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1 trials), and fixed-antibiotic duration (six randomized clinical trials).
2 o reduce visual field deficits, but not in a randomized clinical trial.
3 emia in older adults with type 1 diabetes: a randomized clinical trial.
4 ients with acute coronary syndrome: the TICO randomized clinical trial.
5 diabetic macular edema (CI-DME) in a 2-year randomized clinical trial.
6 fic targets can be prospectively tested in a randomized clinical trial.
7 patients with alcohol withdrawal symptoms: a randomized clinical trial.
8 These results should be validated in a randomized clinical trial.
9 t further evaluation in a larger multicenter randomized clinical trial.
10 study reports 3-y outcomes of a split-mouth randomized clinical trial.
11 patients have not been examined in a large, randomized clinical trial.
12 failure in patients with MRSA bacteremia: a randomized clinical trial.
13 t of Acute Cerebral Hemorrhage II (ATACH-II) randomized clinical trial.
14 reporting the effect of an intervention in a randomized clinical trial.
15 r CSME Secondary to Diabetes Mellitus (DAVE) randomized clinical trial.
16 Zinc Supplementation Trial was a multicenter randomized clinical trial.
17 This is a secondary data analysis of a randomized clinical trial.
18 n psychosocial functioning in a longitudinal randomized clinical trial.
19 ients with acute heart failure: the GALACTIC randomized clinical trial.
20 ults with chronic kidney disease: the Kompas randomized clinical trial.
21 dant findings from observational studies and randomized clinical trials.
22 ter large-scale, phase 3, placebo-controlled randomized clinical trials.
23 cogenetics (PGx) assessments embedded within randomized clinical trials.
24 tes into 2 identically designed, open-label, randomized clinical trials.
25 his observational study must be confirmed in randomized clinical trials.
26 wering treatment can be established only via randomized clinical trials.
27 7 days in fixed-duration antibiotic therapy randomized clinical trials.
28 re intubation is unclear despite a number of randomized clinical trials.
29 This was a multicenter, randomized, clinical trial.
35 elected for inclusion include 3 prospective, randomized clinical trials; 7 nonrandomized, prospective
37 ) is an investigator-initiated, multicenter, randomized clinical trial adding 1.8 g n-3 PUFA (930 mg
38 ng low toxicity intervention to be tested in randomized clinical trials against colorectal cancer and
39 low-risk populations, in properly designed, randomized clinical trials, although data on the long-te
40 of patients (n = 116) enrolled in 3 phase-3 randomized clinical trials (AMAGINE -1 [Efficacy, Safety
41 ind, placebo-controlled, 2 x 2 x 2 factorial randomized clinical trial among 2157 adults aged 70 year
42 DESIGN, SETTING, AND PARTICIPANTS: Cluster randomized clinical trial among 301 hospitals enrolling
43 ired harvesting of CTG were enrolled in this randomized clinical trial and assigned to one of two gro
45 into the evaluation of treatment response in randomized clinical trials and may guide clinical decisi
48 or the reporting of multi-arm parallel-group randomized clinical trials and should help provide great
49 d clinical trials), clinical algorithms (two randomized clinical trials), and fixed-antibiotic durati
50 y, including 9 retrospective reports and one randomized clinical trial, and five retrospective studie
51 el and forward-thinking strategies including randomized clinical trials are important to validate key
52 kin) may improve vascular diseases; however, randomized clinical trials are needed to confirm these f
53 thoughtful planning and data collection from randomized clinical trials are needed to understand what
58 D PARTICIPANTS: Cluster-based, single-blind, randomized clinical trial at 15 sites in 8 US states (Ma
59 ARTICIPANTS: Superiority, placebo-controlled randomized clinical trial at 16 Canadian neonatal intens
60 D PARTICIPANTS: Multicenter, double-blinded, randomized clinical trial at 20 trauma centers and 39 em
66 nt was developed to improve the reporting of randomized clinical trials, but the primary focus was on
70 ze antibiotic use included procalcitonin (14 randomized clinical trials), clinical algorithms (two ra
77 S: Multicenter, single-blind, noninferiority randomized clinical trial comparing rocuronium (1.2 mg/k
82 rane Library up to February 2019 to identify randomized clinical trials comparing SIRT, as monotherap
