ライフサイエンスコーパス: rate-limiting step

1 e-independent, relatively slow, and thus the rate-limiting step).

2 n of the catalyst resting state and turnover-rate limiting step.

3 of H to the aromatic ring is involved in the rate-limiting step.

4 tron transfer from CMPs was likely to be the rate-limiting step.

5 emains linear, consistent with an unchanging rate-limiting step.

6 rmediate to a small-molecule acceptor is the rate-limiting step.

7 t photo-oxidation of PhPyr by the QDs is the rate-limiting step.

8 nd demonstrate that product formation is the rate-limiting step.

9 and a simple classifier for determining the rate-limiting step.

10 ent, suggesting that ejection of the SM is a rate-limiting step.

11 tely 58 s(-1) so that PPi release became the rate-limiting step.

12 fect indicate that H-H bond formation is the rate-limiting step.

13 the requisite allosteric coupling, remains a rate-limiting step.

14 the product complex would correspond to the rate-limiting step.

15 lified quantitative models based on a single rate-limiting step.

16 viously assumed and sorption serves as a key rate-limiting step.

17 es suggest that C-H activation step may be a rate-limiting step.

18 he long-standing controversy surrounding the rate-limiting step.

19 hich under certain circumstances becomes the rate-limiting step.

20 ncovering o-quinone methide formation as the rate-limiting step.

21 dination of the pyridine nitrogen and is the rate-limiting step.

22 D) ~ 1.7), suggesting proton transfer in the rate-limiting step.

23 gradation, consistent with decapping being a rate-limiting step.

24 ropargylic position was determined to be the rate-limiting step.

25 of CO(2) reduction pathways and identifying rate-limiting steps.

26 ation but is useful in diagnosing additional rate-limiting steps.

27 racterized by a global model with three main rate-limiting steps.

28 glc levels suggesting one or more downstream rate-limiting steps.

29 ce and clinical translation are the greatest rate-limiting steps.

30 P14 is formed in the rate-limiting step along the conformational selection pa

31 nformational selection pathway but after the rate-limiting step along the induced-fit pathway.

32 This rate-limiting step also corresponded to and was sufficie

33 des (PS-ASOs) from late endosomes (LEs) is a rate-limiting step and a poorly defined process for prod

34 d, it acts as a viable proton donor past the rate-limiting step and a sluggish buffer that maintains

35 tional strategies agree on the nature of the rate-limiting step and provided close results for the re

36 t tertiary mutations may be used to identify rate-limiting steps and dissect folding and assembly pat

37 in conditions routinely cause shifts in the rate-limiting steps, and autocatalysis is prevalent and

38 The calculated reaction barrier of the rate-limiting step ( approximately 22 kcal mol(-1)) is c

39 this strange region of nonlimiting behavior, rate-limiting steps are often poorly defined, sometimes

40 mechanistic studies provide insights on the rate-limiting step as well as the structure of the actua

41 the proton transfer is occurring during the rate-limiting step, as in the distinction between genera

42 oplet reactions and it is concluded that the rate-limiting step at steady state is reagent transport

43 minant parallel and consecutive pathways and rate limiting steps by estimating the reaction rate cons

44 gy status regulates atRA biosynthesis at the rate-limiting step, catalyzed by retinol dehydrogenases

45 lay between these movements implies a single rate-limiting step dependent on ATP binding and transien

46 strate that Jak3 autophosphorylation was the rate-limiting step during Jak3 trans-phosphorylation of

47 t the gamma-C(sp(3) )-H bond cleavage is the rate-limiting step during the reaction process.

48 ind that substrate unfolding constitutes the rate-limiting step during translocation.

49 somerization of proline peptide bonds is the rate-limiting step during triple-helix formation.

50 Our results thus revealed that different rate-limiting steps (e.g., substrate channel diffusion)

51 he first carbon-carbon bond formation is the rate-limiting step, followed by a rotation about the new

52 suggesting that CGA hydrolysis could be the rate limiting step for CO2 formation from CGA.

53 Rate law analyses reveal that the rate limiting step for each catalyst involves the accumu

54 f the 2-OG dehydrogenase complex (OGDHc)-the rate limiting step for mitochondrial 2-OG metabolism.

55 neO intermediate (O-O bond formation) is the rate limiting step for OER catalysis at low pH.

