ライフサイエンスコーパス: receptor ligand

1 pound A, a novel nonsteroidal glucocorticoid receptor ligand.

2 ceptor type B (ETB(R)) and Jagged1, a Notch1 receptor ligand.

3 ecessary to calibrate the TGT with every new receptor-ligand.

4 expectedly to potent and selective mu-opioid receptor ligands.

5 which can be blocked by injection of mannose receptor ligands.

6 been identified as new potent sigma (sigma) receptor ligands.

7 ture-based discovery and design of chemokine receptor ligands.

8 gnature included several proangiogenic CXCR2 receptor ligands.

9 of aminopyridines, including known estrogen receptor ligands.

10 ith the human endogenous guanylate cyclase C receptor ligands.

11 GF receptor when stimulated by the seven EGF receptor ligands.

12 l molecules, such as epidermal growth factor receptor ligands.

13 by (18)F-FDG- or (68)Ga-labeled somatostatin receptor ligands.

14 atory cytokines in response to the Toll-like receptor ligands.

15 data to guide the design of novel aminergic receptor ligands.

16 GM-CSF, and eotaxin production to Toll-like receptor ligands.

17 ircuits by enabling the regulated release of receptor ligands.

18 ing of 5-HT and different classes of 5-HT(3) receptor ligands.

19 nses was corroborated using beta2-adrenergic receptor ligands.

20 l)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands.

21 5-HT6R as potent dual 5-HT7/5-HT2A serotonin receptors ligands.

22 immuno-modulatory molecule programmed death receptor ligand 1 (PD-L1).

23 dopamine release capacity (using the D(2/3) receptor ligand (11)C-PHNO, n = 23) and dopamine synthes

24 The neurotensin receptor ligand (111)In/(177)Lu-3B-227 has demonstrated

25 tudy demonstrates that mammalian cannabinoid receptor ligands activate a conserved cannabinoid signal

26 h the stationary concentration of the T-cell-receptor-ligand-activated complex, which transfers the s

27 can-binding proteins and help elicit optimal receptor-ligand activity of growth factor receptors, int

28 ersus-leukemia activity modulated by NK cell receptor-ligand affinities in AHCT for AML.

29 ay, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response

30 ntagonized pbPPARG, although their predicted receptor-ligand affinity was weak.

31 h as natural taste receptors (TRs) regarding receptor/ligand affinity.

32 Addition of bivalent D2 receptor ligands also resulted in a large increase in D2

33 The epidermal growth factor receptor ligand Amphiregulin has a well-documented role

34 To optimize the structure of a mu-opioid receptor ligand, analogs H-Tyr-c[D-Lys-Xxx-Tyr-Gly] were

35 Receptor-ligand analysis between teNK cells and tumor ce

36 h capsaicin and the endogenous TRPV1 and CB1 receptor ligand anandamide (ACR neurons).

37 as an example of a new class of cannabinoid receptor ligand and allosteric modulator, with the poten

38 ata establish (R)-PZQ as a G-protein-coupled receptor ligand and suggest that the efficacy of this cl

39 phages in response to a variety of Toll-like receptor ligands and bacteria, without affecting their p

40 ing with IFN then stimulating with toll-like receptor ligands and cytokines, followed by genome-wide

41 signaling, including epidermal growth factor receptor ligands and lysophosphatidic acid, have been id

42 r secretion after stimulation with Toll-like receptor ligands and M. tuberculosis whole-cell lysate,

43 IPP in the presence or absence of 69 nuclear receptor ligands and, similar to TPHP, found that ciglit

44 ssembled nectin-2 oligomers, suggesting that receptor-ligand and ligand-ligand associations are mutua

45 amino acid neurotransmitter D-Ser is a GluD2 receptor ligand, and endogenous D-Ser signaling through

46 and B6-RPE07) were stimulated with toll-like receptor ligands, and energetic pathways were assessed t

47 y not been described for beta (2)-adrenergic receptor ligands, and one of them shows an intrinsic eff

48 ch as tumor necrosis factor-alpha, Toll-like receptor ligands, and oxidized lipids, primarily by supp

49 iability, CSC frequency, expression of death receptor ligands, and tumor burden.

