43 ng of approximately 10 copies each of 10(15) random sequences.

44 dehydrogenase was identified by large-scale random sequencing.

45 rease in gene discovery rates as compared to random sequencing.

46 ur women) were studied on three occasions in random sequence: 1) cycle exercise ( approximately 70% p

47 cise tolerance testing under 2 conditions in random sequence: (1) after a 27-hour washout period (Off

48 e almost 10-fold higher than HU binding to a random sequence 20 bp duplex (6.1 vs 0.68 microM(-1)).

49 nstants observed for counterion binding to a random-sequence 26-base pair (bp) oligomer ranged from 7

50 e TG dinucleotide tract in the minigene with random sequence abolished splicing of exon 9.

51 Randomisation was by a computer-generated random sequence, accessed via an interactive telephone a

52 ids by inserting 90-base oligonucleotides of random sequence ahead of DNA coding for the AraC DNA bin

53 The random sequences also showed over an order of magnitude

54 Recently Jordan et al. reported that the 'random' sequences amplified by degenerate oligonucleotid

55 pendent of their developmental expression, a random sequence analysis of the 10.4-megabase genome of

56 using nucleosomes reconstituted onto 167-bp random sequence and 208-bp (5 S rRNA gene) DNA fragments

57 Biphasic kinetics were observed for both random sequence and CTS-containing DNA complexes, reveal

58 sms of the lower burst amplitudes using both random sequence and CTS-containing DNA substrates.

59 omisation was done with a computer-generated random sequence and stratified by renal impairment, HbA1

60 th potential binding affinity from a pool of random sequences and developed a protocol for RNA 3D str

61 were studied using high-throughput Illumina random sequences and full-length 16S rRNA genes extracte

62 ing cassettes, artificial aptamers, pools of random sequences and natural long noncoding RNAs.

63 For N6= M6= GGGGGG, N6= M6= a 'random' sequence and N6= GGGGGG and M6= a 'random' seque

64 the randomisation with a computer-generated random-sequence and interactive voice-response and web-r

65 -helical potential is a common occurrence in random sequences, and that the presence of amphiphilic a

66 We developed a rapid and random sequencing approach coupled with de novo genome a

67 This AP-1-targeting aptamer, as well as a random sequence aptamer with no target (5ECdsRan) as a c

68 Random sequences are accumulated, and the data are proce

69 for assessing whether a source produce truly random sequences are still missing.

70 Random EGSs that have 14-nt random sequences are used in the selection procedure for

71 s diverged from their D. yakuba orthologs as random sequences are.

72 short A/T tracts, dispersed within seemingly random sequences, are strong terminator elements, and bi

73 f testing was chosen by a computer-generated random sequence, assigned by independent members of the

74 the nucleotide content reveal striking, non-random, sequence-biases that are correlated with genome

75 sphorylthioate-modified oligoDNA (sODN) with random sequence (bio-sODN-Ran) were conjugated with Neut

76 fMRI analyses comparing repeating versus random sequence blocks demonstrated activation of fronta

77 An RNA library was generated by using random-sequence bridges to join a hammerhead self-cleavi

78 imordial proteins presumably originated from random sequences, but it is not known how frequently fun

79 Randomisation was by a computer-generated random sequence by means of an interactive web-response

80 ndomisation was done by a computer-generated random sequence by means of an interactive web-response

81 th predicted stabilities resembling those of random sequences can enhance processing.

82 short oligonucleotides, of both specific and random sequence, can modulate ribozyme activity.

83 t sequencing (HT-SELEX), creates billions of random sequences capable of binding different epitopes o

84 Replacement of IAS2 and the ISAR core with random sequences capable of stem formation resulted in t

85 ligase, a ribozyme previously isolated from random sequence, catalyzes a reaction similar to RNA pol

86 opose that the initial genetic polymers were random sequence chimeric oligonucleotides formed by unte

87 t the degree to which pseudogenes approach a random sequence composition may be useful in dating diff

88 ment over the background rate of cleavage of random sequences containing a single embedded ribonucleo

89 Several virus-targeted P-PMO and a random-sequence control P-PMO showed low inhibitory acti

90 We show that in solutions of completely random sequences, corresponding to a remarkably large nu

91 y to predict cattle chromosome location from random sequence data, demonstrating this tool to be valu

92 Ribozymes could be selected from a pool of random sequences depending on the length of their stems.

93 equences with known secondary structures and random sequences designed with similar melting temperatu

94 Mutagenesis with linkers of random sequence detected two subdomains separated by 21

95 double-stranded DNA (dsDNA) consisting of a random sequence did exhibit the expected single peak.

