ライフサイエンスコーパス: reader

1 dimensional cartridge and a smartphone-based reader.

2 he PHD-containing protein BdES43, an H3K4me3 reader.

3 ing of fluorescence using an automated plate reader.

4 onal 3.7 per patient compared with the first reader.

5 le addition, with a simple photoluminescence reader.

6 block heater/incubator and a handheld sensor reader.

7 e distinct from the typical trimethyl-lysine reader.

8 ologous to the SET oncoprotein acidic domain reader.

9 read at a central location with access to a reader.

10 asured 5 y (median value) later using an AGE Reader.

11 we show that ZZEF1 functions as a histone H3 reader.

12 position the microchannels in the microplate reader.

13 s deployed on a commercially available plate-reader.

14 .98), matching the performance of two expert readers.

15 ndesirably influencing the T/C ratio in LFIA readers.

16 ous CEUS LI-RADS categories by three blinded readers.

17 and spleen), were segmented separately by 2 readers.

18 sing previously validated software with five readers.

19 e longitudinally determined by 2 independent readers.

20 sighted and eight characters for low-vision readers.

21 t were interpreted independently by 3 masked readers.

22 more expensive commercial fluorescence plate readers.

23 ated by mpMRI, was measured by 2 independent readers.

24 up B).All PAD cases were detected by the two readers.

25 tible with PC was evaluated by 2 independent readers.

26 ficient was used to assess agreement between readers.

27 by the majority rule of 3 independent masked readers.

28 was comparable with that of six independent readers.

29 nd specificity ranged from 81% to 85% across readers.

30 tions were systematically re-evaluated by 12 readers.

31 leiomyomas, and it may assist inexperienced readers.

32 rst two image sets was reversed for half the readers.

33 parallel by two commercial fluorescent plate readers.

34 and the overall benefit to both authors and readers.

35 0, negative; 1, equivocal; 2, positive) by 2 readers.

36 performance differences between high-volume readers.

37 luated, with 972 899 assessed by high-volume readers.

38 was determined for PET versus CI by 3 masked readers.

39 acquisition protocol was calculated for both readers.

40 istence and expand the role of acidic domain readers.

41 educed interpretation time for three of four readers.

42 s the individual scan interpretations of the readers.

43 tly partially annotated by three radiologist readers.

44 For both readers, 0.05 mmol/kg of gadopiclenol improved contrast

45 l using semiautomatic measurements by expert readers, 0.065+/-0.033 mm(2) (P = 0.025).

46 to 90% (37 of 41 foci; 95% CI: 81%, 99%) for reader 1 (P = .019) and from 46% (19 of 41 foci; 95% CI:

47 5-point scale, first in routine diagnostics (reader 1) and then by an independent second evaluation (

48 rimental protocol for three of four readers (reader 1, 5.6 minutes +/- 1.7 vs 4.7 minutes +/- 1.4 [P

49 Readers 1, 2, and 3 correctly identified the lesions (n

50 Results: For both readers, (18)F-PSMA-1007 facilitated the interpretabilit

51 to 85% (35 of 41 foci; 95% CI: 75%, 96%) for reader 2 (P = .0001).

52 ivocal locoregional lesions (P = 0.024), and reader 2 reported a significantly higher rate of suspect

53 nd then by an independent second evaluation (reader 2).

54 s +/- 1.7 vs 4.7 minutes +/- 1.4 [P < .001]; reader 2, 2.8 minutes +/- 1.1 vs 2.3 minutes +/- 1.0 [P

55 cases, OCT had no impact, and in the case of reader 2, OCT actually reduced the kappa value from mode

56 s +/- 1.1 vs 2.3 minutes +/- 1.0 [P = .001]; reader 3, 3.6 minutes +/- 1.4 vs 3.3 minutes +/- 1.3 [P

57 es +/- 1.4 vs 3.3 minutes +/- 1.3 [P = .17]; reader 4, 4.3 minutes +/- 1.0 vs 3.8 minutes +/- 1.1 [P

58 can was evaluated using RSNA guidelines by 9 readers (6 fellowship trained thoracic radiologists and

59 ed point-of-care testing (PoCT) fluorescence reader, able to perform both intensity and time-resolved

60 lood with the assistance of a portable Raman reader, achieving a limit of detection of 1.0 ng mL(-1).

