ライフサイエンスコーパス: recombination

1 are crucial for DNA repair, replication, and recombination.

2 functions in genome replication, repair, and recombination.

3 g inter-host bacterial dispersal and genomic recombination.

4 maximize charge transport and avoid exciton recombination.

5 protects short telomeres from inappropriate recombination.

6 ses the carrier mobility and impedes carrier recombination.

7 at viruses and not one acquired recently via recombination.

8 ciency of charge injection and electron-hole recombination.

9 ypermutation levels and in features of V(D)J recombination.

10 g how these dynamic mechanisms control V(D)J recombination.

11 y promotes meiotic DSB repair and homologous recombination.

12 nst illegitimate and potentially tumorigenic recombination.

13 high-fidelity double-strand break homologous recombination.

14 to quantitatively capture kinetics in V(D)J recombination.

15 ctivates Int for gp3-independent attL x attR recombination.

16 ctive in CO(2) conversion due to fast charge recombination.

17 DNA-binding protein, regulates early meiotic recombination.

18 neling and suppresses the interfacial charge recombination.

19 exploit the specificity and stability of DNA recombination.

20 into kinetochore-derived control of meiotic recombination.

21 coupling product by selective radical cross-recombination.

22 MEIOB in crossover formation in late meiotic recombination.

23 le genes in tight linkage through suppressed recombination.

24 phores through singlet fission or via charge recombination.

25 ature intermediates formed during homologous recombination.

26 such as horizontal gene transfer and genetic recombination.

27 ce conservation in the absence of homologous recombination.

28 r lines designed for nervous system-specific recombination.

29 consequential variant of the canonical V(D)J recombination.

30 r enzymatic contribution to RecA-independent recombination.

31 ts role with Dmc1 recombinase during meiotic recombination.

32 o facilitate or to impose a barrier to V(D)J recombination.

33 asymmetrical trade-offs in single-strand-DNA recombination.

34 widespread geographical mixing, and frequent recombination.

35 has adapted to largely control homoeologous recombination.

36 resence of an electron scavenger, minimizing recombination.

37 are assembled in developing B cells by V(D)J recombination(1).

38 ta reflect an expanding region of suppressed recombination [5].

39 pair a DNA double-strand break by homologous recombination, 5'-terminated DNA strands must first be r

40 e deficient in conventional T lymphocytes or recombination-activating gene (Rag) failed to show rescu

41 ly acquired in precursor B cells mediated by recombination-activating genes in both MCL subtypes, whe

42 with a nucleolar marker, and increased V(D)J recombination activity.

43 13578 outbreak clone evolved from ST-1504 by recombination.All tested strains were penicillin-suscept

44 1 (L1) PRRSV was found to be susceptible to recombination among PRRSVs both in China and the United

45 nd that 405 nm irradiation can induce charge recombination and activate the single-particle emission.

46 air by long tract gene conversion, crossover recombination and break-induced replication (BIR), only

47 These include proper pairing, recombination and correct segregation of multiple homolo

48 nitially by patterns of breeding, selection, recombination and differential incompatibilities.

49 ant role in transcription-coupled homologous recombination and DNA replication restart.

50 ing SARS-CoV and SARS-CoV-2-undergo frequent recombination and exhibit spatially structured genetic d

51 r several picoseconds and seeds the eventual recombination and heating dynamics on the nanosecond tim

52 re of significance to influence the carriers recombination and hysteresis in perovskite solar cells,

53 ays that HPV oncogenes manipulate homologous recombination and ideas on how the resulting dysregulati

54 XLF in both variable, diversity, and joining recombination and immunoglobulin class switch recombinat

55 Degradation of RAD21 eliminated all V(D)J recombination and interactions associated with RAG scann

56 on coefficients, and the addition of genetic recombination and local linkage brings about significant

57 on a well-established mathematical model of recombination and make no assumptions about the relation

58 d2 gene using CRISPR/Cas9-induced homologous recombination and observed its dynamics directly at the

59 The electron trapping recombination and plausible photocatalytic mechanism are

60 volving) with the lineage, although frequent recombination and rearrangement events between them have

61 s, inference of natural selective pressures, recombination and reassortment, and structural analysis

62 (Int) can catalyze integrative site-specific recombination and recombinase-mediated cassette exchange

63 of MCM8-9-dependent DNA synthesis during DNA recombination and replication.

