ライフサイエンスコーパス: rationalization

1 g questions about sacrifices or suggesting a rationalization.

2 mmentary, we offer an additional function of rationalization.

3 IUS/CSI:FingerID and MetFrag for MS2 spectra rationalization.

4 the few identified cases lacking mechanistic rationalization.

5 as well as, hydropathicity-based biophysical rationalization.

6 en serendipitous and often requires post hoc rationalization.

7 to show any habits that are apt targets for rationalization.

8 gue that this isn't the paradigmatic form of rationalization.

9 y of rationalization must include antecedent rationalization.

10 in extrapolated models used for MscL gating rationalization.

11 y both points and explicate the rationale of rationalization.

12 t someone has finally tried to make sense of rationalization.

13 tical to fully understand the function(s) of rationalization.

14 ffraction theory or nanohole-based "beaming" rationalizations.

15 nteraction energies have made evaluation and rationalization a challenge for experimental and theoret

16 Through topological rationalization, a zeotype mesoporous Zr-containing meta

17 Although rationalization about one's own beliefs and actions can

18 shman raises the intriguing possibility that rationalization accesses/constructs intuitions that are

19 Cushman's rationalization account can be extended to cover another

20 ine with recent advances, Cushman's rational rationalization account offers a way out of the rational

21 The data available do not show that rationalizations allow us to reason better and make bett

22 tion would help explain the effectiveness of rationalization and its connection with valuation, as we

23 post hoc rationalization but also by ex ante rationalization and other more dynamic processes.

24 This latter finding enables both the rationalization and prediction of catalyst initiation th

25 es are introduced as a tool to assist in the rationalization and prediction of the reactions of nucle

26 dation catalysis is of key relevance for the rationalization and the design of efficient oxygen evolu

27 ational exchange reveals connections between rationalization and theory of mind, inverse reinforcemen

28 ed across heterometallic bonds, allowing for rationalizations and predictions of single-molecule cond

29 While many studies demonstrate rationalization, and a few theories describe its underly

30 tasks such as compound prioritization, motif rationalization, and biased de novo drug design.

31 Lack of imagination, rationalization, and institutional constraints are formi

32 ions combining teamwork training and systems rationalization are more effective than those adopting e

33 We agree with Cushman that rationalizations are the product of biological adaptatio

34 n broad strokes with the characterisation of rationalization as a "useful fiction," we think that Fie

35 ic psychological evidence to support viewing rationalization as a quite suboptimal defense mechanism.

36 's argument is compelling, a full account of rationalization as adaptive will need to account for the

37 The result is a theory of rationalization as representational exchange both wider

38 Cushman characterizes rationalization as the inverse of rational reasoning, bu

39 questions, followed by a suggested possible rationalization (based on sacrifices made in medical tra

40 More generally, rationalization belongs to the broader class of represen

41 ational exchange occurs not only by post hoc rationalization but also by ex ante rationalization and

42 These collective rationalization cases illustrate how adaptive advantages

43 view and suggest a different view upon which rationalization emerges as a consequence of the adaptive

44 " Cushman downplays its signature liability: Rationalization exposes a person to the hazard of delusi

45 most residents disagreed with the suggested rationalization, exposure to it further increased the pe

46 Rationalization extracts implicit information - true bel

47 ssociated with taking the mask off included: rationalization, facilitating interaction, and comfort.

48 Computational studies provide a rationalization for a mechanistic pathway for the retent

49 The model provides structural rationalization for a sizeable body of Taxol structure-a

50 e coupled with asymmetric autocatalysis as a rationalization for absolute asymmetric synthesis and th

51 These results provide a rationalization for apparently contradictory reports fro

52 of the 21b--iNOS monomer complex provided a rationalization for both the SAR and the mechanism by wh

53 We provide a structural rationalization for D box and KEN box recognition by coa

54 f substrate base specificity, and provides a rationalization for elements of the likely enzyme mechan

55 ic MPL activation and providing a structural rationalization for genetic loss-of-function thrombocyto

56 -to-female HIV-1 transmission and presents a rationalization for human-based studies to illuminate th

57 he longer heparin oligosaccharide provides a rationalization for its effectiveness as an inhibitor of

58 amics simulations(10) providing satisfactory rationalization for its singular behaviour.