56 We establish that the main rate limiting step for protein synthesis and the methion

57 the voltage sensor in the first domain is a rate limiting step for release of the inactivation domai

58 We found that the overall rate-limiting step for aldol cleavage shifted from C-C b

59 nts that suggest the isomerization to be the rate-limiting step for bispropargyl ethers, while cycliz

60 t that the C(sp(3))-H bond activation is the rate-limiting step for both the catalytic processes.

61 ate of hydration of [Formula: see text] is a rate-limiting step for calcite dissolution in seawater.

62 es and high-energy states can constitute the rate-limiting step for catalytic turnover.

63 ound charge pairs is identified as the major rate-limiting step for charge carriers' generation.

64 predict that under operating conditions the rate-limiting step for oxygen incorporation from O(2) ga

65 Translation initiation is a major rate-limiting step for protein synthesis.

66 The rate-limiting step for the activation of STING is its tr

67 In samples containing excess albumin the rate-limiting step for the chronopotentiometry readout a

68 del predicted that monomer activation is the rate-limiting step for the entire pore formation process

69 most likely arising from differences in the rate-limiting step for the two activities.

70 ether, these data show that HS17B3 acts as a rate-limiting-step for the maximum level of testosterone

71 flavodoxin reported a major revision of the rate-limiting step from MoFe protein and Fe protein diss

72 ilizing the COOH* intermediates and tune the rate-limiting step from the formation of adsorbed interm

73 action, catalyst resting state, and turnover-rate limiting step has been examined.

74 These changes in dominant rate-limiting steps have a direct effect on the duty rat

75 or (TCR) ligand discrimination; however, the rate-limiting steps have not been identified.

76 It can also be a rate-limiting step if high false positive or negative ra

77 f the flap, product release is no longer the rate-limiting step, implying that the flap is important

78 reduction by substrate is rate limiting, the rate limiting step in turnover of high potential MCOs is

79 pecific aspects include the time scales, the rate limiting steps in the degradation pathway, the effe

80 n of CYP27A1, the enzyme responsible for the rate-limiting step in 27-hydroxycholesterol biosynthesis

81 s and provides a simple means to predict the rate-limiting step in a folding reaction.

82 ing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and

83 E-1 (beta-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-beta (Abeta) production an

84 s in vitro The results identify an important rate-limiting step in assembly and reveal new insights i

85 cid dehydrogenase (BCKD) responsible for the rate-limiting step in BCAA catabolism.

86 on of metastasis suppressor genes is a major rate-limiting step in breast cancer progression that pre

87 Initiation is a rate-limiting step in cap-dependent translation and is t

88 gest that the FRQ-CK1 interaction is a major rate-limiting step in circadian period determination.

89 t tyrosine kinase activation is not the only rate-limiting step in CLEC-2-induced activation of plate

90 Because nucleotide exchange is the rate-limiting step in cyclical activation of G-proteins,

91 toyltransferase that catalyzes the first and rate-limiting step in de novo sphingolipid biosynthesis.

92 ncentrations above approximately 100 nm, the rate-limiting step in detergent- or membrane- induced po

93 onstrate that the search for homology is the rate-limiting step in DSB repair and suggest that cells

94 The rate-limiting step in each mechanism is **COOH formation

95 ons at a rate nearly 10-fold faster than the rate-limiting step in electron transport.

96 ric synthesis remains both a challenge and a rate-limiting step in enzyme discovery.

97 rus internalization into host cells, often a rate-limiting step in establishing infections.

98 ic acid (ACC) synthases (ACS), generally the rate-limiting step in ethylene biosynthesis, which is re

99 KIBRA is not the rate-limiting step in facilitation since overexpression

100 se (ACC), the enzyme that controls the first rate-limiting step in fatty acid biosynthesis.

101 called poly(A) tail shortening, is the first rate-limiting step in general cytoplasmic mRNA degradati

102 n, and that proteolysis is the regulated and rate-limiting step in generating soluble EGF bioactivity

103 A rate-limiting step in gluconeogenesis is the conversion

104 activates GPAT4, which catalyzes the initial rate-limiting step in glycerolipid synthesis.