83 NG, AND PARTICIPANTS: An adaptive phase 2b/3 randomized clinical trial comprising 2 parts that includ
86 DESIGN, SETTING, AND PARTICIPANTS: Phase 2 randomized clinical trial conducted at 14 hospitals in N
87 SIGN, SETTING, AND PARTICIPANTS: Open-label, randomized clinical trial conducted at 17 UK hospitals.
91 SIGN, SETTING, AND PARTICIPANTS: Open-label, randomized clinical trial conducted at 27 hospital sites
92 SETTING, AND PARTICIPANTS: Parallel, 2-group randomized clinical trial conducted at 3 US clinical cen
93 , SETTING, AND PARTICIPANTS: Thirty-six week randomized clinical trial conducted at 4 academic medica
94 multicenter, double-blind placebo-controlled randomized clinical trial conducted at 4 sites in Austra
95 ARTICIPANTS: Parallel, open-label, pragmatic randomized clinical trial conducted at 4 socioeconomical
96 igator-initiated, multicenter, single-blind, randomized clinical trial conducted at 5 referral center
97 SETTING, AND PARTICIPANTS: Cluster crossover randomized clinical trial conducted at 50 ICUs in 5 coun
98 DESIGN, SETTING, AND PARTICIPANTS: Phase 2b randomized clinical trial conducted at 76 centers in the
100 (MEAL) Study (CALGB 70807 [Alliance]) was a randomized clinical trial conducted at 91 US urology and
101 AND PARTICIPANTS: A phase 3, noninferiority randomized clinical trial conducted at 99 sites in 19 co
105 SIGN, SETTING, AND PARTICIPANTS: Multicenter randomized clinical trial conducted from April 2017 to J
106 AND PARTICIPANTS: A 12-month, single-blind, randomized clinical trial conducted from April 22, 2009,
108 N, SETTING, AND PARTICIPANTS: Noninferiority randomized clinical trial conducted from October 26, 201
110 AND PARTICIPANTS: Multicenter noninferiority randomized clinical trial conducted in 42 UK and 5 Austr
111 , SETTING, AND PARTICIPANTS: A double-blind, randomized clinical trial conducted in 6 hospitals in th
112 AND PARTICIPANTS: Three-year, double-blind, randomized clinical trial conducted in a single center i
113 SIGN, SETTING, AND PARTICIPANTS: Single-site randomized clinical trial conducted in Baltimore, Maryla
114 ysis) of patient-level data combined from 18 randomized clinical trials conducted by Janssen or Glaxo
116 ogical therapy has been adequately tested in randomized clinical trials, corticosteroids can be usefu
117 over the left posterior parietal cortex in a randomized clinical trial, either in eight or 16 trains,
118 essing full-text medical records, supporting randomized clinical trials embedded in healthcare delive
119 at Improving Both Mood and Weight (RAINBOW) randomized clinical trial enrolled 409 adults with body
125 as a prospective, multicenter, double-blind, randomized clinical trial enrolling 881 patients with an
127 respecified analysis of the ODYSSEY OUTCOMES randomized clinical trial (Evaluation of Cardiovascular
130 with argon laser trabeculoplasty (ALT) in a randomized clinical trial for patients with medically un
133 PARTICIPANTS: Patients were enrolled in this randomized clinical trial from November 2007 to February
135 ased morbidity and improved outcomes, but no randomized clinical trial has demonstrated the efficacy
138 nknown whether the results of registry-based randomized clinical trials have a sizable impact on dail
142 f breast cancer and less favorable outcomes, randomized clinical trials have yet to provide conclusiv
143 N, SETTING, AND PARTICIPANTS: Double-blinded randomized clinical trial in 2 tertiary NICUs in Baltimo
