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1 ut cnLOH is evident in a greater fraction of recombinants.
2 of the I38T/F/M substitutions, we generated recombinant A/California/04/2009 (H1N1)pdm09, A/Texas/71
4 hods for preparing chemically conjugated and recombinant A99 to elastin-like polypeptides (ELPs) as t
5 a method named phosphotyrosine Targeting by Recombinant Ab Pair, or pY-TRAP, for in vitro engineerin
6 These isoforms were subsequently cloned into recombinant adeno-associated viral (AAV) vector genome a
8 pable of controlled release of a therapeutic recombinant adeno-associated virus (rAAV) vector overexp
9 adult rats induced by the brain delivery of recombinant adenoviral vectors with neuronal-specific ex
10 susceptibility, we infected BALB/c mice with recombinant AIVs with R292K (ma81K-N3(R292K)) or Q136K (
12 The relative levels of membrane-binding of recombinant alphaA(N101D)- and WTalphaA proteins was det
15 ro mineralization assays we showed that both recombinant and enamel-tissue-based amelogenin nanoribbo
16 events have affected the HSV-2 genome, with recombinants and nonrecombinants at each locus circulati
17 rer and restorer (n = 5104) was screened for recombinants and then phenotyped for tassel fertility, r
21 mL (95% CI of 0.53 to 0.77 ng/mL) ng/mL with recombinant antigen using an optical reader with sensiti
26 dies using a murine model displayed that the recombinant Asp t 36 was able to stimulate airway inflam
28 Furthermore, we discovered that the BARLEY B RECOMBINANT/BASIC PENTACYSTEINE transcription factors BP
34 e long-term genomic stability of complex VSV recombinants carrying large transgenes and support furth
35 g long-term genomic stability of complex VSV recombinants carrying large transgenes.IMPORTANCE Vesicu
39 al convergent promoters allows enrichment of recombinant cells independent of transgene expression, p
40 markers that enable drug-based enrichment of recombinant cells, enabling the use of larger libraries
42 created a subunit vaccine by encapsulating a recombinant coccidioidal Ag (rCpa1) in glucan-chitin par
43 assembled core U7 snRNP bound to FLASH from recombinant components and analyzed its appearance by el
48 ECs was inhibited by blocking CXCL11 whereas recombinant CXCL11 significantly induced tumor migration
49 n keratinocyte conditioned media spiked with recombinant cytokines was used as an experimental system
51 ers that become fluorescent upon cleavage by recombinant DENV-2/ZIKV proteases in vitro A version of
55 emphigus antibodies, bead assays coated with recombinant Dsg1, Dsc1, Dsg3, or Dsc3 ectodomains were d
56 G4 homolog) that strongly cross-reacted with recombinant DSG1; these IgG1 antibodies were inhibited b
57 pared antibody responses to vaccination with recombinant E1E2 complex in healthy volunteers, non-huma
59 The patterns of N-glycosylation within the recombinant ectodomain and S1 subunit of the SARS-CoV-2
62 Escherichia coli, purified the corresponding recombinant enzymes, and performed in vitro assays with
63 incubating the macrophages with the purified recombinant EsxA or EsxB protein or the EsxBA heterodime
65 nd chimeric vesicular stomatitis virus (VSV) recombinants expressing the RABV glycoprotein (G) demons
66 nd inexpensive procedure that allows for the recombinant expression and purification of full-length h
67 hsTYR in human pathologies, the advances in recombinant expression systems and structural data retri
69 The Hsp70 disaggregation machinery processed recombinant fibrils assembled from all six Tau isoforms
73 main circulating forms were the circulating recombinant form (CRF) 02_AG (44% of the analysed sequen
75 most relevant HIV-1 types (B and circulating recombinant forms [CRFs] CRF01_AE, CRF07_BC, CRF08_BC, a
77 lar bases of their partnership, we generated recombinant forms of the two proteins and carried out a
78 pigtail macaques using an intranasal (i.n.) recombinant Fowl Pox Virus (FPV)-gag pol env-IL-4R antag
79 The intrinsic dynamics of A1 observed in recombinant fragments of VWF are conserved in plasma-der
80 protein from a combination of synthetic and recombinant fragments-is a burgeoning field of chemical
89 n immobilized GCSF-R and all three different recombinant GCSF-based homo-dimeric derivatives were eva
90 have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phe
92 lude life-long intravenous administration of recombinant glucocerebrosidase and orally-available gluc
96 e confirmed the interaction of horcolin with recombinant gp120 and gp140 with high affinity and inhib
97 Here, we present glycosylation profiles of recombinant gp120 proteins from four major clades of HIV
100 TMPRSS2 proteolytic activity than HAI-1, and recombinant HAI-2 proteins had a high affinity to form a
101 levels vary, they are present in all tested recombinant HAs and whole viruses and can be specificall
103 m tuberculosis By comparing native HBHA with recombinant HBHA produced in Mycobacterium smegmatis (rH
105 estingly, although EcLamB-dependent in their recombinant heterologous hosts, these newly isolated ZZ
106 n and purification of a catalytically active recombinant hGFAT2 (rhGFAT2) in Escherichia coli cells f
116 we found that the combination of KY1070 and recombinant human EPO improved the erythroid response co
119 ndomized at birth to receive early high-dose recombinant human erythropoietin (rhEpo) vs placebo.