105 xylase (GLDC), which catalyzes the first and rate-limiting step in glycine breakdown with the product

106 Pyruvate kinase catalyzes the last and rate-limiting step in glycolysis and theMtbgenome harbor

107 The rate-limiting step in green fluorescent protein is assig

108 using by RNA polymerase II (Pol II) is a key rate-limiting step in HIV-1 transcription and latency re

109 iption of Atgl, the enzyme that mediates the rate-limiting step in lipolysis, is a key point of this

110 se (SCD1, SCD), an enzyme that catalyzes the rate-limiting step in monounsaturated fatty acid synthes

111 We find that the rate-limiting step in mRNA cleavage frequently involves

112 iological functions including catalyzing the rate-limiting step in NAD synthesis.

113 amide phosphoribosyltransferase (NAMPT), the rate-limiting step in NAD(+) synthesis, is highly expres

114 dent expression of NLRP3, which represents a rate-limiting step in NLRP3 inflammasome assembly.

115 g kinase (NIK, also known as MAP3K14) is the rate-limiting step in non-canonical NF-kappaB pathway ac

116 se-alpha (CCTalpha) and CCTbeta catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthe

117 ns at a rate nearly 10 times faster than the rate-limiting step in photosynthetic electron transport.

118 cellular carboxylesterases is considered the rate-limiting step in polyester biodegradation.

119 nzymatic hydrolysis, which is considered the rate-limiting step in polyester biodegradation.

120 -trans isomerization of xaa-proline bonds, a rate-limiting step in protein folding which has been sho

121 suitable conditions for crystallization is a rate-limiting step in protein structure determination.

122 that MOR conformational changes are not the rate-limiting step in receptor activation.

123 RP3) inflammasome activation often acts as a rate-limiting step in regulating critical cell-fate deci

124 In eukaryotes, ribosome assembly is a rate-limiting step in ribosomal biogenesis that takes pl

125 mediated by RNA polymerase I represents the rate-limiting step in ribosome biogenesis.

126 so2-Sec9 'binary' t-SNARE complex, the early rate-limiting step in SNARE complex assembly, and stimul

127 nsferase, an enzyme catalyzing the first and rate-limiting step in sphingolipid biosynthesis: the con

128 Although STING ER exit is the rate-limiting step in STING signaling, the mechanism tha

129 nzyme A reductase (HMGCR), which catalyzes a rate-limiting step in synthesis of cholesterol.

130 thesis of 5-aminolevulinic acid (ALA) is the rate-limiting step in tetrapyrrole biosynthesis in land

131 nit of PRC2 indicate that demethylation is a rate-limiting step in the activation of such genes.

132 We now conclude that the rate-limiting step in the base-catalyzed aldol condensat

133 butyrate dehydrogenase 2 (Bdh2), catalyzes a rate-limiting step in the biogenesis of the eukaryotic s

134 Retinol dehydrogenases catalyze the rate-limiting step in the biosynthesis of retinoic acid,

135 This is the rate-limiting step in the biosynthesis of the catecholam

136 The rate-limiting step in the biosynthesis of the major memb

137 ioxygenase (TaNCED-5BS), which catalyzes the rate-limiting step in the biosynthesis of the phytohormo

138 ive sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the catabolism of heme into the bi

139 First, the rate-limiting step in the catalytic cycle is the formati

140 on of relative configuration is frequently a rate-limiting step in the characterization of small orga

141 d others demonstrated that the regulated and rate-limiting step in the choline pathway for PC biosynt

142 ydroxylase (CYP7A1) performs the initial and rate-limiting step in the classical pathway, and sterol

143 essively toward each terminus, and a similar rate-limiting step in the closing of the beta-barrel und

144 f goethite, suggesting Fe(II) release is the rate-limiting step in the conduction mechanism during re

145 regulation of proteostasis is a critical and rate-limiting step in the consolidation of new memories(

146 osomal proteases functioning in a direct and rate-limiting step in the Ctr1 ectodomain cleavage.

147 H) is an essential enzyme that catalyzes the rate-limiting step in the de novo guanine nucleotide bio

148 IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine n

149 des a powerful approach for overcoming a key rate-limiting step in the design and construction of an

150 Axin, a scaffolding protein that controls a rate-limiting step in the destruction of beta-catenin, t

151 tional theory calculations, we show that the rate-limiting step in the ENRR is likely the initial N=N

152 Phospholipase A2s mediate the rate-limiting step in the formation of eicosanoids such

153 esulting from the C-terminal cleavage is the rate-limiting step in the formation of fully cleaved Va.

