ライフサイエンスコーパス: reductively

1 he method in enabling simultaneous access to reductively 1,2-diarylated and oxidatively [3 + 2]-annul

2 With GTN, the secondary nitrate was removed reductively 6 times faster than the primary nitrate, wit

3 only constructs of the E. coli PDHc-E1 could reductively acetylate E. coli PDHc-E2.

4 e of PDHc-E2, as reflected by the ability to reductively acetylate the latter; and (2) amino terminal

5 ffect on the ability of the E2p domain to be reductively acetylated but did confer a slight increase

6 the lipoyl-lysine residue could no longer be reductively acetylated by E1p.

7 main significantly reduces its ability to be reductively acetylated by the cognate E1.

8 Monooxygenase enzymes commonly reductively activate dioxygen by sacrificing one of the

9 ihemoprotein oxidoreductase, EC 1.6.2.4) can reductively activate mitomycin antibiotics through a one

10 the wild-type rat enzyme in their ability to reductively activate the cytotoxic drug CB 1954 (5-(azir

11 '-deoxyguanosine adduct (C8-AP-dG) formed by reductively activated 1-nitropyrene (1-NP).

12 Reductively activated 1-NP forms a major DNA adduct, N-(

13 athway to the inhibition of transcription by reductively activated adriamycin and daunomycin.

14 Leveraging a reductively activated boron-group transfer reagent, this

15 toxic potency of MA is MA's propensity to be reductively activated by cellular thiols while MC is res

16 Mitomycin C (MC) was reductively activated by DT-diaphorase [DTD; NAD(P)H:qui

17 The PBIs are reductively activated by DT-diaphorase and alkylate the

18 re capable of accessing both oxidatively and reductively activated coupling partners, illustrated thr

19 ings for five of the seven iron sites of the reductively activated E(4) FeMo-co, and given the magnit

20 ox catalysis to transform alkyl bromides and reductively activated N-centered radical precursors into

21 We show that a reductively activated pimonidazole metabolite can be ima

22 ed as prototypical members of a new class of reductively activated prodrugs of the duocarmycin and CC

23 Interestingly, MCRPS can also be reductively activated with analogues of CoBSH such as Co

24 m transfer (XAT) reagent, which is the first reductively activated XAT reagent to be reported.

25 show that holomycin, a prototypical DTP, is reductively activated, and reduced holomycin chelates zi

26 oli contains a dinuclear iron cluster, which reductively activates O2 to produce the enzyme's functio

27 f-1), which repairs oxidative DNA damage and reductively activates transcription factors including AP

28 dox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including a

29 R2 is capable of reductively activating O(2) to produce a stable tyrosine

30 ormed in situ such that the ligands could be reductively adsorbed onto glassy carbon electrode surfac

31 dervied from unstable parent aldehydes were reductively alkylated in a direct fashion with a variety

32 ine 6, containing an ester group at C-6, was reductively alkylated to give dihydroindolizines 8 and 9

33 n artifact of acid hydrolysis, proteins were reductively alkylated with formaldehyde to convert ornit

34 n 1e led to aniline derivative 1t, which was reductively alkylated with hexanal and coupled to l-prol

35 vealed that the active site Lys1003 had been reductively alkylated with the aldehyde inhibitor.

36 formation of alpha-ketoisocaproate, which is reductively aminated back to L-leucine by leucine dehydr

37 Acid hydrolysis of 6 gave 11, which was reductively aminated to give (+/-)-narwedine 2.

38 e fragmentation characteristics of N-glycans reductively aminated with 2-aminobenzoic acid and 2-amin

39 The resulting oligosaccharides were then reductively aminated with 2-aminopyridine and the struct

40 re released by treatment with N-glycanase F, reductively aminated with anthranilic acid, and fraction

41 velopment of a complementary reaction, which reductively aminates the C-C sigma-bond of carbonyls, no

42 a non-redox manner by epoxide hydrolases or reductively by oxidoreductases.

43 Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondri

44 connection with both protease-cleavable and reductively cleavable antibody-drug conjugates that were

45 this reaction by using a [4Fe-4S] cluster to reductively cleave AdoMet to form a transient 5'-deoxyad

46 t) enzyme that uses a [4Fe-4S](+) cluster to reductively cleave AdoMet to methionine and a 5'-deoxyad

47 t several of the mutant enzymes were able to reductively cleave AdoMet, but none were able to produce

48 Additionally, they reductively cleave ArC-X, ArX-C (X = N or O) and ArC-C b

49 n at 365 nm, they are even more powerful and reductively cleave aryl chlorides.

