コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 urements over times long enough for cells to rearrange.
2 en when underlying cancer genomes are highly rearranged.
3 ; adult, DDX41 mutated; and pediatric, NUP98 rearranged.
4 de chains become disordered and which become rearranged.
5 grated vectors were partially deleted and/or rearranged.
6 None are degraded or rearranged.
7 cipal discriminating feature: it drastically rearranges a network of proximal hydrogen bonds, modifyi
8 advanced our assay to investigate effects of rearranging actin filaments on the lateral membrane orga
13 t, TP53 mutated; NPM1 mutated; KMT2A mutated/rearranged; adult, DDX41 mutated; and pediatric, NUP98 r
14 possess a visible tail structure, one vertex rearranges after interacting with host lipopolysaccharid
15 ression was also variable in a pediatric MLL-rearranged ALL patient dataset, highlighting the existen
16 e acetyltransferases EP300 and CREBBP ZNF384-rearranged ALL showed significant up-regulation of CLCF1
17 pediatric mixed-lineage leukemia gene (MLL)-rearranged ALL were established in NOD.Cg-Prkdc(scid) Il
19 dels in vitro, as well as in the in vivo MLL-rearranged AML BMT model coupled with treatment of "5 +
20 ate that AMPK maintains the epigenome of MLL-rearranged AML by linking acetyl-coenzyme A (CoA) homeos
22 as further confirmed in human and murine MLL-rearranged AML cell models in vitro, as well as in the i
23 B) in human and mouse mixed lineage leukemia-rearranged AML cells, which were further increased after
24 d induces apoptosis of primary LSCs from MLL-rearranged AML patients in vitro and in vivo in xenograf
25 ncy granulopoiesis in a murine model of MLL1-rearranged AML, associated with accelerated leukemogenes
26 d postchemotherapy relapse in mice with MLL1-rearranged AML, but remission was sustained by ongoing R
27 at ALOX5 is especially down-regulated in MLL-rearranged AML, via transcription repression mediated by
36 tin binding did the catalytic triad in OTUB2 rearrange and bring the active site into a catalytically
37 ynthetic pathway, an isomerocyclase that can rearrange and cyclize geranylated indolenine (2) to a pr
39 entified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that sha
41 by duplication and translocation, frequently rearranged and lost in most Mycena species, but conserve
42 of Streptomyces sp.QL37, elucidated 24 other rearranged and non-rearranged angucyclines, 11 of which
43 the transcription factor ERG is recurrently rearranged and plays a critical role in prostate oncogen
44 1, triggering a series of transitions, first rearranging and bringing the two transmembrane domains i
45 QL37, elucidated 24 other rearranged and non-rearranged angucyclines, 11 of which were previously und
46 amount of information encoded by all of the rearranged antibody and T cell receptor genes in one per
47 linearity, whereas the remaining were highly rearranged as a result of inversions and inter- and intr
48 class of systems that the time delays can be rearranged as long as the total time delay over the cons
50 a palladium(II) complex, but this gradually rearranged at higher temperatures to afford a C-methyl c
51 the less thermodynamically stable isotopomer rearranges at cryogenic temperatures in the dark to the
54 Highlighting the central role of BCL6 in MLL-rearranged B-ALL, conditional deletion and pharmacologic
57 ed in mixed lineage leukemia-rearranged (MLL-rearranged) B-acute lymphoblastic leukemia (B-ALL), whic
60 ent option for infants and children with MLL-rearranged BCP-ALL who have a poor outcome when treated
65 annealing reveal that on Ag(111), structures rearrange by rotation and elongation of bonds in order t
66 eleton of a young adult male in a bear nest, rearranged by postdecomposition inundation, and the vari
67 nfected with a DFMO output strain containing rearranged cagY or the parental strain in which the wild
68 ovel methodological framework for recovering rearranged cancer chromosomes from karyotype graphs.