154 ch slower than either fingers closing or the rate-limiting step in the forward direction; this rate b

155 substrate molecules from the bilayer is the rate-limiting step in the hydrolysis of GPLs by some sec

156 R by suppressing end resection, which is the rate-limiting step in the initiation of HDR.

157 amine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in the kynurenine pathway of tryptoph

158 yptophan 2,3-dioxygenase, which catalyze the rate-limiting step in the kynurenine pathway, producing

159 l colonization of the secondary organ is the rate-limiting step in the metastatic process; thus, expe

160 and -2.8, respectively, indicating that the rate-limiting step in the oxidations involves hydride ab

161 tidic acid phosphatase (PAP) controlling the rate-limiting step in the phospholipid synthesis pathway

162 ot observed with 1b, which suggests that the rate-limiting step in the reaction is neither C-H activa

163 It becomes the rate-limiting step in the spinodal region.

164 enhances product release, which also is the rate-limiting step in the steady-state.

165 sion of l-tyrosine into l-DOPA, which is the rate-limiting step in the synthesis of catecholamines, s

166 -prenyltransferase (cis-PTase) catalyzes the rate-limiting step in the synthesis of glycosyl carrier

167 Glucosamine treatment, which bypasses the rate-limiting step in the synthesis of substrate for gly

168 this case, a slow transient process was the rate-limiting step in the transitions.

169 The rate-limiting step in the two-step sequence depends on t

170 t catalyses the first committed reaction and rate-limiting step in the urea cycle.

171 ve analysis of this demonstrates CymA is the rate-limiting step in this electron conduit.

172 genic substrate, and its availability is the rate-limiting step in this pathway.

173 Initiation is a highly regulated, rate-limiting step in transcription.

174 ing lesions, with the promotion stage as the rate-limiting step in tumor formation.

175 t mechanism of adaptation was to relieve the rate-limiting steps in cofactor metabolism and substrate

176 e microtubule (MT; KT capture) is one of the rate-limiting steps in establishing proper KT-MT interac

177 scription start site (TSS) is one of the key rate-limiting steps in regulating genome-wide gene expre

178 ngs help reveal the nature and origin of the rate-limiting steps in substrate translocation on the ba

179 a1, which encode enzymes responsible for the rate-limiting steps in the classic and alternate bile ac

180 xygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic aci

181 nate T cells represents the most crucial and rate-limiting steps in the development of personalized c

182 ation of the rates, and determination of the rate-limiting steps in the paradigmatic case of the tryp

183 entify the primary HS response genes and the rate-limiting steps in the transcription cycle that GAGA

184 C7, C8 and C9, but little is known about the rate-limiting steps in this process.

185 lained by differences in the kinetics of the rate-limiting steps in transcription between promoters a

186 and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated

187 ggest that anatomical modifications are the 'rate-limiting step' in each trajectory, which in large p

188 encing (WGS), genetic mapping has become the rate-limiting step, inhibiting unbiased forward genetics

189 The overall nitrogenase rate-limiting step is associated with ATP-driven electro

190 The rate-limiting step is formation of an activated copper c

191 on, (b) not inhibited by product and (c) the rate-limiting step is most likely the C-C bond formation

192 dissect complex biological processes, but a rate-limiting step is often the cloning of targeted gene

193 In addition, the rate-limiting step is shown to be the cyclization of the

194 he diffusion through the coating and (2) the rate-limiting step is the diffusion through the aqueous

195 s can be simplified into two models: (1) the rate-limiting step is the diffusion through the coating

196 according to the theoretical discussion, the rate-limiting step is the diffusion through the coating;

197 The rate-limiting step is the iodine abstraction from an alk

198 he self-immolative reaction reveals that the rate-limiting step is the release of the first fluoride

199 ng the mechanisms behind translation and its rate-limiting steps is crucial for both the development

200 uropsychiatric disease genetics in which the rate-limiting step may no longer be gene discovery.