96 A pool of random sequence DNA molecules were immobilized via a cap

97 on the burst amplitude were determined using random sequence DNA substrates.

98 n more diverse pools of chemically synthetic random sequence DNA.

99 gment; replacing all five A- and T-tracts by random-sequence DNA causes the 199-bp mutant to adopt a

100 on mononucleosomes reconstituted from either random-sequence DNA derived from native nucleosomes or a

101 on constant for [Rh(phi)(2)(phen')](3+) with random-sequence DNA is 7.0 x 10(-7) M.

102 e been identified by in vitro selection from random-sequence DNA pools.

103 ons the pools are typically transcribed from random-sequence DNA templates, yielding a highly diverse

104 selection to isolate aptamers from a pool of random-sequence DNAs and subjected two distinct clones t

105 measure the binding of monovalent cations to random sequence, double-stranded (ds) DNA.

106 d every 30 min from -60 through 180 min with random-sequence, double-blind administration of diazoxid

107 A)/poly(T) is at least two-fold stiffer than random-sequence dsDNA in bending, stretching, and torsio

108 Monovalent cation binding to random-sequence dsDNA would be expected to occur in addi

109 Z-DNA to be at least three-fold stiffer than random-sequence dsDNA, with a near-zero link-extension c

110 ut a 2:1 stoichiometry to the T4A4 tract and random sequence duplex.

111 ls (allocation done on the basis of a pseudo-random sequence-eg, odd/even hospital number or date of

112 ing of nucleotide types in heterozygotes and random sequencing error.

113 in infection according to a simple model of random sequence evolution.

114 d in the classification of enhancers against random sequences, exhibiting advantages of deep learning

115 We use a large-scale random sequence experiment to show that while most align

116 a molecular "slithering" mechanism, whereas random sequences favor a restrictive pathway involving t

117 optimal gapped local alignment score of two random sequences follows a Gumbel distribution.

118 ro selection to search an unbiased sample of random sequences for comparably active self-cleaving mot

119 otein-protein or DNA-DNA local alignments of random sequences, for arbitrary substitution score matri

120 es with small divergence, and within 30% for random sequences, for which Affine-DO produced the worst

121 Duplex DNAs of random sequence from 20 to 500 bp were efficiently packa

122 uent double noise bursts were presented in a random sequence from these eight locations.

123 gainst amyloid-beta using immunoselection of random sequences from a phage display library, deep sequ

124 The earliest RNA molecules must have been random sequences, from which the first genomes that code

125 e methods for sample size calculation (45%), random sequence generation (43%), allocation concealment

126 sessed as being at low risk of bias for both random sequence generation and allocation concealment.

127 Low rates of reports of random sequence generation, allocation concealment, and

128 ale, which assesses the adequacy of reported random sequence generation, allocation concealment, blin

129 ity of the trials, but the rates of reported random sequence generation, allocation concealment, powe

130 s lack of allocation concealment, inadequate random sequence generation, lack of reporting of power,

131 ls with inadequate or unclear (vs. adequate) random-sequence generation (ratio of odds ratios, 0.89 [

132 were randomly assigned (1:1) using an online random sequence generator to either a 4-h face-to-face R

133 exhibits non-distinguishable behaviors from random-sequence genomic DNA, AA-TT condenses in all alka

134 of normal numbers, reasonable candidates for random sequences, given their limiting equidistribution

135 delineation of individual, infinite-length "random" sequences have been longstanding yet incompletel

136 d bimodal entropy, possibly corresponding to random sequences (high entropy) and sequences that posse

137 were offered for 4 consecutive days each in random sequence: high energy density, high viscosity (HD

138 cent of base pairs as the AQP1-siRNAs but in random sequence (i.e. scrambled siRNAs) had no effect.

139 tion of active mutants from 10(6) completely random sequences identified hairpin structures that func

140 retrospect, but so are some features of most random sequences--if the features are selected after loo

141 acteria form a sister group when rooted with random sequences; (iii) Planctomycetes, which possesses

142 replicons from plasmid libraries containing random sequences in the distal element.