61 n brain flatmap vector graphics files (Adobe Reader/Acrobat viewable and Adobe Illustrator editable)

62 nd specificity were calculated for nonexpert readers after OCT interpretation of the TECS protocol us

63 Reader agreement for image quality and overall degree of

64 Inter-reader agreement was 0.95.

65 Inter-reader and intra-reader agreement was substantial for most diagnoses (kap

66 Two-reader agreement, as assessed by pairwise Cohen kappa st

67 Two neuroradiologist readers analyzed the pre-resection MRI findings (and CT

68 tor of venous invasion (TTPVI), using single-reader and consensus annotations.

69 Inter-reader and intra-reader agreement was substantial for mo

70 near mixed-effects model with intercepts for reader and subject.

71 All UHRF1 reader and writer domains were necessary for silencing a

72 diographs were independently analyzed by six readers and by the AI system.

73 ption and reading abilities in typical child readers and children with dyslexia and identify novel el

74 of PSMA-positive lesions was determined by 3 readers and compared with the reference standard.

75 with the incorporation of portable hand-held readers and miniaturized devices are then surveyed.

76 their use is a simple change that would help readers and potentially increase the value of science.

77 in titles and abstracts is essential to help readers and reviewers identify potentially relevant stud

78 c pharmaceuticals are highlighted to provide readers and scientists with an extensive toolbox for the

79 Mean HKAAs and AMAs as measured by the readers and the algorithm ranged from 0.05 degrees to 0.

80 The ILD contours from the three readers and the deep learning neural network were compar

81 content is perceived to be more engaging to readers and thus enhances publisher visibility and engag

82 e protein interactions between acidic domain readers and unacetylated, lysine-rich regions, opposite

83 Cohen (two-reader) and Fleiss (three-reader) kappa and the bootstra

84 including DNA or histone modifiers, histone readers, and chromatin regulatory protein complexes, has

85 s of a larger family of DNA/RNA modification readers, apparently having originated from bacterial mod

86 Our findings suggest that WPM readers appear to use links to external sources to verif

87 hese findings, and results may change if the readers are glaucoma or retina specialists instead of no

88 is expensive and slow because human central readers are needed.

89 measurements of pancreas volume between two readers are repeatable and reproducible with ICCs that c

90 Chromatin 'readers' are central interpreters of the epigenome that

91 ocity (PWV) was assessed three times by five readers as Deltax/Deltat: Deltax was measured on a paras

92 Expert central readers assigned each full-length endoscopy videos 1 end

93 Beyond projecting the reader at the forefront of this exciting field of physic

94 a measurements repeated three times by three readers at three aortic levels on three retrospectively

95 uidic channels using a commercial microplate reader based on this principle, yielding detection limit

96 39 benign nodules) was performed in a three-reader blinded read format, with the use of the CEUS LI-

97 CT scans in different reading sessions, with readers blinded to clinical information and other images

98 rmance and confidence were evaluated for two readers blinded to final diagnosis.

99 n as enhancer RNA) that binds to the H3K27ac reader BRD4 and participates in regulating CHPT1 SE acti

100 ug JQ1, which inhibits histone acetyl-lysine reader bromodomains, has shown promise for multiple canc

101 mance and reduced the workload of the second reader by 88%.

102 s in consensus and an additional independent reader by using full-lesion segmentations on a single tr

103 Our aims are two-fold: (i) to inspire readers by further elucidating the properties and functi

104 bodies of glyphosate and a custom electronic reader capable of reporting pesticide contamination.