201 Whether the rate-limiting step occurs early or late in the evolution

202 inhibition of acetyl CoA carboxylase 1, the rate limiting step of FAS, inhibit generation of early m

203 ed in the presence of the secretome, and the rate limiting step of the reaction was the oxidation of

204 of activation or repression depending on the rate-limiting step of a given promoter's basal initiatio

205 ting cytosines and causing U:G mismatches, a rate-limiting step of Ab gene diversification.

206 cetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induce

207 SS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis.

208 ASS1 catalyzes the rate-limiting step of arginine synthesis in urea cycle a

209 itching from dormancy to colonization is the rate-limiting step of bone metastasis.

210 rogenase that is required for the second and rate-limiting step of branched amino acid catabolism and

211 lcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney

212 n dispersion experiments as well as with the rate-limiting step of catalytic turnover.

213 Prolidase catalyzes the final and rate-limiting step of collagen degradation during BBB re

214 cine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: the transfe

215 se, the enzyme responsible for the first and rate-limiting step of de novo sphingolipid biosynthesis.

216 Ribonucleotide reductase (RNR) catalyzes the rate-limiting step of de novo synthesis of deoxyribonucl

217 The rate-limiting step of eicosanoid generation is the liber

218 a general acid nor a reaction partner in the rate-limiting step of electrochemical CO2 reduction cata

219 catalyzing the crucial hypusination and the rate-limiting step of elF5A activation.

220 EEDs address the critical rate-limiting step of endosomal escape in delivery of ma

221 However, overcoming the rate-limiting step of endosomal escape into the cytoplas

222 he prominent role played by exosite 2 in the rate-limiting step of factor V activation.

223 e 1a (CPT1a) is a protein that catalyzes the rate-limiting step of FAO, here we investigated the in v

224 sion that FOL2 was the key gene encoding the rate-limiting step of folate biosynthesis in wine yeast.

225 ctions in the viral envelope may control the rate-limiting step of fusion.

226 enzyme in glycogen metabolism, catalyzes the rate-limiting step of glycogen mobilization.

227 vealing that a single H/D is involved in the rate-limiting step of H2 formation.

228 t Trp(72) impairs cholesterol efflux and the rate-limiting step of HDL biogenesis both in vitro and i

229 Kinetic analysis revealed the rate-limiting step of inactivation of the PLP-dependent

230 rsion to N-formylkynurenine in the first and rate-limiting step of kynurenine pathway.

231 leamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of L-tryptophan metabolism, and emerg

232 A carboxylase, which catalyzes the first and rate-limiting step of lipid biosynthesis), as well as in

233 hortening, also termed deadenylation, is the rate-limiting step of mRNA degradation in eukaryotic cel

234 eins, the last of which acts to accelerate a rate-limiting step of nucleotide exchange of Hsc70.

235 The rate-limiting step of PAR signaling is determined by the

236 nt of viral hemagglutinin, which affects the rate-limiting step of pH-triggered fusion.

237 the activation loop which might speed-up the rate-limiting step of phosphorylation.

238 Our data demonstrate that the rate-limiting step of PrimPol-catalyzed DNA elongation d

239 d suggest that PCSK9 self-proteolysis is the rate-limiting step of secretion.

240 Arguably, the first and rate-limiting step of SNARE assembly is the formation of

241 ained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that foll

242 o 0.05 s(-1), making the hydrolysis step the rate-limiting step of the ATPase cycle in the presence a

243 tion - the correlation is linear because the rate-limiting step of the catalytic cycle, nucleotide re

244 In addition to decreasing the rate-limiting step of the cycle (phosphate release), mav

245 The second and rate-limiting step of the de novo phosphatidylcholine bi

246 tification has been widely recognized as the rate-limiting step of the experimental workflow.

247 ferase (GFAT), the enzyme that catalyzes the rate-limiting step of the hexosamine biosynthesis pathwa

248 ansition state supports a model in which the rate-limiting step of the hybridization reaction is the

249 dynamic drivers of enzyme catalysis for the rate-limiting step of the industrially important enzyme

250 kov state model that allowed identifying the rate-limiting step of the ligand unbinding process.

251 emonstrated that the second arylation is the rate-limiting step of the overall transformation.

252 2,3-dioxygenase 1 (IDO1) that catalyzes the rate-limiting step of the pathway.

