ライフサイエンスコーパス: rate-limiting enzyme

1 l synthesis as measured via SQLE, its second rate-limiting enzyme.

2 ndent transcription of genes coding for key, rate-limiting enzymes.

3 mRNA levels of the cholesterol biosynthesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-coenzyme

4 Most work has focused on the two rate-limiting enzymes: 3-hydroxy-3-methylglutaryl CoA re

5 This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an at

6 late in the cell cycle including Acc1p, the rate-limiting enzyme acetyl-CoA carboxylase.

7 Expression levels of the rate-limiting enzyme aromatase, but not estrogen recepto

8 Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation,

9 Tissue factor (TF), a rate-limiting enzyme cofactor in activating coagulation,

10 ide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme, converting nicotinamide into nicot

11 Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of end

12 affinity small-molecule inhibitor of the NSP rate-limiting enzyme dC kinase (dCK).

13 press argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sens

14 The rate-limiting enzyme for BH(4) production is guanosine t

15 overexpression of GTP cyclohydrolase 1 (the rate-limiting enzyme for BH4 biosynthesis) in ECs by gen

16 pression of GTP cyclohydrolase I (GCH1), the rate-limiting enzyme for BH4 synthesis, restored cellula

17 , via immunofluorescent visualization of the rate-limiting enzyme for CA synthesis, tyrosine hydroxyl

18 etermined by a high protein abundance of the rate-limiting enzyme for carotenoid biosynthesis, phytoe

19 show that, like other YUCs, CKRC2/YUC8 is a rate-limiting enzyme for catalyzing the conversion of in

20 horylated tyrosine hydroxylase (pTH-ir), the rate-limiting enzyme for catecholamine synthesis, in bra

21 oxylase (CYP46A1), the neuronal-specific and rate-limiting enzyme for cholesterol conversion to 24S-h

22 sitivity was driven by HMGCR expression, the rate-limiting enzyme for cholesterol synthesis, which co

23 hylglutaryl coenzyme A reductase, which is a rate-limiting enzyme for cholesterol synthesis.

24 show that IMP dehydrogenase-2 (IMPDH2), the rate-limiting enzyme for de novo guanine nucleotide bios

25 a C57 background in which expression of the rate-limiting enzyme for dopamine synthesis, tyrosine hy

26 amide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for endogenous production of NAD(+)

27 Recently, elevated levels of aromatase, the rate-limiting enzyme for estrogen biosynthesis, were fou

28 ing the expression of aromatase, the key and rate-limiting enzyme for estrogen synthesis.

29 ported by lower gene expression of FAR1, the rate-limiting enzyme for ether-lipid synthesis in VAT.

30 sm, PPARG and PPARGC1A, as well as SCD1, the rate-limiting enzyme for fatty acid metabolism.

31 se (GAD), GAD65 (GAD2) and GAD67 (GAD1), the rate-limiting enzyme for GABA synthesis, exhibits altere

32 expressed inducible isoform of the first and rate-limiting enzyme for heme degradation.

33 Gamma glutamyl cysteine ligase (GCL) is the rate-limiting enzyme for intracellular glutathione (GSH)

34 r of adipose triglyceride lipase (ATGL), the rate-limiting enzyme for intracellular lipolysis.

35 ies of adenylate cyclase and tyrosinase, the rate-limiting enzyme for melanogenesis.

36 ylalkylamine N-acetyltransferase (AANAT; the rate-limiting enzyme for melatonin synthesis from seroto

37 succinyl-CoA:3-oxoacid-CoA transferase, the rate-limiting enzyme for myocardial oxidation of beta-hy

38 ng nicotinamide phosphoribosyltransferase, a rate-limiting enzyme for NAD synthesis, specifically in

39 st central complex with TBH likely being the rate-limiting enzyme for octopamine synthesis in a small

40 FADS1 encodes a rate-limiting enzyme for omega-3 and omega-6 fatty acid

41 ed ex vivo, and identify DECR1, encoding the rate-limiting enzyme for oxidation of polyunsaturated fa

42 yltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthe

43 ry cells, strongly suggesting that Far1 is a rate-limiting enzyme for plasmalogen synthesis.

44 , ornithine decarboxylase appeared to be the rate-limiting enzyme for polyamine production.

45 YC and ornithine decarboxylase 1 (ODC1), the rate-limiting enzyme for polyamine synthesis.

46 nvolves feed forward regulation of Raldh2, a rate-limiting enzyme for RA biosynthesis, and requires M

47 hyde dehydrogenase family 1, subfamily A2, a rate-limiting enzyme for RA synthesis in DCs.

