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1 oxidant-induced protein thiyl radicals with reduced glutathione.
2 ygen species and exhibited less depletion of reduced glutathione.
3 l but shows a >100-fold lower k cat/ K m for reduced glutathione.
4 g it to a disulfide reductase that generates reduced glutathione.
5 in the presence of a mixture of oxidized and reduced glutathione.
6 zes the reduction of oxidized glutathione to reduced glutathione.
7 d that this is correlated with the levels of reduced glutathione.
8 ation was not observed in cells treated with reduced glutathione.
9 increase in antioxidants including NADPH and reduced glutathione.
10 neurons to maintain intracellular levels of reduced glutathione.
11 ctaldehyde, which is paralleled by a loss of reduced glutathione.
12 -reducing agents, such as dithiothreitol and reduced glutathione.
13 and identified by the reaction of UQ(0) with reduced glutathione.
14 nd a marked increase in endogenous levels of reduced glutathione.
15 eurons, and MPP(+) failed to alter levels of reduced glutathione.
16 and not simulated by oxidized glutathione or reduced glutathione.
17 eversed by dithiothreitol, ascorbic acid, or reduced glutathione.
18 the oxidized Ng could be reduced by NADPH or reduced glutathione.
19 reduced rapidly by ascorbic acid but not by reduced glutathione.
20 acid, coumaric acid, acetaldehyde, total and reduced glutathione.
21 des, and TGFbeta1, and erythrocyte levels of reduced glutathione.
22 -terminal kinase activation, or depletion of reduced glutathione.
23 ivity against DPPH radicals when compared to reduced glutathione.
24 ls of oxidized glutathione with reference to reduced glutathione.
25 d to the increased production of taurine and reduced glutathione.
26 erine treatment with concomitant decrease in reduced glutathione.
27 n reactive oxygen species and a reduction in reduced glutathione.
28 ered in the presence of physiologic level of reduced glutathione (1 mmol/L), suggesting that selenocy
29 nd, glycine and the higher concentrations of reduced glutathione (1.0 and 2.0%) were able to promote
31 in a 35% decrease in the hepatic content of reduced glutathione 4 days after lipopolysaccharide chal
33 folding of RfBP even in the presence of 5 mM reduced glutathione, a competing ligand for As(III) spec
36 ctivity (complexes I-IV), ATP concentration, reduced glutathione (an intracellular antioxidant) conce
38 inetic constants of approximately 1.4 mM for reduced glutathione and approximately 6.5 microM for APS
40 the use of chemical trapping agents, such as reduced glutathione and cyanide, to form stable adducts
41 tol was unable to compensate for the lack of reduced glutathione and did not promote secretion of per
42 s judged by an elevated ratio of oxidized to reduced glutathione and enhanced oxidative folding in th
43 y during the acute phase of illness leads to reduced glutathione and glutamate in the residual phase
45 tion, CD34(+) AML cells have lower levels of reduced glutathione and increased levels of oxidized glu
46 ultures seeded on dicarbonyl-modified FN had reduced glutathione and increased levels of reactive oxy
49 valuate the ability of gallic acid, glycine, reduced glutathione and l-cysteine at 0.1, 0.5, 1.0 and
50 polynitroxyl albumin groups had hippocampal reduced glutathione and manganese superoxide dismutase a
52 hromate exposure depleted cellular levels of reduced glutathione and other free thiols to a greater e
53 ells offered protection against depletion of reduced glutathione and oxidative stress mediated by TNF
55 by initiating an enhanced generation of both reduced glutathione and oxidized glutathione and enhance
56 and simultaneously to quantify the levels of reduced glutathione and products of its oxidation as pot
57 rs after asphyxial cardiac arrest, levels of reduced glutathione and protein-thiols (fluorescent assa
58 h concentrations of oxidant scavengers (i.e. reduced glutathione and sodium azide) indicating a possi
59 levels of malondialdehyde and low levels of reduced glutathione and superoxide dismutase; these effe
61 rovides the site for entry of electrons from reduced glutathione and that the Cys166-Cys285 disulfide
62 tic hearts, as were the ratio of oxidized to reduced glutathione and the immunohistochemical staining
63 ng to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effe
64 NACA functioned by increasing the levels of reduced glutathione and the phase II detoxification enzy
65 tinamide nucleotides, acetoacetyl-CoA, H2O2, reduced glutathione, and 2-monoacylglycerol were not glu
67 electron donors, ascorbate, dithiothreitol, reduced glutathione, and NADH, were each able to provide
68 xidative stress parameters (malondialdehyde, reduced glutathione, and superoxide dismutase) and expre
69 ibited by dialysis of the cell interior with reduced glutathione, and were markedly enhanced by inhib