69 nding a collection of linear and/or circular rearranged cancer chromosomes that are determined by the
70 and/or circular structure of the underlying rearranged cancer chromosomes, thus limiting possible an
72 ation in inferring chromosomal structures of rearranged cancer genomes and advancing our understandin
73 haplotype-specific karyotypes of one or more rearranged cancer genomes from DNA sequencing data from
75 6051b is effective in treating ROS1- or NTRK-rearranged cancer in preclinical models, including crizo
77 ion of both wild type and G2032R mutant ROS1-rearranged cancers or NTRK-rearranged cancers in vitro a
79 o a solid-like dorsal region with larger non-rearranging cells, and a more fluid-like ventral region
80 dhesion at apical vertices is compromised in rearranging cells, with apical tears in the cortex formi
81 esponse to external cues, molecular machines rearrange/change their structures to perform certain fun
83 ealed that radio-sensitivity of structurally rearranged chromosomes is dependent on radiation dose.
84 f ATP hydrolysis and conformational flipping rearranges client-binding sites, providing a paradigm of
86 cell clones, characterized by their uniquely rearranged complementarity-determining region 3, were de
88 -, eight-, and twelve-membered rings, the un-rearranged dibenzothiophene Diels-Alder adduct is isolat
89 al work reveals that TFIID's conversion to a rearranged DNA binding conformation is enhanced in the p
91 naptic connections in the nervous system are rearranged during development and in adulthood as a feat
93 inase (ALK), ROS proto-oncogene 1 (ROS1) and rearranged during transfection (RET)) has established an
94 Asp act as an integral until which minimally rearranges even as the bulk undergoes extensive reorgani
98 taining, we investigate how dendritic spines rearrange following contextual fear conditioning (CFC) i
99 e., the variety of ways the analyte ions can rearrange following electrospray into kinetically stable
100 and M4 helices of agonist-activated receptor rearrange, forming a tighter interaction with the GluN1
101 ndomness of the order and orientation of the rearranged fragments, are all consistent with a chromoth
103 Igs ABCs express, we sequenced VH and Vkappa rearranged genes from unimmunized 22-mo-old C57BL/6 mice
107 e and complex, consisting of deletion(s) and rearranged genomic fragments, which sometimes originated
108 stitutively activate GPHR, (b) can by itself rearrange GPHR into a fully active conformation, (c) sta
109 ecific complete sequences for mRNAs encoding rearranged heavy and light chain immunoglobulins in B ce
110 odent cardiac phospholipidome is extensively rearranged; however, whether specific acyl chains impair
111 ) technology, involving inserting functional rearranged human variable exons into the mouse IgH and I
112 rules for Watson-Crick base pairing but have rearranged hydrogen bonding donor and acceptor groups.
113 m paired heavy- and light-chain sequences of rearranged Ig genes from multiple descendants of the sam
114 S(-) PC in H. pylori infection, we sequenced rearranged Ig genes from single cell-sorted PC from biop
116 C), where the IgHC encoded by a productively rearranged Igh allele assembles into a PreB cell recepto
117 ger RNA (mRNA) (IgHR) from a nonproductively rearranged Igh allele is degraded by nonsense-mediated d
120 of particles are thermodynamically driven to rearrange in regions of low density and bond orientation
123 m di-n-butylboron triflate and triethylamine rearranged in good yields and high selectivities with ex
125 egulate the cell secretory pathway and to be rearranged in thyroid and lung cancers, was strongly enr
126 which bears an unsaturated phosphanyl ring, rearranges in solution to yield a spirocyclic compound (
129 to overcome a barrier of 9.1 kcal mol(-1) to rearrange into cyclohexyne (with DeltaE for ring expansi
130 to surmount a barrier of 1.6 kcal mol(-1) to rearrange into cyclopentyne (with DeltaE for ring expans
134 H(4)(+)C o-Me(2)-2.1.1], which spontaneously rearranged into the larger and thermodynamically more st
137 ucleic-acid sequence being transcribed, RNAP rearranges into an elemental, catalytically inactive con
143 r, we find that ribavirin treatment of KMT2A-rearranged (KMT2A-R) infant ALL cells and the KMT2A-AFF1
145 dels, we found that cancer cells dynamically rearrange leader and follower positions during collectiv
146 lence subbands of the AlN/GaN DA is properly rearranged leading to the heavy-hole (HH) miniband being
149 he basis for a new therapeutic target in MLL-rearranged leukemia and act as further validation of a b
150 he relevance of MLL2 as a drug target in MLL-rearranged leukemia and suggest its broader significance
151 and apoptosis in a subset (7/11, 64%) of MLL-rearranged leukemia cell lines within a few hours of tre
152 sensitized an intrinsically unresponsive MLL-rearranged leukemia cell to CCI-006, indicating that thi