253 he transition state, thereby determining the rate-limiting step of the phosphorylation reaction of ar

254 by the catalyst as well as to determine the rate-limiting step of the process, which consists in the

255 icated that one proton is transferred in the rate-limiting step of the reaction at pD 7.0.

256 activation is associated with changes in the rate-limiting step of the reaction caused by additional

257 The rate-limiting step of the transport cycle is the dissoci

258 y when physiologically oriented and that the rate-limiting step of the transport cycle varies with th

259 of the transporter, likely representing the rate-limiting step of the transport process.

260 the other hand, for nonpolar compounds, the rate-limiting step of the uptake process is diffusion th

261 glycerol acyltransferases (DGATs) catalyze a rate-limiting step of triacylglycerol (TAG) biosynthesis

262 at dysregulation of cell fate may be a novel rate-limiting step of tumorigenesis.

263 l-tRNA reductase, which catalyzes one of the rate-limiting steps of chlorophyll biosynthesis.

264 ered to be of importance for hemostasis, the rate-limiting steps of CLEC-2-induced platelet activatio

265 ring and signalosome formation are among the rate-limiting steps of CLEC-2-mediated platelet activati

266 uent refolding and provides key insight into rate-limiting steps of G-quadruplex conformational dynam

267 Given that rate-limiting steps of metastasis are known to occur whi

268 n a dimer that reduces the energy barrier of rate-limiting steps of the catalytic cycle of Ca(2+) tra

269 l protein hubs and DNA processing during the rate-limiting steps of transcription.

270 on that is 10(2)-10(3) times faster than the rate limiting step on the Sr-rich (La,Sr)O termination.

271 that spontaneously converted CO2 to CO in a rate-limiting step on the second time scale in the dark

272 orbital (EHOMO)] to specific for the likely rate-limiting step [one-electron oxidation potentials (E

273 rone, indicating that C-H bond breaking is a rate-limiting step over a 10(4)-fold range of catalytic

274 control lipid A biogenesis, focusing on the rate-limiting step performed by LpxC.

275 binding events are productive and implies a rate-limiting step, probably associated with recruitment

276 e promoter-proximal pausing of RNAPII, a key rate-limiting step required for productive elongation.

277 proofreading, and translocation, focusing on rate-limiting steps, structural elements that modulate t

278 e been extensively investigated but the main rate-limiting step that determines circadian period rema

279 ch dichotomous kinetics implicate additional rate-limiting steps that are essential for DNA-damage-in

280 d unactivated amide consist of two different rate limiting steps: the formation of Cu-H monomer from

281 mental CO polarization curve and reveals the rate-limiting step to be *COOH to *CO at low overpotenti

282 phasizes that niclosamide degradation is the rate-limiting step to dehalogenation and mineralization

283 f.i-Bu3N bearing a hindered amine shifts the rate-limiting step to proton transfer.

284 ay, and that this pathway does not present a rate-limiting step to the export of alpha3beta4 nAChRs;

285 nd use different substrates, reveal that the rate-limiting step under these conditions is the H2 form

286 ichiometric analysis to identify potentially rate-limiting steps underpinning diurnal malate mobilisa

287 ich and electron-poor arenes showed that the rate-limiting step varies with the electronic properties

288 tion mechanism for NDMA reduction, where the rate-limiting step was a direct electron transfer reacti

289 l complexes have been characterized, and the rate-limiting step was shown to be reductive elimination

290 The DFT results showed that the rate-limiting step was the first electron abstraction fr

291 To exert control over this rate-limiting step, we designed sequence-specific synthe

292 (+)) binding result in a voltage-independent rate-limiting step where SERT may return to the outward-

293 present in both intermediate states, and the rate-limiting step which is likely to involve the thread

294 H the OH(-) anion nucleophilic attack is the rate-limiting step, which changes at high pH to the O-O

295 n barrier and a greater entropy gain for the rate-limiting step, which eventually leads to propene.

296 single proton is critical in the peroxidase rate-limiting step, which is very likely the proton-coup

297 tial allenic C(sp(3))-H bond cleavage is the rate-limiting step, which was supported by DFT calculati

298 ion of the compound II to resting state is a rate-limiting step, which will explain the contradictory

299 Methane activation is the rate-limiting step, while the activation of CO(2) and th

300 ailoring elegantly precise inhibitors of the rate-limiting steps within the signaling pathways that c