105 uses a previously uncharacterized chromatin reader cassette to bind hypo-acetylated histone 4 tails

106 one case, OCT worsened the agreement of the reader compared with the FTF.

107 Two clinical readers compared the resulting images and retrospective

108 The BAH-PHD bivalent histone reader complex silences a substantial subset of H3K27me3

109 retina specialists instead of nonexpert OCT readers, comprehensive and anterior segment specialists.

110 Reader confidence improved with dual-energy CT compared

111 dual-energy CT improved polyp detection and reader confidence in a dedicated dual-energy CT colonogr

112 and a Wilcoxon signed-rank test was used for reader confidence.

113 We demonstrate that, in typical readers, cortical representation of the phrasal content

114 the 3 dosing levels when using the averaged reader data (all P values > 0.103).

115 and 2 as positives, consensus between the 2 readers deemed 66% of the (11)C-choline PET/CT scans as

116 concepts in machine learning for unfamiliar readers, details machine learning's current applications

117 ast sensitive and most sensitive high-volume readers detecting 53% and 89% of cancers, respectively (

118 In the absence of a reader device at the testing site, the strips after runn

119 Integrated with a reader device based on a mobile phone, this assay has th

120 ed of an intraocular sensor, and a hand-held reader device.

121 e 3 at baseline, 1, and 5 years using an AGE reader (DiagnOptics).

122 Reader diagnostic performance was evaluated with receive

123 In the remaining 14 patients, the readers disagreed on the number of lesions in 13 patient

124 s show that hotspot mutations in a chromatin-reader domain drive self-reinforced recruitment, deraili

125 lding blocks to develop engineered chromatin readers (eCRs) selective for DNA methylation and histone

126 We have compared these articles, and reader engagement with them, to other articles on Wikipe

127 al media and to assess how adherence affects reader engagement.

128 of adherence to safe-reporting practices on reader engagement.

129 We discuss the hypothesis that the writer-reader-eraser of N6mA-containining ssDNA is associated w

130 ing in bacteria in the context of the writer-reader-eraser paradigm, and progress toward ascribing re

131 epigenetic regulators, including 'writers', 'readers', 'erasers', and 'remodelers', is able to normal

132 One reader evaluated all cross-sectional imaging datasets (C

133 Both readers evaluated all images (40 of 40) as being of diag

134 Two independent readers evaluated vessels for diameter, stenosis or occl

135 Masked-reader evaluations were compared with a patient-specific

136 Quantitative and qualitative reader evaluations were performed on the denoised hb DW

137 l plate readers, until recently, no CD plate readers existed.

138 y (16 sarcomas; 26 leiomyomas) and impact of reader experience (29 sarcomas; 30 leiomyomas).

139 aging phase, ranging from 0.02 to 0.6; three-reader Fleiss kappa varied from -0.17 to 0.56.

140 We asked if MeCP2 is the sole reader for Dnmt3a dependent methylation by comparing mic

141 d the ubiquitylated H3 (H3Ub), as a specific reader for H3K9me3/H3Ub, with the recognition mode disti

142 with an inexpensive and portable electronic reader for point-of-care applications.

143 The inter-rate reliability between 2 readers for each imaging modality ranged between 0.76 an

144 nosis (TRIPOD) guidelines, to which we refer readers for further details.

145 Light kappa agreement between readers for LI-RADS categorization was 90%.

146 MRI studies were scored by two independent readers for tenosynovitis, synovitis, and bone marrow ed

147 dictive value (PPV) were calculated for each reader, for both real-life screening and the PERFORMS te

148 To help readers garner hands-on experience, this Primer is accom

149 positivity) was based on consensus among our readers (>=3 readers regarding a scan positive for BCR),

150 nt per the Bell spin states for the "general reader." He then challenged the "physicist reader" to ex

151 The second reader identified 96% (210 of 219) of nodes with an addi

152 ists, of whom 24 were defined as high-volume readers (ie, those who interpreted more than 5000 annual

153 d images was accomplished by two independent readers; images were assessed for lesion visibility, ade

154 The average AUC of all readers improved from 0.71 to 0.76 (P = .04) when using

155 cond nuclear medicine physician to the first reader in 20 of the patients.