59 His207-Arg208 cis peptide bond, providing a rationalization for its spontaneous cleavage.

60 Further rationalization for observed high diastereoselectivity i

61 The electronic rationalization for stereoselectivity is discussed.

62 Mechanistic considerations provide rationalization for the differences between sites in mon

63 r beta-sheet extension to occur, and offer a rationalization for the experimental observation that ov

64 Moreover, we provide a rationalization for the experimentally observed preferen

65 round state information, but also provides a rationalization for the extent to which ground state pro

66 lcium-binding proteins provides a structural rationalization for the folding behavior of this protein

67 roperties of histidine, a refined structural rationalization for the folding cooperativity of AR prot

68 Mechanistic rationalization for the formation of the various product

69 ially formed, is used to develop a molecular rationalization for the observed trends in helix stabili

70 lexes modified with either monomer provide a rationalization for the opposing stability effects and p

71 m pores in zwitterionic membranes provides a rationalization for the peptide's cytotoxicity.

72 nvestigations, we also propose a mechanistic rationalization for the reaction outcomes.

73 ositively charged guests and also provides a rationalization for the rejection of anionic guests.

74 Such perturbations also provide a rationalization for the reported nonadditivity effect fo

75 Computational studies provide a rationalization for the selective appearance of these is

76 The detailed mechanism for this reaction and rationalization for the selectivity are provided using k

77 ng interactions with cytisine that provide a rationalization for the stoichiometry selectivity seen w

78 ctive attractions between pores, providing a rationalization for the tendency of bicelle mixtures to

79 e spectra of molecular systems and provide a rationalization for the underlying physics.

80 positive subsites, thus providing structural rationalization for the unique, single monosaccharide tr

81 g recognized as enigmatic because a chemical rationalization for their biosynthesis has not been obvi

82 Rationalization for these cleavage ratios at Xxx-Pro may

83 stems, and although some questions remain, a rationalization for these results is put forward.

84 pore region is used to provide a structural rationalization for these surprising results.

85 A rationalization for this observation is proposed based o

86 entals of water-splitting reactions, and the rationalization for utilizing mechanical strain to tune

87 hough several theories have been proposed, a rationalization for why proliferating cells seemingly wa

88 hydrophobic interactions, (b) gives a clear rationalization for why salt exerts different effects on

89 Our results provide simple rationalizations for (i) pronounced even/odd alternation

90 litical anger at out-partisans, or providing rationalizations for (lack of) enthusiasm for voting dur

91 m a broader perspective, this study provides rationalizations for overlooked and fundamental steps wi

92 cs simulations with vigabatrin bound provide rationalizations for the inhibitory properties of these

93 s formal dyotropic rearrangement and provide rationalizations for the significant substitution-depend

94 Rationalizations for the small increase in potency are c

95 The crystal structures are able to provide rationalizations for the structure-activity data, and in

96 y of both primary and metastatic lesions and rationalizations for tumor recurrence and therapeutic fa

97 necessary to obtain reliable predictions and rationalizations from theory.

98 Rationalization has been found to be associated not only

99 on from amino acid derivatives, two distinct rationalizations have been put forward for the relative

100 Cushman seeks to explain rationalization in terms of fundamental mental processes

101 Such a respiratory system enables rationalization in this organism of an unusual glycolyti

102 point to the problematic characterization of rationalization in traditional dual-process models and s

103 empirical challenge to Cushman's claim that rationalization is adaptive because it allows humans to

104 A ligand field rationalization is advanced and supported by DFT calcula

105 Rationalization is based on the difference in metal-comp

106 This rationalization is generalized to explain the nominally

107 This rationalization is in agreement with the measured fibril

108 hat the most important adaptive advantage of rationalization is instead that it increases our predict

109 xplanation of the function and usefulness of rationalization is less broad-reaching than he intends.