50 jawed vertebrates arose from closely linked receptor, ligand, and antigen-processing genes in the pr

51 critically on context, i.e. the interplay of receptors, ligands, and regulators that form the TGF-bet

52 ide effects; endogenous and exogenous opioid receptor ligands; and conventional and novel opioid comp

53 Four arginine-containing peptide receptor ligands (angiotensin II, neurotensin(8-13), an

54 l distinct physiological end points but FFA2 receptor ligands appropriate to test this hypothesis hav

55 f each form and whether this is regulated by receptor ligands are unknown.

56 Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the

57 a wide panel of protein kinase, enzyme, and receptor ligand assays.

58 nd agonist behavior of these novel melatonin receptor ligands based on superposition models and confo

59 dulators are an intensively studied group of receptor ligands because of their selectivity and preser

60 method is ideal to probe the lipid effect on receptor ligand binding as demonstrated by antagonist bi

61 I genotypes predictive of varying degrees of receptor-ligand binding affinities influence clinical ou

62 chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to th

63 g the AmAc concentration for quantifying the receptor-ligand binding strengths.

64 se changes together with the raft-associated receptor-ligand binding through the surface plasmon reso

65 mal initial cell-cell separation for fastest receptor-ligand binding, which could have relevance for

66 adigm for hierarchical mechano-regulation of receptor-ligand binding.Von Willebrand factor (VWF) is a

67 ta on how membrane-proximal domains modulate receptor ligand-binding affinity and dimerization effici

68 ulations of the GluA2 AMPA subtype glutamate receptor ligand-binding domain (LBD) dimers to character

69 However, steroid receptor ligand-binding domains (LBDs) are inherently un

70 st cancer is strictly dependent on an intact receptor ligand-binding pocket and that FES binds to ERa

71 forms a coherent signaling pathway from the receptor ligand-binding pocket to the G-protein activati

72 d the surrounding amino acid residues in the receptor ligand-binding pocket.

73 ic core and promote access of ghrelin to the receptor ligand-binding pocket.

74 The results of receptor-ligand-binding and cell-based gene activation a

75 targeting, agonistic receptor engagement, or receptor-ligand blockade, having contrasting requirement

76 forces increase the lifetimes of stimulatory receptor-ligand bonds (catch-bond behavior).

77 activation, where small numbers of antigenic receptor-ligand bonds at a cell-cell interface can stimu

78 Forces on receptor-ligand bonds impact the motion of the microvill

79 The strength, availability, and number of receptor-ligand bonds regulate the rate by which tumor c

80 data, we observed a distinct force range for receptor-ligand bonds, which allowed us to precisely ide

81 he vessel wall via the formation of specific receptor-ligand bonds.

82 tethers which report cell-exerted tension on receptor-ligand bonds.

83 rmediates, which might be relevant for other receptor-ligand bonds.

84 The conjugation of ASOs to a receptor ligand can dramatically increase their entry in

85 s in the tumor microenvironment by toll-like receptor ligands can lead to a powerful systemic antitum

86 esponse in cells activated by RNA, Toll-like receptor ligands, cGAMP, or recombinant interferon.

87 models guided the design of novel melatonin receptor ligands characterized by a 2-acylaminomethyltet

88 lic series in which numerous highly diverged receptor-ligand combinations are segregating in natural

89 two allelic variants segregating as distinct receptor-ligand combinations diverged through an asymmet

90 MADD-4 and NLG-1, suggestive of a tripartite receptor ligand complex.

91 LECT-2 functions in a multi-protein receptor-ligand complex that also contains two transmemb

92 onalize these results, a homology model of a receptor-ligand complex was built using the published cr

93 sest atoms (200-1000 atoms), or for the full receptor-ligand complex, but it is likely that with a pr

94 drive affinity and enhance stability of the receptor-ligand complex.

95 ification onto three-dimensional models of a receptor-ligand complex.

96 re of an intact, full-length, and functional receptor.ligand complex.

97 s phosphorylation by segregating the engaged receptor/ligand complex from receptor protein tyrosine p

98 al effects including spatial organization of receptor-ligand complexes and development of mechanical

99 Examination of the x-ray structures of the receptor-ligand complexes further showed two distinct fo

100 at of unliganded receptors, agonist-bound D2 receptor-ligand complexes resulted in an increase in dim

101 the prediction of the structure of chemokine receptor-ligand complexes that have not been crystallize

102 t and integrates the information from sparse receptor-ligand complexes, coordinating the progression

103 plains how alterations in the level of death receptor-ligand complexes, their clustering properties a

104 termined structures of 52 distinct aminergic receptor-ligand complexes.

