ライフサイエンスコーパス: redesign

1 ith various linkers in the context of an HR1 redesign.

2 esign, miniaturization processes and protein redesign.

3 information to guide HIV-1 vaccine immunogen redesign.

4 e, Beta peptide design, NCBB design, and VIP redesign.

5 ying function and rationally guiding protein redesign.

6 before and 12 rounding events after process redesign.

7 kg/kg when all components are available for redesign.

8 ts makes them straightforward to dissect and redesign.

9 iltering, can allow successful whole-protein redesign.

10 id (Hby), a compound crafted through pathway redesign.

11 ar website, the Variation page, was recently redesigned.

12 , could be possible if the waste handling is redesigned.

13 The CATH website has been redesigned.

14 First, we computationally redesign a largely disordered bend in heptad region 1 (H

15 rget for rational design of enzymes, showing redesigned activities to produce tailor-made fructooligo

16 Here, we present a completely redesigned algorithm, GRASP2, for this computational pro

17 As a case study, the method is extended to redesign all 243 structurally resolved proteins in the p

18 an extended version of the Chado schema and redesigned all user and back end interfaces.

19 les which, if followed, will ensure that the redesigned allocation system is effective and efficient

20 n binding sites on the padlock probe without redesigning amplification primers or fluorescent molecul

21 this multistate design method, we used it to redesign an antiinfluenza antibody against a large panel

22 graphene and peptides, here we systemically redesigned an important protein for better conformationa

23 Now we have redesigned an infrared fluorescent protein so that its c

24 The feasibility of the approach of redesigning an existing pharmaceutical through nontarget

25 hysicochemical lessons from previous work to redesign and improve the antibacterial potency of pyrido

26 ecies in mixed-species infections prompted a redesign and improvement of the assay.

27 both machine-learning-guided binding-pocket redesign and iSeroSnFR will have broad utility for the d

28 Electronic health record redesign and new documentation regulations may help to a

29 reactions offers new directions for rational redesign and optimization of photosynthesis to satisfy g

30 tions, using teamwork training (TT), systems redesign and standardization (SOP), Lean quality improve

31 ayer channel formation without requiring the redesign and synthesis of the cyclic peptide core.

32 Importantly, MoonDB's interface was fully redesigned and improved, and its entries are now cross-r

33 In 2015, the database was redesigned and relocated to EMBL-EBI.

34 these policies may be outdated and should be redesigned and updated to achieve success in the current

35 or additional sample manipulation, microchip redesigns, and/or system expansions required for traditi

36 activity to all four serotypes, and that the redesigned antibody has potent antiviral activity in a m

37 ent of diabetes and later considered insulin redesign, as synthetic insulins became possible.

38 lows users to apply experimental outcomes to redesign assembly plans interactively.

39 The PDBe website has been redesigned based on an analysis of user requirements, an

40 Genes redesigned based on our analyses are transcribed with un

41 at penetration and efflux properties of many redesigned BC inhibitors could be improved to various ex

42 nt including added sources of research data, redesigned BioAssay record page, new BioAssay classifica

43 needs, we present BiGG Models, a completely redesigned Biochemical, Genetic and Genomic knowledge ba

44 uch as enzyme mechanistic studies and enzyme redesign by mutagenesis, are discussed.

45 DGDH (Pcyb-AfGDH) enzymes were strategically redesigned by performing docking simulation, following s

46 The purification of biotinylated nuclei was redesigned by replacing the outer nuclear-envelope-targe

47 Such redesigning can be performed by small molecular changes

48 lemedicine tools and new care models, we can redesign chronic disease management to include fewer in-

49 There is also increasing interest in redesigning clinical care to improve patient education,

50 ive strategy has been tested in this work by redesigning common porcine meat products (chorizo sausag

51 at risk of stressful claims experiences and redesigning compensation processes to reduce their stres

52 The redesigned compound exhibits a MLCT lifetime that is mor

53 l and antigenic analyses of two distinct HR1 redesigns confirm that redesigned Env closely mimics the

54 te interest in surgical trials by offering a redesigned cooperative framework that builds on a core o

55 lycans were posttranslationally added to the redesigned cores.

