ライフサイエンスコーパス: refinement

1 ation before alphabetaTCR-mediated selection refinement.

2 e role of plant research in its progress and refinement.

3 allows for on-chip protocol development and refinement.

4 ontain uncertainties that may require manual refinement.

5 ust tools for cryo-EM structure modeling and refinement.

6 ion and selection, but also useful for model refinement.

7 ivity undergoing a more protracted period of refinement.

8 types and opens avenues for future treatment refinement.

9 gene is linked to schizophrenia and synaptic refinement.

10 ritical for survival, maturation and circuit refinement.

11 e movements, trial and error, adjustment and refinement.

12 go through various stages of maturation and refinement.

13 t with a complex answer in continual need of refinement.

14 tom force field is found to further speed up refinement.

15 ng of synapses which underlies tonotopic map refinement.

16 work to enable community-driven curation and refinement.

17 estraints remains a major issue in structure refinement.

18 ling plays a crucial role in receptive field refinement.

19 ost suitable model in which to conduct their refinement.

20 can support the diagnostic process but need refinement.

21 a profound role in regulating visual circuit refinement.

22 s of the trapezoid body, shows architectonic refinement.

23 hat exists between degree and consistency of refinement.

24 retinal waves, essential for visual circuit refinement.

25 al columns is critical for postnatal circuit refinement.

26 rovements, and active-learning-based network refinement.

27 visual mapping to ensure congruent bilateral refinement.

28 is a complex procedure and demands technical refinement.

29 NMDA receptors is required for OSN synaptic refinement.

30 nd atomic-level density map-guided structure refinement.

31 rther community-driven model development and refinement.

32 common motif of over-innervation followed by refinement.

33 ransmission electron microscopy and Rietveld refinement.

34 ecades of surgical technique development and refinement.

35 evolutionary mechanisms of assimilation and refinement.

36 s critical for proper maturation and circuit refinement.

37 ttings, and for further application-specific refinements.

38 ackground information for further structural refinements.

39 these environments and suggest future model refinements.

40 Thus, the refinement added by considering both isotopic and bipola

41 ndergo substantial structural and functional refinements after hearing onset.

42 Structure refinements against neutron diffraction and total scatte

43 Protein structure refinement aims to bring moderately accurate template-ba

44 Additionally, our proposed novel feature refinement algorithm could lead to significant enhanceme

45 t, we proposed a novel feature selection and refinement algorithm in conjunction with well-known mach

46 A helix-refinement algorithm made further improvements to the al

47 naptic densities appear to undergo a similar refinement alongside presynaptic maturation.

48 The ensemble refinement analyses show directly, for the first time to

49 Our results thus demonstrate rapid trait refinement and adaptation to the new citrate niche, whil

50 cific cases, suggesting the need for further refinement and analyses of the relationships between use

51 her systematic data are important for policy refinement and assurance of patient safety.

52 This model requires further refinement and external validation, but it may hold prom

53 ity-dependent mechanisms lead to progressive refinement and formation of sharp boundaries between fun

54 ng spontaneous spike bursts to tonotopic map refinement and further highlight the importance of the c

55 ay for their potential use in the reduction, refinement and partial substitution of both animal and h

56 LKB1 modulated postsynaptic horizontal cell refinement and presynaptic photoreceptor axon growth.

57 d-driven activity accelerates the excitatory refinement and shortens the period of activity-dependent

58 This framework's refinement and use will guide interdisciplinary study ar

59 s' critiques and suggestions point to useful refinements and applications of the model.

60 ll-atom molecular dynamics simulations-based refinement, and (iii) a quantitative quality estimate fo

61 such tools is essential for model criticism, refinement, and calibration.

62 ds, with short read sequences (Illumina) for refinement, and constructed telomere-to-telomere assembl

63 Use, refinement, and expansion of this model could lead to th

64 ear signs of diversification and progressive refinement, and it seems likely that at least some tool-

65 l tools for protein structure determination, refinement, and prediction programs.

66 Using cryo-EM and a custom sub-particle refinement approach, we resolved an MuPyV:Fab complex ma

67 Additional refinements based on AFP and wait time may further impro

68 thelium and then undergo a process of branch refinement before forming synapses with sensory hair cel

69 Maintenance of refinement beyond puberty requires a brief, early exposu

70 ably well suited to its function, suggesting refinement by evolution.