105 formed, including the equilibrium number of receptor-ligand connections.

106 Parabens and human epidermal growth factor receptor ligand cross-talk in breast cancer cells.

107 teractions and the landscape of dysregulated receptor-ligand crosstalk in cancer, including selective

108 increased expression of the CXCR3 chemokine receptor ligands CXCL9 and CXCL10 in VV-infected skin.

109 s point to a complex interplay among nuclear receptor ligands, cytosine methylation, and the metabolo

110 Many subtype-selective dopamine receptor ligands developed for the D(2)-D(4) family inco

111 of testosterone to the more potent androgen receptor ligand dihydrotestosterone.

112 of counterintuitive mechanical regulation of receptor-ligand dissociation have been described.

113 ing mice with multivalent forms of the Notch receptor ligand DLL-1, but the immunologic correlates of

114 er extended well beyond the perimeter of the receptor-ligand engagement zone.

115 These cell signals are propagated following receptor-ligand engagement, controlling recruitment and

116 We also show that HER receptor ligands exert unique effects on signaling by mo

117 erent growth factors suggests that these EGF receptor ligands fall into two major groups as follows:

118 neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells was needed to restric

119 to functional LRP1 clusters was tested in a receptor-ligand fluorometric assay made by immobilizing

120 lized transcription of the G-protein-coupled receptor ligand Fog.

121 , despite ongoing clinical trials with sigma receptor ligands for multiple conditions, relatively lit

122 h spawned an explosion of small-molecule NOP receptor ligands from discovery programs in major pharma

123 Galectin-3-binding protein (gal3bp) and its receptor/ligand, galectin-3 (gal3), are secreted protein

124 neurogenesis is normally driven by both TAM receptor ligands Gas6 and protein S.

125 finity ligand for and modulator of ryanodine receptors-ligand-gated ion channels that are critical fo

126 The TAM receptor ligand, growth arrest specific 6, re-establishe

127 e of clinical benefit even if the endogenous receptor ligand has not been identified.

128 K11195), a typical peripheral benzodiazepine receptor ligand, has been established as a potent hCAR d

129 [3,2-b]carbazole (FICZ), an aryl hydrocarbon receptor ligand, has been found to be a potent UVA photo

130 IL-1beta), an inflammatory cytokine and IL-1 receptor ligand, has diverse activities in the brain.

131 ls elicited in the presence of C-type lectin receptor ligands have an increased ability to produce cy

132 ls express the epidermal growth factor (EGF) receptor ligand, heparin-binding EGF (HB-EGF), with no d

133 included missing killer immunoglobulin-like receptor ligand, human antimouse antibody response, and

134 iochemical approaches to show that loss of a receptor-ligand hydrogen bond drives these remarkable th

135 Toll-like receptor ligands in indoor dust act as environmental adj

136 enylalanine (FDOPA), and (68)Ga somatostatin-receptor ligands in NETs has been expanding.

137 rgues for evaluating the implication of UNC5 receptor ligands in other oncogenic microbial species.

138 nto the CNS while masking them as functional receptor ligands in the periphery.

139 ar to consist of autoinhibited resting-state receptors, ligand-induced conformational changes, and hi

140 peutic against established mouse tumors in a receptor-ligand inter-dependent manner.

141 n lipid A molecules using multiple sites for receptor-ligand interaction and propose that host-specif

142 on of Notch signaling occurs following Notch receptor-ligand interaction and subsequent enzymatic pro

143 t peptide-Fc fusion protein, neutralizes the receptor-ligand interaction between Tie2 and angiopoieti

144 strate how the cellular compartment in which receptor-ligand interaction occurs can influence functio

145 ubes provide a novel mechanism for selective receptor-ligand interaction, contributing to the short-r

146 n helps to elucidate the mechanism of native receptor-ligand interaction.

147 splaying cell-like behavior through a native receptor-ligand interaction.

148 TcSKR1 was more flexible than TcSKR2 during receptor-ligand interaction.

149 most notably the mechanical stability of the receptor-ligand interaction.

150 CR7 signaling following ligation by CCL19, a receptor:ligand interaction critical for T-cell migratio

151 antifies the capacity of antibodies to block receptor-ligand interactions (i.e. antibody blockade).

