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1 rmentation conditions so that we are able to redirect 89% of acyl-CoAs from the synthesis of neutral
2 w influenza virus uses this same activity to redirect a classically antiviral protein into a proviral
3 tle variations in pH and redox potential can redirect a non-equilibrium crystallization pathway throu
5 se findings were corroborated by experiments redirecting a signal-peptide-containing FGF family membe
6 ion by expressing HBV X protein (HBx), which redirects a host ubiquitin ligase to target Smc5/6 for d
8 compounds, EGCG, resveratrol, and curcumin, redirect Abeta(17-36) from a fibrillar aggregate to an u
10 ltrafast energy transfer to individual light-redirecting acceptor molecules oriented parallel to the
11 tic shedding of the ectodomain is thought to redirect activated T-cells from lymph nodes to sites of
13 that intracellular antiviral immunity can be redirected against host-origin endopathogens involved in
14 nd compromising cytotoxic program, failed to redirect all MHCI-signaled thymocytes into the CD4 helpe
15 n intranasal (IN) nanoemulsion adjuvant that redirects allergen-specific Th2 responses toward Th1 and
16 dvantage of the dynamic nature of the MSC to redirect and coopt cellular translation factors to enhan
17 fluorescein isothiocyanate (folate-FITC) can redirect and regulate FITC-specific CAR-T cell activity
18 eceptors (CARs) are synthetic receptors that redirect and reprogram T cells to mediate tumour rejecti
19 ibody productivity in CHO cells, possibly by redirecting antibody molecules from degradation to secre
21 an important role when cues are learned that redirect attention away from previously relevant to newl
22 idden in America's drinking water supply and redirect attention to ensure safe water among affected h
24 timing of Hgf/Met signaling is sufficient to redirect axon targeting and disrupt the topographic map.
25 overriding competing endogenous signals and redirecting axons across potent repulsive barriers to co
26 le CD40L multimers to T cell/B cell cultures redirects B cell differentiation toward plasma cells, in
27 the positive condition, as well as increased redirected behavior and a left-eye lateralization in the
30 Drug Administration for brain aneurysms that redirects blood flow away from the aneurysm, thereby pro
31 emphasize the potential of combining T-cell-redirecting bsAbs with antagonists or agonists that miti
32 he two magnetic forces, the flow is not only redirected, but also a local change of concentration of
33 us Vangl2 in the neuroectoderm was similarly redirected by an ectopic Wnt source and disrupted after
35 ated that the outcome of the reaction can be redirected by installation of an assisting group within
37 ells could be more effectively activated and redirected by oncolytic adenoviruses that were armed wit
42 roenvironment can suppress tumorigenesis and redirect cancer cells to adopt a normal mammary epitheli
44 h switch formats can be readily optimized to redirect CAR-T cells (specific for the corresponding FIT
45 BiTE cells secreted EGFR-specific BiTEs that redirect CAR-T cells and recruit untransduced bystander
46 tion in patients with AML treated with CD123-redirected CAR T cells and mandates novel approaches for
49 itches capable of throttling and selectively redirecting carbon flux in Escherichia coli We anticipat
53 eered expression of the CCR9 homing receptor redirected CD8 T cells to the small intestine in rhesus
54 umor regression in combination with NY-ESO-1-redirected CD8+ T cells in a mouse model of adoptive T c
55 of a high-affinity Gag293-specific TCR also redirected CD8+ T cells to target HIV-1 capsid via nonco
56 phase III clinical trials, substituted for Y-redirected cells and enabled tumor debulking by tumor-re
57 teract cellular innate immune mechanisms and redirect cellular processes toward viral replication.
59 precision-medicine therapies to "rewire" or redirect cellular transitions at an early stage, such as
61 pomer analysis, we show that BDQ-treated Mtb redirects central carbon metabolism to induce a metaboli
62 Taken together, our results suggest that CS redirects certain S aureus strains to a virulence profil
63 y to manipulate light-matter interactions to redirect chemical or spectroscopic outcomes through the
64 ported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in pr
65 growing class of immunotherapeutics work by redirecting components of the immune system to recognize
66 noncytotoxic mechanism, the NS3-specific TCR-redirected CTLs were polyfunctional and inhibited HCV RN
68 develop innovative strategies to recruit and redirect cytotoxic effector cells to eliminate the HIV-1
69 th CD3 signaling modules into complexes that redirect cytotoxic T lymphocyte (CTL) specificity and fu
70 form of chemically programmed biAbs aimed at redirecting cytotoxic T cells to eliminate cancer cells.