153 o observe an unexpected role for MLL2 in MLL-rearranged leukemia cells and identify potential therape
154 novel small molecule that rapidly kills MLL-rearranged leukemia cells by targeting a metabolic vulne
157 to the sensitive cells, the unresponsive MLL-rearranged leukemia cells were characterized by a more g
159 scover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a novel inhibi
161 suffering from mixed lineage leukemia (MLL)-rearranged leukemia remain below 50% and more targeted,
162 sly undescribed metabolic variability in MLL-rearranged leukemia that may contribute to the heterogen
163 ness of the biologic features underlying MLL-rearranged leukemia, targeted therapies for this leukemi
171 eral genes including those essential for MLL-rearranged leukemogenesis, such as DOT1L and SETD1A.
172 nation of the unique features of the sirtuin rearranging ligands (SirReals) as highly potent and isot
173 lament in which the molecules adopt a vastly rearranged, lower energy fold compared to wild-type fibr
174 12, and April 30, 2016, 26 patients with RET-rearranged lung adenocarcinomas were enrolled and given
177 1 have nonredundant roles in controlling ALK-rearranged lymphoma survival and morphology but are redu
178 rently dire outcomes for patients with NUP98-rearranged malignancies, therapeutic strategies have bee
180 thylation in the egg cell depends on DOMAINS REARRANGED METHYLASE 2 (DRM2) and RNA polymerase V (Pol
181 including RNA POLYMERASE V (POL V), DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) and SAWADEE HOMEOD
183 clude the de novo methyltransferase, DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2), which methylates
185 aused them to expand their apical cytoplasm, rearrange mitochondrial/lysosome trafficking, and genera
189 ally overexpressed in mixed lineage leukemia-rearranged (MLL-rearranged) B-acute lymphoblastic leukem
192 ith PML had a single neurotropic strain with rearranged NCCR, and 1 patient had a single strain with
193 The natural history of PDGFRA- and PDGFRB-rearranged neoplasms has been dramatically altered by im
194 eukoencephalopathy of the brain is caused by rearranged neurotropic JCPyV, little is known about vira
195 f clinical response are unpredictable in ALK-rearranged non-small cell lung cancer (NSCLC) patients t
196 ddress this, we evolved resistance in an ALK rearranged non-small cell lung cancer line (H3122) to a
197 K)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non-small-cell lung cancer (NSCLC) are sensit
198 h untreated anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) is not kno
199 t chemotherapy in patients with advanced ALK-rearranged non-small-cell lung cancer who had previously
201 in untreated patients with stage IIIB/IV ALK-rearranged non-squamous NSCLC was done in 134 centres ac
204 Patients with brain metastases from ALK-rearranged NSCLC treated with radiotherapy (SRS and/or W
210 recede those in IgL loci, 2) IgLlambda genes rearrange only when IgLkappa genes are consumed, and 3)
211 Vbetas rearrange only by deletion and TRBV31 rearranges only by inversion to create VbetaDJCbeta gene
212 enient and robust method to site-selectively rearrange or cleave bonds with submolecular precision in
214 gression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia, including patient-d
215 tients with anaplastic lymphoma kinase (ALK)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non
218 , however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.7
219 be an adaptive signaling plasticity of CRLF2-rearranged Ph-like ALL following selective TKI pressure,
226 ide chains of residues coordinating the zinc rearrange quickly to promote the nucleophilic attack of
227 contrast, our results demonstrate the use of rearranged receptors to mediate diverse modes of recogni
228 mmune system relies on germline-encoded, non-rearranging receptors expressed by innate immune cells r
229 g of Pm1a and its identification in a highly rearranged region of chromosome 7A provides insight into
230 , we demonstrate that targeting structurally rearranged regions, in particular tandem or interspersed
232 g of the ArfA N-terminus in the second state rearranges RF2 into an extended conformation that docks
233 solution of 3a or 3b at reflux afforded the rearranged species ArSn(3-tricyclo[2.2.1.0(2,6)]heptane)
234 The enantioselective total synthesis of the rearranged spongian diterpenoid (-)-macfarlandin C is re
236 lution of a strategy to access the family of rearranged spongian diterpenoids harboring a concave-sub
237 ted patients aged at least 18 years with ALK-rearranged stage IIIB or IV non-small-cell lung cancer (
238 played a role in the emergence of the highly rearranged structure of the gibbon genome by disrupting
239 le repetitions of the same conspecific song, rearranging syllable order reinstated strong responses.