144 PARTICIPANTS: Assessor-blinded, multicenter, randomized clinical trial in 35 French ICUs from October
147 oc analysis was performed of a double-blind, randomized clinical trial in septic shock (VANISH [Vasop
149 , participating institutions, countries, and randomized clinical trials in higher impact journals as
150 l setting stand in contrast to outcomes from randomized clinical trials in which myocarditis is a rar
154 Hyperglycemia Insulin Network Effort (SHINE) randomized clinical trial included adult patients with h
155 RTICIPANTS: This multicenter 2 x 2 factorial randomized clinical trial included overweight adults (bo
156 y reviewed and selected studies if they were randomized clinical trials, included adults hospitalized
157 udy from the PREDIMED-Plus trial, an ongoing randomized clinical trial including 6874 participants al
158 : Multicenter, noninferiority, point-of-care randomized clinical trial including adults hospitalized
161 SETTING AND PARTICIPANTS: Cluster-crossover randomized clinical trial involving patients, family mem
167 shed from January 2015 through June 2020 for randomized clinical trials, meta-analyses, systematic re
174 RTICIPANTS: Single-center, assessor-blinded, randomized clinical trial of 1236 patients older than 40
175 TING, AND PARTICIPANTS: Double-blind phase 2 randomized clinical trial of 139 patients with advanced
178 ETTING, AND PARTICIPANTS: Placebo-controlled randomized clinical trial of 310 care home residents, ag
179 : Multicenter, double-blind, parallel-group, randomized clinical trial of 775 adult patients at incre
180 ening from sleep, closed eye tears, during a randomized clinical trial of a non-pharmaceutical dry ey
181 ING, AND PARTICIPANTS: An open-label, 8-week randomized clinical trial of adolescent boys aged 11 to
183 Patients Offers Ways to Enhance Recovery), a randomized clinical trial of an innovative intervention
185 oint Prevention) ancillary study to VITAL, a randomized clinical trial of cardiovascular disease and
186 GN, SETTING, AND PARTICIPANTS: An open-label randomized clinical trial of catheter ablation vs drug t
187 f 2 events in 2009: (1) the publication of a randomized clinical trial of extracorporeal life support
188 ND PARTICIPANTS: A substudy of a multicenter randomized clinical trial of hypertensive adults 50 year
190 thods: We mathematically simulated a two-arm randomized clinical trial of LTBI in which the experimen
194 DIGE 24/CCTG PA.6, a phase III, multicenter, randomized clinical trial of postoperative leucovorin ca
196 N, SETTING, AND PARTICIPANTS: Noninferiority randomized clinical trial of preterm infants (born at 23
197 ry PTSD diagnosis (N = 66) participated in a randomized clinical trial of prolonged exposure therapy
198 t Response for Clinical Care (EMBARC) 8-week randomized clinical trial of sertraline versus placebo f
200 ost hoc analysis of a prematurely terminated randomized clinical trial of umbilical cord milking vs d
201 NTS: Multicenter, parallel-group, open-label randomized clinical trial of upper airway surgery vs ong
202 placebo-controlled, partial 2 x 2 factorial, randomized clinical trial of vitamin D, calcium, or both
203 ence provides support for further testing in randomized clinical trials of a new class of non-D2-rece
204 orts use of PB-MRD as a primary end point in randomized clinical trials of chemoimmunotherapy in CLL.