152 tem from multiple factors, including complex receptor-ligand interactions among CD28 family members,

153 enables detailed investigation of structural receptor-ligand interactions and assessment of the trans

154 sicles (EVs) regulate signaling pathways via receptor-ligand interactions and content delivery, after

155 irect signal-processing role for promiscuous receptor-ligand interactions and establish operational p

156 Receptor-ligand interactions are essential for biologica

157 These receptor-ligand interactions are in competition with the

158 Antibodies that antagonize extracellular receptor-ligand interactions are used as therapeutic age

159 ethods to explore conformational changes and receptor-ligand interactions associated with LRH-1 activ

160 invasion of reticulocytes relies on distinct receptor-ligand interactions between the parasite and ho

161 pitfalls-hyperstimulation of finely balanced receptor-ligand interactions could also be detrimental.

162 surface that directly implicates Skint-1 in receptor-ligand interactions crucial for DETC selection.

163 network in fine-tuning receptor mobility and receptor-ligand interactions for modulating B cell signa

164 Receptor-ligand interactions induce changes in gene expr

165 To identify distinct receptor-ligand interactions leading to these difference

166 nation of tumor secreted soluble factors and receptor-ligand interactions mediate activation of Src w

167 ulation is dynamically tuned by steady-state receptor-ligand interactions of an NK cell with its cell

168 by computational docking studies, revealing receptor-ligand interactions similar to KOR agonist dyno

169 These compounds highlight receptor-ligand interactions that control efficacy at D(

170 mportant mediators of adaptive immunity, and receptor-ligand interactions that regulate their surviva

171 fying the relative contribution of different receptor-ligand interactions to a given HLA class I dise

172 age phagocytosis can be triggered by diverse receptor-ligand interactions to clear pathogens and dead

173 gest a novel kinetic approach to quantifying receptor-ligand interactions via the cellular transport

174 Stimulatory or inhibitory signals from these receptor-ligand interactions work in tandem to preserve

175 Using specific examples of promiscuous receptor-ligand interactions, a case is made for expandi

176 ate-of-the-art in vitro methods characterize receptor-ligand interactions, highlighting experiment st

177 ate how phagocytosis is affected by specific receptor-ligand interactions, ligand density, lipid char

178 cytic targets with different combinations of receptor-ligand interactions, making comparisons difficu

179 In order to understand receptor-ligand interactions, many groups working with d

180 thogen vs sterile inflammation, inflammatory receptor-ligand interactions, microbial-associated molec

181 ersal as we demonstrate using two additional receptor-ligand interactions, P-selectin &PSGL-1 and Not

182 ain have provided atomic-scale insights into receptor-ligand interactions, while high-resolution stru

183 echanisms such as antagonism at the level of receptor-ligand interactions, whose existence and preval

184 oes not correlate with specific RBC-parasite receptor-ligand interactions.

185 hod" for the biochemical characterization of receptor-ligand interactions.

186 ands and can arise directly from competitive receptor-ligand interactions.

187 nation of tumor secreted soluble factors and receptor-ligand interactions.

188 e cell and provide a better understanding of receptor-ligand interactions.

189 the potential for regulation by and of other receptor-ligand interactions.

190 ses, which are likely the result of multiple receptor-ligand interactions.

191 from diffusion and the stochastic nature of receptor-ligand interactions.

192 EV mimetics permits the study of specific EV receptor-ligand interactions.

193 ted cells through multiple germ line-encoded receptor-ligand interactions.

194 Our results provide evidence that receptor/ligand interactions, involving alphavbeta3 and

195 vely charged iron, independent of biological receptor/ligand interactions.

196 ns that range from conformational control to receptor/ligand interactions.

197 A challenge with receptor ligands is that the distribution volume is conf

198 A challenge with receptor ligands is, that the distribution volume is con

199 hiregulin (AREG), an epidermal growth factor receptor ligand, is implicated in tissue repair and fibr

200 t of serial TGT independent of the choice of receptor-ligand, it is able to reconstruct force history

201 ntroduced into the endogenous peptide opioid receptor ligand Leu-enkephalin as a model compound.