71 s of retinal waves and limits visual circuit refinement by phosphorylation at T138.

72 d experimentally that more significant grain refinement can be achieved through increasing nucleation

73 ssively refined during development, but this refinement can be impacted by the emergence of psychiatr

74 a few major classes, followed by definitive refinement, creating subclasses upon settling within the

75 oreover, significant climbing fiber synaptic refinement deficits along with an increased engulfment o

76 not C4B) rescued the visual system synaptic refinement deficits of C4 knockout mice.

77 ddition of secondary pharmacology screens to refinement delivered lead compounds with improved select

78 nation of axonal refinement in species where refinement depends upon spontaneous retinal waves.

79 With successive waveform refinement, durability at 3 months improved from 18% to

80 nsequence of synaptic plasticity and circuit refinement during adolescence.

81 on microglia and on climbing fiber synaptic refinement during cerebellar postnatal development using

82 Auditory experience drives neural circuit refinement during windows of heightened brain plasticity

83 echanism of excitatory and calcium-dependent refinements during late postnatal development, we quanti

84 , acquire their specialized function through refinements during late postnatal development.

85 We present a refinement for finer grained parsing of SDI results in s

86 ody, rendering possible viral adaptation and refinement for humans.

87 tate NMR, XRD, and DFT can improve structure refinement for hydrated materials.

88 automated analysis and incorporating manual refinement for smaller downstream populations.

89 Real-space refinement from pre-existing ligand coordinates of 150 m

90 n improve with training, although perceptual refinements generally require weeks to months of trainin

91 In the medial superior olive (MSO), these refinements generate precise coincidence detection to lo

92 In addition to their role in synaptic refinement, glial cells have also been implicated in pat

93 Grain refinement has been a topic of extensive research due to

94 proaches have shown great promise, but their refinement has been slow and fundamental questions about

95 The traditional approach to grain refinement has been to reduce nucleation undercooling by

96 -quality and complete data set for structure refinement, hierarchical cluster analysis was employed t

97 lopment, (ii) items and conceptual framework refinement, (iii) psychometric property testing, and (iv

98 social and aggressive behavior, but call for refinement in future replications.

99 Technological advances and refinement in implantation techniques have resulted in i

100 In the rat primary auditory cortex, such refinement in layer (L)4 is mainly attributed to improve

101 n as well as their patterns of developmental refinement in naked and Damaraland mole rats.

102 signaling during the critical period for RF refinement in SC.

103 red for the bilateral coordination of axonal refinement in species where refinement depends upon spon

104 nd SC.SIGNIFICANCE STATEMENT Receptive field refinement in superior colliculus differs from more comm

105 Continuing refinement in the capabilities of multimodality imaging,

106 roles in regulating synapse development and refinement in the developing brain, but it is unknown wh

107 which patterned activity regulates synaptic refinement in the MNTB-LSO pathway are still poorly unde

108 erspective, the FBI represents a significant refinement in the use of zebrafish and could be adopted

109 lays a role in experience-dependent synaptic refinement in the visual system at later stages of devel

110 to key populations at highest risk for HIV, refinements in measurement and shifts in the outcomes of

111 This Tansley insight documents how key refinements in molecular cytogenetic approaches, from si

112 rmation of topologically associated domains, refinements in nucleosome positioning on promoters, and

113 Refinements in procedure and patient selection seem poss

114 Refinements in the selection of grafts and transplant ca

115 Refinements in the selection of grafts and transplant ca

116 We report technical refinements, including removal of extracellular antioxid

117 analyses, computational modeling, and Pawley refinement indicate that the solvated 2D COFs experience

118 al experience in maintaining receptive field refinement into adulthood, and that this maintenance is

119 Protein structure refinement is an important step of protein structure pre

120 swarm optimization algorithm-based structure refinement is designed, where each structure is consider

121 However, further signal processing refinement is needed in addition to utilization of an in

122 However, further refinement is needed to this class of agents, particular

123 sense and modulate neural activity, further refinement is required on the spatiotemporal resolution,

124 as initially made slow (70 s(-1)), but after refinement, it became fast (~500 s(-1) for model A and ~

125 With the refinement iterations, the particles move around.

126 e window for activity- and calcium-dependent refinements limited to shortly after hearing onset.

127 e highlighted, along with strategic research refinements made by the Joint Center for Energy Storage

128 lustrated by grain initiation maps and grain refinement maps and validated by experiments.