143 , we analyzed the splicing of pre-mRNAs with random sequences in the exon bases at the splice junctio

144 or without atropine) were both performed, in random sequence, in each patient of a study group of 36

145 mian immunodeficiency virus that has a short random sequence inserted directly into the viral genome.

146 tinin 307-319 presented by HLA-DR4, but with random sequences inserted at CDR1alpha or CDR2alpha, wer

147 The random sequence inserts were sequenced for phage populat

148 gnment by a centralized, computer-generated, random-sequence interactive voice-response system to exe

149 reas CRISPR Cas1-Cas2 integrates essentially random sequences into a specific site in the CRISPR locu

150 how catalytic activity is distributed across random sequences is fundamental to estimating the probab

151 Furthermore, the majority of random sequences is not structured and has a high propen

152 sought to extend this strategy for use with random sequence libraries by combining a quality-control

153 ed from the yeast genome and from completely random sequence libraries, and compare the results to re

154 s that can bind a specific ligand, from both random-sequence libraries and libraries based on a known

155 ency of occurrence of functional proteins in random-sequence libraries appears to be similar to that

156 he selection of bicyclic peptides from large random-sequence libraries.

157 sphorothiolated hairpins appended to a short random sequence library (N10).

158 s of displayed protein library: a completely random sequence library, a library of concatemerized oli

159 silico mutated native protein sequences into random sequence-like ensembles and monitored the change

160 sed in antisense-treated muscles compared to random sequence-loaded controls.

161 e in protein levels of CaP to 54% of that in random sequence-loaded muscles, but no change in the pro

162 Starting from random sequences, low free energy sequences were generat

163 ly bound to the polyguanosine tract than the random sequence, making it less available for crosslink

164 segment just 5' of the BPS with a series of random sequences markedly repressed splicing, whereas su

165 of structurally related pseudoknots with non-random sequence matches and reveals modular units in rRN

166 but could not be distinguished reliably from random sequence matches.

167 These probes include random-sequence MB, dye-labeled single-strand linear oli

168 n-binding phNA aptamer ligands directly from random-sequence mixed P-methyl/P-ethyl phNA repertoires.

169 repetitive patterns, for which weaknesses in random sequence models yield notably inaccurate statisti

170 roteins to the frequencies predicted by four random sequence models.

171 somes from a mixture of approximately 10(14) random sequence molecules contain sequence motifs shown

172 t-containing aptamer isolated from a pool of random sequence molecules has been shown previously to r

173 display a low affinity for a small dsDNA of random sequence, mthCdc6-1 binds tightly to a short dupl

174 We have used random sequence mutagenesis to gain structure-function i

175 olate biologically active mutants created by random sequence mutagenesis, synthesized the mutant prot

176 ed agents, with 2'-deoxyguanosine (dGuo) and random-sequence native DNA by in-line liquid chromatogra

177 ability to isolate new functional RNAs from random sequences now ultimately makes the world of possi

178 bust interference effects when switched to a random sequence of cued responses (at 4-, 8-, and 12-seq

179 In SYNSeq, each neuron is tagged with a random sequence of DNA-a "barcode"-and synapses are repr

180 ed denaturation bubbles in a long, stretched random sequence of DNA.

181 A random sequence of equiprobable loud and soft speech sou

182 patial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the r

183 Subjects viewed a pseudo-random sequence of smoking images, neutral nonsmoking im

184 or example, when measuring the response to a random sequence of tones, frequencies that appear rarely

185 coded information and became errors when the random sequence of trials conflicted with these constrai

186 Assignment to random sequences of 2- and 4-week rotations.

187 with two retroviral libraries that contained random sequences of 9 or 18 nt in the intercistronic reg

188 al isolation, traditional cloning methods or random sequences of complementary DNAs.

189 all sizes stacking-disordered, consisting of random sequences of cubic and hexagonal ice layers.

190 ss of biological information generation from random sequences of heteropolymers, where unfavorable Sh

191 Participants listened to random sequences of high or low tones.

192 We study the folding and binding of random sequences of hydrophobic ([Formula: see text]) an

193 known GPx is 6.3 SD higher than expected for random sequences of similar composition.

194 tabolism in A. nidulans is that expected for random sequences of the same composition.