48 By assaying activity and kinetics of the rate-limiting enzyme for serotonin biosynthesis, tryptop

49 nt mice have reduced expression of Tph1, the rate-limiting enzyme for serotonin biosynthesis.

50 NCED3 encodes a rate-limiting enzyme for stress-induced ABA synthesis.

51 Cyclooxygenase (COX)-2 is the rate-limiting enzyme for synthesis of PGE(2) from arachi

52 ssion of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme for the classical pathway of bile s

53 cholesterol 7alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme for the conversion of cholesterol t

54 beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer

55 disease, and lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides

56 Tyrosinase is the rate-limiting enzyme for the production of melanin pigme

57 against the glutamic acid decarboxylase, the rate-limiting enzyme for the production of the inhibitor

58 YME A REDUCTASE1 (HMGR1) and MAKIBISHI1, the rate-limiting enzyme for triterpene biosynthesis and an

59 , brain cholesterol, its precursors, and the rate-limiting enzymes for cholesterol synthesis, HMG CoA

60 hythmic expression of the genes encoding the rate-limiting enzymes for glycogenolysis and gluconeogen

61 mus, significantly reduced the expression of rate-limiting enzymes for lipid synthesis and the expres

62 rescent images presented upregulation of the rate-limiting enzymes for the production of dopamine and

63 lencing of molecular expression of the Taxol-rate limiting enzymes (GGPPS, TDS, DBAT and BAPT) by qPC

64 ate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase.

65 gosterol biosynthetic pathway, including the rate-limiting enzyme HMG-CoA reductase.

66 expression of tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine catalysis, could be enh

67 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in 5-HT biosynthesis.

68 cis-epoxycarotenoid dioxygenase 6 (NCED6), a rate-limiting enzyme in abscisic acid (ABA) biosynthesis

69 (25-50 mg/kg, IP), an inhibitor of the main rate-limiting enzyme in allopregnanolone synthesis.

70 histone deacetylation at the YUCCA8 locus, a rate-limiting enzyme in auxin biosynthesis, at warm temp

71 H4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses

72 opterins, GTP-cyclohydrolase 1 (GTPCH-1, the rate-limiting enzyme in BH4 synthesis), and NOS activity

73 xpression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis, to determine the

74 cellular cholesterol levels, and CYP7A1, the rate-limiting enzyme in bile acid biosynthesis (p<0.05).

75 CH1 gene, encoding GTP-cyclohydrolase I, the rate-limiting enzyme in biopterin biosynthesis, was asso

76 Argininosuccinate synthase (ASS) is the rate-limiting enzyme in both the urea and the L-citrulli

77 (Bsl1) locus in S. viridis, which encodes a rate-limiting enzyme in BR biosynthesis.

78 c deletion of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, prot

79 rter [VAChT]), tyrosine hydroxylase (TH; the rate-limiting enzyme in catecholamine synthesis), and se

80 aised against tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis.

81 Squalene monooxygenase (SM) is the second rate-limiting enzyme in cholesterol biosynthesis and is

82 tion in Sqle, encoding squalene epoxidase, a rate-limiting enzyme in cholesterol biosynthesis, underl

83 ualene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis.

84 Interestingly, HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, was reduc

85 Squalene monooxygenase (SM) is a rate-limiting enzyme in cholesterol synthesis.

86 sing upregulation of HMG Co-A reductase, the rate-limiting enzyme in cholesterol synthesis.

87 ox (am) ine 5'-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (V

88 e amidinotransferase (GATM) that encodes the rate-limiting enzyme in creatine synthesis.

89 on and lead to significant inhibition of the rate-limiting enzyme in DA synthesis, tyrosine hydroxyla

90 all subunit of ribonucleotide reductase, the rate-limiting enzyme in de novo deoxyribonucleoside trip

91 hosphate (IMP) dehydrogenase 2 (IMPDH2) is a rate-limiting enzyme in de novo guanine nucleotide biosy

92 osine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de novo guanine nucleotide biosy

93 It inhibits IMP dehydrogenase, a rate-limiting enzyme in de novo synthesis of guanidine n

94 orresponding deoxyribonucleotides and is the rate-limiting enzyme in DNA synthesis.

95 de reductase regulatory subunit M2 (RRM2), a rate-limiting enzyme in dNTP synthesis, induced prematur

96 modulator of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, and hence MT

97 eactivity for tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis.