110 In this commentary, we ask when rationalization is most likely to occur and to not occur

111 e substantially over-reaches in arguing that rationalization is mostly right on average, based on cla

112 Mechanistic rationalization is proposed for these observations.

113 A review of key evidence indicates that rationalization is rare and confined to choices among co

114 In making the case that "rationalization is rational," Cushman downplays its sign

115 Cushman argues that "rationalization is rational." We show that there is reas

116 One rationalization is that many naturally occurring metabol

117 Cushman argues that the function of rationalization is to attribute mental representations t

118 The adaptiveness of "bounded rationalization" is domain specific and is unlikely to b

119 I suggest a different explanation of rationalization: making representations available to oth

120 Within the constraints of reasoning, rationalization may operate in ambiguous situations.

121 plete account of the evolutionary history of rationalization must include antecedent rationalization.

122 According to Cushman, rationalization occurs when a person has performed an ac

123 Rationalization occurs when a person has performed an ac

124 The observed conformational state allows the rationalization of a model of structurally and chemicall

125 arguments can be justifiably invoked in the rationalization of a particular chemical event.

126 echniques have provided a fully quantitative rationalization of all the experimentally determined R :

127 These findings enable the rationalization of apparent contradictions between previ

128 nt of innovative catalytic reactions and the rationalization of catalytic performances in terms of ac

129 ronics and sterics has a long history in our rationalization of chemical phenomena.

130 eaction mechanism, our model also allows the rationalization of different chemical yields obtained fr

131 hip-based rational drug discovery or for the rationalization of drug pharmacokinetics.

132 cess involving end-to-end annealing and that rationalization of empirical aggregation data composed o

133 The structure allows rationalization of existing genetic and biochemical data

134 This helps rapid rationalization of experimental data and understanding o

135 omated experimental workflow for post priori rationalization of experimental outcomes.

136 e experimental conditions rather than of the rationalization of fluorine effects.

137 Cushman claims that post hoc rationalization of habitual behavior can improve future

138 The present results provide a rationalization of how F1-ATPase achieves the coupling b

139 tent with experimental results and allow for rationalization of how substitution on the substrate bac

140 Rationalization of how the nature and arrangement of pol

141 for providing a minimalist phenomenological rationalization of in vitro observations regarding the e

142 These data aid the rationalization of in vivo differences in response to DA

143 -Cu bonds, (S(Cys)-Cu-N(deltaH46)), allowing rationalization of increases in E degrees ' of green Cu

144 action between HA and its receptor, allowing rationalization of influenza virus-cell binding quantita

145 wed comparison with acetylcholinesterase and rationalization of its ability to protect insects agains

146 This additional stabilization allows rationalization of its lowered cooperativity within the

147 Our structural rationalization of key catalytic differences between alt

148 This topology has been used for rationalization of ligand design and occurs experimental

149 d determination of activation parameters and rationalization of observed solvent effects in different

150 that provides a template for the structural rationalization of other proteins defective in Fanconi A

151 ith a computational analysis that allows for rationalization of paralogue selectivity and defines not

152 The results reported herein allow the rationalization of peroxide detoxification actions infer

153 olecular scale, paving the way toward better rationalization of photoexpansion and the athermal malle

154 The structural data allowed for the rationalization of physical properties of the cyanobacte

155 q and fibroblast growth factor-2, as well as rationalization of previous biochemical data.

156 re may present a productive strategy for the rationalization of protein crystallization.

157 isual inspection" traditionally used for the rationalization of protein-ligand affinity cannot always

158 review article overviews the development and rationalization of regiodivergence in these fundamental

159 In addition to providing a rationalization of relative strand polarity with nucleic

160 strom of human Pol III, allowing mapping and rationalization of reported genetic mutations.

161 The X-ray structure allowed for the rationalization of SAR data and potencies of the compoun

162 onal theory (DFT) calculations, enabling the rationalization of screening outcomes, and setting the s

163 the first time a consistent explanation and rationalization of several different experiments that ha

164 inhibition of cationic pLGICs and allows the rationalization of several structural and functional fea

165 These results provide rationalization of some of the findings by others using

166 atic and aromatic chiral amines based on the rationalization of stereoselective three-point interacti

167 In recent years, the rationalization of structure-properties relationship has

168 DFT calculations led to a clear rationalization of such stereochemical behaviors, pointi

169 ionships of the cinchona amine catalyst, and rationalization of the absolute stereoselectivity by NMR

170 The atomistic rationalization of the activity of transition metal oxid

171 The enhancement of affinities and rationalization of the binding mechanism require structu

172 ransition states by DFT calculations for the rationalization of the catalyst structure-selectivity re

173 twist, and computational studies provided a rationalization of the CD spectra.

174 usion in purely mesoporous materials and the rationalization of the complex concentration patterns re

175 lectivity, which can in part be explained by rationalization of the current reaction mechanism, but n

176 The three structures allow a qualitative rationalization of the differing stabilities of duplexes

177 rse could improve the efficiency and support rationalization of the dosing regimen of immunotherapies

178 However, rationalization of the effects of cyclopentadienyl (Cp(X

179 l structure at 1.85A resolution that enabled rationalization of the effects of disease-related mutati

180 rostatic contributions led to a quantitative rationalization of the effects of point mutations on the

181 contradiction is here addressed through the rationalization of the electrochemical mechanism underly

182 Rationalization of the enhancing potential of catalysts,

183 These structural data allow rationalization of the enzyme's preference for short pep

184 a member of the alpha-kinase family, enables rationalization of the existing structure-activity relat

185 rtaken at the B3LYP/6-31G(d) level permitted rationalization of the experimental data and provided in

186 ism using extensive DFT computations allowed rationalization of the experimental product ratio and it

187 terminal tail and Asp-92, providing a direct rationalization of the experimentally determined role of

188 A general rationalization of the factors that influence both relat

189 a significant advance for the prediction and rationalization of the geometric features of the corresp

190 The structure allows a rationalization of the inability of allo-, altro-, and g

191 Structural rationalization of the incorporation preference opposite

192 The hydrophobic effect--a rationalization of the insolubility of nonpolar molecule

193 Thus, the comprehension and rationalization of the interaction of these small molecu

194 However, rationalization of the limiting factors to access such r

195 Computational studies gave a first rationalization of the low activation energy for the cyc

196 Despite their extensive use, a deep rationalization of the main factors controlling the ther

197 The rationalization of the main scenarios in the generation

198 We provide rationalization of the mode of binding by solving co-cry

199 ctures of human coronavirus S domains allows rationalization of the molecular basis for species speci

200 Mechanistic rationalization of the observed behavior is presented ba

201 rformed within a TDDFT scheme allowed a full rationalization of the observed ECD spectra of 1 and 2.

202 effects in the supramolecular aggregation, a rationalization of the observed effects on a molecular l

203 gest suitable geometric models that enable a rationalization of the observed experimental preferences

204 level of theory, were in agreement with the rationalization of the observed reactivity.

205 chemistry computations are employed for the rationalization of the observed results.

206 Molecular modeling enabled the rationalization of the observed SAR and supported struct

207 lico docking using a model of AChE permitted rationalization of the observed SAR.

208 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity.

209 Computational (DFT) studies allow rationalization of the origin of reactivity and the unus

210 more, molecular modeling studies allowed the rationalization of the pharmacodynamic properties of the

211 conditions for its observation leading to a rationalization of the phenomenon.

212 d (-)-endo-4 does not lead to a satisfactory rationalization of the product distribution.

213 Rationalization of the reaction mode and regiochemistry

214 e consequences of these observations for the rationalization of the reactivity of the Jorgensen-Hayas

215 a departure from the predictions of TST for rationalization of the regiochemical outcome of the hydr

216 ith the Curtin-Hammett principle allowed the rationalization of the regioselectivity.