64 ed and examined by integrative site-specific recombination and RMCE assays in human cells using nativ

65 In addition, we reveal a bias in TCR recombination and selection, which is attributed to geno

66 dependent kinase G1 (CDKG1) is necessary for recombination and synapsis during male meiosis at high a

67 isms that might contribute to aberrant V(D)J recombination and the development of lymphoid tumors.

68 substantial contributions to intermolecular recombination and to recombination events involving rela

69 mouse allele generated by serial Dre to Cre recombination and use it to explore the expression overl

70 o improved charge transport, reduced carrier recombination, and a high power conversion efficiency ap

71 eep-level defects, incur nonradiative charge recombination, and induce photocurrent hysteresis, all o

72 Multiple DSBs initiate recombination, and most are repaired without crossover f

73 ity, somatic mutational status, class switch recombination, and oncogenic Ig translocations.

74 n new functions that impact homolog pairing, recombination, and the orientation of kinetochore attach

75 G1/S transition of mitotic cell cycle," "DNA recombination," and "telomere maintenance," respectively

76 hat, owing to junctional biases during V(D)J recombination, appear much more frequently than predicte

77 RAG2, a late evolutionary addition in V(D)J recombination, appears to enforce the sharp kinks and ad

78 he double-strand breaks (DSBs) that initiate recombination are not located arbitrarily(2).

79 Given that defects in homologous recombination are present in only a subset of breast can

80 tion, alternative splicing, and class switch recombination are required to facilitate development, ac

81 Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional

82 A recombination assay and omission tests, showed the relev

83 The suppression of recombination at mating-type loci in fungi has long been

84 re likely mediated by non-allelic homologous recombination at regions of high sequence identity in AT

85 e discover that HELLS facilitates homologous recombination at two-ended breaks and contributes to rep

86 Telomerase-free cancer cells employ a recombination-based alternative lengthening of telomeres

87 Utilizing Cre-lox recombination-based mosaic sectors that overexpress eith

88 Genome editing typically involves recombination between donor nucleic acids and acceptor g

89 q11.2DS) results from non-allelic homologous recombination between low-copy repeats termed LCR22.

90 forks to NPCs and restriction of error-prone recombination between repeated sequences.

91 rative in the composite mechanism for charge recombination between the injected electron and the oxid

92 We found that while recombination between the Sb and SB haplotypes is severe

93 the syndrome and are held together, because recombination between them is suppressed.

94 Recombination between viruses provides evidence of a sha

95 D51AP1) plays an integral role in homologous recombination by activating RAD51 recombinase.

96 However, it is unknown whether interspecies recombination can affect other loci and whether new reco

97 Regions lacking recombination can extend beyond the genes determining se

98 However, misplaced meiotic recombination can have catastrophic consequences on geno

99 such as halide interstitials, act as charge recombination centers, induce degradation of halide pero

100 er transport and behave as the non-radiative recombination centers.

101 sin, to locate Ds and assemble a DJ(H)-based recombination centre(2).

102 Upon binding a recombination centre-based J(H), RAG scans upstream chro

103 urrent host, demonstrating that interspecies recombination continues to occur today.

104 tually exclusive states of proliferation and recombination, coordinated by cytokines and chemokines.

105 The reduction of recombination could additionally result in rapid fixatio

106 lin (Ig) loci promotes antibody class switch recombination (CSR) and somatic hypermutation (SHM), whe

107 nctions of 53BP1 coevolved with class switch recombination (CSR) in the immune system.