50 al SAM superfamily, composed of enzymes that reductively cleave S-adenosyl-l-methionine (SAM or AdoMe

51 SPL utilizes a special [4Fe-4S] cluster to reductively cleave S-adenosylmethionine (SAM) to generat

52 ymes that contain an iron-sulfur cluster and reductively cleave S-adenosylmethionine, forming an enzy

53 cus infernus is a radical SAM enzyme able to reductively cleave SAM to 5'-deoxyadenosine radical and

54 cal by the very same reducing system used to reductively cleave SAM to initiate catalysis.

55 nine (SAM) methylase; however, TsrM does not reductively cleave SAM to the universal 5'-deoxyadenosyl

56 emonstrate that Ni-DBA-2D-COF can be used to reductively cleave the aryl C-S bonds of several organos

57 have developed a mild and general method to reductively cleave the N-S bonds of sulfonamides to gene

58 employed dithiothreitol as a cosubstrate to reductively cleave the persulfide intermediate, and it h

59 The ability of professional APC to reductively cleave this peptide modification presumably

60 This ester is reductively cleaved by a thiol molecule (RSH) such as GS

61 reported as new members of a unique class of reductively cleaved prodrugs of the duocarmycin family o

62 ethora of aryl chloride substrates have been reductively cleaved to fabricate molecules of the class

63 site-differentiated [4Fe-4S] cluster and is reductively cleaved to generate a 5'-deoxyadenosyl radic

64 luster and S-adenosyl-L-methionine, which is reductively cleaved to L-methionine and 5'-deoxyadenosin

65 s 7 upon further reaction with NaTeC6H5 were reductively cleaved to provide 2 equiv of the correspond

66 f the alpha-ester at C16, the ether bond was reductively cleaved with TFA/Et3SiH in high yield.

67 dical S-adenosylmethionine (SAM) enzyme that reductively cleaves S-adenosylmethionine, generating 5'-

68 However, although viperin reductively cleaves SAM to form 5'-deoxyadenosine in a s

69 A [4Fe-4S](+) cluster reductively cleaves SAM to form the Omega organometallic

70 A [4Fe-4S](+) cluster reductively cleaves SAM to form the organometallic inter

71 of the clusters, a 4Fe-4S cluster, binds and reductively cleaves SAM to generate the 5'-deoxyadenosyl

72 yme superfamily in which a [4Fe-4S]+ cluster reductively cleaves SAM to produce the 5'-deoxyadenosyl

73 ) family of enzymes, which are important for reductively cleaving S-S bonds, to have carboxylation ac

74 e thorium-bpy complex (1) that is capable of reductively cleaving the R-NC bond in a series of organi

75 tochemical and thermal activation methods to reductively couple abundant aryl and alkyl electrophiles

76 d the precursors to P-clusters, which can be reductively coupled into the mature [Fe(8)S(7)] structur

77 ferred from GLRX3 to monomeric apo NUBP1 and reductively coupled to form [4Fe-4S](2+) clusters on bot

78 scU homodimer and that these clusters can be reductively coupled to form a single [4Fe-4S] cluster.

79 'Sn(mu-OCO(2))SnAr' ligand, whereas CS(2) is reductively coupled to form an ethylene tetrathiolate li

80 ns, a variety of aryl and vinyl bromides are reductively coupled with alkyl bromides in high yields.

81 i)Pr(2)-4-methylphenyl)-2,4,6-Me(3)C(6)H(2)) reductively couples CO and isocyanides in the presence o

82 nalogue, (C(5)Me(5))(2)Sm(THF)(2), complex 1 reductively couples CO(2) to form the oxalate-bridged di

83 alpha-diimine chromium dimer [(H)L(iPr)Cr]2 reductively couples cyclohexyl isocyanide to produce var

84 complex, [Cu(I)(tmpa)(MeCN)](+), effectively reductively couples NO(g) at RT in methanol (MeOH), givi

85 Benzaldehyde reductively couples to stilbene with 100% selectivity an

86 wild-type Nei and Nei-Q261A mutants could be reductively cross-linked to damaged base-containing DNA.

87 atalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to gi

88 dibromoazabicyclo[2.1.1]hexanes 9 have been reductively debrominated to afford the first reported 2-

89 emonstrate that the D. mccartyi strain CBDB1 reductively debrominated two oligocyclic aromatic phenol

90 s ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tet

91 prominent groundwater pollutant that can be reductively dechlorinated by mixed anaerobic microbial p

92 DDT is reductively dechlorinated to DDD and dehydrochlorinated

93 ous operation, 1,1,1-TCA and TCE were 95-98% reductively dechlorinated to ethane in the H(2)-MPfR, an

94 h high total organic carbon (TOC) and VC was reductively dechlorinated to ethene.