72 Alternatively, predator avoidance might also redirect dispersal towards nearby predator-free patches
74 tunity to treat these patients with leukemia-redirected donor-derived T cells, which may be more func
75 he knowledge gaps in TB transmission and may redirect efforts towards cost-effective contact investig
77 tamaterials have been proposed to reflect or redirect elastic waves at different length scales, rangi
78 enable the elimination of infected cells by redirecting endogenous non-HBV-specific T cells, bypassi
79 ne lysine methyltransferases/demethylases to redirect epigenetic programming of M(LPS + IFN-gamma)/M(
80 nduction of adaptive programs, including the redirected expression of gene networks toward the synthe
82 gamma, required for basolateral trafficking, redirects FGF from T-tubules to surface, increasing trac
83 s rise to transverse pressure gradients that redirect flow from wide to narrow vessels, reducing the
84 us, and acute T cell-mediated rejection have redirected focus on long-term allograft structural integ
85 d state, Abeta peptides are only transiently redirected from fibril formation, and eventually almost
86 In adult erythroid cells, the LCR can be redirected from the adult beta- to the fetal gamma-globi
87 o certain cellular stimuli, but how LysRS is redirected from the MSC to viral particles for packaging
88 his study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways
89 our module to identify the optimal point to redirect glycolytic flux into heterologous engineered pa
91 aching implications for marine ecosystems by redirecting grazing pressure and facilitating the format
96 ion and no longer localizes to the pole, and redirecting HspX to the septum radically disrupts the no
99 nt AC133xCD3 bispecific antibody (bsAb) that redirects human polyclonal T cells to AC133(+) GBM stem
100 Fus3 and human MAPK ERK2 can be functionally redirected if only two conditions are met: the kinase an
102 4(gag) plasmid DNA (pDNA) vaccine is able to redirect immunodominant responses to otherwise subdomina
103 w that broadband light can be controlled and redirected in a volume of >10(5)lambda x 10(5)lambda x 1
104 erated therapy achieves tumor specificity by redirecting inflammation to a functional target fundamen
105 ng factor for the insulin receptor (IR) that redirects internalized receptor molecules from endosomes
106 ites, PVM-associated LC3 becomes immediately redirected into the TVN, where it accumulates distally f
107 A and AlsSD counters the effects of CidBC by redirecting intracellular carbon flux towards acetoin fo
110 onarily conserved mechanism whereby the cell redirects its energy from maintaining its translational
112 o expansion of the stem cell compartment and redirects keratinocytes in the interfollicular epidermis
113 Indeed, the BsAbs were able to efficiently redirect killing of HLA-DR(+) leukemic cells by human CD
114 ere well above those considered adequate for redirected killing activity against Env-expressing targe
115 NK cell polyfunctionality in both direct and redirected killing assays with anti-NKp30 Abs (p = 0.009
118 r cambium to provide meristematic tissue and redirects leaf development towards formation of carpels.
120 determine the mechanisms by which root cells redirect lipid biosynthesis during AMS we analyzed the r
121 the tumor site, where in synergy with tumor-redirected lymphocytes, they instructed TNFalpha express
123 Moreover, other GGPS fusions may be used to redirect metabolic flux into the synthesis of other isop
124 tracing studies revealed that TLR signaling redirected metabolic fluxes to generate acetyl-Coenzyme
125 ealed that LBL favored energy metabolism and redirected metabolic pathways toward the synthesis of di
126 phorylation-dependent signaling pathway that redirects metabolic flux in response to amino acid starv
128 ve phenotypes in Escherichia coli, including redirecting metabolism to increase succinic acid product
129 cytotoxic program by ThPOK is sufficient in redirecting MHCI-restricted thymocytes into the CD4 help
130 Accordingly, loss and gain of ThPOK function redirects MHCII- and MHC class I (MHCI)-signaled thymocy
131 metabolic milieu during the perinatal period redirect mitochondrial substrate preference from carbohy
132 or 1 (IRF-1) with apoptotic functions, which redirect murine neonatal Th1 reactivation to cell death.