108 Naive B cells undergo class switch recombination (CSR) to generate antibodies with differen

109 tions to moderately enhance class-switch DNA recombination (CSR), while decreasing at higher doses ov

110 Thus, the entire ligand dissociation-recombination cycle in MbNO is a spin cross-over followe

111 The rate of charge recombination decreases from 1.2 x 10(11) to 1.0 x 10(9)

112 2, making APE2 a prime target for homologous recombination-defective cancers.

113 boring BRCA mutations, generating homologous recombination deficiencies (HRDs).

114 ith BRCA mutations, patients with homologous recombination deficiencies, and the intention-to-treat p

115 LC1 loss is synthetic lethal with homologous recombination deficiency (HRD), which we attribute to ch

116 were associated with APOBEC3B and homologous recombination deficiency, increasing neoantigen loads (a

117 s not classically associated with homologous recombination deficiency.

118 a primary functional component of homologous recombination deficient cellular phenotypes, the image-b

119 gulated in cancers, especially in homologous recombination-deficient cancers, which display a distinc

120 or target for cancer therapies in homologous recombination-deficient cancers.

121 an placebo in the BRCA-mutant and homologous recombination-deficient cohorts.

122 ease of base substitutions in the homologous recombination-deficient Rad51 mutant, specifically depen

123 sent a tractable vulnerability in homologous recombination-deficient tumor cells.

124 a novel clinical therapy to treat homologous recombination-deficient tumors.

125 on while suppressing excessive RF restart by recombination-dependent replication (RDR) and checkpoint

126 s study explores the concept that homologous recombination DNA repair is not an all-or-nothing concep

127 signature 3 reflecting defective homologous recombination DNA repair, and positive immune score as a

128 e genome supports regulated gene expression, recombination, DNA repair, and chromosome segregation du

129 ore the population genetic forces (mutation, recombination, drift, and selection) that shape microbio

130 , multi-allele PV of restriction systems and recombination-driven antigenic variation.

131 A case in point is the control of genetic recombination during meiosis, which leads to crossovers

132 veral internal LTRs, suggestive of extensive recombination during retrotransposition.

133 s as well as the charge injection and charge recombination dynamics depend largely on the presence or

134 ples of genomes while accounting for genetic recombination effect and local linkage information.

135 c mechanism that stochastically limits Vbeta recombination efficiency governs monogenic TCRbeta expre

136 g or lagging strand has limited influence on recombination efficiency.

137 Meiotic recombination enables reciprocal exchange of genetic inf

138 sition and suppressing antigen receptor gene recombination, ensuring that only one productive Igh all

139 ription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT

140 een lost during domestication through a rare recombination event between male and female haplotypes.

141 f a sweep coalesce during the sweep before a recombination event can occur, reducing their expected c

142 be essential to prevent deleterious meiotic recombination events at repetitive centromeric sequences

143 r to be the result of previously undescribed recombination events between ssDNA and ssRNA viruses.

144 Subsequent recombination events between these allele lineages have

145 4 small, ancient HSV-1 x HSV-2 interspecies recombination events have affected the HSV-2 genome, wit

146 tions to intermolecular recombination and to recombination events involving relatively short (<200 bp

147 However, the interpretation of historical recombination events is hampered by the fact that driver

148 at metaphase and increased sister chromatid recombination events leading to rampant chromosome insta

149 We describe 2 large (>5 kb) recombination events, one of which arose in its current

150 ealing evidence of extensive duplication and recombination events.

151 tion loops that undergo complex dynamics and recombination events.

152 relation to their involvement in homologous recombination, exemplifying a duplicate retention model

153 Aroma recombination experiments in pea protein samples confirm

154 ogenesis with Prdm9, as an essential meiotic recombination factor required for efficient repair of PR

155 since the classical 12/23 rule for the V(D)J recombination fails to explain the V(DD)J recombination,

156 ese loci are found in a region of suppressed recombination, forming a supergene.