95 This study suggests that PCDD/Fs are reductively dechlorinated to nontoxic non-2,3,7,8 PCDD/F

96 5-chloro-1,2, 4-trihydroxybenzene, which is reductively dechlorinated to produce the common key meta

97 2,6-dichloro-1,4-dihydroxybenzene, which is reductively dechlorinated to yield 2-chloro-1,4-dihydrox

98 of an anaerobic bacterium, strain TCA1, that reductively dechlorinates TCA to 1,1-dichloroethane and

99 Strain 11a reductively dechlorinates TCE, 1,1-DCE, cis-DCE, trans-D

100 ccurring Mn(III)-oxalic acid complexes could reductively decompose certain organic compounds in the e

101 3-dimethylimidazol-2-ylidene borane provides reductively decyanated products in good yields.

102 high potential of plastisphere microbiota to reductively dehalogenate a variety of organohalide pollu

103 nt this difficulty by allowing the enzyme to reductively dehalogenate CHBr(2)NO(2), thereby generatin

104 nic chain reaction by which the precursor is reductively deiodinated with HI.

105 Since alkanethiolate surfactants reductively desorb at potentials close to the onset of C

106 CH(x) and vinyl/vinylidene ad-species can be reductively desorbed only at potentials below 0.2 and 0.

107 ylthio-d-xylulose 5-phosphate (MTXu 5-P) and reductively dethiomethylated to 1-deoxy-d-xylulose 5-pho

108 1,4-Aromatic diesters were reductively dialkylated and then transformed into norbor

109 PCA and other phenazines reductively dissolve Fe and Mn oxyhydroxides in bacteria

110 hown that anaerobic methanogenic archaea can reductively dissolve pyrite and assimilate its products

111 rs coated with Fe or Mn oxides, which can be reductively dissolved from the device under suitable red

112 After 300 days, ferric sorbents were reductively dissolved.

113 reactive organic material, rather than from reductively dissolving Fe or Mn oxides, and that they we

114 he dimer (BFD1) and the trimer (BFD2) can be reductively doped by several mechanisms, including hydri

115 This reductively driven, single-electron chemistry now enable

116 y = 4'-vinyl-2,2':6',2''-terpyridine) can be reductively electropolymerized on nanocrystalline TiO2 f

117 orizontal lineCH2)(O2CCH3-O,O')](-) (6) that reductively eliminate 1-butene, to form [(CH2CO2-C,O)M(O

118 These complexes reductively eliminate Ar-X (X = OH, Br, Cl) in water at

119 he reducing equivalents in hydride bonds and reductively eliminate H(2) upon substrate binding.

120 , reduce some nitrogenase substrates, and/or reductively eliminate H2 to generate reduced iron center

121 ation forms [Cu(III)](C=CAr)(R) species that reductively eliminate R-C=CAr products.

122 These complexes reductively eliminate to form chiral a-aryl-a-fluorooxin

123 The platinum complexes reductively eliminated biaryl compounds in quantitative

124 Compound 2 reductively eliminates benzene upon addition of NCMe at

125 an Ir(V) complex ((carb)PNP)Ir(H)3(Et) which reductively eliminates ethane with a very low barrier to

126 At much slower rates, hydride 20 reductively eliminates free ligand, which ultimately gen

127 of an unprecedented [10-S-4] sulfurane that reductively eliminates to afford a 3,6-dihydrothiazine,

128 oduce a seven-coordinate intermediate, which reductively eliminates to afford product with retention

129 lable Cu(III)-aryl complex that subsequently reductively eliminates to form a C(sp(2))-CF(3) bond.

130 with a copper-mediated transmetalation that reductively eliminates to yield the octapyrrolyl cyclooc

131 f main group elements known to be capable of reductively eliminating a C-F bond to include tellurium.

132 C-H bond of a second styrene molecule before reductively eliminating product.

133 Reductively evolved linker sequence lengths in growth ra

134 The key vinylidene intermediate is generated reductively from a 1,1-dichloroalkene precursor, and DFT

135 ligand, is likely obtained from the in situ, reductively generated 16 VE Fe(0) complex, [Fe{((Dipp)C:

136 rk exploits a through-space interaction of a reductively generated benzylic radical and the nitrogen

137 2) evolution likely occurs by protonation of reductively generated Co(II)H rather than homolysis of t

138 Thus, addition of the reductively generated trichloromethyl radical to a heme

139 imple triamidoamine uranium(III) complex can reductively homologate CO and be recycled for reuse.

140 at in spheroids, isocitrate/citrate produced reductively in the cytosol could enter the mitochondria

141 lecule that activates the drug metronidazole reductively in the treatment of trichomoniasis.