56 The main redesign criteria were to reduce the number of rotatable

57 The redesigned data model supports arbitrarily large, N-dime

58 linical information systems, delivery system redesign, decision support, organizational support, and

59 ts opportunities for a generalizable process redesign, differences in the criticality and nature of f

60 proach, we tested different balance aids and redesigned doffing area layouts with 38 students.

61 ticipants reported a similar workload in the redesigned doffing layout (P = .43).

62 ciplinary HCV Innovation Teams, whose system redesign efforts have produced innovative HCV practice m

63 might represent appropriate targets for care redesign efforts.

64 ions in manufacturing and operating costs of redesigned emission aftertreatment systems of line-haul

65 s of two distinct HR1 redesigns confirm that redesigned Env closely mimics the native, prefusion trim

66 Here we computationally redesign essential enzymes in the first organism possess

67 lico predictions of assay success, and assay redesign exhibits improved coverage uniformity relative

68 eceptor, it may be possible to strategically redesign existing drugs and win the race against mutatio

69 easingly makes it possible to experimentally redesign existing pathways and implement de novo ones in

70 Recently, we redesigned ferric hydroxamate uptake component A (FhuA),

71 We redesigned five segments of the Fab gene with a "codon h

72 ents undergoing total joint replacement were redesigned following the VA-TAMMCS model--the VA's offic

73 at human health is placed at the centre of a redesigned food system, as that will also help ensure pl

74 h for cargo loading that avoids nanoparticle redesign for each individual application.

75 Middleware is redesigned for improved performance by using a hybrid of

76 t our approach using existing Gibbs samplers redesigned for parallel hardware.

77 versatile platform which can also be easily redesigned for the automated and arrayed analysis of cel

78 arches, data sets and genome browser tracks; redesigned gene pages; effective integration of alternat

79 ity and task load ratings suggested that the redesigned gown is perceived more favorably by HCP.

80 and use problems between the current and the redesigned gown, differences in usability and task load

81 ease in adherence to protocol when using the redesigned gown, it is likely that higher usability and

82 nitive task load ratings of the standard and redesigned gowns.

83 The website includes a redesigned graphical interface, a better search engine,

84 Recent improvements include redesigned handling of unclassifiable species hypotheses

85 These findings point to the need of redesigning healthcare services to account for these ine

86 a chromophore inside the protein cavity, we redesigned human cellular retinol binding protein II (hC

87 c efficiencies that match the most-efficient redesigned hydrolases based on natural protein scaffolds

88 onomeric building block, and the surface was redesigned in Rosetta to enable self-assembly into a 2D

89 LIS has been redesigned in the last three years both to better integr

90 nd highlight the new features in the website redesign, including new browse/search options, plasmid a

91 d utilize a synthetic biological approach to redesign inositol phosphate signaling pathways.

92 veloping evidence-based team guidelines, and redesigning inpatient care processes.

93 The redesigned interface allows researchers direct access to

94 The completely redesigned interface, more intuitive and more integrativ

95 cture, (TriCyt1)(3.) This nascent trimer was redesigned into second and third-generation variants (Tr

96 ubsequent labeling of internal membranes, we redesigned it by introducing a membrane anchor group bas

97 se its binding affinity for hIgG1 as well as redesign its specificity toward multiple IgGs from other

98 The program redesigned its incentive structure in 2006 to also rewar

99 In phase III, we tested 1 redesigned layout with an additional 10 trained HCWs.

100 In our redesign, LB [V(Ru(2+)X)2] was synthesized and treated w

101 including systems-based approaches, process redesign, lean methodology, checklists, root cause analy