98 h as tyrosine hydroxylase (TH), which is the rate-limiting enzyme in dopamine synthesis.

99 oxylase 1 (Tph1) messenger RNA, encoding the rate-limiting enzyme in enterochromaffin cell serotonin

100 Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are incre

101 ponsible for local induction of aromatase, a rate-limiting enzyme in estrogen biosynthesis.

102 on of ACC Synthase 7 (ACS7), which encodes a rate-limiting enzyme in ethylene biosynthesis.

103 l-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis.

104 Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis and is frequentl

105 sphoenolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90.

106 f Molecular Cell, Jiang et al. show that the rate-limiting enzyme in gluconeogenesis, phosphoenolpyru

107 n the yeast homotetrameric FBP1 complex, the rate-limiting enzyme in gluconeogenesis.

108 vity of glutamate cysteine ligase (GCL), the rate-limiting enzyme in glutathione biosynthesis.

109 Furthermore, the expression of PFKM, a rate-limiting enzyme in glycolysis, was nominally associ

110 tion of glutamate cysteine ligase (GCL), the rate-limiting enzyme in GSH biosynthesis).

111 nit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have increased de

112 monophosphate dehydrogenase 2 (IMPDH2), the rate-limiting enzyme in GTP biosynthesis.

113 elta aminolevulinate synthase 1 (ALAS1), the rate-limiting enzyme in heme biosynthesis.

114 xygenase mRNA (HMOX1; 68-fold increase), the rate-limiting enzyme in heme catabolism.

115 The rate-limiting enzyme in heme synthesis, delta-aminolevul

116 ment of mice or cultured cells to bypass the rate-limiting enzyme in hepatic heme synthesis, ALA synt

117 ypothesis that delta-6 desaturase (D6D), the rate-limiting enzyme in long-chain polyunsaturated fatty

118 amide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in mammalian NAD(+) biosynthesis, d

119 Tyrosinase is the central and rate-limiting enzyme in melanin biosynthesis.

120 Methyl-coenzyme M reductase, the rate-limiting enzyme in methanogenesis and anaerobic met

121 ide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in nicotinamide adenine dinucleotid

122 namide mononucleotide adenylyltransferase, a rate-limiting enzyme in nicotinamide adenine dinucleotid

123 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide metabolism, demonst

124 liance induces transcription of aromatase, a rate-limiting enzyme in oestrogen biosynthesis.

125 f microsomal prostaglandin E synthase-1, the rate-limiting enzyme in PGE(2) synthesis, sensitized OXR

126 ical ripening but also the expression of the rate-limiting enzyme in PGE2 synthesis-namely, cyclooxyg

127 osphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in phosphatidylcholine (PC) synthes

128 ene encodes GDP-L-galactose phosphorylase, a rate-limiting enzyme in plant vitamin C biosynthesis.

129 bition of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, phenocop

130 ine/spermine acetyltransferase (SAT1) is the rate-limiting enzyme in polyamine catabolism and a prima

131 SAT1 is a rate-limiting enzyme in polyamine catabolism critically

132 /spermine N1-acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism, has broad

133 Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been w

134 adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required

135 he expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in prostaglandin biosynthesis, whic

136 sine triphosphate cyclohydrolase (GCH1), the rate-limiting enzyme in pterin synthesis, thereby elevat

137 ore phosphoglycerate dehydrogenase (PHGDH, a rate-limiting enzyme in serine synthesis) than periphera

138 phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in serine synthesis.

139 Brain TPH2 mRNA, encoding the rate-limiting enzyme in serotonin synthesis, was induced

140 resulted in ORMDL-mediated inhibition of the rate-limiting enzyme in sphingolipid biosynthesis, serin

141 serine palmitoyl-CoA transferase (SPT), the rate-limiting enzyme in sphingomyelin synthesis.

142 oxy-3-methylglutaryl coenzyme A reductase, a rate-limiting enzyme in synthesis of cholesterol and non

143 in D signaling via suppression of CYP24A1, a rate-limiting enzyme in the 1alpha,25-dihydroxyvitamin D

144 11B2) gene encodes aldosterone synthase, the rate-limiting enzyme in the biosynthesis of aldosterone.

145 s to localize tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamin

146 Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the biosynthesis of deoxyribonuc

147 SCD1 is the rate-limiting enzyme in the biosynthesis of monounsatura

148 hydroxylase 1 (Tph1(-/-) mice), which is the rate-limiting enzyme in the biosynthesis of mucosal but

149 hisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pa

150 eral mechanisms for feedback control of this rate-limiting enzyme in the branched pathway that produc

151 sphorylation of tyrosine hydroxylase (TH), a rate-limiting enzyme in the CA synthetic pathway.