195 In contrast, it predicts that random sequences of the same length and many partially r

196 e compound, (T,G)-A-L, was tipped with short random sequences of tyrosine and glutamic acid.

197 selected in vitro from libraries containing random sequences of up to a few hundred nucleotides.

198 uence tag (EST) sequences were obtained from random sequencing of 16,152 cDNA clones.

199 ins of this complex natural product pathway, random sequencing of a cDNA library derived from Taxus c

200 By random sequencing of a library prepared from developing

201 Random sequencing of a peppermint oil gland secretory ce

202 ell-wall-degrading enzymes were found during random sequencing of an opium poppy latex cDNA library.

203 Random sequencing of cDNA clones from a hepatopancreas c

204 Random sequencing of cDNA clones identified approximatel

205 es expressed wild-type K-ras mRNA based on a random sequencing of eight K-ras cDNA samples obtained b

206 This study suggests that the random sequencing of Mutator-tagged fragments is capable

207 Random sequencing of this material revealed 75 genes tha

208 d rats received an injection of antisense or random-sequence oligodeoxynucleotide for VIP in the SCN

209 A 26-basepair random-sequence oligomer was used as the reference; lith

210 free solution mobilities of the A-tract and random-sequence oligomers were identical in solutions co

211 resemble the Rep binding sites identified by random sequence oligonucleotide selection, and the trans

212 1 exon 18 was replaced with two libraries of random sequences, one seven nucleotides in length, the o

213 unlike intact controls that experienced the random sequences only.

214 rees (i) Archaea, Bacteria, Eukaryota, and a random sequence outgroup are clearly separated; (ii) Arc

215 random order, based on a computer-generated random sequence, over an 85-week period with one geograp

216 nucleotides of the DEN-2 virus genome and a random-sequence P4-PMO showed relatively little suppress

217 cilitate the construction of high-complexity random sequence peptide libraries on MS2 VLPs and that a

218 on of antibody-specific peptide ligands from random sequence peptide library.

219 Random-sequence peptide libraries are a commonly used to

220 Experiments with random-sequence peptide libraries show the single-chain

221 The array consists of 10,000 random sequence peptides (20-mers) capable of detecting

222 mixtures of antibodies binding to arrays of random sequence peptides.

223 incubated with a microarray of thousands of random sequence peptides.

224 on many-to-many binding of antibodies to the random sequence peptides.

225 NA ligase ribozyme, isolated previously from random sequences, performs an efficient RNA ligation rea

226 ibution of optimal local alignment scores of random sequences plays a vital role in evaluating the st

227 binding and catalytic structures in pools of random sequence polynucleotides versus polypeptides.

228 we find that the hydrodynamic radius of this random sequence polypeptide also approaches that of the

229 ule-like compaction, we have characterized a random sequence polypeptide of identical amino acid comp

230 distribution of fitness and activity in the random sequence pool for the first time.

231 ot select for a specific DNA sequence from a random sequence pool.

232 sphorothioester linkage were selected from a random sequence pool.

233 de kinase-like activity were isolated from a random-sequence pool by using in vitro selection.

234 n were isolated by in vitro selection from a random-sequence pool of DNA.

235 monophosphate (cAMP; 1) were isolated from a random-sequence pool using in vitro selection.

236 ugh identification of active motifs in large random sequence pools is central to RNA in vitro selecti

237 equency of functional RNAs from that seen in random-sequence pools, providing a facile experimental a

238 re identified from each of N30, N40, and N50 random-sequence pools.

239 elected an allosteric ribozyme ligase from a random sequence population that is activated up to 10,00

240 that can be obtained from entirely unbiased (random) sequence populations.

241 ing RNAs isolated by in vitro selection from random-sequence populations can rival the catalytic effi

242 rapid presentation was evident even when the random sequence preceding a stimulus did not stimulate t

243 selected from a total of 10(8)-10(9) unique random sequences present in the library.

244 ne or that received a SPION conjugate with a random-sequence probe and amphetamine showed no retentio

245 pre-mRNAs generated by this method contained random sequences ranging from 0 to 18 nucleotides in len

246 proximately 25% of the sunflower genome from random sequence reads and assembled bacterial artificial

247 he BAC clones analyzed, a global analysis of random sequence reads indicates that the evolutionary pa

248 we can refine our estimates of the number of random sequences required for a 50% probability of findi

249 ated the synthesis of short- and medium-size random sequence RNA analogues and thereby provided a mic

250 CA to a greater extent than a similar length random sequence RNA mixture.

251 al 40mer library of approximately 6 x 10(14) random-sequence RNA molecules for their ability to bind

252 c acid enzymes starting from a population of random-sequence RNA or DNA molecules.