102 The redesigned lens demonstrates operation with high directi

103 Redesigning lignin, the aromatic polymer fortifying plan

104 Here we report the use of a redesigned LRP reporter (rdLRP), aimed to provide excell

105 Intervention schools received a redesigned menu where the target items were positioned f

106 vel optimization has been a great success in redesigning metabolic networks for biochemical overprodu

107 his restriction may have to be considered in redesigning minimal MPER immunogens aimed at exclusively

108 duce Sequence-based Toehold Optimization and Redesign Model (STORM) and Nucleic-Acid Speech (NuSpeak)

109 lity for computer-based protein engineering: redesigned models and redesigned X-ray structures exhibi

110 Redesign/modification of previous N3S tetradentate ligan

111 sults indicated that the sensor employed the redesigned mutant Pcyb-AfGDH can be used for future cont

112 proved much easier than previous attempts to redesign natural aldolases, suggesting that such protein

113 de novo membrane protein design(7,8) and in redesigning naturally occurring channel-containing prote

114 otein decreases the abundance of RNAs in its redesigned network.

115 system of today, efforts are now underway to redesign nutrition delivery so as to provide the contemp

116 Here we report the redesign of a current state-of-the-art soluble Env mimic

117 study provides an approach for the rational redesign of a given pharmaceutical (Propranolol as an ex

118 Our findings confirm that redesign of alpha1AT strongly alters its inhibitory beha

119 Redesign of an initial benzofuran-amide scaffold yielded

120 A regions, an important finding for rational redesign of aptamers and their incorporation into sensin

121 ring the assembly process, and a significant redesign of assembly steps that enables multi-threaded e

122 strategies demonstrated in this article, the redesign of beta-sheets to contain a global, or local, p

123 y enables effective affinity improvement and redesign of binding specificity.

124 proaches from engineering and computation to redesign of biology, with goals such as generating new c

125 dvanced, responsive, multi-device compatible redesign of canSAR with a question-led interface.

126 al structure, and by structural model-guided redesign of channelrhodopsins for altered ion selectivit

127 g the potential for the rational and focused redesign of cleavage specificity in MMPs.

128 clinical trials and tissue procurement; and redesign of clinical trials in metastatic breast cancer.

129 This in turn allowed mutational redesign of disassembly and testing in both bacterial an

130 lly-guided approach that can enable both the redesign of endogenous promoter sequences and the de nov

131 tal structures permit the identification and redesign of Env elements involved in trimer stability.

132 The redesign of enzyme active sites to alter their function

133 k illustrates the power of Rosetta for major redesign of enzyme specificity and introduces a tool for

134 esign of new pharmaceutical molecules or the redesign of existing pharmaceutical molecules that prese

135 The redesign of FluoRender not only maintains the existing m

136 ts, predicts function, guides the mutational redesign of functional and allosteric specificity, and i

137 rase-mediated site-specific recombination by redesign of higher-order protein-DNA architectures.

138 use of time and technology, but involves the redesign of how in person time between faculty and resid

139 sed access or quality with implementation or redesign of Medicaid managed-care programs.

140 o-inspired light-harvesting antennas and the redesign of natural photosynthetic systems.

141 United States because of new legislation and redesign of payments from the Centers for Medicare and M

142 nt; and how new gene-editing approaches, the redesign of plant cell walls, and deciphering herbicide

143 B, new opportunities emerge for the rational redesign of plant Phys with novel photochemistries and s

144 The strategy combines redesign of protein-protein interaction specificity with

145 nd are an attractive target for the rational redesign of proteins.

146 Herein, we present the architectural redesign of RCSB PDB data delivery services that build o

147 ns, provides evidence for extensive adaptive redesign of snake metabolic pathways.

148 d approach should enable the elucidation and redesign of specificity landscapes of a wide variety of

149 ized for thermodynamic stability by rational redesign of surface charge-charge interactions is charac

150 utations remains sparse, limiting the design/redesign of synthetic catalysts in a predictable way.

151 , which will provide the opportunity for the redesign of systems to enhance patient safety.