206 tients with resistant hypertension; however, randomized clinical trials of OSA treatment have not dem
207 and BCL6 translocations in two prospectively randomized clinical trials of patients with diffuse larg
208 this systematic review and meta-analysis of randomized clinical trials of patients with primarily no
209 n and reduce the risk of ESKD in large-scale randomized clinical trials of patients with type 2 diabe
210 venous and arterial thromboembolism in large randomized clinical trials of patients with VTE and AF,
211 re included in this review, of which 12 were randomized clinical trials of therapy that included 3074
212 duced mortality, although adequately powered randomized clinical trials of this intervention have not
214 Based on the current available evidence, a randomized clinical trial on complications, hospital sta
216 been under-represented or not studied in the randomized clinical trials on NOACs for stroke preventio
217 itute (NCI) sponsored, multicenter, phase 3, randomized clinical trial open to patients with biopsy-p
218 rnational, double-blind, placebo-controlled, randomized clinical trial, participants received approxi
220 ING, AND PARTICIPANTS: Preliminary unblinded randomized clinical trial performed in a tertiary center
221 was an international, multicenter, blinded, randomized clinical trial, performed between February 20
222 we sought systematic reviews, meta-analyses, randomized clinical trials, prospective comparative obse
225 rtic Valve Implantation) trial is an ongoing randomized clinical trial randomly allocating subjects t
227 treatments, disappointing results of many HF randomized clinical trials (RCT), and variable treatment
229 e designed a systematic review including all randomized clinical trials (RCTs) assessing the outcomes
230 eterogeneity, can induce self-selection into randomized clinical trials (RCTs) by patients with distr
231 sed medicine require that it be validated in randomized clinical trials (RCTs) by showing parallel be
236 ic search was performed to identify eligible randomized clinical trials (RCTs) reporting on the chang
237 formed by 2 individual reviewers to identify randomized clinical trials (RCTs) reporting the outcomes
240 s about the external validity of traditional randomized clinical trials (RCTs), together with the wid
243 se-to-human translation of this biology in a randomized clinical trial, showing that 24 Gy SDRT, but
247 xploratory analysis of the multicenter FinXX randomized clinical trial that accrued 1500 women in Fin
248 cagrelor in Peripheral Artery Disease) was a randomized clinical trial that assigned patients with pe
252 , SETTING, AND PARTICIPANTS: A double-masked randomized clinical trial that took place at 2 optometry
253 ETTING, AND PARTICIPANTS: Parallel, 2-group, randomized clinical trial that was conducted at 22 US cl
256 Long-term follow-up of 2 placebo-controlled randomized clinical trials that involved 27 347 postmeno
258 Exemption program, which is comprised of the randomized clinical trial, the prospective High-Risk Reg
261 a 3-year, double-blind, placebo-controlled, randomized clinical trial to test whether oral azithromy
262 tional meta-analysis and create a network of randomized clinical trials to compare outcomes after spe
263 ne (R-CHOP; or variant) across 7 multicenter randomized clinical trials to determine which scoring sy
264 ird, to integrate companion diagnostics into randomized clinical trials to enable prediction of treat
266 i, is a global but neglected disease without randomized clinical trials to guide antibiotic therapy.
267 this area are conflicting, and there are no randomized clinical trials to guide practitioner decisio
268 ent effect modifications by subphenotypes in randomized clinical trials to inform precision therapeut
269 and replacement be incorporated into future randomized clinical trials to properly clarify the role
270 ow how Bayesian analysis takes evidence from randomized clinical trials to update what is already kno
275 N, SETTING, AND PARTICIPANTS: This unblinded randomized clinical trial was conducted at Massachusetts
276 IPANTS: A double-blind, within-participants, randomized clinical trial was conducted at the Faculty o
278 AND PARTICIPANTS: A multicenter, pragmatic, randomized clinical trial was conducted in 65 ICUs in th
282 of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose
286 smodium falciparum isolates (n = 914) from 2 randomized clinical trials were screened for pfmdr1 copy
288 his study, we investigated, in a small pilot randomized clinical trial, whether expansion of inflamma
291 ntario-based cardiologists in the EchoWISELY randomized clinical trial (Will Inappropriate Scenarios
292 nitive and neurological performance within a randomized clinical trial with 3 arms containing World H
294 informed they would participate in a 2-week randomized clinical trial with a 50% chance of receiving
295 ANTS: A multicenter, parallel-group, cluster-randomized clinical trial with integrated economic and p
296 17 PICO questions, 145 studies, including 63 randomized clinical trials with 23 143 patients and 82 o
298 cted a multicenter, blinded, parallel group, randomized clinical trial, with 3,957 mechanically venti
299 of care lifestyle advice in 2 double-blind, randomized clinical trials within the nonalcoholic steat
300 search questions, especially those for which randomized clinical trials would present major challenge