157 o the role of the meiotic axis in patterning recombination frequency within plant genomes.

158 developed statistical methods for ancestral recombination graph inference and machine-learning metho

159 rived from inferred gene trees and ancestral recombination graphs (ARGs).

160 some translocations generated via centromere recombination have reshaped the genomes of different spe

161 ecombination and immunoglobulin class switch recombination, here, using Cre/lox-specific deletion to

162 and levels of linkage, suggesting different recombination histories.

163 Recombination hot spots are decorated by a unique combin

164 vercoming is poorly understood, is access to recombination hot spots during meiosis.

165 d suggests that white-tailed deer may have a recombination hotspot between these MHC regions similar

166 Loss of TRDMT1 compromises homologous recombination (HR) and increases cellular sensitivity to

167 hich is associated with increased Homologous Recombination (HR) and TERRA transcription.

168 mline mutations are deficient for homologous recombination (HR) DNA repair and are sensitive to DNA-d

169 shown that NUCKS1 helps maintain homologous recombination (HR) DNA repair in human cells and functio

170 BRCA1 gene mutations impair homologous recombination (HR) DNA repair, resulting in cellular sen

171 Ino80 is selectively required for homologous recombination (HR) DNA repair, which is mechanistically

172 hat can target BRCA wild-type and homologous recombination (HR) DNA repair-proficient cancers, includ

173 p harboring evidence of defective homologous recombination (HR) DNA repair.

174 uce genome editing reagents and a homologous recombination (HR) donor template into embryos to trigge

175 ed replication forks and recruits homologous recombination (HR) factors such as CtBP interacting prot

176 Homologous recombination (HR) mediates the error-free repair of DNA

177 f the Fanconi anemia (FA) and the homologous recombination (HR) pathways.

178 For example, defects in homologous recombination (HR) repair arise in cancer cells through

179 ten robustly activated during the homologous recombination (HR) repair of DNA double strand breaks (D

180 ed and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform post-replica

181 To correct this mutation by homologous recombination (HR), we designed a series of single guide

182 f cisplatin and Nutlin-3 inhibits homologous recombination (HR), which leads to persistence in DNA da

183 rs in PFA ependymomas, suppresses homologous recombination (HR)-mediated DNA repair.

184 1/2 mutations or g/s mutations in homologous recombination (HR)-related genes other than BRCA1/2.

185 ity gene II (BRCA2) is central in homologous recombination (HR).

186 h to kill cancers with defects in homologous recombination (HR).

187 Interhomolog recombination (IHR) occurs spontaneously in somatic huma

188 ation layer resulting in increased interface recombination, (iii) thermal treatments of devices with

189 nsufficient charge transfer and rapid charge recombination impede the sunlight-driven photocatalytic

190 o utilise this trait to exploit homoeologous recombination in a crop.

191 lts demonstrate that MEIOB regulates meiotic recombination in a dosage-dependent manner.

192 phisticated features of gene segregation and recombination in an autotetraploid meiosis.

193 Most, but not all, homologous genetic recombination in bacteria is mediated by the RecA recomb

194 varying probabilities of unexpected germline recombination in distinct Cre driver lines designed for

195 ntravenous injection, we achieved 8.2 % gene recombination in mouse T lymphocytes.

196 Collated data reveal germline recombination in over half of 64 commonly used Cre drive

197 tive route to control the interfacial charge recombination in perovskite solar cells which is in comp

198 The effect of molecule recombination in the MS source is known from the literat

199 ated process involving charge generation and recombination in the time domain and carrier transport i

200 ich conclusively support the significance of recombinations in the serotype-specific locus.