152 low-nanomolar binding affinity by in silico redesign of the CDRH3 sequences.

153 A modeling study and redesign of the core scaffold led to the stereoselective

154 arning healthcare system requires systematic redesign of the current healthcare system, focusing on 4

155 We report herein a critical redesign of the HPD chemotype featuring an additional wi

156 eta-barrel membrane proteins to the complete redesign of the lipid-facing surface of Escherichia coli

157 These transpositions enable rapid redesign of the main aromatic skeleton to generate good

158 This article describes the recent redesign of the NDB Web site with special emphasis on ne

159 of unknown function, and facilitate rational redesign of the NTR scaffold.

160 We present here ABRA2, a redesign of the original ABRA implementation that offers

161 mzTab-M is a redesign of the original mzTab format which was geared t

162 The redesign of the previously reported thiophene-3-yl-methy

163 e energy values for compounds and reactions; redesign of the primary gene/protein page; addition of a

164 micromolar concentrations, and an empirical redesign of the protein exterior produced a stable monom

165 omprehensive dataset in the IEDB, a complete redesign of the query and reporting interface has been p

166 Optimization of such systems requires redesign of the synthetic indicator to allow cell-specif

167 Recent changes to PATRIC include a redesign of the web interface and some new services that

168 es against multiple sequence alignments; the redesign of the web pages and download site.

169 The exWHO-FAST assay is an expanded redesign of the WHO-recommended reverse transcriptase PC

170 Motivated by the merger and redesign of these long-standing HIV cohort studies in 20

171 ersible peptide-peptide interaction, through redesign of this domain and genetic dissection into thre

172 We pioneered the redesign of this targeting ligand by altering the ligand

173 To meet these demands, a redesign of translational approaches is urgently needed.

174 ion of the natural protein phospholamban and redesign of variants, we define a steric packing code un

175 cumented as instrumental in the designing or redesigning of macrocyclic frames, particularly in the s

176 te to stabilize its conformation, as well as redesigns of an immunogenic region to add a new N-glycos

177 lturally important processes, their rational redesign offers great promise toward accelerating crop i

178 ging and boosting- that enlist these cues to redesign online environments for informed and autonomous

179 port quantitative fitness measurements in 27 redesigned operons that suggested that protein productio

180 THI4s are thus candidate parts for rational redesign or directed evolution of efficient, nonsuicidal

181 We redesign our earlier algorithm, VALOR, and implement our

182 We have redesigned our report pages and search forms to support

183 modifications to our production pipeline and redesigned our website with improved gene tree visualiza

184 d in 3 phases: hospital-based inpatient care redesign, outpatient-based care enhancements, and commun

185 We redesigned parts of the original Balding algorithm to im

186 Unless significantly redesigned, pay-for-performance may not be a successful

187 The redesigned peptide possessed a 4.5-fold improvement in p

188 ultidisciplinary collaboration among systems redesign personnel, clinicians, and surgical staff to re

189 After 5 multicenter design-test-evaluate-redesign phases with a total of 319 BCP-ALL patients at

190 ng-term potential for both interrogating and redesigning phosphorylation dependent signaling pathways

191 te the entire ImageJ codebase, engineering a redesigned plugin mechanism intended to facilitate exten

192 An improved multiplex PCR, using redesigned primers targeting the serovar 3 capsule locus

193 ion EHV-1 rPCR assay (E(1)) was developed by redesigning primers and probes specific to ORF30.

194 The Joint Replacement Program system redesign project was initiated following the Vision-Anal

195 The redesigned protein decreases the abundance of RNAs in it

196 only against the BH3 region of Bim, the best redesigned protein was globally specific against binding

197 e protein orientation on graphene surface by redesigning protein mutants.