240 s, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selec
241 -associated TCRbeta paired with endogenously rearranged TCRalpha endowed unprimed T cells with autoan
243 nd leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfull
245 -cellular ciliary and contractile activities rearrange the cell's underlying helical cytoskeleton to
246 on levels due to a repeated measurement will rearrange the grouping of data points such that these cl
251 meable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding.
253 Flavin monooxygenase RslO9 then oxidatively rearranges the carbon backbone, presumably via lactone-f
256 of guide RNA fastens the subdomains, thereby rearranging the active-site residues and increasing the
257 d then resolves the structure by iteratively rearranging the local genome structure, in a randomized
260 is believed to underlie adaptive behavior by rearranging the way neuronal circuits process informatio
264 n time and temperature, the obtained allenes rearrange to 1,3-biaryl-1-trifluoromethyl-1H-indenes.
265 erate nitrile imines (13, 19, and 38), which rearrange to 1H-diazirines, imidoylnitrenes, and carbodi
266 e latent regime, the adsorbed polymer chains rearrange to anchor their ends onto the surface and cont
268 re precursors of imidoylnitrenes, which also rearrange to carbodiimides or add intramolecularly to ar
271 *)) to produce a phenolic compound or it can rearrange to form a bicyclic peroxy intermediate that su
273 ing group, such as C(4)-Cl or C(5)-NO2, they rearrange to products 4 in the presence of aqueous ammon
274 2,5)]pent-3-ylidene is a carbene foreseen to rearrange to pyramidane (c-C(4)H(4))C, a highly strained
275 methylazines and azinylcarbenes, which often rearrange to the energetically more stable arylnitrenes.
276 h, in the presence of protic or Lewis acids, rearranged to dienes or lupanes bearing a bicyclo[3.3.1]
278 nt, while the tRNA cluster trnW-trnC-trnY is rearranged to trnY-trnW-trnC in J. hyalinus, the first r
279 rt a mechanism whereby the borepin initially rearranges to a boranorcaradiene by a thermal 6pai-elect
280 tions are released and a single 14-3-3 dimer rearranges to bridge the C-terminal pS729 binding sites
282 ] induces formal oxidation, and the compound rearranges to incorporate the Si atom into the carbocycl
286 and produce cytoplasmic protrusions, before rearranging to form two continuous epithelial layers.
288 ntly, Matsuda et al. (Pioneer factor NeuroD1 rearranges transcriptional and epigenetic profiles to ex
289 ngton's disease model, that integration of a rearranged transgene with coincident deletion of 5,444 b
293 g strategies using targeted amplification of rearranged variable regions comprised of V(D)J gene segm
294 al regioisomeric species, which subsequently rearrange via stepwise [1,3]- or concerted [3,3]-sigmatr
295 ghly labile and by visible or IR irradiation rearranges via a 1,2-fluorine migration from boron to ca
297 ks mediating the interactions are constantly rearranged with a characteristic timescale and, possibly