156 dye applications, using a conventional plate reader in a high-throughput manner.

157 pealing and intuitive picture that draws the reader in.

158 lume measurements were obtained by all three readers in 120 of 147 nodules (82%).

159 ound Screening technologists may function as readers in breast cancer screening programs.

160 were segmented on b of 1500 sec/mm(2) by two readers in consensus and an additional independent reade

161 e Speckled Protein (SP) family of chromatin 'readers' in humans consists of SP100, SP110, SP140, and

162 metastases was determined by an experienced reader independently for both the PET and the morphologi

163 Three readers independently delineated the myocardium to inves

164 Two readers independently recorded if structural lesions (er

165 Two readers independently reviewed conventional 120-kVp CT a

166 P values and error bars help readers infer whether a reported difference would likely

167 Durations of reader interpretations were recorded.

168 and specificity were calculated for the TECS readers' interpretations versus the FTF examination.

169 Readers interpreted each examination twice.

170 re are discordant results between individual readers interpreting screening mammograms, consensus by

171 roup protein CBX2 is an important epigenetic reader involved in cell proliferation and differentiatio

172 Therefore, LANA's acidic domain reader is critical for viral latency.

173 cal eye to the most recent achievements, the reader is guided through this exciting, emerging field,

174 For training purposes, the reader is led through a 90- to 120-min procedure that st

175 ting challenging C-H activation methods, the reader is provided with an overview of this important ar

176 The reader is referred to the full guideline for graphical f

177 Cohen (two-reader) and Fleiss (three-reader) kappa and the bootstrap method were used to anal

178 reening mammograms, consensus by independent readers may reduce unnecessary recalls for further work-

179 Masked central readers measured neurotrophic lesions in randomized clin

180 Readers measured the longest dimension and lesion-averag

181 real-life performance metrics of individual readers (n = 452) in the National Health Service Breast

182 PPV of outliers were compared against other readers (nonoutliers) using analysis of variance.

183 eened and was significantly lower than other readers (nonoutliers) where the real-life CDR was 7.9 (P

184 e previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, link

185 tructurally complex molecules, it works as a reader of molecular information.

186 l, respectively, in the absence of mammalian readers of DNA methylation.

187 r mammalian YTH domains are also methyl mark readers of N6mA DNA.

188 the functional repertoire by which chromatin readers operate and provides mechanistic understanding o

189 The system significantly outperformed each reader (P < .001 using the McNemar test) at their highes

190 eceived higher image quality scores from the readers (P < .0001).

191 s were greater than or equal to 0.95 for all reader pairs using all measurement methods and were high

192 effect of DBT slab thickness and overlap on reader performance and interpretation time in the absenc

193 For RVI and TTPVI, the best single-reader performance had sensitivity and specificity of 52

194 urpose To determine the range of human first-reader performance measures within a population-based sc

195 The mean values per quartile of high-volume reader performance ranged from 63% to 84% for sensitivit

196 olution of a dual histone methylation writer/reader (PRDM9/ZCWPW1) system in vertebrates remodeled ge

197 phases of the cell cycle, and that the m(6)A reader promoting mRNA degradation, YTHDF2 (ref.

198 Further, we showed that the m(5)C reader protein ALYREF plays an important role in regulat

199 pped its location, and showed that ALYREF, a reader protein that specifically recognizes m(5)C, regul

200 m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protei

201 EMT is mediated via binding of the chromatin reader protein, bromodomain containing 4 (BRD4) in the N

202 (6)A demethylases (ALKBH5 and FTO), or m(6)A reader proteins (YTHDF1, YTHDF2, and YTHDF3).