142 jor groove interactions, while the APBIs are reductively inactivated by this enzyme since only the qu

143 a previously unrecognized pathway involving reductively induced transmetalation between Ni(I)(Ar) an

144 S](2+) and [4Fe-4S](2+) clusters in IscU are reductively labile and are degraded within minutes upon

145 omposition was developed that incorporates a reductively labile cross-linker to achieve activated rel

146 By incorporating a reductively labile disulfide linkage in the lipid tail,

147 endered transiently insoluble using a novel, reductively labile disulfide-based cross-linker.

148 n originally introduced for formation of the reductively labile prodrug functionality are detailed.

149 hondrial NFU1, which appears to dimerize and reductively mediate the formation of a bridging [4Fe-4S]

150 Reductively metabolized glutamine is a major cellular ca

151 assigning the NMR peaks to the corresponding reductively methylated amine hinders its use.

152 However, reductively methylated apoE was unable to inhibit smooth

153 Additional experiments showed that reductively methylated apoE, which is incapable of recep

154 umulation because accumulation occurred with reductively methylated LDL and in the presence of an ant

155 e strategies used to assign the NMR peaks of reductively methylated protein amines.

156 oteins containing covalent cross-link(s) are reductively methylated to convert lysine residues to dim

157 free, ferritin bound (from which iron can be reductively mobilized), or transferrin bound (which gene

158 nctionalized, 1,2-heterodifunctionalized, or reductively monofunctionalized byproducts, thereby offer

159 ed P(C) can be both oxidatively (p-type) and reductively (n-type) doped to a conductive state, wherea

160 These can be intercepted reductively or with organolithium reagents to produce di

161 avidus metallidurans, a bacterium capable of reductively precipitating toxic, aqueous gold(I/III)-com

162 are renowned, in part, for their ability to reductively quench excited states by outer-sphere electr

163 he beneficial charge carrier dynamics of the reductively quenched [Ru(bpy)(3)](+) species when the en

164 y)2(dtbbpy)](+)* can be both oxidatively and reductively quenched by Ni4P2 and TEOA, respectively.

165 excited state of the organophotocatalyst is reductively quenched by the hydrogen atom donor, and ret

166 e about 70 ns, and this excited state can be reductively quenched by triethylamine or 1,4-diazabicycl

167 nocyclohexadien-1-ones, which can in turn be reductively quenched for the synthesis of trans-aminoalc

168 on collection at Rh in the excited state and reductively quenched state.

169 ain sufficient thioredoxin NADPH activity to reductively reactivate oxidized PTEN and oppose Akt down

170 The oligoglycosyl alditol reductively released from the least polar pGPL-I was ful

171 the bacterial and mammalian enzymes must be reductively remethylated.

172 The auxiliaries can be reductively removed or cleaved by nucleophilic acyl subs

173 study implied that Tc(VII) migration can be reductively retarded at Hanford site with a retardation

174 (VII) migration in the diffusion columns was reductively retarded with retardation degrees correlated

175 First, the flavin-dependent RslO5 reductively ring-opens the epoxide moiety of an advanced

176 tress response in low-oxygen environments by reductively scavenging nitric oxide (NO).

177 Here, its catalytic A chain (RTA) is reductively separated from the cell-binding B chain, and

178 appearance of dTDP-hexopyranose-5,6-ene (the reductively stabilized dTDP-4-ketoglucose-5,6-ene), and

179 borohydride, which stopped the reaction and reductively stabilized the intermediates and product.

180 we constructed plasmid molecules containing reductively stabilized, site-specific 5fC-polypeptide le

181 R-group" approach, high molecular weight and reductively stable conjugates were accessible without ex

182 of the IPrCO(2), indicating a need for more reductively stable NHCs.

183 rapid and clean conversion of diselenides to reductively stable selenoethers.

184 The Te atomic layer was then reductively stripped from the deposit, leaving the Ge an

185 of producing large amounts of net acetyl-CoA reductively, the cells adapt by reducing their demand fo

186 ecursor is oxidized, decarboxylated and then reductively thiolated to form CoM.

187 The resulting cycloadducts are cleaved reductively to provide azapolycyclic scaffolds with stra

188 Characterization of MRD revealed that it reductively transforms MC into 1,2-cis-1-hydroxy-2,7-dia

189 ic changes allows the mutant IDH1 enzymes to reductively trap alphaKG directly into 2HG, rather than

190 was quantified through a kinetic analysis of reductively triggered chloride dissociation, revealing t

191 f these highly reactive species are shown to reductively trimerize CO to yield rare crystallographica

192 studying the conformational propensities of reductively unfolded RNase A under folding conditions, s

193 e 2,3-epoxide ring in FST C is shown to open reductively via a putative enol intermediate, or oxidati

194 s, the protein linkers of prokaryotes evolve reductively whereas those of eukaryotes do not.