152 Phytoene synthase (PSY), the rate-limiting enzyme in the carotenoid biosynthetic path

153 (gene HMOX1; protein HO-1) is the inducible, rate-limiting enzyme in the catabolism of heme and might

154 As the rate-limiting enzyme in the CDP-choline pathway for PC s

155 ryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting enzyme in the cholesterol biosynthesis pat

156 inhibitors of the ectonucleotidase CD39, the rate-limiting enzyme in the conversion of ATP to immunom

157 Expression of Odc1, the rate-limiting enzyme in the conversion of ornithine into

158 ntributed by 5alpha-reductase (5alphaR), the rate-limiting enzyme in the conversion of progesterone i

159 Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleosid

160 , we identified HO-1 (heme oxygenase-1), the rate-limiting enzyme in the degradation of heme to biliv

161 cells requires deoxycytidine kinase (dCK), a rate-limiting enzyme in the deoxyribonucleoside salvage

162 sphate amidotransferase (GFAT), which is the rate-limiting enzyme in the HBP pathway.

163 levulinate synthase 2 (ALAS2), the first and rate-limiting enzyme in the heme biosynthetic pathway.

164 -6-phosphate transaminase 1 (GFPT1) is a key rate-limiting enzyme in the hexosamine biosynthetic path

165 dehydrogenase multienzyme complex (OGDHc), a rate-limiting enzyme in the Krebs (citric acid) cycle.

166 alpha-ketoglutarate dehydrogenase (OGDH), a rate-limiting enzyme in the Krebs cycle.

167 ells of people with DS overexpress IDO1, the rate-limiting enzyme in the kynurenine pathway (KP) and

168 amine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of trypto

169 otein indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the L-tryptophan-kynurenine meta

170 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway, which a

171 ide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD(+) salvage pathway from

172 gene (TKTL1), which encodes an essential and rate-limiting enzyme in the nonoxidative part of the pen

173 smic reticulum-associated degradation of the rate-limiting enzyme in the pathway, HMG-CoA reductase (

174 infection upregulated the expression of the rate-limiting enzyme in the polyamine biosynthetic pathw

175 ice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine

176 ursor protein-cleaving enzyme (BACE1) is the rate-limiting enzyme in the production of amyloid-beta,

177 decarboxylase (Gad1), which encodes GAD67, a rate-limiting enzyme in the production of gamma-aminobut

178 ryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies,

179 ere we describe p53-dependent control of the rate-limiting enzyme in the pyrimidine catabolic pathway

180 es retinaldehyde dehydrogenase 2 (RALDH2), a rate-limiting enzyme in the retinoic acid (RA)-producing

181 ribosyltransferase (Nampt) gene encoding the rate-limiting enzyme in the salvage pathway of NAD(+) bi

182 amide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the salvage pathway of nicotinam

183 nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in the salvage pathway that convert

184 , a cytochrome P450 enzyme, is the first and rate-limiting enzyme in the steroidogenic pathway, conve

185 stribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines

186 methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in the synthesis of cholesterol via

187 r composed of RRM1 and RRM2 subunits, is the rate-limiting enzyme in the synthesis of deoxyribonucleo

188 Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of gamma-aminobuty

189 CHKB is a rate-limiting enzyme in the synthesis of phosphatidylcho

190 hionine beta-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway, wh

191 Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the tryptophan-kynurenine pathwa

192 Overexpression of the rate-limiting enzyme in this pathway, nicotinamide phosp

193 e cytidylyltransferase 1 alpha (PCYT1A), the rate-limiting enzyme in this pathway.

194 ity of nitrate reductase (NR), the first and rate-limiting enzyme in this pathway.

195 y of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis.

196 rain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a k

197 or example, TCDD flattened expression of the rate-limiting enzymes in both gluconeogenesis (Pck1) and

198 at these PFKL clusters colocalize with other rate-limiting enzymes in both glycolysis and gluconeogen

199 -carboxylic acid (ACC) synthases (ACSs), the rate-limiting enzymes in ethylene biosynthesis.

200 l lipid synthesis and lipolysis, ablation of rate-limiting enzymes in hepatic PC biosynthetic pathway

201 Although genes encoding the rate-limiting enzymes in Norway spruce stilbene and flav

202 aded nanoparticles induced the expression of rate-limiting enzymes in polyamine catabolism (SMOX, SSA

203 s-Epoxycarotenoid Dioxygenase3, which encode rate-limiting enzymes in proline and abscisic acid (ABA)

204 1 (WT1), which drives the expression of two rate-limiting enzymes in retinol metabolism.