203 Importantly, m(6)A reader proteins (YTHDF2 and YTHDF3) inhibit RIG-I-transd

204 es, cellular settings where these epigenetic reader proteins couple proximal stimuli to chromatin, ac

205 d the testis-restricted BRDT, are epigenetic reader proteins that bind to specific acetylated lysine

206 mily of ubiquitously expressed acetyl-lysine reader proteins, plays a pivotal role as a coactivator o

207 s well as previously reported and novel hPTM reader proteins.

208 sona Aspergillus LFA, when used with a cube reader, provides a rapid alternative to the well-establi

209 rminate, atypical, and negative by the three readers ranged from 18 to 29, 26 to 43, 19 to 31, and 5

210 ubject, sensitivity of tumor necrosis across readers ranged from 40% to 77%, and specificity ranged f

211 viable, sensitivity of tumor necrosis across readers ranged from 81% to 87%, and specificity ranged f

212 the experimental protocol for three of four readers (reader 1, 5.6 minutes +/- 1.7 vs 4.7 minutes +/

213 as based on consensus among our readers (>=3 readers regarding a scan positive for BCR), as well as t

214 The reader reported more and smaller lesions with higher cer

215 y, we determined the repeatability and inter-reader reproducibility of pancreas volume measurements b

216 ; 95% CI: 83%, 99%) for the less experienced reader, respectively.

217 Two blinded readers retrospectively graded radiological abnormalitie

218 A domains (the latter a DNA 5-methylcytosine reader) revealed them to be diverse members of a larger

219 Eye care providers ("readers") review the clinical data and recommend appropr

220 ng outcomes were examined based on the first reader's sensitivity quartile with 10 000 screening mamm

221 entilation defect percentage (VDP) and image reader score were calculated and compared with clinical

222 -read endoscopy score with the human central reader score.

223 xed regression model was used to compare the readers' scores.

224 First-reader sensitivity was determined for each tumor subgrou

225 roup, overall and by quartile of high-volume reader sensitivity.

226 KSHV LANA mutants lacking the acidic domain reader sequence are deficient for establishment of laten

227 The TECS readers showed substantial agreement for cataract (kappa

228 vice works "in terms meaningful to a general reader struggling with the dilemma raised by the device.

229 A reader study demonstrated that real and synthetic images

230 ials and Methods In a retrospective clinical reader study, images from breast DCE MRI examinations we

231 g 71 BCS patients were included in a blinded reader study, which resulted in 69.0% sensitivity and 79

232 the model presented here compared with human readers suggests that this work may provide a new method

233 R)-IO sensor communicates with the hand-held reader telemetrically, some patients might fear that the

234 taining posttranslational modification (PTM) reader that recognizes acetylated H4.

235 -terminal (BET) domain family are epigenetic readers that bind acetylated histones through their brom

236 haracterization of the writers, erasers, and readers, the breadth of chromatin functions associated w

237 For all readers, the FROC performance was higher for PET/MRI tha

238 When an abnormality was detected by the readers, the subject was recalled for retesting to confi

239 the AI system outperformed all of the human readers: the area under the receiver operating character

240 In this review, we guide the reader thorough experimental description of PEEM as a ch

241 inical question as a case study to guide the reader through (1) the pros and cons of each approach, (

242 help answer those questions as it guides the reader through the new update of the National Heart, Lun

243 al coupling of an Advion Plate Express plate reader to a liquid sampling-atmospheric pressure glow di

244 eport the utility of using the EKKO CD plate reader to analyze a chlorocoumarin amine derivatization

245 Second, we developed an external optical reader to detect and quantify the fluorescence activity

246 the manufacturer's instructions using a cube reader to generate a galactomannan index (GMI).

247 and up-to-date progress that will allow the reader to judge where the field stands currently and wha

248 he intent of the following is to provoke the reader to reflect on how we as a nation can move toward

249 descriptions of contextual details to permit readers to apply the findings.