122 gemcitabine levels with injectable PEGylated recombinant human hyaluronidase (PEGPH20) to test whethe
123 ous daratumumab co-formulated with 2000 U/mL recombinant human hyaluronidase PH20 or 16 mg/kg of intr
124 te whether postnatal treatment with rhIGF-1 (recombinant human IGF-1)/BP3 (binding peptide 3) improve
125 developed a therapeutic regimen of low-dose recombinant human interleukin-2 (IL-2) combined with low
126 scans of monkeys injected with radiolabeled recombinant human LCN2 (rh-LCN2) and autoradiography in
129 rotein epitope MOG(35-55) or the full-length recombinant human MOG protein, the latter representing t
130 slatable topical, neuroprotective treatment (recombinant human nerve growth factor, rh-NGF) predomina
134 Here, we investigate the activities of two recombinant human SP-D forms against representative LPAI
135 NAR) was used for in vitro selection against recombinant human TfR1 ectodomain (rh-TfR1-ECD) followed
137 ication of a recombinant fusion protein from recombinant human-like collagen (HLC) and human BMP-2 (h
139 red Th2 responses, whereas administration of recombinant IFNgamma during HDM sensitization in C57Bl/6
141 opment harnessing the antitumor potential of recombinant IgE antibodies in cancer patients is also di
143 tics and pharmacodynamics when compared with recombinant IL-2 to enhance this type of immunotherapy.
146 facility was used to measure WUE(plant) in a recombinant inbred line (RIL) population created between
147 says (KASP) and analyzed in two F(6)-derived recombinant inbred line (RIL) populations derived from t
148 The limited number of recombinant events in recombinant inbred lines suggests that for a biparental
149 parental population with a limited number of recombinant inbred lines, it is unnecessary to genotype
152 ring dsRNA virus coinfection, we rescued two recombinant infectious bursal disease viruses (IBDVs) of
154 influenza vaccine [IIV3-HD], or quadrivalent recombinant influenza vaccine [RIV4]), safety and immuno
155 was to evaluate the effect of ribavirin and recombinant interferon (RBV/rIFN) therapy on the outcome
158 vated ZIKV-specific CD8(+) T cells primed by recombinant L. monocytogenes is associated with reductio
161 e mortality in the Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin trial: absolute risk reduc
162 rm for rapid phage display screening of deep recombinant libraries consisting of as few as one major
163 te NMR, we studied the fibril structure of a recombinant light chain fragment corresponding to the fi
166 Fusion of LPL to GPIHBP1 increased yields of recombinant LPL, prevented LPL aggregation, stabilized L
167 rface plasmon resonance data indicating that recombinant lubricin (rhPRG4) devoid of core 2 structure
168 biology, and cheminformatics to construct a recombinant M protein-based vaccine that included six St
169 e determined the ability of a C. trachomatis recombinant major outer membrane protein (rMOMP) vaccine
171 Using U(S)3 deletion and U(S)3 kinase-dead recombinant MDV, we identified U(S)3-responsive MDV gene
174 ated targeting vectors to produce homologous recombinant mice directly by pronuclear injection, but t
176 IL-4R antagonist prime, intramuscular (i.m.) recombinant Modified Vaccinia Ankara Virus (MVA)-gag pol
178 ave established the therapeutic potential of recombinant mouse VEGFD delivered intraventricularly to
181 were selected against the globular domain of recombinant murine PrP (rPrP(90-231)) using SELEX method
182 three-plasmid system to efficiently generate recombinant MVA vectors from chemically synthesized DNA.
185 We have developed a genetically modified recombinant NDV (rNDV) that has much reduced pathogenici
186 e the efficacy of intratumoral injections of recombinant NDVs engineered to express multiple immunoth
187 sion of netrin-1 and brain administration of recombinant netrin-1 are neuroprotective and neurorestor
188 his was further confirmed in vitro using the recombinant NIS synthetase, synthesizing rhizoferrin fro
189 passaging of both NiV clinical isolates and recombinant NiV in Vero cells generated an extensive DI
196 ture of polyclonal antibodies raised against recombinant nucleoproteins of representative strains fro
197 demonstrate 5-InsP(7) inhibits decapping by recombinant NUDT3 (Nudix [nucleoside diphosphate linked
203 and monoclonal antibodies on overlapping and recombinant peptides of Gly-m-Bd-30K by SPOT and cell pr
204 human CD8(+) T cell blasts are stimulated by recombinant peptides presented on MHC Ag alone, we show
205 periostin, or treating such macrophages with recombinant periostin, directly induced macrophage proli
206 we demonstrated the feasibility of isolating recombinant phage-antibodies against gluten from a non-i
208 from in vitro phosphorylation studies using recombinant PKA, the response to the broad-spectrum kina
210 ng molecular linkers to create a multivalent recombinant protein against Candida albicans (mvPC).