205 diet exhibited decreased mRNA expression of rate-limiting enzymes in several important glucose and l

206 oid (17-HAS) inhibitors of Cyp17, one of the rate-limiting enzymes in the biosynthesis of testosteron

207 Overexpression of rate-limiting enzymes in the endogenous heme biosyntheti

208 at members of the proprotein convertase were rate-limiting enzymes in the truncation of TSLP between

209 an is catabolized in the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO) e

210 Isyna1 (designated mIno1), which encodes the rate-limiting enzyme inositol-3-phosphate synthase.

211 ketone bodies and hepatic expression of the rate-limiting enzyme involved in ketone body production.

212 Here we investigated the biologic role of a rate-limiting enzyme involved in NAD(+) synthesis, Nampt

213 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme involved in the conversion of nicot

214 e cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosph

215 mutation in the gene encoding the pathway's rate-limiting enzyme, ninaB1, abolished photoperiod resp

216 synthesis by conditional inactivation of the rate-limiting enzyme Nsdhl or treatment with cholesterol

217 Surprisingly, PKM2, a rate limiting enzyme of glycolysis displayed a nuclear l

218 ion of adipose triglyceride lipase (ATGL), a rate limiting enzyme of TAG hydrolysis.

219 osynthesis, such as Hmgcr, which encodes the rate-limiting enzyme of cholesterol biosynthesis called

220 ssion of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme of cholesterol catabolism and bile

221 y-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme of de novo cholesterol (Chol) synth

222 High expression of the rate-limiting enzyme of de novo GTP synthesis is associa

223 If the rate-limiting enzyme of de novo NAD synthesis, NAPRT, is

224 oline cytidylyltransferase A (CCTalpha), the rate-limiting enzyme of de novo PC biosynthesis pathway,

225 f the dNTPs are synthesized "on the go." The rate-limiting enzyme of dNTP synthesis, ribonucleotide r

226 down-regulation of tyrosine hydroxylase, the rate-limiting enzyme of dopamine (DA) biosynthesis, spec

227 expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine biosynthesis [5, 13].

228 rs expressing tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, were also ob

229 acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme of FA de novo synthesis.

230 n of carnitine palmitoyl transferase 1a, the rate-limiting enzyme of FAO, in activated CD8(+) T cells

231 rther show that the CPT1/whd (withered), the rate-limiting enzyme of FAO, is transcriptionally regula

232 Importantly, the rate-limiting enzyme of fatty acid biosynthesis, acetyl-

233 results indicate that HCMV targets ACC1, the rate-limiting enzyme of fatty acid biosynthesis, through

234 we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), caus

235 l for metastasis, and we determined that the rate-limiting enzyme of glutathione synthesis, GCLC, bec

236 T1A_i2 proteins in human tissues-namely, the rate-limiting enzyme of glycolysis pyruvate kinase (PKM)

237 t isoform of phosphofructokinase (PFKP), the rate-limiting enzyme of glycolysis that catalyzes the ir

238 We also found that glycerol can induce a rate-limiting enzyme of GNG, glucose-6-phosphatase.

239 ructose-6-phosphate amidotransferase 1), the rate-limiting enzyme of HBP, promotes cardiomyocyte grow

240 uce transcription of INO1, which encodes the rate-limiting enzyme of inositol biosynthesis.

241 etoacid-CoA transferase (SCOT) activity, the rate-limiting enzyme of ketone body utilization, in the

242 rnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) tr

243 ression of the gene Cpt1a, encoding CPT1A, a rate-limiting enzyme of mitochondrial fatty acid oxidati

244 s along with hematopoietic PGD synthase, the rate-limiting enzyme of PGD2 synthesis.

245 ornithine decarboxylase (ODC), which is the rate-limiting enzyme of polyamine biosynthesis, decrease

246 Degradation of ornithine decarboxylase, the rate-limiting enzyme of polyamine biosynthesis, is promo

247 n with ornithine decarboxylase 1 (ODC1), the rate-limiting enzyme of polyamine synthesis, was observe

248 hoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme of serine synthesis, is frequently

249 cting tyrosine hydroxylase (TH), the initial rate-limiting enzyme of the CA synthesis, to study: 1) t

250 es tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catecholamine synthesis, del

251 palmitoyltransferase (SPT) is the first and rate-limiting enzyme of the de novo biosynthetic pathway

252 -B inhibits serine palmitoyltransferase, the rate-limiting enzyme of the de novo sphingolipid biosynt

253 -6-phosphate amidotransferase 1 (GFAT1), the rate-limiting enzyme of the HBP.