253 nonaggregating, monomeric subpopulation of a random-sequence RNA pool will yield pools of folded, fun

254 from a conformationally constrained pool of random sequence RNAs.

255 exhaustively within a starting population of random-sequence RNAs.

256 itro evolution starting from a population of random-sequence RNAs.

257 We test six coalescent priors and six random sequence samples of H3N2 influenza during the 201

258 nserved central Gly(6)-Gln(7) residues or by random sequence scrambling demonstrated a crucial role f

259 the study reported here, a restricted set of random sequences (semi-random) was introduced into the a

260 paring them to null models constructed using random sequence sets from the same genomes.

261 The control is a random-sequence sODN (Ran).

262 Nucleic acid polymers selected from random sequence space constitute an enormous array of ca

263 chips on which 130,000 peptides chosen from random sequence space have been synthesized.

264 'random' sequence and N6= GGGGGG and M6= a 'random' sequence, spermine concentrations of 20, 1 and 3

265 tin mRNA (SPION-beta-actin) and to sODN with random sequence (SPION-Ran).

266 ecific conditions, this ligase ligated 30-nt random sequence ssDNA (5'-N(30)-3') to a specified 20-nt

267 to other "primer-free" approaches where the random sequence ssDNA starting pool has no fixed sequenc

268 so occur on specific templates found within 'random' sequence substrates and on G-rich motifs proxima

269 We have solved these problems by including a random sequence tag in the initial primer such that each

270 mationally complex (i.e., rarer in a pool of random sequences) than aptamers selected to bind a large

271 he simplest way to obtain maximally unbiased random sequences that are subject to GC usage and primar

272 more matches between the two halves than do random sequences that can form the tRNA structure, but t

273 ch can easily be expanded to create unbiased random sequences that incorporate more complicated const

274 erase, concatemers quickly formed, and those random sequences that templated the insertion of purines

275 t we have selected a dual-catalytic RNA from random sequences: the RNA promotes both cleavage at one

276 For random sequences this distance is approximately 12, cons

277 eb response system with a computer-generated random sequence to 8 mg/kg intravenous ramucirumab every

278 different from the predicted stability of a random sequence to be useful as a general genefinding ap

279 igher and lower energies were delivered in a random sequence to develop a distribution curve.

280 allocentric head direction in rats running a random sequence to light locations around a circular pla

281 mly assigned (1:1:1) by a computer-generated random sequence to receive a subcutaneous injection of 8

282 domly assigned (1:1) by a computer-generated random sequence to receive subcutaneous injections of pl

283 the monomer, indicating that the ability of random sequences to aggregate into amyloid is a critical

284 illing in gaps, blunting the ends, or adding random sequences to the 3' ends of DNA, producing 3' fla

285 plates for threading calculations and adding random sequences to the analysis.

286 To address this issue, we used random sequencing to survey the pheromone composition of

287 domly assigned (1:1:1) by computer-generated random sequence via an interactive voice or web response

288 The random sequence was fused to the CCR5 chemokine receptor

289 condition (implicit sequence learning versus random sequence) was observed across diagnostic groups i

290 Oligodeoxynucleotides that contained 16-bp random sequences were purified by vnd/NK-2 affinity colu

291 library and identifying those peptides with random sequence which can recognize mAb aggregates.

292 mly assigned (1:2:2:2) by computer-generated random sequence with an interactive voice response syste

293 n was done according to a computer-generated random sequence with an interactive voice response syste

294 andomly assigned (1:1) by computer-generated random sequence with an interactive voice-response syste

295 Studies were performed in random sequence with vitamin E 800 IU and vitamin C 1 g

296 web response system using computer-generated random sequences with a block size of 3.

297 cture decrease reaction rates; however, even random sequences with no known internal single-stranded

298 e developed a method that generates unbiased random sequences with pre-specified amino acid and GC co

299 in sequences have been minimized compared to random sequences with uniform and natural amino acid com

300 duced a population of HIV-2 DNA genomes with random sequences within the 5' side of pal and transfect