202 We show that the Toll-like receptor ligands lipopolysaccharide and CpG DNA, which a

203 peptides (C-type natriuretic peptide and EGF receptor ligands) maintain the low level of cGMP in the

204 ior of the TGT is influenced by the tethered receptor-ligand, making it necessary to calibrate the TG

205 ioid receptor, and injection of human opioid receptor ligands mimics exogenous opiates, highlighting

206 Here, we developed a novel receptor-ligand model of the adenosine system to test th

207 We also reveal novel candidate receptor-ligand networks involving SSCs and the developi

208 The evaluation of a novel group of dopamine receptor ligands now showed that highly subtype-selectiv

209 nts with NASH Trial (PIVENS) and Farnesoid X Receptor Ligand Obeticholic Acid in NASH Treatment Trial

210 o-treated patients in the FLINT (farnesoid X receptor ligand obeticholic acid in NASH trial).

211 The farnesoid X receptor ligand obeticholic acid in the NASH treatment t

212 The kinase activity responses to receptor ligand occupancy changes can be highly cooperat

213 In contrast, receptor ligand occupancy did not have a discernable eff

214 intravaginal instillation of CXCR3 chemokine receptor ligands or TLR 3, 7, and 9 agonists to recruit

215 satisfied for specific interactions such as receptor-ligand or protein-drug.

216 glucocorticoid-induced tumor necrosis factor receptor ligand, or GITRL.

217 Using a model receptor-ligand pair (FRB-FKBP), we first test physical

218 mplying that the intracellular route of this receptor-ligand pair is largely independent of the TGN/E

219 The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental proc

220 and allele combinations of the most diverse receptor-ligand pair, KIR3DL1 and HLA-B, correspond to h

221 We use a receptor-ligand pairing analysis and a high-throughput i

222 applied PhOTseq to the challenge of mapping receptor-ligand pairings among pheromone-sensing neurons

223 nt clinical trials targeting these promising receptor/ligand pairings in cancer.

224 s this study considered how the emergence of receptor:ligand pairings shaped the distribution of bloo

225 t follows that the reproducibility of orphan receptor ligand pairs should be of fundamental importanc

226 eractome by assessing the gene expression of receptor-ligand pairs across cell types.

227 amilies, which constitute genetically linked receptor-ligand pairs and are thought to allow for NK ce

228 Receptor-ligand pairs are ordinarily thought to interact

229 One class of such receptor-ligand pairs involves formyl peptide receptors

230 O1/SGN3-CIF2 represents one of the strongest receptor-ligand pairs known in plants.

231 Costimulatory and coinhibitory receptor-ligand pairs on T cells and APC control the imm

232 e that the binding energies of physiological receptor-ligand pairs on the T cell are sufficient to cr

233 d temporal dynamics of tension among various receptor-ligand pairs remains a significant challenge.

234 ng that the parasite may utilize alternative receptor-ligand pairs to complete the erythrocyte invasi

235 ously undocumented, and confirm more than 60 receptor-ligand pairs using orthogonal assays.

236 reconstitute segregation of CD45 from bound receptor-ligand pairs using purified proteins on model m

237 Nkrp1g was previously shown to form several receptor-ligand pairs with the CLEC2 proteins Clr-d, Clr

238 t studies have indicated specificity between receptor-ligand pairs within each subfamily, the functio

239 We identified ~50 previously-unknown receptor-ligand pairs, including new interactions among

240 rticle and a substrate due, for instance, to receptor/ligand pairs on particle and substrate.

241 ceptor and FGF receptor activity domains) to receptor-ligand parameters.

242 hat FOP-ACVR1 is not constrained by the same receptor/ligand partner requirements as WT-ACVR1.

243 entification of additional immune regulatory receptor/ligand pathways.

244 cyte antigen-4 (CTLA4) or programmed death-1 receptor/ligand (PD-1/PD-L1) improve patient outcomes by

245 (68)Ga-labeled somatostatin receptor ligand PET imaging has recently been shown in p

246 NOP receptor agonists may play a role in NOP receptor ligand pharmacology.

247 The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play

248 Activation of this reporter, using Toll-like receptor ligands, resulted in GFP expression, which coul

249 cripts identified protein-modifying enzymes, receptors, ligands, RNA-binding proteins, transcription

250 efore, we investigated whether different NOP receptor ligands showed differential signaling or functi

251 Moreover, regulatory circuits that include receptors, ligands, signal transduction components, epig

252 the in vivo consequences of activating these receptors, ligands specific for TLR2 or dectin-1 were mi

253 and suggest that modification of endothelin receptor-ligand specificity was a key step in the evolut

254 ence of a midline signal provided by the EGF receptor ligand Spitz.