70 ck(Delta19) mice, the levels of NRF2 and the reduced glutathione are constitutively low, associated w
72 ic green alga Enteromorpha intestinalis uses reduced glutathione as the electron donor for the reduct
73 tected from dopamine-induced inactivation by reduced glutathione, ascorbic acid, and dithiothreitol b
74 n of p21(ras) and p21(rac), protected nigral reduced glutathione, attenuated nigral activation of NF-
77 A reduction depends not only on the level of reduced glutathione, but also on the rate of NADPH produ
78 hrough the increase in soluble lens protein, reduced glutathione, catalase and SOD activity on in vit
79 ied by increased intracellular ROS level and reduced glutathione concentration in intestinal epitheli
80 significant decrease (approximately 50%) in reduced glutathione concentration, along with the rapid
83 ol treatment further decreased mitochondrial reduced glutathione content and exacerbated mitochondria
84 reatment with l-buthionine-(S,R)-sulfoximine reduced glutathione content by 99% and prevented glucose
86 slices of EAAC1(-/-) mice were found to have reduced glutathione content, increased oxidant levels an
87 el of the primary intracellular antioxidant, reduced glutathione, corresponding to increasing AH resi
90 s a His-tagged recombinant protein catalyzes reduced glutathione-dependent reduction of APS to sulfit
91 p38 kinase because of its ability to prevent reduced glutathione depletion and scavenge hydrogen pero
93 diated dichlorodihydrofluorescein oxidation, reduced glutathione depletion, aconitase inactivation, T
97 wild-type mice had similar levels of hepatic reduced glutathione, endogenous reactive oxygen species,
98 The highest level of 2.0% for glycine and reduced glutathione favored protein extractability and a
99 f thiol-containing model substrates, namely, reduced glutathione (gamma-Glu-Cys-Gly) and the carrier
100 drolyze the unique N-terminal amide bonds of reduced glutathione (gamma-L-glutamyl-cysteinyl-glycine)
101 creasing glycolysis and increasing levels of reduced glutathione, generated by metabolism of glucose
103 ve at preventing a decrease in intracellular reduced glutathione:glutathione disulfide ratios, protec
106 ons of two major non-enzymatic antioxidants, reduced glutathione (GSH) and ascorbate, and completely
108 e is characterized by glutathione imbalance, reduced glutathione (GSH) and cysteine were quantified i
110 superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GP
112 ion of individual ingredients disclosed that reduced glutathione (GSH) and lactobionate in UW solutio
113 ed in significant increases in the levels of reduced glutathione (GSH) and NAD(P)H:quinone oxidoreduc
114 In this study, we investigated the role of reduced glutathione (GSH) and nuclear factor-kappaB (NFk
115 re used to assess relative concentrations of reduced glutathione (GSH) and oxidized disulfide glutath
120 er on platelet aggregation and the effect of reduced glutathione (GSH) and platelet activation on sul
121 ductase (GSR) activities, while the level of reduced glutathione (GSH) and the activities of superoxi
122 rph2(rds/rds)) and compared the abundance of reduced glutathione (GSH) and the activity of mitochondr
123 This shift, in turn, caused an increase in reduced glutathione (GSH) and, ultimately, resulted in R
126 its biospecific interaction with tripeptide reduced glutathione (GSH) bioreceptor directly immobiliz
130 ADP(+) to NADPH and promotes regeneration of reduced glutathione (GSH) by supplying NADPH to glutathi
134 orrelated with a deficiency in intracellular reduced glutathione (GSH) concentrations in diabetic pat
135 tathione-S-Transferase (GST) activities, and reduced glutathione (GSH) content, higher level of malon
137 esis that depolarization-enhanced release of reduced glutathione (GSH) contributes to this phenomenon
139 ells to toxic chemical species can result in reduced glutathione (GSH) depletion, generation of free
141 t systems involved in the export of cellular reduced glutathione (GSH) have not been identified, alth
142 as the rate of depletion of the antioxidant reduced glutathione (GSH) in a model of human respirator
145 for low-potential amperometric detection of reduced glutathione (GSH) in pH 7.2 phosphate buffer sol
146 opeptidase (FCGAP) with BOC-Leu-Met-CMAC and reduced glutathione (GSH) in the absence of Ca(2+).
148 ) increased metal donation fourfold, whereas reduced glutathione (GSH) inhibited donation by approxim
149 ng to the presence of high concentrations of reduced glutathione (GSH) inside the cells, thereby faci
150 rons and contributes to injury, we delivered reduced glutathione (GSH) into microglia, again using li
154 ition to its intracellular antioxidant role, reduced glutathione (GSH) is released by CNS cells and m
155 ciation with a decrease in the mitochondrial reduced glutathione (GSH) level and activity of MnSOD.