135 inant T cell receptors (TCRs) can be used to redirect naive T cells to eliminate virally infected or
136 ENT Targeted muscle reinnervation surgically redirects nerves that lost their target in the amputatio
137 CARs) in NK cells is a promising strategy to redirect NK cells to otherwise NK cell-resistant tumor c
140 ed with host development can be exploited to redirect novel AAV vectors to specific cell types in the
141 nner to dismantle the vegetative tissues and redirect nutrients towards metabolic pathways supporting
143 fection or whether their presence reflects a redirecting of the humoral response away from targeting
145 that increases the excitation efficiency and redirects part of the laterally-emitted fluorescent ligh
147 re needs, either accelerating needed care or redirecting patients toward care most appropriate to the
148 introducing the cosmid St4A10lsp, as part of ReDirect PCR mutagenesis protocol, which transiently dup
149 This protein, which we have named Rpp (for redirecting phage packaging), interacts with the phage t
150 ralized strategy among marine cyanophages to redirect photosynthesis to support phage development, wh
152 insect species have acquired the ability to redirect plant development to form unique organs called
153 gineered to express synthetic receptors that redirect polyclonal T cells to surface antigens for subs
154 The ability of ImmTAV-Env to activate and redirect polyclonal T cells toward cells containing inte
158 -linking of FcgammaRIIb by the IgG4 subclass redirects pro-allergic M2a macrophages to an M2b-like im
161 rafficking by cleaving RILP, which serves to redirect Rab7-containing vesicles to a kinesin-dependent
162 ur results expand on potential strategies to redirect recombinant AAV vectors toward more productive
163 ip, shifted traditional compensation models, redirected research programs, and led to cultural confli
165 s my responsibility as a program director to redirect residents who should not be surgeons." The over
167 ver, disrupting starch biosynthesis does not redirect resources to other bioproducts (lipids or prote
169 d consideration of when it is appropriate to redirect resuscitation efforts after significant efforts
173 ng to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent p
174 Similarly, exposure to oxidative stress redirects SKN-1 activity away from pathogen response gen
175 (i.p.) delivery of SSO Ex5 in MMTV-PyMT mice redirects SmgGDS splicing in the mammary gland and slows
176 utilization of the entire solar spectrum by redirecting solar photons to maximize FEW production fro
177 ere we ask whether and how motor control and redirected somatosensory stimulation provided via TMSR a
183 rom antibodies to CD3 and CD123, designed to redirect T cells against acute myeloid leukemia blasts.
184 CD3 effector function are being developed to redirect T cells against these targets using 2 different
185 t picomolar concentrations of ImmTAV-Env can redirect T cells from healthy and HBV-infected donors to
188 thetic chimeric antigen receptors (CARs) can redirect T cells to recognize and eliminate tumor cells
191 ing mRNA electroporation to engineer HBV TCR-redirected T cells in patients with chronic HBV infectio
193 tive on how expanding the use of genetically redirected T cells to treat the majority of patients wit
195 transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less stri
196 tor and the targeting ligand still permitted redirected T-cell function but significantly compromised
198 Among different forms of immunotherapy, redirecting T cells to hematological malignancies with b
199 l immunology and have clinical relevance for redirecting T cells to target virally infected hepatoma
200 BiFab-BCMA), which potently and specifically redirects T cells to lyse malignant multiple myeloma cel
201 stimulates CD8 T-cell effector function and redirects T cells to lyse these previously latent-infect
203 ow now that CDDO-Me remodels the breast TME, redirecting TAM activation and T cell tumor infiltration
204 ts a promising immunotherapeutic approach to redirect TAMs to serve as tumor killers for late-stage o
205 ic health strategies and suggest the need to redirect TB transmission-associated research efforts tow
206 s isolated from omental fat and lung did not redirect testicular cells to a MEC fate, indicating the
207 from adult mice and rats were sufficient to redirect testicular derived cells to produce normal mamm
208 tly, orthogonal induction of Irf4 expression redirected Tfh cell fate trajectories toward those of Te
210 types of receptor systems have been used to redirect the activity of T cells, normal heterodimeric T
211 t different chaperones could be exploited to redirect the amyloid-elicited immunity both for basic st
215 results will help guide therapies that will redirect the gut microbiome towards a healthy state and
216 Vpx that bind the SAMHD1 N or C terminus and redirect the host cullin-4 ubiquitin ligase to target SA
217 family is commonly hijacked by pathogens to redirect the host ubiquitin proteasome machinery to spec
221 with a specific inhibitor could effectively redirect the mating differentiation, confirming the caus
222 tain substitutions on the 2-indolyl position redirect the mode of cytotoxicity from methuosis to micr
224 suggests that tumor vascular remodeling may redirect the organism-wide signaling activity of tumor-d
225 the clinical development of strategies that redirect the power of the immune system to target and el
227 nslatable synthetic fusion proteins that can redirect the specificity of T cells toward designated an
228 s, while the other adjuvants utilized in AIT redirect the Th2 immune response towards Th1 immunity.