129 Continued refinement may improve AI applicability and allow for au

130 ance, early interventions, and cHL treatment refinements may favorably affect patient longevity, part

131 hts a broadly applicable nanoscale structure-refinement method and provides insights into the structu

132 ificial Intelligence-based protein structure Refinement method called AIR.

133 n particular, after using our torsion angles refinement method OPUS-Refine as the post-processing pro

134 We developed a high-resolution cryo-EM refinement method that divides an imaged microtubule int

135 we exploit our recent advances in structure-refinement methodology to demonstrate how such models ca

136 chical neural pathway where excitatory input refinement might occur.

137 A new Rietveld refinement model including preferred orientation paramet

138 ALS and discuss the further developments and refinements needed to accelerate the introduction of eff

139 ype by the genetic assimilation and adaptive refinement of a plastic trait can be a source of biologi

140 cement (MR) model identified by unsupervised refinement of a pool of 50 candidate MR models.

141 Further refinement of a roadmap of breast cancer progression wil

142 (such as those with cryptogenic stroke), the refinement of AF and stroke prediction schemes through c

143 ibution within cluster materials by the free refinement of atomic scattering factors.

144 lecular dynamics (CDMD) method for automated refinement of atomistic models into cryo-electron micros

145 cues in sequential fashion, allowing precise refinement of axon trajectories.

146 These novel findings could lead to refinement of BCG as both a vaccine for infectious disea

147 the use of group metrics could allow for the refinement of behavioural protocols carried out in a ran

148 ill highlight knowledge gaps, further inform refinement of biological models, and support new experim

149 ability track individual differences in the refinement of borders between brain systems.

150 increases overall activity, accelerates the refinement of calcium signaling and excitatory inputs wi

151 To allow for systematic refinement of candidate network models by comparison wit

152 There has been great progress in the refinement of clinical diagnostic criteria in the past d

153 healthcare education, allowing rehearsal and refinement of clinical skills.

154 for including spectral data as input in the refinement of coarse-grained potentials.

155 that innate connectivity instructs the later refinement of cortex.

156 plasticity and modulate experience-dependent refinement of cortical circuits during development.

157 Here, ensemble refinement of crystallographic structures, which uses mu

158 Further refinement of culture media is needed to improve the qua

159 wareness of lifestyle factors and a possible refinement of current assisted reproduction techniques a

160 with established DKD will facilitate further refinement of current guidelines.

161 haracterization of transmission dynamics and refinement of disease burden estimates and will provide

162 tial acuity depend upon experience-dependent refinement of distinct stages in the mammalian visual sy

163 inclusion of a biological repair model, (3) refinement of DNA damage parameters for direct damage an

164 orts to improve existing families, including refinement of domain boundaries, their classification in

165 gions and provide evidence of layer-specific refinement of DSD over adolescent brain development.

166 nd evidence for cooperative facilitation and refinement of each TF's binding profile in a combinatori

167 y exhibit heightened synaptic plasticity and refinement of electrophysiological properties and connec

168 In addition, the refinement of emerging biomarkers of therapeutic benefit

169 Thus, the refinement of excitation, inhibition, and intrinsic prop

170 tatory connections plays a major role in the refinement of excitatory input tuning of L4 neurons.SIGN

171 ical excitation plays a dominant role in the refinement of excitatory input tuning.

172 Which cues instruct the refinement of excitatory inputs, calcium signaling, and

173 This renewed interest has spurred the refinement of existing computational methods as well as

174 knowledge of species relationships, and the refinement of existing species concepts.

175 This allows the refinement of experimental protocols because immunity ca

176 risk assessment and case-mix adjustment, but refinement of factor weights may be indicated.

177 During learning, the refinement of fine and gross movements was behaviorally

178 -wide chromatin accessibility through subtle refinement of H2A.Z patterns, providing a means to repro

179 framework have been revealed by the Rietveld refinement of high-resolution synchrotron X-ray powder d

180 The refinement of inhibitory inputs that convey sensitivity

181 sessment is being recognized through ongoing refinement of interpretative guidelines and emerging evi

182 n on the mechanisms that guide formation and refinement of intrinsic connections between amygdaloid n

183 e hypothesis that in long-lived species, the refinement of migratory behaviour and year-round spatial

184 beta-dependent processes in the learning and refinement of motor skills and the balanced expression o

185 interneuron types shapes the development and refinement of negative prediction-error neurons in a com

186 ave been implicated in the establishment and refinement of neural circuits during development.

187 can potentially contribute to developmental refinement of neuronal circuits and associated behaviors

188 of the nervous system, experience-dependent refinement of neuronal circuits predominantly involves s

189 can potentially contribute to developmental refinement of neuronal circuits.SIGNIFICANCE STATEMENT T

190 arly postnatal development, we find that the refinement of OHC afferent innervation is regulated by c

191 need for further research, development, and refinement of online interventions for women experiencin

192 with different site positions and scaffolds, refinement of our cupredoxin models, and enhancement of

193 the PFC during adolescence is necessary for refinement of prefrontal GABAergic function, the absence

194 For successful translation, MSOT requires refinement of probes and data-acquisition systems to tai

195 prostate cancer risk delineation can enable refinement of prostate cancer molecular taxonomy into cl

196 Our findings suggest that refinement of recommended screening strategies for IGHG

197 Therefore, the simple refinement of replacing tail with tunnel handling for ro

198 The development and refinement of SCS technologies has led to massive reduct

199 e last several decades have seen substantial refinement of SMS techniques, recording excitation spect

200 o the hA(2B) receptor, and we herein provide refinement of such models with the fluorinated compounds

201 in oncology.ASCO's 2020 Advance of the Year-Refinement of Surgical Treatment of Cancer-highlights ho

202 ng the brain, including in the formation and refinement of synapses.

203 f dendritic spines is a key component of the refinement of synaptic connections during learning.

204 e roles in CNS homeostasis through continued refinement of synaptic connections.

205 ssion and, hopefully, to the development and refinement of tau-based therapeutics.

206 in metagenomic binning, (ii) development and refinement of technology for the rapid identification an

207 Here, we initially pursued computation-based refinement of the ACAP1 lattice to identify its critical

208 We report chemical refinement of the antiarrhythmic drug mexiletine via hig

209 Further refinement of the characterization of interindividual va

210 s is feasible and reliable; however, further refinement of the criteria specifically for children is

211 ts and may require further investigation and refinement of the developed techniques.

212 We propose a refinement of the hypothesis of 'facilitated poaching' t

213 Bunch Energy Acoustic Tracing (I-BEAT), is a refinement of the ionoacoustic approach.

214 We provide a rigorous and traceable refinement of the IPCC 2006 default rates in tropical an

215 values increased two to threefold due to the refinement of the microstructural constituent.

216 This method is a refinement of the minHash LSH used to approximate the Ja

217 e will guide further biochemical studies and refinement of the model to increase the accuracy of the

218 For organic acids, a further refinement of the model will be required as large deviat

219 ort the discrimination of xylene isomers via refinement of the pore size in a series of porous metal-

220 Our findings suggest a refinement of the prevailing ideas regarding coding sche

221 Based on results presented here, involving refinement of the surgical technique and donor selection

222 mature nervous system requires a significant refinement of the synaptic connections initially formed

223 europsychological circuitries is an original refinement of the theory of conflict.

224 This calls for refinement of the theory which posits that to integrate

225 icroscopy maps enabled de novo modelling and refinement of the transposition protein TniQ, which bind

226 We highlight that refinement of the weak empirical evidence base is vital

227 This synchronization is required for the refinement of their immature afferent innervation.

228 Analysis of directed mutants enabled refinement of these motifs and characterization of prote

229 A refinement of these variables is advocated in order to f

230 A recent refinement of this approach allows the roles of essentia

231 Refinement of this library with NMR residual dipolar cou

232 Further refinement of this study, including larger cohorts with

233 Beyond the indispensable refinement of tools and procedures, resolving crises wou

234 cting antidepressant and the development and refinement of tools capable of selectively altering the

235 fore the onset of hearing is involved in the refinement of topographic maps as well as in setting the

236 portant implications for the development and refinement of treatment strategies for psychiatric disor

237 ontaneous activity is sufficient for spatial refinement of visual receptive fields (RFs) in superior

238 n which learning takes place and calls for a refinement of VPL theories to incorporate exposure-based

239 dentify gaps in the knowledge, including the refinement of waist circumference threshold values for a

240 Further refinement of who would benefit most and when best to ad

241 Crystallographic refinements of high-resolution synchrotron powder X-ray

242 ion, which are associated with developmental refinements of neuronal circuits.

243 Rietveld refinements on X-ray and neutron powder diffraction data

244 t and improve upon atomic model building and refinement options.

245 l encompasses procedural memories, kinematic refinement, or both is still debated.

246 to improve protein structure prediction and refinement outcomes.

247 used to guide dendrimer construct design and refinement prior to embarking on more time consuming and

248 We describe a two-step refinement procedure that involves identifying collectiv

249 ling and refined by a least-squares Rietveld refinement procedure.

250 development, the nervous system undergoes a refinement process by which neurons initially extend an

251 lies in the uniform structure prediction and refinement protocol, as well as the extensive structural

252 entions of sensory circuits demonstrate that refinement rates depend on distinct inputs from sensory-

253 nded regime of strength weakening with grain refinement, referred to as the inverse HP relation.

254 The structure refinement required the use of a (3+1)-dimensional super

255 We find that this synaptic refinement requires the OSN-specific olfactory receptor

256 Reductions in input-dependent refinement result in mature functional interhemispheric

257 attering data with comprehensive docking and refinement revealed how XPA DBD and RPA70AB orient on mo

258 cessary and sufficient to maintain visual RF refinement, robust looming responses, and visual acuity

259 These refinements show that the coherence length of the rhombo

260 agment adjustment and atomic-level structure refinement simulations.

261 us identifying priorities for the structural refinement studies described herein.

262 XRD Rietveld refinement studies reveal the hexagonal Wurtzite ZnO NRs

263 d to guide further inhibitor development and refinement targeting EBOV.IMPORTANCE The most recent Ebo

264 Experimental results on CASP11, CASP12 refinement targets and blind tests in CASP 13 turn to be

265 The method is tested on 20 refinement targets from the CASP12 competition and is fo

266 fit using the empirical potential structure refinement technique (EPSR) to elucidate the nearest nei

267 T), which was developed initially as a grain refinement technique, was extended recently to the mecha

268 add predictive ability to the RMBF, a major refinement that extends its practical applications.

269 method for X-ray density ligand fitting and refinement that is suitable for a wide variety of small-

270 stsynaptic targets, followed by a process of refinement that takes place during development and is in

271 he 3R-principles (replacement, reduction and refinement), the well-established and easy-to-handle CAM

272 We envision that, with further refinement, this label-free method of T cell phenotyping

273 roduce consistent and substantial structural refinement through the use of cumulative and non-cumulat

274 ing conformational sampling during structure refinement through the use of machine learning based res

275 lopment, sensory cortex undergoes functional refinement, through which the size of sensory receptive

276 We here use subvolume refinement to achieve a 3.4 angstrom resolution structur

277 Here, we describe a refinement to core genome multilocus sequence typing (cg

278 ially resolved anomalous dispersion (SpReAD) refinement to determine oxidation assignments for the in

279 ed into the approach to enable the iterative refinement to identify molecular phenotypes associated w

280 mational sampling and template-guided energy refinement to produce a variety of possible poses, and t

281 X-ray crystallography coupled with ensemble refinement to study the AS-associated HLA-B*27:05 subtyp

282 As part of the 2019 Refinement to the 2006 IPCC Guidelines for National Gree

283 nical features, and interventions, can bring refinement to the prediction of 30-day readmission in hi

284 These data introduce important refinements to current models, show that molecular infor

285 Results suggest possible refinements to current policies, including emphasizing t

286 We propose refinements to current protocols to monitor and exclude

287 l and spatial resolution of data, as well as refinements to data on workplace skills.

288 e critical point, agents exploit incremental refinements to systematically advance towards success, w

289 nsplant pathology details clarifications and refinements to the criteria for chronic active (CA) T ce

290 Structure refinement unveiled the successful formation of entangle

291 Rietveld refinement using synchrotron X-ray diffraction data reve

292 users to submit selected models for further refinement via convenient push buttons.

293 h the image fitting and subsequent structure refinement was found to be strongly correlated with the

294 ryo-electron microscopy and forcefield-based refinement, we characterize the binding of eight analogu

295 With more characterization and refinement, we envision that marcAST can become a potent

296 Furthermore, box-car type refinements were conducted.

297 Further testing and refinement will likely be needed, but this basket can be

298 es are excellent starting points for further refinement with additional experimental restraints (stru

299 age cleaning and procedures provides a major refinement with little if any cost for familiarisation.

300 ulated annealing, and allows fully automated refinement without manual intervention or any additional