211 hatidic acid-producing kinase activity, DGK4 recombinant protein also revealed guanylyl cyclase activ
216 ulating protein expression levels to improve recombinant protein production has become an important t
217 d Motif V mutations in both the replicon and recombinant protein systems to investigate viral genome
218 cellular events, we verified by generating a recombinant protein that CXXC5 is indeed an unmethylated
219 ation with SARS-CoV-2 mRNA, but not with the recombinant protein vaccine, elicited potent SARS-CoV-2-
220 y in the 1970s, followed by the invention of recombinant protein-based therapeutic agents in the 1980
221 ningococcal group B vaccine 4CMenB is a new, recombinant protein-based vaccine that is licensed to pr
222 zone High-Dose (egg-based, n = 16), Flublok (recombinant protein-based, n = 23), or Flucelvax (cell-b
227 stigated a vaccine formulation consisting of recombinant proteins from a surface-localized heme trans
228 his strategy could improve the expression of recombinant proteins from anaerobic origin or those with
233 Treatment of Ocy454-Gsalpha(cont) cells with recombinant proteins or knockdown of Nrp-1 and Grn in Oc
234 Functional characterization of the purified recombinant proteins revealed that NnOMT1 is a regiospec
235 to synthesize complex N-glycan structures on recombinant proteins to study their contribution to immu
238 and enzyme-linked immunosorbent assay using recombinant proteins, we verified the direct interaction
245 unization using CoPoP liposomes admixed with recombinant RBD induces multiple orders of magnitude hig
246 Here, it is shown that rapid conversion of recombinant RBD into particulate form via admixing with
247 based on detecting direct binding of soluble recombinant receptor ectodomains have been successful, b
248 enzyme-linked immunosorbent assay utilizing recombinant receptor-binding domain (RBD) of the SARS-Co
251 at least 19.8 kbp and can be used to produce recombinant rotaviruses expressing a full complement of
253 ological role of these RSV G gene mutations, recombinant RSV strains harboring either a wild-type A2
254 The second BSR-Seq utilized bulks of genetic recombinants screened from a fine-mapping population to
257 ugs (alemtuzumab and adalimumab) to generate recombinant single chain GloBodies, which retain the dru
258 The globular domains are often omitted in recombinant spidroins, but are thought to be essential f
261 with immune-mediated clearance we developed recombinant strains of SINV that have genomic and subgen
265 the first time the feasibility of generating recombinant TCRV (rTCRV) using reverse genetics approach
267 cts of a TNF-alpha neutralizing antibody and recombinant TNF-alpha soluble receptor on LPA-stimulated
271 n and mouse macrophages in experiments using recombinant TSP4 variants and in cells derived from P387
272 ysfunction in AD patients, and indicate that recombinant uPA is a potential therapeutic strategy to p
275 ole of the mutations was confirmed by making recombinant VACV with A26L or G6R or both deleted, which
277 ivery platforms, methyltransferase-defective recombinant vesicular stomatitis virus (mtdVSV) and a DN
278 ent formulation of VesiculoVax that contains recombinant vesicular stomatitis virus (rVSV) vectors ex
279 The rapid immunostimulatory properties of recombinant vesicular stomatitis virus (rVSV)-based vacc
280 l blood mononuclear cells were infected with recombinant vesicular stomatitis virus encoding EBOV ant
285 P in supporting mRNA transcription in vitro Recombinant virus VSV-P(DeltaOD) exhibits a pronounced k
289 ORF showed that it was possible to generate recombinant viruses encoding 2 heterologous proteins (mR
291 In this study, we engineered six different recombinant viruses: NDVs expressing checkpoint inhibito
292 h our two previously described oncolytic VSV recombinants, VSV-p53wt and VSV-p53-CC, we generated nov
293 F, plasmin-cleaved dimers of VWF, multimeric recombinant VWF, and normal VWF plasma concentrates.
294 The proportion of HIV-1 infections due to recombinants was highest in Southeast Asia (>95% of infe
296 owing hyperoxia exposure, and treatment with recombinant Wnt5a reproduced features of the BPD phenoty
297 Asp(320) Using constructs to produce either recombinant XoxF1 or its D320A variant, we show that Asp
298 atment of D. discoideum and macrophages with recombinant yeast exopolyphosphatase reduced the surviva
300 immunogenicity and safety of the adjuvanted recombinant zoster vaccine (RZV) in previous ZVL recipie