198 Redesigned proteins could be used as research tools, dia

199 However, many de novo and redesigned proteins exhibit poor hydrophobic packing in

200 The redesigned proteins harbor mutations at up to 53 residue

201 g key signatures of toxicity can also aid in redesigning proteins, so as to maintain their desirable

202 The website was redesigned providing new query options.

203 Based on this architecture, we redesign Puf2p to bind UAAG and identify the targets of

204 ET) algorithm previously proved effective in redesigning receptors to mimic the ligand specificities

205 We have completely redesigned result visualizations and user interfaces to

206 The redesigned rrnDB brings a substantial increase in the nu

207 clear Magnetic Resonance-derived structures, redesigned search and browse interfaces, and new or upda

208 Testing the impact of the individual redesigned segments revealed that the most significant e

209 Here, we show completely redesigned selenium devices with improved back and front

210 In ongoing development, we are redesigning SemRep to increase its modularity and flexib

211 A second SIRPalpha Syk-iSNAP with redesigned sensor and activator modules can likewise rew

212 The surgery service and systems redesign service held a value stream analysis in FY 2013

213 CPD was used previously to redesign several proteins, employing a knowledge-based e

214 ettings and include care standardization and redesign, shared decision making, palliative care, care

215 A redesigned SNP reference panel with additional functiona

216 lt, a number of monitoring programs may need redesigning, some sampling and analytical procedures may

217 e inhibitors of ataxin-3 expression and then redesign ss-siRNAs to optimize their selectivity.

218 supportive Brownian Dynamics (BD) interface redesign strategies, one a new "heme-filtering" approach

219 lights the benefit of a mechanism-based drug redesign strategy that can maximize the translational va

220 We developed and applied a binding-pocket redesign strategy, guided by machine learning, to create

221 Through transfer-learning, we redesign sub-optimal toehold sensors, even with sparse t

222 Using the redesigned subtype B and C trimer representatives as res

223 escribe an effective strategy to extensively redesign such an extensive biomolecular interface.

224 When modelling or redesigning such systems, functional subsystems are ofte

225 The redesigned synthesis features a Buchwald-Hartwig aminati

226 " of biocatalysts opens new opportunities to redesign synthetic strategies to target molecules by inc

227 The redesigned system allows for quantitative analysis of th

228 may prompt hospitals to implement broad care redesign that produces benefits regardless of insurance

229 are examined, prompting recommendations for redesign that would facilitate future reuse.

230 used the Rosetta Molecular Modeling Suite to redesign the active site of the acid-active gliadin endo

231 It may thus be possible to redesign the acyl-donor specificity of DGAT2 enzymes, po

232 hat extent the fractional-order dynamics may redesign the firing properties of excitable systems.

233 We redesign the functional surface of Tk-hefu to better mat

234 Here we redesign the molecule in such a way that its anti-tumor

235 ibraries to engineer a more stable NEDD8 and redesign the NEDD8-NAE interface.

236 of concept, we used these new algorithms to redesign the protein-protein interface (PPI) of the c-Ra

237 The purpose of the server is to redesign the specified complex chain to increase its sta

238 use they provide a wide researching space to redesign the textured structures.

239 get specific structural elements in EF-Tu to redesign the thermodynamic landscape.

240 e investigators a second chance to modify or redesign the trial while the study is still ongoing.

241 sed aiming to provide meaningful examples to redesign the world of disposable electrodes.

242 In next-generation (NG) Capture-C, we have redesigned the Capture-C method to achieve unprecedented

243 We redesigned the DAP synthetic pathway to generate L,L-NSD

244 We also redesigned the data schema to ensure the compliance of f

245 Further, we redesigned the FP at position 518 to reinstate the bNAb

246 y (NTRL) and National TB and Leprosy Program redesigned the tuberculosis specimen transport network a

247 Recently, we refactored the codebase, redesigned the user interface, and developed various nov

248 ddition to an update of the data content, we redesigned the website interface to improve both user ex

249 The approach was applied to redesigning the BIR3 domain of the X-linked inhibitor of

250 After redesigning the existing gown, a high-fidelity patient s

251 numerous different target enzymes by simply redesigning the overhang sequence of detection probe, wh