254 We describe the rate-limiting enzyme of the ketogenic energy metabolism

255 esterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme of the metabolic pathway that produ

256 ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that prod

257 -hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme of the mevalonate pathway, by lipop

258 ytogenes lacking the gene hmgR, encoding the rate-limiting enzyme of the mevalonate pathway, had a do

259 and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway.

260 n resulted in a decreased activity of COX, a rate-limiting enzyme of the mitochondrial electron trans

261 Statins block HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the MVA pathway.

262 Dependence on another rate-limiting enzyme of the NAD synthesis pathway, NAMPT

263 NAMPT is the rate-limiting enzyme of the NAD(+) salvage pathway and e

264 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the NAD(+) salvage pathway, gove

265 lciparum (PfIspC, PfDxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of iso

266 The rate-limiting enzyme of the pathway, glutamine-fructose

267 Aldose reductase, the rate-limiting enzyme of the polyol pathway, plays a key

268 PI3K/AKT activation stabilizes G6PD, the rate-limiting enzyme of the PPP, by inhibiting the newly

269 lucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, is dynamically modified

270 ne palmitoyltransferase (SPT), the first and rate-limiting enzyme of the sphingolipid biosynthetic pa

271 e dehydrogenase complex (KGDHC), an arguably rate-limiting enzyme of the TCA cycle, declines with AD,

272 idine dehydrogenase (DPD) is the initial and rate-limiting enzyme of the uracil catabolic pathway, be

273 1 (acyl-CoA oxidase 1) encodes the first and rate-limiting enzyme of the very-long-chain fatty acid (

274 leamine 2,3-dioxygenase (IDO), the first and rate-limiting enzyme of tryptophan catabolism in the kyn

275 by L. johnsonii, with specific focus on the rate-limiting enzyme of tryptophan catabolism, indoleami

276 blot analysis shows significant increase in rate-limiting enzymes of pentose-phosphate pathway and 1

277 xpression of hexokinase II (HK2), one of the rate-limiting enzymes of the glycolytic pathway.

278 Consequently, the rate-limiting enzymes of the mevalonate pathway are majo

279 female mice revealed decreased expression of rate-limiting enzymes of triacylglycerol synthesis but i

280 have implicated polyamines, generated by the rate-limiting enzyme ornithine decarboxylase (ODC), in g

281 tabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and

282 ells, as well as by the up-regulation of the rate-limiting enzymes PEPCK and G6Pc.

283 Based on our results, the rate-limiting enzyme PEPCK1 is the primary target of sir

284 We find that a single rate-limiting enzyme, phosphoribosyl-pyrophosphate synth

285 A1; median 12-fold induction; P<0.0001), the rate-limiting enzyme promoting the conversion of cholest

286 ed with tryptophan hydroxylase 1 (Tph1), the rate limiting enzyme regulating peripheral serotonin syn

287 -617, a small molecule inhibitor of NAMPT, a rate-limiting enzyme required for NAD generation, to pro

288 ine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme required for the production of guan

289 of nicotinamide phosphoribosyltransferase, a rate-limiting enzyme required for the regeneration of NA

290 regulating the activity of their respective rate-limiting enzymes, ribonucleotide reductase (RNR) an

291 t de novo synthesis of ceramide, through the rate-limiting enzyme serine palmitoyltransferase long ch

292 BACE1 is the rate-limiting enzyme that cleaves amyloid precursor prot

293 al prostaglandin E synthase-1 (mPGES-1) is a rate-limiting enzyme that is coupled with cyclooxygenase

294 ase/fructose-2,6-biphosphatase 3 (PFKFB3), a rate-limiting enzyme that promotes glycolysis.

295 , also known as aldehyde dehydrogenases, are rate-limiting enzymes that convert retinaldehyde (Rald)

296 ethylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme, to relieve strain.

297 essary for neurotransmitter synthesis by the rate-limiting enzymes tyrosine and tryptophan hydroxylas

298 NE is synthesized from tyrosine by the rate-limiting enzyme, tyrosine hydroxylase (TH), and tyr

299 al delta-aminolevulinic acid synthase 2, the rate-limiting enzyme upstream of delta-aminolevulinic ac

300 CYP11A1 (rate-limiting enzyme) was expressed in cancerous and non