255 of Tnfa and its receptors or major chemokine receptor-ligand subsets persisted in the long term.

256 rmacological treatments include somatostatin receptor ligands (such as octreotide, lanreotide and pas

257 uses only minimization with a fully flexible receptor-ligand system was observed.

258 surrogate ligands in a prototypical dimeric receptor-ligand system, the cytokine Erythropoietin (EPO

259 lutionary novelty in this highly diversified receptor-ligand system.

260 significant because the mouse NKR-P1B:Clr-b receptor:ligand system represents the closest homolog of

261 and outputs has applications to many dimeric receptor-ligand systems.

262 One obstacle to a broader use of these receptor/ligand systems is that the contribution of spec

263 Thus, these two receptor:ligand systems appear to have complementary fun

264 a-derived polyphenol, is an aryl hydrocarbon receptor ligand that attenuated inflammatory responses a

265 l. report a beta-arrestin-biased neurotensin receptor ligand that may curtail drug abuse without the

266 Octreotide, a somatostatin receptor ligand that targets somatotroph adenoma GH secr

267 nt status of established and novel mu-opioid-receptor ligands that are proposed to be biased ligands.

268 ing the first class of potent pan-xenobiotic receptor ligands that can serve as potential antidotes b

269 emerging Rho-kinase inhibitors and adenosine receptor ligands that offer the potential to improve aqu

270 ges, including the correct classification of receptor ligands, the identification of the signaling pa

271 diated by cell surface upregulation of NKG2D receptor ligands, thereby sensitizing melanoma cells to

272 fibroblast growth factors (FGFs) function as receptor ligands through their conserved FGF domain, but

273 pound: inhibits necroptosis induced by death receptors ligands TNF-alpha (Tumor Necrosis Factor) or T

274 al codelivery of tumor antigen and Toll-like receptor ligand to CD169(+) moDCs and Axl(+) CD169(+) DC

275 downregulate natural killer cell-activating receptor ligands to evade immune surveillance via the tr

276 -33 (IL-25/IL-33), or a mixture of Toll-like receptor ligands to evaluate their ability to produce cy

277 ique insights into the selective capacity of receptor ligands to promote and/or stabilize receptor di

278 In response to toll-like receptor ligands, TRAF6 is demethylated by the Jumonji d

279 e of early activation antigen CD69 and death receptor ligand TRAIL, as well as interferon-gamma (IFN-

280 is of ligands, but is required for efficient receptor ligand transendocytosis and Notch activation up

281 Primary HSCs were treated with nuclear receptor ligands, transfected with small interfering RNA

282 ceptor antagonist or a solubilized BMPR1a-FC receptor ligand trap prevents trabecular and cortical bo

283 the basis for biological activity of activin receptor ligand traps, novel fusion proteins such as lus

284 we show that the concentration of the P2Y14 receptor ligand UDP-glucose (UDP-Glc) was higher in urin

285 Equimolar infusion of the VPAC1/2 receptor ligand vasoactive intestinal polypeptide (VIP)

286 ockdown results in overexpression of the EGF receptor ligand vein (vn), which further activates EGF r

287 cells migrating along gradients of adhesion receptor ligands vs. any soluble cue.

288 exposure to innate stimuli such as Toll-like receptor ligands was not sufficient.

289 Activity of the conjugates as adenosine receptor ligands was tested by their capacity to stimula

290 Using standard receptor ligands we have validated pharmacological respo

291 To obtain selective and potent opioid receptor ligands, we synthesized dehydro derivatives of

292 ion and key mechanism insights that multiple receptor ligands were able to induce distinct functional

293 rly imprinted polymers (MIPs) are artificial receptor ligands which can recognize and specifically bi

294 ILC subsets expressed TNF receptor ligands, which limited sebocyte growth by repre

295 e further enhanced by inclusion of Toll-like receptor ligands, which many VLPs naturally package.

296 Compound 9h is a potent alpha4beta2 receptor ligand with a K(i) value of 1.5 nM.

297 nuclein toxicity and suggest that retinoid X receptor ligands with appropriate pharmacological proper

298 ent the first example of mirror image opioid receptor ligands with both optical antipodes having high

299 eutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selective properties

300 k was uniquely sensitive to modulation by D3 receptor ligands, yet these drugs did not alter decision