252 ity, we make critical information salient by redesigning the summons form and providing text message

253 We show that redesigning the top contact of the laser allows one to e

254 We show that in nearly all of our redesigns the sequence found by the continuous-rotamer m

255 g HF care and examples of innovation in care redesign, the quality of HF care varies greatly across t

256 gnaling and provide an essential scaffold to redesign their activities for agricultural benefit and a

257 These new discoveries outline the need to redesign therapeutic strategies to target this underappr

258 -2536, we employed structure-based design to redesign this series toward compounds with a dual ALK-BR

259 e to recipients, and the organisation should redesign this system to explicitly link a portion of the

260 In particular, we redesign three singular omnidirectional devices: the Eat

261 n the implementation procedure and guide the redesign to achieve the required performance.

262 t (QI), namely behavioral change and systems redesign to improve patient outcomes.

263 Austerity measures and health-system redesign to minimise hospital expenditures risk adversel

264 tion genetics with applications from protein redesign to the clinical assessment of human genetic var

265 Finally, the website has been redesigned to allow search and retrieval of records base

266 The server's webpage is now redesigned to allow users easier access to data for diff

267 randomization of 34 patients, the trial was redesigned to also include patients who had stable COPD

268 The enzyme has been redesigned to catalyse the oxidation of non-natural subs

269 Its introduction pages have been redesigned to enable the user to easily navigate between

270 itions in the soil, the root architecture is redesigned to generate numerous lateral roots (LRs) that

271 The METLIN Exposome database has been redesigned to help identify environmental toxicants, foo

272 A THPI selective for MMP-2 and MMP-9 was redesigned to incorporate non-native amino acids (Flp an

273 e and analysis tool set have been completely redesigned to increase speed, flexibility and user frien

274 ture of NV protease with the C-terminal tail redesigned to mimic P4 to P1 of another substrate site p

275 Decitabine regimens can be redesigned to minimize cytotoxicity and increase exposur

276 to a different antigen, were computationally redesigned to predict antibodies that could engage multi

277 nation: the web frontend has been completely redesigned to reduce dependency on outdated browser tech

278 regulatory proteins, but few aTFs have been redesigned to respond to new effectors beyond natural aT

279 This public version has been redesigned to run in a wide range of parallel Linux comp

280 The website has been significantly redesigned to take advantage of current web technologies

281 In addition, its interface has been redesigned to take advantage of flexible web services, p

282 o adaptive, permitting them to be instantly "redesigned" to respond to individual storms and evolving

283 Therefore, processed meat products can be redesigned towards functional prebiotic foods of interes

284 New features include a completely redesigned user interface with an interactive tutorial a

285 th 40 HCP as participants evaluated the gown redesign using 2 commonly performed tasks.

286 We show that a PDZ domain can be entirely redesigned using a "physics-based" energy for the folded

287 arget a genomic region; that protein is then redesigned using iterative rounds of in vitro selections

288 best energy conformations in 69 protein-core redesigns using a rigid-rotamer model versus a continuou

289 We generated redesigned variants of antibody C05 to the HA RBD and ex

290 We describe a new, substantially redesigned version of our tool Metscape that allows user

291 clusion of siRNA interactions we introduce a redesigned web interface to enhance viewing, filtering a

292 tion of supplementary data; and a completely redesigned web interface, with enhanced search and filte

293 , as a web-service, and through a completely redesigned web interface.

294 s such as HPO and uPheno); user interface (a redesigned website); and community development.

295 The primary goals of the redesign were to (1) simplify SID by reducing the number

296 The web interface has been improved/redesigned with a quick search option to rapidly extract

297 The microelectrodes were redesigned with compact size, fabricated using an improv

298 Much of the design/redesign work on overcoming this resistance has been foc

299 d protein engineering: redesigned models and redesigned X-ray structures exhibit very similar native

300 provides new drug targets and guidelines to redesign Zn-ejecting compounds with improved specificity