229 nversely, immunotherapy and chemotherapy may redirect the tumor microenvironment and allow the activa
231 try, combined with very low CCR5 levels, may redirect the virus to different cell targets in natural
233 mated in WinSAAM software.VA supplementation redirected the flow of CM-REs from peripheral to central
234 Participants initiated straight reaches and redirected the hand toward a target presented in midflig
235 atment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells.
238 on the laser irradiation wavelength, thereby redirecting the ablation process through photochemical o
239 ) (-)) and sulfonated (C(P)SO(3) (-)) forms, redirecting the C(P)SOH intermediate from the catalytic
242 ality for marine phytoplankton and bacteria, redirecting the flow of organic material throughout the
245 play a role in either directly launching or redirecting the jets within the inner few hundred gravit
246 ologic intervention in tuberculosis involves redirecting the outcome of the host immune response from
247 elongation of the isolation membrane, and by redirecting the protein phosphatase 1alpha (PP1alpha) to
248 s study sought to evaluate the potential for redirecting the SVC and RUPV flow to the right and left
249 e histone tail domains with nucleosomal DNA, redirecting the tails to more interior positions within
251 ion by expressing the X protein (HBx), which redirects the cellular DNA damage-binding protein 1 (DDB
253 ion by expressing the X protein (HBx), which redirects the host DNA damage-binding protein 1 (DDB1) E
254 s' pi*-orbitals makes reductions easier, but redirects the protonation and reduction to sites that po
256 w this single viral glycoprotein efficiently redirects the U21/class I MHC complex to the lysosomal c
258 its receptor on non-professional phagocytes redirected their phagocytosis, such that uptake of large
261 motility of breast cancer cells, but simply redirects their migration to produce largely one-dimensi
264 ognized by plant cell secretory machinery to redirect these peptides from the cytoplasm to the apopla
266 haperone-binding domain, previously shown to redirect this substrate pair to the ESX-5 system, also r
267 ase domains are modular payloads that can be redirected through different import pathways when fused
268 by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p
271 ansporter (Protective antigen, PA) which was redirected to Epidermal Growth Factor Receptors (EGFR) o
273 g that certain methylation pathway(s) may be redirected to genes upon the loss of heterochromatin.
275 ered tagmentation of accessible DNA sites is redirected to produce chromatin accessibility maps that
277 e spinal segment whose axons were surgically redirected to remnant muscles (targeted muscle reinnerva
279 MHC Class II-restricted OT-II thymocytes are redirected to the CD8 cytotoxic lineage, which occurs wi
280 cal rivers, DSi in groundwater and runoff is redirected to the combined stormwater-sewage overflow sy
281 2-oxoglutarate aminotransferase pathways and redirected to the de novo synthesis of nitrogen assimila
283 is persister population requires the glucose redirected to the synthesis of cellulose to maintain a s
284 order to sustain rapid proliferation but are redirected to triacylglycerol (TAG) stored in lipid drop
285 attended objects and that attention could be redirected to unattended objects by activation of a rewa
286 can no longer be used for cell division are redirected toward carbohydrates and triacylglycerols (TA
287 ally destined for growth and development are redirected toward elevated accumulation of specialized m
290 nitiated in 12 patients (11%), treatment was redirected toward palliative care in 14 patients (13%),
291 presenting the highest sum/mean before being redirected toward the choice representing the maximal re
292 which the vast majority of private funds are redirected towards influencing the prescription behaviou
293 r initiation, the translational apparatus is redirected towards unconventional upstream initiation si
295 virus (IAPV) intergenic region captures and redirects translating ribosomes toward viral RNA message
298 eratrol nullifies the catalytic activity and redirects TyrRS to a nuclear function, stimulating NAD(+
300 herapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors