ライフサイエンスコーパス: reengineer

1 of spatial patterns in proliferation may be reengineered.

2 nding and reaction mechanism for biochemical reengineering.

3 ts from the same vector without the need for reengineering.

4 n excellent example of how to systematically reengineer a pharmacophore in order to overcome toxicolo

5 ortance of stability differences in vivo, we reengineered a partially humanized variant of the amino-

6 We have reengineered a red-emitting dicyanomethylenedihydrofuran

7 f promoting CST axon regeneration in vivo by reengineering a developmentally down-regulated, growth-p

8 we compare the efficacy of these methods in reengineering a protein homodimer into a heterodimer.

9 ABY-025 is a small reengineered Affibody molecule targeting a unique epitop

10 The anticancer activity of the reengineered agent, called WBZ_4, was instead preserved

11 ate mechanisms of mAb-mediated protection to reengineer an anti-stalk bNAb to selectively enhance Fcg

12 nize biotechnology by providing the means to reengineer and reprogram cellular regulatory mechanisms.

13 Our reengineering and physiological experiments indicate tha

14 elements align with the concept of knowledge reengineering and represent a sharp departure from top-d

15 ved after the implementation of a systemwide reengineering and, during the period from 1997 through 2

16 ve and noninvasive assay that uses nontoxic, reengineered anthrax toxin-beta-lactamase fusion protein

17 the hypothesis that it should be possible to reengineer archetypal enzymes to achieve substrate speci

18 The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription factor.

19 binding motif does not bind dsRNA but can be reengineered as an RNA ligand.

20 Finally, we demonstrated that these mAbs, reengineered as IgGs, inhibit significant, but variable,

21 g the applicability of synonymous codon pair reengineering as a strategy to effect phenotypic endpoin

22 ions in cells has important applications for reengineering biological functions.

23 Thus, genetically reengineered BoNTs can be targeted to nonneural cells to

24 s provide key insight into how strategies to reengineer both flexible loop and regions distal to the

25 de that retroviral tropism can be rationally reengineered by insertion of short peptide ligands and w

26 elusive in molecular terms and has not been reengineered by site-directed mutagenesis.

27 ors for systemic or hepatic gene transfer by reengineering capsid-glycan interactions.

28 ote efforts to block viral propagation or to reengineer capsids for gene therapy applications.

29 The molecular dynamics of reengineered CAR with CCT fusion results in reduced CAR-

30 More broadly, the reengineered carboxysomes represent a proof of concept f

31 proteins have become prospective targets for reengineering cell wall biosynthetic pathways for the ef

32 evelopment of fermentation processes for the reengineered CEN.PK2 amorpha-4,11-diene strain led to pr

33 . coli, into one of the 'best' substrates by reengineering chromosomal promoters of the mannose trans

34 tructure-activity relationship to rationally reengineer cisplatin could have a major impact globally

35 ntibodies (mAbs) have become one of the most reengineered classes of biological molecules.

36 roposed Cro evolutionary code can be used to reengineer Cro specificity.

37 Successful reengineering depended on choosing a thermostable starti

38 helator or anionic lipids, respectively, the reengineered dynamin displayed the capacity to constrict

39 s the starting point for additional antibody reengineering (e.g. affinity maturation) to generate pot

40 Expanding the genetic code rested on reengineering EF-Tu to relax its quality-control functio

41 plexity and fragility that encumbers protein reengineering efforts and obfuscates the underlying desi

42 ims to design de novo biological systems and reengineer existing ones.

43 ecades, protein engineers have endeavored to reengineer existing proteins for novel applications.

44 Reengineering experiments in the sister species S. pombe

45 plications of DNA electrophoresis can now be reengineered for lower ionic strength, higher field stre

46 vivo RNA binding sites of wild-type (WT) and reengineered forms of the PUF protein Saccharomyces cere

47 chnologies that are capable of fundamentally reengineering genomes from the nucleotide to the megabas

48 We used the atomic-level structure to reengineer gp120 cores to preferentially present the cys

49 These reengineered gp120s are prospective immunogens that may

50 We have reengineered granulocyte colony-stimulating factor to im

51 Strikingly, we could reengineer hepatocyte polarity in embryonic liver tissue

52 DOTA (ABY-027), was created by fusion of the reengineered HER2-binding Affibody molecule ZHER2:2891 t

53 An evolved and reengineered high-specificity M6P/IGF2R domain 11 bindin

54 These reengineered human A1 ARs revealed orthogonality similar

55 These findings identify the reengineered imatinib as an agent to treat GISTs with cu

56 We show that heat sensitivity can be reengineered in both TRPV1 orthologs by a single amino a

57 s of the TS structure, based on their highly reengineered interfaces.

58 Lcn1 can be reengineered into the Anticalin antagonist PRS-060 (elar

59 use of computational protein design tools to reengineer its specificity toward immunogenic elements f

60 As the US health care system begins to reengineer itself to address the need for quality improv

61 We sought to reengineer Lcn1 into an inhalable IL-4Ra antagonist and

62 rategy that, by truncation and computational reengineering, led to a stable construct where both can

63 Our previous formal synthesis was reengineered, leveraging only productive transformations

64 ce, making them among the most significantly reengineered ligand-binding proteins to date.

65 ther, these data support the hypothesis that reengineered ligand-mediated gene delivery should be con

66 Our methods for reengineering lipid A structure may be useful for genera

67 Our reengineered microinjection method results in efficient

68 Our most potent reengineered molecules contain three essential design fe

69 They constitute original platforms for reengineering multiphase reactors towards a higher degre

70 nalyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics.

71 tive, and readily generalizable strategy for reengineering NHRs to respond specifically to a selected

72 wild-type v-Src despite the proximity of the reengineered nucleotide binding site to the phosphoaccep

73 The efficacy and efficiency of the reengineered obligate heterodimer variants of the FokI c

74 The study shows that structural reengineering of a kinase-inhibitory drug to improve tol

75 Minor reengineering of a powerful inhibitor guided by wrapping

76 tion of T-cell epitopes to achieve extensive reengineering of a protein sequence for reduced MHC-II b

77 ble yields; this can be achieved through the reengineering of agrosystems to incorporate built-in dyn

78 Protein reengineering of cellular retinoic acid binding protein

79 Reengineering of cellular retinoic acid binding protein

80 g, the domestication of orphan crops and the reengineering of metabolism in a more directed manner th

81 , and have become exemplary scaffolds in the reengineering of new RNA specificities.

82 PSs) and lay the groundwork for the rational reengineering of NRPSs by swapping domains handling diff

83 The reengineering of protein-small molecule interfaces repre

84 The discovery, design and reengineering of riboswitches offer an alternative means

85 ly focused on transcriptional circuits, with reengineering of signaling circuits hampered by limited

86 y of conventional agonist therapy can be the reengineering of the GPCRs and their agonists.

87 n, nondestructive penetration, and elaborate reengineering of the host's cells to promote their growt

88 mpanying manuscript, Tanaka et al. show that reengineering of the isoprenoid biosynthetic pathway in

89 erminus of the NKG2D ectodomain should allow reengineering of the membrane anchoring from a native N-

90 This fast and scalable reengineering of the MIDAS pipeline enables thousands of

91 Here we showed that reengineering of the receptor binding surface of arresti

92 l recognition particle pathway combined with reengineering of the signal peptide sequence results in

93 out domain or module interactions may enable reengineering of this assembly line enzymatic organizati

94 partment assembly, our results may guide the reengineering of viruses as nanoreactors that self-assem

95 However, this concept reengineers, on increasing temperature, the originally e

96 Here, we introduce PCA-PAM50 as a reengineered, open-source R package PCAPAM50 available o

97 additional variant B.1.617.2 (Delta) without reengineering or reoptimizing the assay.

98 smate mutase activity in Escherichia coli by reengineering parts of the aromatic amino acid biosynthe

99 uccessful policies do not seem to culturally reengineer people.

100 ion of proton-motive force in artificial and reengineered photosynthesis, as well as for management o

101 ntially scalable and cost-effective promoter reengineering platform should streamline the discovery o

102 s identified, the product was submitted to a reengineering process.

103 into a gene cluster, thereby expediting the reengineering process.

104 (4) Reengineer products and systems to make prevention simpl

105 putational approaches have been developed to reengineer promising chimeric proteins one at a time thr

106 The chemical design strategy used to reengineer protein-small molecule interfaces is particul

107 We then display a modified GP muc trimer on reengineered protein nanoparticles that encapsulate a la

108 Reengineering protein-protein recognition is an importan

109 cal activity, measured as the ability of the reengineered proteins to stimulate the proliferation of

110 o bind UAAG and identify the targets of this reengineered PUF in vivo.

111 A reengineered receptor (neoceptor) could be selectively a

112 A reengineered regulatory system inserted into the embryo

113 are these events to other mutations, we have reengineered reporters that detect specific base substit

114 We chemically reengineered rifabutin to enhance its potency against M.

115 opy expression plasmids were introduced into reengineered S. Typhi strains previously tested in clini

116 However, reengineering scientific concepts in light of data is ch

117 and magnitude of subunit communication in a reengineered single-chain version of the homodimeric tra

118 nt studies by Park, Zarrinipar, and Lim with reengineered Ste5 scaffold proteins underscore the funda

119 The primary macrolide produced by the reengineered strain was 6-ethylErA.

120 Such insights will be critical in reengineering suboptimal immune systems in immunocomprom

121 ctional regeneration include gene therapy to reengineer surviving salivary gland tissue, cell-based t

122 ethod of codon harmonization was employed to reengineer the gene sequence for expression in Escherich

123 rystallographic information is available, to reengineer the interface at the sequence-specificity lev

124 state of PAK1, we used molecular modeling to reengineer the isolated IS domain so that it was soluble

125 nowledge of in vivo fluxes can be applied to reengineer the metabolic, regulatory, and phenotypic cha

126 ork, we used a library screening approach to reengineer the multi-specific anti-apoptotic protein Bcl

127 ng mode and leveraged the resulting model to reengineer the Rb so as to significantly increase its bi

128 p sequences, prompting us to computationally reengineer the Rep gene by using synonymous codon pair r

129 hat recognizes an orthogonal promoter and to reengineer the tryptophanyl tRNA-synthetase:suppressor t

130 Here, we reengineered the BG505 SOSIP.664 glycoprotein to engage

131 of bacterial and mitochondrial dynamins, we reengineered the classical dynamin by replacing its PHD

132 We reengineered the human A(2A) adenosine receptor by repla

133 We therefore reengineered the nucleotide-binding pocket of SpoIVA to

134 odel for non-LTR retrotransposition, we have reengineered the Zorro3 retrotransposon, an L1 homolog f

135 discovery, research teams of the future, and reengineering the clinical research enterprise.

136 re, including network-based annotation; (ii) reengineering the database backend and supporting code r

137 strate specificity and provides guidance for reengineering the enzyme to further improve its utility

138 t linkage of the trimers to the liposomes by reengineering the polyhistidine tail to include a free c

139 uld alter the specificity of the reporter by reengineering the protease recognition sequence.

140 Reengineering the receptor footprints of adeno-associate

141 The result of reengineering the regulatory circuitry in this way was t

142 nding diversity within the superfamily or by reengineering the specificity of individual proteins.

143 Reengineering the substrate specificity of BoNT/A's prot

144 experiments also highlight the potential of reengineering the sugar substituents on plant wall polys

145 e cell sources, multi-antigen targeting, and reengineering the TME, are discussed.

146 The results suggest that reengineering the VH/VL interface could be useful in imp

147 e kainic acid biosynthetic pathway, KabA, to reengineer their isoprene donor specificities (geranyl d

148 roenvironment, but instead, they dynamically reengineer their surroundings.

149 the number of such switches is limited, and reengineering them is challenging.

150 entury efficiently, a drastic need exists to reengineer this system into a coordinated, safe, and mor

151 Reengineering this change back into the wild-type cowpox

152 Reengineering this knowledge back into molecular structu

153 tor proteins, and thus are a good target for reengineering through synthetic biology.

154 quality-of-care indicators from 1994 (before reengineering) through 2000 and compared the quality of

155 netic circuits and metabolic pathways can be reengineered to allow organisms to process signals and m

156 ies in rhesus monkeys, the humanized mAb was reengineered to bind to rhesus CD11a by changing four re

157 the 6-deoxyerythronolide B synthase has been reengineered to catalyze two successive rounds of chain

158 When the phage genome is further reengineered to contain like green fluorescent protein o

159 recognition principles, a homeodomain can be reengineered to create factors where its specificity is

160 In some cases, these enzymes have been reengineered to create novel products.

161 which the potent Ad5 vector was genetically reengineered to display the mucosal-targeting sigma1 pro

162 We demonstrate that T cells can be reengineered to express functional ASS or OTC enzymes, i

163 Clones were reengineered to express soluble Fab, and neutrophil bind

164 ow that both luciferase and luciferin can be reengineered to extend the scope of this light-emitting

165 that the alphaI domain of CHD(SOS) could be reengineered to preserve Ras binding, while engaging ano

166 Similar results were obtained when AOX1a was reengineered to target the plastid.

167 Here, we utilized stromal reengineering to disrupt these barriers and move the str

168 A) health care system initiated a systemwide reengineering to, among other things, improve its qualit

169 is infection and for clinical development of reengineered toxin variants for cancer treatment.

170 Our reengineered tumor-selective anthrax toxin exhibits pote

171 cians, systems for managing tests need to be reengineered using methods from reliability sciences.

172 These results suggest that reengineering using the PUF scaffold redirects and can e

173 ficity for acetone as the aldol donor can be reengineered via single active site mutations to accept

174 The reengineering was accomplished through a series of chore