250 eporting is vital to this process; it allows readers to assess the reliability of the findings and re

251 n that in endometrium or lymph nodes allowed readers to confidently diagnose as benign a uterine mass

252 displaying the results graphically, allowing readers to identify consequential specifications decisio

253 in Molecular Biology of the Cell that allows readers to request detailed protocols directly from the

254 and instrument aspects, thereby allowing the readers to select the best-suited approach.

255 In this article, we introduce readers to the mechanisms isolating Saccharomyces specie

256 cation, and provide resources for interested readers to use and apply to their own research and pract

257 l reader." He then challenged the "physicist reader" to explain the way the device works "in terms me

258 f seropositivity threshold determination and reader training for reliable LFA deployment.

259 patients served to build a set of images for reader training.

260 rom readily available 96- and 384-well plate readers, until recently, no CD plate readers existed.

261 At this point, we try to pull the reader up, giving the opposing view of an optimistic, li

262 At this point, we try to pull the reader up, giving voice to the opposing view of an optim

263 TV (TMTV(REF)) was measured by 2 experienced readers using independent semiautomatic software.

264 pectively and graded manually by six trained readers using the United States Risser staging system.

265 he work here also includes the largest inter-reader variability study involving 24 participants to ev

266 Inter-reader variability, lot-to-lot variability and rate of i

267 Two readers visually graded the 3D LGE images (conspicuity,

268 A compact fluorescence reader was designed to measure fluorescence images of th

269 The average AUC across readers was 0.769 (95% CI: 0.724, 0.814) without AI and

270 The average score from the readers was used as consensus score for each case, and a

271 pancreas regions of interest between the two readers, was 0.77.

272 Using a synthetic dual-modification reader, we also uncovered the protein composition at biv

273 In addition, to aid readers, we have assimilated redox potentials of photoca

274 The readers were asked to classify presence of tumor on a fi

275 The TECS readers were masked to the results of the FTF examinatio

276 Patients, investigators, and MRI readers were unaware of treatment allocation.

277 manual diameter measurements by at least one reader, whereas the reverse occurred for four of 120 (3%

278 An automated digital cube reader which allows for quantification of results has re

279 also facilitated development of an automated reader, which resulted in 100.0% sensitivity and 97.7% s

280 rgy CT and MRI, and images were read by four readers who were blinded to clinical information.

281 Readers who wish to access the definitive published vers

282 Where appropriate, the reader will be directed to more comprehensive reviews of

283 Due to their pleiotropic nature, the reader will be specifically directed toward various inbo

284 Further, the reader will get insights into the mechanism of the diffe

285 Consequently, the reader will understand why some crystals break during po

286 arge human population studies to provide the reader with a snapshot into these emerging fields of res

287 We aim to provide the reader with an overview of the fundamental principles on

288 along with other key updates, to provide the reader with an updated review that extends beyond the ba

289 Subsequently, we update the reader with intervening discoveries that underpin our cu

290 tive of this review is to provide the novice reader with literacy of AI/ML methods and provide a foun

291 mL with recombinant antigen using an optical reader with sensitivity equivalent to a visual read.

292 cise definitive review is to familiarize the reader with The Joint Commission standards and their app

293 In this review, we intend to provide the reader with the key elements allowing for mastering the

294 erall objective of this review is to provide readers with an extensive overview of gas hydrates that

295 In this review, we provide our readers with the most recent understanding of the intera

296 This review will provide readers with the opportunity to learn about the ML tools

297 ut of the m(6)A writer Mettl3 or the nuclear reader Ythdc1 in mouse embryonic stem cells increases ch

298 However, whether m6A, especially its 'reader' YTHDF1, targets a gene involving in protein tran

299 little is known regarding the role of m(6)A reader YTHDF3 in human diseases.

300 re, we identify the dual histone methylation reader ZCWPW1, which is tightly co-expressed during sper