156 ested a significant age-related reduction of reduced glutathione (GSH) level in all brain regions exa
157 dant defense function in cells by increasing reduced glutathione (GSH) levels and decreasing ROS leve
165 ceptor (IR) sulfhydryl groups in response to reduced glutathione (GSH) or N-acetyl-L-cysteine (NAC).
167 II iron-limited cells similarly oxidized the reduced glutathione (GSH) pool, phase II iron limitation
168 pectrofluorometrically by enzymatic methods, reduced glutathione (GSH) spectrofluorometrically with O
169 ition, antioxidant activity, effect on total reduced glutathione (GSH) synthesis and protective effec
170 active oxygen species (ROS) and depletion of reduced glutathione (GSH) that together inhibited histon
171 nstrated by (a) the ability of intracellular reduced glutathione (GSH) to eliminate EPR-detectable et
173 a chemical oxidant that selectively converts reduced glutathione (GSH) to its disulfide (GSSG) and pr
174 in increased ROS production and oxidation of reduced glutathione (GSH) to its oxidized form (GSSG).
176 lthough a similar rapid depletion of hepatic reduced glutathione (GSH) was found in both GstP1/P2((+/
178 minations of oxidized glutathione (GSSG) and reduced glutathione (GSH) were performed in monolayer cu
179 reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH) with the accompanying oxidatio
181 nicotinamide dinucleotide phosphate (NADPH), reduced glutathione (GSH), and shear-induced adenosine t
182 emical quantification of oxidized (GSSG) and reduced glutathione (GSH), biomarkers of oxidative stres
185 tathione (GSSG), and total glutathione (GT), reduced glutathione (GSH), catalase (CAT), peroxidase (P
186 cetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, a
187 hibition of K(+) channels of glomus cells by reduced glutathione (GSH), dithiothreitol (DTT) and by c
189 causes oxidative stress through depletion of reduced glutathione (GSH), increases the passive K+ perm
190 induction of oxidative stress, depletion of reduced glutathione (GSH), inhibition of IKK activity le
191 ighly sensitive and inexpensive detection of reduced glutathione (GSH), over its oxidized form (GSSG)
192 rs of NOx formation, levels of intracellular-reduced glutathione (GSH), protein nitrosothiols, and th
193 but the levels of an endogenous antioxidant, reduced glutathione (GSH), remained subnormal in the ret
194 a, interleukin (IL)-1beta, IL-6, IL-8, IL10, reduced glutathione (GSH), superoxide dismutase (SOD), a
195 of cancer cells by producing an antioxidant, reduced glutathione (GSH), through HIF-1-mediated metabo
196 ferase (GST) and non-enzymatic antioxidant - reduced glutathione (GSH), vitamin E and C generation in
197 Detoxification of methylglyoxal requires reduced glutathione (GSH), which accumulates to high lev
198 recycling of oxidized glutathione (GSSG) to reduced glutathione (GSH), which is due to the augmented
206 M and APAP lead to a significant decrease in reduced glutathione (GSH)/glutathione disulfide (GSSG) r
207 er oxidative stress, the mean value for the [reduced glutathione (GSH)]/[oxidized glutathione (GSSG)]
208 l concentrations of either E2 (200 nM) or of reduced glutathione (GSH; 325 microM) can protect SK-N-S
209 hermore, cells sorted according to differing reduced-glutathione (GSH) contents exhibited differing s
211 ynthesis (cysteine: higher in AD, p < 0.001; reduced glutathione [GSH]: higher in AD, p < 0.001); (3)
212 ); and antioxidants, the sum of oxidized and reduced glutathione (GSSG and GSH) can be measured with
213 lood pressure, lipid panel, oxidized (GSH) & reduced glutathione (GSSG) were also evaluated for each
215 ow a similar pattern of responses to applied reduced glutathione, GSSG and MRP1 inhibitors (indometha
216 sported glutathione disulfide (GSSG) but not reduced glutathione in agreement with a 3-fold stimulati
219 ncrease in malondialdehyde and a decrease in reduced glutathione in most organs, as well as liver (in
220 treatment significantly increased levels of reduced glutathione in the liver and lowered levels of o
221 glutathione and a decrease in mitochondrial reduced glutathione in the WT, but not in the MT-TG, dia
222 mitation on the capacity for regeneration of reduced glutathione in this compartment may contribute t
224 ol, Tris(2-carboxyethyl)phosphine (TCEP), or reduced glutathione increased the fraction of anomalousl
227 n be partially reduced by monothiols such as reduced glutathione, L-cysteine or N-acetyl-L-cysteine a
228 which correlated with a greater decrease in reduced glutathione level in Raji clones expressing GSTP
229 modulation of trace elements, alteration in reduced glutathione level, glutathione-s-transferase and
230 e poorly and exhibit oxidative stress due to reduced glutathione levels and impaired expression of se
231 rly [altered oxidized glutathione (GSSG) and reduced glutathione levels and ratio; increased reactive
232 ne potential (DeltaPsim), and superoxide and reduced glutathione levels in individual dopaminergic an
233 d with 100% oxygen had decreased hippocampal reduced glutathione levels vs. sham (15.3 +/- 0.4 vs. 20
236 but not female, 17-day-old rats to maintain reduced glutathione levels within cerebral cortex acutel
237 thiobarbituric acid reactive substances and reduced glutathione levels, tissue markers of oxidative
242 -1beta), tumor necrosis factor-alpha, IL-10, reduced glutathione, malonaldehyde, and nitrate/nitrite
243 ility of natural host defenses to regenerate reduced glutathione may explain failure of recovery from
