ライフサイエンスコーパス: reactivation

1 we demonstrate that NMD restricts KSHV lytic reactivation.

2 ork via participation in distinct flavors of reactivation.

3 we found evidence for simultaneous clustered reactivation.

4 no morbidity or mortality despite partial X reactivation.

5 ing lytic replication, remains silent during reactivation.

6 ATP hydrolysis to protein disaggregation and reactivation.

7 nome that has been associated with efficient reactivation.

8 HIF-1alpha-stabilizing drugs can induce EBV reactivation.

9 to become hyperexcitable also induced HSV-1 reactivation.

10 aches should focus on preventing latency and reactivation.

11 ined sterile clearance and prevented disease reactivation.

12 protein BGLF2 activates p38 and enhances EBV reactivation.

13 n would protect astronauts from latent viral reactivation.

14 ART does not decrease the short-term risk of reactivation.

15 gD, is required for WT levels of latency and reactivation.

16 ing further modification of specificity upon reactivation.

17 gainst infected human cells undergoing lytic reactivation.

18 g from IL-1 stimulation of neurons to induce reactivation.

19 the establishment of viral latency and viral reactivation.

20 atment regimens and strategies to prevent TB reactivation.

21 ells, before latency establishment and after reactivation.

22 f AR and AR splice variants to circumvent AR reactivation.

23 F-beta-mediated effects on viral latency and reactivation.

24 increased expression of viral proteins upon reactivation.

25 al therapy may begin at the earliest sign of reactivation.

26 id lineage triggers cellular cues that drive reactivation.

27 estrict HIV expression and were resistant to reactivation.

28 (BoHV-1) and herpes simplex virus 1 (HSV-1) reactivation.

29 ry and cell line models of HIV-1 latency and reactivation.

30 y siRNA interference mimicks transcriptional reactivation.

31 tructural diversity of OPs impedes efficient reactivation.

32 K27ac, which correlates with transcriptional reactivation.

33 afted cells across tissues, reflecting viral reactivation.

34 ly treatment with FTY720 led to cryptococcal reactivation.

35 w show AP-1 is a critical component for HCMV reactivation.

36 also assumed prevention of reinfections and reactivations.

37 cases, resulting in a low detection rate of reactivation (12.5%).

38 icant increase in chronic GVHD following EBV reactivation (62.5% versus 8%; P = 0.01).

39 associated with a 39% reduced risk of viral reactivation, a longer time to viral reactivation, and l

40 e ripples (SWRs) to identify times of memory reactivation across brain regions.

41 ere, we identified LINC00313 as a novel KSHV reactivation-activated long noncoding RNA (lncRNA) that

42 on, brincidofovir prophylaxis reduced HHV-6B reactivation after allogeneic HCT in a post hoc analysis

43 back to their tissue of origin on subsequent reactivation and a heightened capacity to redifferentiat

44 ed substantially and persisted following EBV reactivation and chronic GVHD, with a reciprocal decreas

45 Yet, how reactivation and congruency interact to optimize memory

46 -gamma occurred within the early hours after reactivation and correlated with local viral load.

47 nding of cellular targets required for HIV-1 reactivation and drug candidates that may reduce HIV-1-r

48 2013 and 2014 shifted the timing of cambial reactivation and had different effects on cambial reacti

49 er it is explained by the higher risk of CMV reactivation and infection.

50 prospectively evaluated the incidence of EBV reactivation and its impact on transplantation outcomes

51 maging revealed unsynchronized initiation of reactivation and KSHV replication with diverse kinetics

52 we replicated prior reports of post-encoding reactivation and memory-related hippocampal-LOC interact

53 offer a strategy in vaccine design to reduce reactivation and recurrent disease.

54 -1-suppressing agents that can inhibit HIV-1 reactivation and reduce HIV-1-induced immune activation.

55 periphery is an important component of this reactivation and reinfection.