201 Homolog pairing depends on recombination initiation via programmed double-strand br

202 hat CDKG1 is necessary for the processing of recombination intermediates in the canonical ZMM recombi

203 ibution of MutSgamma and RFC-PCNA on meiotic recombination intermediates may drive biased DNA cleavag

204 tiation and maturation of crossover-specific recombination intermediates requires the cyclin-like CNT

205 Crossover recombination is critical for meiotic chromosome segrega

206 The V(DD)J recombination is currently viewed as an aberrant and inc

207 Crossover recombination is essential for accurate chromosome segre

208 p) homologous sequences, where RecA-mediated recombination is inefficient.

209 Selective maternal or paternal germline recombination is showcased with sample Cre lines.

210 ion rate rather than remodeling of the local recombination landscape.

211 ion influence the shape and evolution of its recombination landscape.

212 s of deuterated perovskites, such as shorter recombination lifetimes and lower/invariant efficiencies

213 template switching, a process that generates recombination-like branched DNA intermediates.

214 ace residual stress, suppressed nonradiative recombination loss, and more n-type characteristics for

215 a combination of resistive and non-radiative recombination losses.

216 The detailed architecture of this intricate recombination machine remains unclear.

217 irpins during DNA replication, repair and/or recombination may contribute to TR expansion.

218 vivo DNA engineering such as recombineering (recombination-mediated genetic engineering) and DNA gap

219 Facilitated by linear plus linear homologous recombination-mediated recombineering (LLHR), we directl

220 Multiple recombination models currently available have been compa

221 eletion breakpoints indicates that preferred recombinations occur between FAM230 and specific segment

222 at the capsule locus, along with additional recombination occurring at distal sites harboring virule

223 ight-emitting diodes relies on the radiative recombination of electrically generated excitons.

224 the histone modifications that initiate the recombination of genetic information during meiosis.

225 contribute to a deeper understanding of the recombination of PRRSVs and indicate the need for coordi

226 ng of select transformants demonstrated that recombination of up to 56.7 kbp length occurred at the c

227 e highly relevant in this matter: The charge recombination of, for example, the adjacent C(60)(*-)-Zn

228 ype, most paths are non-biological, unlikely recombinations of true haplotypes.

229 with subsequent feedback inhibition of V(D)J recombination on the other allele.

230 cur during normal processes, such as meiotic recombination or B cell development, and others result f

231 omolog pairing as a critical determinant for recombination outcome.

232 ow BRCA1 influences the choice of homologous recombination over non-homologous end joining and potent

233 mbination intermediates in the canonical ZMM recombination pathway and that loss of CDKG1 results in

234 that HPV oncogenes activated the homologous recombination pathway to facilitate the HPV lifecycle.

235 hes and experimental infections to show that recombination plays little role in diversifying T. vivax

236 how to suppress the loss of free carriers by recombination-poor diffusion and significant Coulombic a

237 Additional pathways for RecA-independent recombination, possibly mediated by helicases, are suppr

238 Meiotic recombination proceeds via binding of RPA, RAD51, and DM

239 Exploiting bacteriophage-derived homologous recombination processes has enabled precise, multiplex e

240 However, the phylogenetic and genomic recombination properties of this virus have not been com

241 gnificant positive correlation between local recombination rate and local DNM rate, and that DNM rate

242 al populations, (2) at the 200-400 kb scale, recombination rate appears to vary largely genome-wide,

243 Nevertheless, DNA methylation and recombination rate are anticorrelated in all three speci

244 MHz, k(T,s) = (43.97 +/- 0.01) MHz, and the recombination rate for singlet polaron pair k(S,r) = (88

245 vals, and (3) interpopulation differences in recombination rate may be the result of local adaptation

246 ely manifested as differences in genome-wide recombination rate rather than remodeling of the local r

247 For even moderate ratios of the recombination rate to the selection coefficient, the sim

248 Local and genome-wide recombination rate variation is shaping patterns of intr

249 terns and revealed how local and genome-wide recombination rate variation shapes patterns of introgre

250 Interestingly, variation in recombination rate within and between populations largel

251 ference between subpopulations and increased recombination rates across pericentromeric regions.