245 AIIt-mediated liposome aggregation, whereas reduced glutathione, nitrate, or nitrite had no effects.
246 but was significantly enhanced by 500 microM reduced glutathione or 100 microM dithiothreitol, agents
247 by preincubation with antioxidants including reduced glutathione or by expression of a dominant-negat
248 atment with the reductants dithiothreitol or reduced glutathione or by incubation with the thioredoxi
251 fect on longevity, protein carbonyl content, reduced glutathione, or glutathione disulfide content, a
252 T); oxidative stress (malondialdehyde [MDA], reduced glutathione/oxidative glutathione ratio [GSH/GSS
253 the cellular contents of total glutathione, reduced glutathione, oxidized glutathione, and intracell
254 nce of oxidants to antioxidants, measured as reduced glutathione, oxidized glutathione, and their rat
255 nse enzyme activities rather than changes in reduced glutathione, oxidized glutathione, ascorbate and
256 sympathetic neuronal marker profiles, tissue-reduced glutathione/oxidized glutathione (GSH/GSSG) rati
257 in bronchial epithelial cells, and increased reduced glutathione/oxidized glutathione following Cl2 e
258 ficantly lower mean plasma concentrations of reduced glutathione (P < 0.0001), GluCys (P < 0.0001), a
261 urce of cysteine; however, in the absence of reduced glutathione, pertussis toxin was not efficiently
263 nt Zn(2+) release from the vesicles, whereas reduced glutathione prevents TRPM7-dependent cytosolic Z
264 , whilst oxidized Tim10 cannot be reduced by reduced glutathione, reduced Tim10 is effectively oxidiz
266 sults suggest that the autism LCLs exhibit a reduced glutathione reserve capacity in both cytosol and
267 s of histones, tubulin, and lumican and (ii) reduced glutathione S-transferase, annexin, and dermatop
269 age loss of freely diffusing thiols (chiefly reduced glutathione) that have been derivatized with the
270 esence of a low concentration of diamide and reduced glutathione, the kinase was rapidly and reversib
271 of AMPKalpha1, which maintains high level of reduced glutathione to keep reduction-oxidation reaction
273 duced a significant increase in the ratio of reduced glutathione to oxidized glutathione consistent w
274 e stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children
275 vated lipid peroxidation, decreased ratio of reduced glutathione to oxidized glutathione, and up-regu
278 with a significant decrease in the ratio of reduced glutathione-to-oxidized glutathione (GSH/GSSG),
280 two endogenous channel effectors, MgATP and reduced glutathione, using the planar lipid bilayer meth
281 Mg2+ deprivation causes release of neuronal reduced glutathione via a mechanism involving excessive
283 d 1.0 +/- 0.2 mM in normal prostate, whereas reduced glutathione was 2.0 +/- 0.3 mM and 0.8 +/- 0.3 m
287 ant activity was enhanced by the addition of reduced glutathione, was proteinase K sensitive and heat
288 s (ROS) levels was reduced whereas levels of reduced glutathione were elevated in TIGAR-expressing ce
289 e, cystathionine, cysteine, and oxidized and reduced glutathione were measured in 20 children with au
290 ric acid-reactive substance and oxidized and reduced glutathione were measured on frozen brains.
292 intracellular and extracellular oxidized and reduced glutathione were temporally associated with eGPx
293 ing in HepG2 cells by MR was associated with reduced glutathione, where it functions as a cofactor fo
295 iotics and oxidatively produced compounds to reduced glutathione, which facilitates their metabolism,
296 ucing equivalents, which generates NADPH and reduced glutathione, which in turn activates sentrin/SUM
297 nd NAD-binding (KTN) domains that sense both reduced glutathione, which inhibits Kef activity, and gl
298 PI activity was inhibited by incubation with reduced glutathione while bacterial TPI was unaffected.
299 roteins also shared the same specificity for reduced glutathione, with no activity against either gam
300 iciencies are up to 100-fold higher than for reduced glutathione, with typical K(m) values of about 1