56 oters decreased HCMV IE gene expression upon reactivation and significantly decreased the production

57 Furthermore, memory reactivation and subiculum representation predicted fast

58 events in subfield CA(1) Furthermore, memory reactivation and subiculum representation predicted succ

59 ammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases

60 The traditional view attributes CMV reactivation and the ensuing clinical disease primarily

61 ore TG neurons during BoHV-1 latency than in reactivation and uninfected calves.

62 ment and maintenance of viral latency, viral reactivation, and changes in the functional expression o

63 ore the ability of LAT to establish latency, reactivation, and immune exhaustion as well as induce th

64 f viral reactivation, a longer time to viral reactivation, and lower peak viral DNA concentrations, p

65 Silencing/inhibiting ABL1/2 blocks pathway reactivation, and resensitizes resistant cells to BRAF/M

66 orientations that are nonproductive for AChE reactivation, and the structural diversity of OPs impede

67 n to play a crucial role in inhibiting viral reactivation, and with a portion of these cells exhibiti

68 f CD80 fully rescues LAT function in latency reactivation, apoptosis, and immune exhaustion, suggesti

69 We find that strain-specific differences in reactivation are recapitulated in LUHMES.

70 hways might ultimately enable their targeted reactivation as a means to treat human injuries and dege

71 fied 11 cellular pathways required for HIV-1 reactivation as druggable targets.

72 313, an lncRNA upregulated during KSHV lytic reactivation, as a novel HIV Tat-interacting lncRNA that

73 ion of alternative MIE promoters during HCMV reactivation, as mutating FOXO binding sites in alternat

74 is, IC(50) and K(i) ), as well as inhibition-reactivation assays.

75 Eight patients developed EBV reactivation at a median of 96 days with no incidence of

76 Avoidance memory reactivation at recall triggers theta-gamma hippocampal

77 D8(+) T cells (Trm) are poised for immediate reactivation at sites of pathogen entry and provide opti

78 compared with pretransplant levels until CMV reactivation, at which point they increased during the v

79 We assessed memory reactivation by matching activity patterns from the appr

80 early during infection and were resistant to reactivation by vorinostat and interleukin 1beta.

81 of-of-concept study, we tested whether virus reactivation can be induced by administration of N-803 t

82 ransplantation of a latently infected organ, reactivation can occur and consists of a spectrum of cli

83 The endocervical cells' HIV-1 reactivation capacity further increased upon Toll-like r

84 F-alpha), CCL3, CCL4, and CCL20, their HIV-1 reactivation capacity was almost completely blocked by T

85 This reactivation causes significant morbidity and mortality

86 light had a 29% reduced risk of latent viral reactivation compared to crew with lower CRF.

87 nscripts during latency and impaired induced reactivation compared to that of 17syn (+) These results

88 molecular mechanisms underlying latency and reactivation continues to evolve.

89 Avoiding HIV-1 reactivation could be important for maintaining a functi

90 T cells and HSV-1 appear to control latency/reactivation cycles.

91 eal (IP) infection required M2, although the reactivation defect was retained.

92 ndent reconsolidation made it susceptible to reactivation-dependent amnesia.

93 or tuberculosis (TB) are not able to predict reactivation disease progression from latent TB infectio

94 imum translational interventions directed at reactivation due to co-infection.

95 oinfection and study the impact of ART on TB reactivation due to HIV infection.

96 We found that memory reactivation during learning promoted formation of diffe

97 subfields depends on the strength of memory reactivation during learning.

98 ess may protect astronauts from latent viral reactivation during long duration spaceflight missions.

99 Simultaneously, memory reactivation during new learning promoted integration in

100 equate in reversing the clinical signs of TB reactivation during the relatively short duration of ART

101 blishment of latent infection and subsequent reactivations, during which newly assembled virions are

102 t (EE) prior to learning improved the engram reactivation efficacy and rescued memory recall in the F

103 zoster ophthalmicus are uncommon because the reactivation efficiently boosts anti-VZV immunity.

104 However, because reactivation emphasizes similarities between perceptual

105 Finally, with reactivation, engram neurons use a subset of de novo lon

106 Behaviorally, both congruency and reactivation enhanced memory integration.

107 assumes that a single successful latent cell reactivation event leads to observable viremia after a p

108 r than a model with only a single successful reactivation event.

109 d, HSV-1 can reactivate, and these recurrent reactivation events can lead to blinding scarring of the

110 t al. of this simple model in which multiple reactivation events can occur, each contributing to the

111 bling time, a model with multiple successful reactivation events fits the data better than a model wi

112 s of the immune response induced by repeated reactivation events.

113 on is necessary and sufficient to induce CMV reactivation following murine transplantation of a laten

114 Although reactivation from latency can cause life-threatening dis

115 Importantly, SP inhibits HIV reactivation from latency in both cell line models and r

116 Reactivation from latency is controlled by processes tha

117 Certain external stressors can trigger reactivation from latency, in part because activation of

118 gene expression, viral DNA replication, and reactivation from latency.

119 o destroy latently infected cells or inhibit reactivation from latency.

120 B, inhibiting HIV transcription and blocking reactivation from latency.

121 id dexamethasone consistently induces BoHV-1 reactivation from latency.

122 the bICP0 E promoter, during early stages of reactivation from latency.

123 an important role in facilitating efficient reactivation from latency.IMPORTANCE While HSV antiviral

124 We demonstrate HSV-1 reactivation from latently infected mouse neurons induce

125 in subregions of the human MTL and how this reactivation guides recall of episodic information.

126 HbF reactivation has long been an area of intense interest g

127 The stimuli that trigger HSV-1 reactivation have not been fully elucidated.

128 nsformed cancer treatment by enabling T cell reactivation; however, response biomarkers are required,

129 of virus-mediated pain linked to latency and reactivation.IMPORTANCE The reactivation of herpesviruse

130 cts the ability of IFN-alpha to suppress EBV reactivation.IMPORTANCE Type I interferons are important

131 nitively determine whether prevention of CMV reactivation improves clinical outcomes of patients with

132 for calculation of CRI predicted the cambial reactivation in 2015.

133 serum levels of the ISG CXCL10 predicted HBV reactivation in a cohort of coinfected people taking DAA

134 ep architecture, SWR-DW dynamics, and memory reactivation in a mouse model of tauopathy and amyloidos

135 t reduce the relative risk of SIV-induced TB reactivation in ART-treated macaques in the early phase

136 d FDA-approved drugs that can suppress HIV-1 reactivation in both cell line models and CD4+ T cells f

137 Unexpectedly, DFO failed to induce EBV reactivation in cell lines that express mutant or no p53

138 s residual HIV replication and/or latent HIV reactivation in CNS reservoirs, thereby reducing HIV-ass

139 suppress residual HIV replication and/or HIV reactivation in CNS reservoirs, thereby reducing neuroin

140 Only those patients with HBV reactivation in cohort C had detectable HBV RNA at treat

141 A key step during HCMV reactivation in latently infected HPCs is reexpression o

142 ced these processes, such that post-encoding reactivation in LOC and memory-related hippocampal-LOC f

143 e expressed in only germ cells with aberrant reactivation in multiple cancers.

144 tor-memory T cells and inducing robust viral reactivation in plasma and peripheral blood mononuclear

145 re consistent with the hypothesis that viral reactivation in sepsis is a consequence of immune compro

146 on and N-803 administration can induce virus reactivation in SHIV(SF162P3)-infected RMs despite subop

147 es, the precise mechanics governing TRM cell reactivation in situ are unknown.

148 ortex was not correlated with the functional reactivation in the area 3b hand cortex.

149 ggest that NPC pools could be sites of HSV-1 reactivation in the central nervous system (CNS).

150 Persistent viral replication and latent HIV reactivation in the CNS, even under ART, are believed to

151 ples that mediate transcriptional memory and reactivation in the daughter cells remain unclear.

152 We studied HIV-1 reactivation in the female genital tract, a dynamic anat

153 We studied HIV-1 reactivation in the female genital tract, which is often

154 One patient showed reactivation in the form of a reactive retinal astrocyti

155 n mice with telomere dysfunction, telomerase reactivation in the intestinal epithelium or pharmacolog

156 ive replication in the HSV-1 lytic cycle and reactivation in the latent cycle.

157 was severely impaired in epinephrine-induced reactivation in the rabbit ocular model.

158 PML results from JCV reactivation in the setting of impaired cellular immunit

159 toneal cavity and, to a lesser extent, viral reactivation in the spleen.

160 ivation and had different effects on cambial reactivation in the two consecutive years because of var

161 factor in determining the timing of cambial reactivation in trees.

162 ines over time, other factors modulate viral reactivation in vivo despite robust HDAC activity.

163 cells in suppressing virus production and/or reactivation in vivo under ART.IMPORTANCE The "shock and

164 0 renders them more refractory to latent HIV reactivation, indicating an epigenetic reprogramming eff

165 which are autophagy targets, this autophagy reactivation induces degeneration.

166 However, AR reactivation inevitably drives disease progression to ca

167 LINC00313, which is upregulated during KSHV reactivation, interacts with HIV Tat to promote endothel

168 system is crucial for T cell recruitment and reactivation into a pathogenic Th17/GM-CSF phenotype.

169 Latent viral reactivation is a commonly reported manifestation of imm

170 Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer ce

171 frequently occurs in plant cells, and RNAPII-reactivation is essential for correct transcriptional ou

172 Such reactivation is observed during sharp-wave ripples (SWRs

173 However, rates of TB reactivation long after infection remain poorly quantifi

174 rising a neocortical-hippocampal-neocortical reactivation loop initiated by the neocortex.

175 neuronal cell line model of HSV latency and reactivation (LUHMES) to characterize the latent infecti

176 ivirals as suppressive therapy for EBV lytic reactivation may aid efforts aimed at disease prevention

177 However, such reactivation may have different representational consequ

178 ons enables long-term persistence from which reactivation may occur to cause recurrent diseases, such

179 intravenous group (sepsis [n=2], hepatitis B reactivation [n=1], and Pneumocystis jirovecii pneumonia

180 CMV reactivation occurred earlier in cyclosporine A-treated

181 er from late winter to early spring, cambial reactivation occurred earlier.

182 CMV reactivation occurred in 100% of seropositive animals in

183 This could represent a reactivation of a developmental phenotype because using

184 we can assume that VDZ may have promoted the reactivation of a latent HHV-8 infection endowed with on

185 enatally diagnose a congenital infection and reactivation of a past infection in an immunocompromised

186 Thus, ketamine reactivation of adult visual cortical plasticity is medi

187 DBeQ inhibited the reactivation of aggregated proteins by the ClpB-DnaK bic

188 human primary adipocytes, whereas selective reactivation of ALMS1 gene in AT of an ALMS conditional

189 GRB1 gene expression in MB, demonstrate that reactivation of BAI1 expression underlies EPZ-6438 antit

190 sympathetic nerves regulate accumulation and reactivation of bone marrow-residing hypertension-specif

191 Unlike the reactivation of CD8+ TLN cells, which is strictly depend

192 udy interventions to suppress replication or reactivation of chronic herpes infections.

193 talk with HSC and macrophages, including the reactivation of developmental pathways such as TAZ, Notc

194 The ectopic reactivation of developmental programmes has been propos

195 observed in human development, suggesting a reactivation of developmental programs.

196 between B and T cells in the generation and reactivation of different memory T cell subsets after tr

197 medical staff (ophthalmic graders) to detect reactivation of disease was compared with the current st

198 Hence, reactivation of divergent pathways can be leveraged as a

199 h a healthcare worker presenting with a late reactivation of Ebola virus disease (EVD) in the United

200 exposed to a patient presenting with a late reactivation of EVD.

201 overlap with previous experience may trigger reactivation of existing memories.

202 Reactivation of fetal hemoglobin remains a critical goal

203 s unstructured polypeptides and mediates the reactivation of heat-denatured model substrates without

204 Reactivation of herpes simplex virus 1 (HSV-1) from neur

205 d to latency and reactivation.IMPORTANCE The reactivation of herpesviruses, most commonly varicella-z

206 sed multivariate pattern analyses to measure reactivation of initial pair memories (A items) during o

207 Chemical reactivation of integrin bypassed CD47-mediated inhibiti

208 rbored persistent Mtb infection, as shown by reactivation of latent infection following simian immuno

209 of primary infection with M tuberculosis or reactivation of latent M tuberculosis infection during s

210 ion is the most critical risk factor for the reactivation of latent tuberculosis (TB) infection (LTBI

211 Previous paradigms that included reactivation of latent virus as the source of infection

212 ) infection result from primary infection or reactivation of latent virus is a longstanding question

213 V infections are due to primary infection or reactivation of latent virus remains unknown, and knowle

214 ssociated with primary infection rather than reactivation of latent virus.

215 host's antiviral response and promotes virus reactivation of latently infected cells.

216 is review builds on compelling data that the reactivation of LTBI during HIV co-infection is likely t

217 en considered the major cause of HIV-induced reactivation of LTBI, recent work in macaques co-infecte

218 ulation of T cell homeostasis correlate with reactivation of LTBI.

219 ing a novel tissue-specific paradigm for the reactivation of memory CD8+ T cells.

220 ore, DNA demethylation on such loci leads to reactivation of MLL2-dependent genes not only by removin

221 However, for the detection of regression or reactivation of neovascularization (NV), B-scan OCTA had

222 y afterdepolarizations were rather linked to reactivation of nonequilibrium Na(+) current, as they we

223 Reactivation of NRF2 signaling, conditional deletion of

224 We found that reactivation of ocular dominance plasticity in the adult

225 Does this mental replay involve a reactivation of our original perceptual dynamics?

226 site, which is indispensable for ABA-induced reactivation of PP2C-dephosphorylated SnRK2 kinases.

227 involvement of the hippocampal system in the reactivation of procedural memories.

228 elop following organ transplantation through reactivation of recipient human herpesvirus 8 (HHV-8) in

229 These data show that reactivation of related memories during new learning lea

230 is (TB) disease in the U.S. is attributed to reactivation of remotely acquired latent TB infection (L

231 ether silent rehearsal of sentences involved reactivation of sentence-specific representations establ

232 isruption of TI1 and TI2 function results in reactivation of stem cells and concomitant conversion of

233 Pharmacological reactivation of suppressed divergent circuits synergizes

234 TB and HIV to potentially reduce the risk of reactivation of TB due to HIV to inform treatment strate

235 t effectively cleared bacteria and prevented reactivation of TB in latently infected macaques.

236 Both reactivation of telomerase and silencing of p53 rescued

237 Now that there is more insight into the reactivation of the cell cycle machinery, other prerequi

238 er using three guide RNAs causes significant reactivation of the inactive allele in combination with

239 nsactivator have a synergistic effect on the reactivation of the inactive allele to levels >60% of th

240 detachment of the froth vesicles and prompt reactivation of the nucleation site favoured the packing

241 Importantly, the reactivation of the protein kinase B pathway by injectin

242 ART treatment induced robust and persistent reactivation of the virus in vivo.

243 Cyclic reactivation of these MBs through persistent antigen exp

244 We found that optogenetic reactivation of these socially active neuronal ensembles

245 entally regulated and may play a part in the reactivation of this latent stem cell niche after injury

246 teins Hsp104 and Hsp70, are essential in the reactivation of toxic protein aggregates that occur duri

247 derly or immunocompromised individuals after reactivation of varicella zoster virus (VZV).

248 activities, STW may orchestrate synchronized reactivations of multifocal activities, allowing tagging

249 There was no impact of EBV reactivation on acute graft-versus-host disease (GVHD),

250 accessions, exploring Lov-1, which shows FLC reactivation on return to warm, a feature characteristic

251 calcium-dependent phosphatase, following the reactivation or extinction of a cocaine-cue memory, indu

252 dulatory functions contribute to latency and reactivation or whether its binding to gD is necessary.

253 t evidence of strain-specific differences in reactivation outside the context of the whole animal at

254 bitory protein) gene restored the WT latency reactivation phenotype to that of a LAT-minus [LAT(-)] v

255 to spread back to the periphery) and to the reactivation phenotype.

256 Lytic reactivation plays a central role in the development of

257 We propose that this decrease in reactivation probability is due to reduced DNA replicati

258 Since the switchover from quiescence to reactivation provides a remarkable case of a cell physio

259 Postmigration reactivation rates appeared to show dependency on both t

260 Within 5 years of migration, annual reactivation rates were approximately 400 per 100 000 (u

261 and multiple zwitterionic forms optimal for reactivation reactions.

262 Reactivation refers to the phenomenon wherein patterns o

263 ted endothelial cells undergoing viral lytic reactivation remain unclear.

264 less, the circuit-level consequences of such reactivations remain unclear.

265 nsolidation of spatial memory depends on the reactivation ('replay') of hippocampal place cells that

266 ly dephosphorylated threonines, whereas PP2A reactivation results in dephosphorylation of clustered a

267 This approach to quantifying reactivation risks will enable evaluations of the potent

268 umans, would likely significantly reduce HSV reactivation, shedding, and lesions.

269 ve promoters in the MIE locus are induced by reactivation stimuli.

270 had had several episodes of Cytomegalovirus reactivation subsequent to the introduction of belatacep

271 uced macroH2A deposition and transcriptional reactivation supporting a pathogenic role for altered ma

272 te, turn expression of the replication/lytic/reactivation switch protein on to enter the replicative

273 LF1 gene product, Zta, usually controls this reactivation switch.

274 D), and that could be further evaluated as a reactivation TB predictor.

275 ic for disease and as predictive markers for reactivation TB.

276 sing CD80 in place of LAT had higher latency reactivation than a LAT-null virus.

277 nuclear protein expressed early during lytic reactivation that binds to viral RNAs and enhances RNA s

278 viral genome is an important determinant of reactivation that varies in a strain-specific manner.

279 This suggests that malaria may lead to KSHV reactivation, thereby increasing the transmission and pa

280 Conversely, during reactivation to known sites, dances are relatively less

281 arcoma tumor cells undergo spontaneous lytic reactivation to produce viral progeny for infection of n

282 Pharmacological HIV-1 reactivation to reverse latent infection has been extens

283 ed transcription and reduce the incidence of reactivation triggered by low levels of stress.

284 Viral reactivation triggers cell death specifically in HIV-1-i

285 ur results suggest that inappropriate engram reactivation underlies cognitive deficits in FXS, and en

286 processes of HSV-1 latency establishment and reactivation using human dorsal root ganglion-derived ne

287 Thus, DEPTOR reactivation via a variety of means would have therapeut

288 the meiotic programme requires CHK-2 kinase reactivation via signalling from chromosome axes contain

289 Mean age at onset of late reactivation was 25.6 years (range, 13-43 years).

290 However, EBV reactivation was associated with a sustained alteration

291 to misinformation, whereas stronger auditory reactivation was associated with increased susceptibilit

292 EBV reactivation was associated with longer ICU stay (12.9 v

293 Stronger visual reactivation was associated with reduced susceptibility

294 tinguish "antigen-specific" from "bystander" reactivation, we demonstrate that lung CD8+ TRM cells ar

295 Cytomegalovirus and Epstein-Barr virus reactivations were well controlled, but 9 patients exper

296 hat HIF-1alpha-stabilizing drugs only induce reactivation when they also induce accumulation of phosp

297 This interaction allows memory reactivations, which enhance serial biases in spatial wo

298 increased antibody titres may indicate KSHV reactivation, while the transmission of KSHV occurs via

299 nal clinical data linking development of CMV reactivation with worse outcomes in patients in the inte

300 n was associated with a low incidence of EBV reactivation without EBV-lymphoproliferative disorder.

301 ies that the timing of motor reduction after reactivation would be critical because progeny particles