252 Recombination rates vary between species and individuals

253 scriptional control elements affect germline recombination rates.

254 ced DNA damage by attenuating DNA homologous recombination repair activity and RAD51 foci formation.

255 num agents owing to deficiency in homologous recombination repair of DNA damage.

256 evere DNA damage is corrected via homologous recombination repair.

257 e that requires BRCA1/2-dependent homologous recombination repair.

258 evious in planta or intra-genomic homologous recombination reports in which the original chimeric GT

259 Repair of broken DNA by homologous recombination requires coordinated enzymatic reactions t

260 arge-separation, charge-transfer, and charge-recombination routes have been demonstrated, both by tra

261 ing FAM230 gene members suggesting preferred recombination sequences.

262 A new form of somatic gene recombination (SGR) has been identified in the human bra

263 lves the RAG recombinase binding and cutting recombination signal sequences (RSSs) composed of conser

264 We show that the poor qualities of recombination signal sequences (RSSs) flanking Vbeta gen

265 ss megabase-long AgR loci and locally at the recombination signal sequences (RSSs).

266 ompeting Tcrb alleles, with suboptimal Vbeta recombination signal sequences limiting synchronous rear

267 reviously overlooked cryptic nonamers in the recombination signal sequences of human IGHD genes and d

268 During recombination, sister chromatids are tethered as loops t

269 e initiates DNA strand exchange when two res recombination sites and six resolvase dimers interact to

270 nslocates double-stranded DNA until both dif recombination sites are placed at mid cell for subsequen

271 age, CDR3 length distributions, class switch recombination, somatic hypermutation levels and in featu

272 Meiotic recombination starts with the formation of DNA double-st

273 Here we review the evidence for recombination suppression around mating-type loci in fun

274 eview more recent evidence for expansions of recombination suppression beyond mating-type genes in fu

275 unchanged in strepsirrhines whereas several recombination suppression events moved the PAB and short

276 (mechanistic) causes for such expansions of recombination suppression, including (1) antagonistic se

277 Furthermore, polyploidy induces recombination suppression, which correlates with altered

278 mating types, by several successive steps of recombination suppression.

279 review focuses on conservative site-specific recombination that generates reversible DNA inversions a

280 This process called V(D)J recombination that involves the RAG recombinase binding

281 )J recombination fails to explain the V(DD)J recombination, the molecular mechanism of tandem D-D fus

282 are limited by low efficiency, a reliance on recombination, the need for multiple vectors, and challe

283 In Cre site-specific recombination, the synaptic intermediate is a recombinas

284 oward cathode side, which reduces the charge recombination there.

285 ecific target loci demonstrated differential recombination; thus, reporters are not reliable proxies

286 We used Cre/loxP recombination to express enhanced GFP (EGFP) in neurons

287 ct bandgap and two donor-acceptor pair (DAP) recombination transitions.

288 con PV, perovskites are not limited by Auger recombination under 1-sun illumination.

289 rate-determining HAA, and subsequent radical recombination was corroborated by intramolecular isotope

290 RAG1-RAG2 recombinase, which initiates V(D)J recombination, we find that the active site is reconfigu

291 Since DSS1 is required for BRCA2 function in recombination, we speculate that the monomeric and oligo

292 m the CSS to the ground state through charge recombination were experimentally observed only for tria

293 osomes would be at risk of missegregation if recombination were randomly distributed, the double-stra

294 These DNA breaks are repaired by homologous recombination, which facilitates proper chromosome segre

295 diversity in offspring is induced by meiotic recombination, which is initiated between homologs at >2

296 creates mosaic Pdgfr mutant cells by Cre/lox recombination with a linked Flp/frt reporter to track in

297 p in the deadtime is possibly due to reduced recombination with increasing voltage.

298 explained by donor-independent, fast charge recombination with rates of ~0.2 ps(-1), thus inhibiting

299 the ancestral haplotypes have been eroded by recombination, with selection preserving differentiation

300 brates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and dep