217 catalyst resting state, which thus provides rationalization of the relative decreased rate of coupli

218 Importantly, these structures allow rationalization of the relative rates and yields of chem

219 raction and fluorescence spectroscopy allows rationalization of the remarkable thermometric luminesce

220 omology modeling alone and provided a deeper rationalization of the SDM data obtained.

221 have to be simultaneously accounted for the rationalization of the selectivity obtained with dienoph

222 This Perspective offers a rationalization of the Soai autocatalytic reaction; acco

223 Rationalization of the special role played by butynyl su

224 t 2.8 A resolution, enabling molecular level rationalization of the SPR data.

225 Rationalization of the stereochemical model through comp

226 through NMR and VCD spectroscopy and allowed rationalization of the stereochemical outcome of these r

227 This study provides a rationalization of the stereoinduction step of the react

228 ctures and docking experiments supported the rationalization of the structural determinants essential

229 All these features allow a rationalization of the structural determinants of the 2'

230 An experimental rationalization of the structure type encountered in DNA

231 Such an analysis allows a rationalization of the trends observed for the pi-electr

232 m the structure-property relationship to the rationalization of their electronic properties through m

233 Furthermore, successful rationalization of these aspects allows us to point out

234 Rationalization of these contradictions is discussed.

235 ty functional theory calculations provided a rationalization of these outcomes and, in particular, so

236 Rationalization of these phenomena with a ligand binding

237 The most plausible rationalization of this behavior postulates a decrease i

238 The rationalization of this phenomenon by negative hyperconj

239 Orbital-based arguments allow rationalization of this transition between homoaromatici

240 es and site-directed mutagenesis, allows for rationalization of this wide substrate scope.

241 chanistic hypothesis that suggests a partial rationalization of values of rectification available in

242 It allows rationalization of why the NaI-mediated process is more

243 The simulation results provide potential rationalizations of a number of experimental observation

244 y is the mind designed to construct post hoc rationalizations of its behavior, and then to adopt them

245 ation/crystallization processes, fine-tuning rationalizations of one-pot synthesis approaches can sub

246 cterize many new SC motifs, provide detailed rationalizations of sequence preferences, and support mu

247 Different rationalizations of the observed trends had been propose

248 s of the enzyme/substrate contacts suggested rationalizations of the product distribution.

249 In such contexts, rationalization often facilitates distortion of rather t

250 In other words, rationalization often occurs antecedent to a behavioral

251 Following an in depth computational rationalization on the origin of reactivity difference o

252 ionalization account offers a way out of the rationalization paradox.

253 This rationalization predicted that Ins(1,4,5)P3 regioisomers

254 al and usage factors, indicating a cognitive rationalization process .

255 Cushman's account also obscures some of rationalization's pernicious consequences.

256 The data suggest instead that rationalizations serve reputation management goals, and

257 conscious self is involved just in post hoc rationalization should also be tested against concrete a

258 Rationalization sometimes generates more adaptive decisi

259 Including a rationalization statement further increased gift accepta

260 The suggested rationalization survey (n = 121) presented the same sacr

261 dissonance proposes an adaptive function for rationalization that differs from the one offered by Cus

262 They clearly distinguish two varieties of rationalization - the traditional "motivated reasoning"

263 In this rationalization, the negative shift in the formal potent

264 Critical aspects of the "rationality of rationalizations" thesis are open empirical questions.

265 Rationalization through reduction of cognitive dissonanc

266 Cushman uses rationalization to refer to people's explanations for th

267 he density functional theory have provided a rationalization to the selective C-5 arylation of N-aryl

268 In paradigm cases, rationalization undermines instrumental rationality by i

269 Rationalization (using rational management, i.e., based

270 This rationalization usually only applies at the genetic leve

271 o the changes in electron density supports a rationalization via two main electronic stages character

272 The selectivity rationalization was made on the basis of different confo

273 If rationalization were ubiquitous, it would undermine a fu

274 ring-driven approaches of modularization and rationalization, which may expand our understanding of t

275 Contrary to previous rationalizations, which indicate dominating steric or el

276 Incorporating such rationalization would help explain the effectiveness of