ライフサイエンスコーパス: regenerative

1 mature mouse hearts that were otherwise non-regenerative.

2 resources provide a platform to leverage the regenerative abilities of neonatal skin to develop clini

3 In this Primer article, we review these regenerative abilities, highlighting the phylogenetic po

4 hed conditioning significantly increases the regenerative ability of dorsal root ganglia (DRG) sensor

5 e studies provide a paradigm that drives the regenerative ability of sensory neurons offering a poten

6 Overcoming the restricted axonal regenerative ability that limits functional repair follo

7 hypoxia signaling holds promise for rescuing regenerative activity in old muscle.

8 gh) cells account for virtually all in vitro regenerative activity of airway lineages.

9 whereas the fast events represent intrinsic regenerative activity, the slow events reflect the elect

10 iate natural tissue rejuvenation and perform regenerative acts prompted by injuries.

11 r plasmonic nanoantenna-based biosensors are regenerative, allowing multiple measurements using the s

12 Distal (regenerative) and proximal (non-regenerative) amputations showed significant differences

13 ase of high economic impact and the reported regenerative and antibacterial effects of mesenchymal st

14 sm of Yap and Tgf-beta activities to balance regenerative and fibrotic signals.

15 enic properties, which, in turn, facilitates regenerative and hypertrophic processes that restore str

16 In particular, regenerative and immunomodulatory EVs hold potential as

17 cells (MSCs) represent a novel approach for regenerative and immunosuppressive therapy.

18 a simple carbon-mediated 'trade-off' between regenerative and vegetative growth.

19 Distal (regenerative) and proximal (non-regenerative) amputation

20 Together, our data indicate that highly-regenerative animals employ a robust DNA damage response

21 ed to influence the material's potential for regenerative applications.

22 an be used for the development of cell-based regenerative approaches in dentistry and medicine.

23 HSCs present a complex variety of regenerative behaviours at the clonal level, but the mec

24 injury are critical for our understanding of regenerative biology, and might facilitate the identific

25 espite its importance in human fertility and regenerative biology, our understanding of this unique t

26 t an extraordinary pace in developmental and regenerative biology.

27 itive manufacturing processes used to create regenerative bone tissue engineered implants are not bio

28 annels play a critical role in mediating the regenerative Ca(2+) oscillations induced by physiologica

29 mice, which may contribute to the different regenerative capabilities of MG from fish and mammals.

30 lthough the mammalian retina has no inherent regenerative capabilities, fish have robust regeneration

31 g materials with promising adaptive and self-regenerative capabilities.

32 rian worms, which due to their extraordinary regenerative capability can experimentally result in phe

33 Regenerative capability of the peripheral nervous system

34 entral nervous system (CNS) has very limited regenerative capability, and injury at the cellular and

35 RREs are likely a crucial source of loss of regenerative capacities in vertebrates.

36 Using models with different regenerative capacities, followed by gain- and loss-of-f

37 However, for reasons unknown, such regenerative capacity (plasticity) is lost once supporti

38 characterize its biophysical properties and regenerative capacity both in vitro and in vivo.

39 rganisms replace lost or damaged tissue, and regenerative capacity can vary greatly among species, ti

40 This loss of regenerative capacity coincides with reduced damage-resp

41 s in animal species with substantial cardiac regenerative capacity dominantly comprise diploid cardio

42 hanosensitive Hippo pathway, correlates with regenerative capacity in acceleration-sensing utricles o

43 de that polyploid hepatocytes have extensive regenerative capacity in situ and routinely undergo redu

44 ents a default tissue program activated when regenerative capacity is limited.

45 Regenerative capacity is robust in the neonatal mouse he

46 l mammals have convincingly demonstrated the regenerative capacity of cardiomyocytes.

47 edly enhanced the ischemic tolerance and the regenerative capacity of fatty liver.

48 nsplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs

49 a requirement for the intrinsic clock in the regenerative capacity of insulin-producing cells followi

50 The poor regenerative capacity of neural tissue highlights the ne

51 ng via syndecan binding may also enhance the regenerative capacity of other growth factors.

52 The regenerative capacity of the heart has long fascinated s

53 d decline in the levels of neurogenesis, the regenerative capacity of the hippocampus also subsided w

54 stinal stem cells in vitro recapitulates the regenerative capacity of the intestinal epithelium(1,2).

55 Intestinal stem cells (ISCs) maintain regenerative capacity of the intestinal epithelium.

56 e polyploidy was not associated with altered regenerative capacity or tissue fitness, changes in gene

57 Satellite cells provide regenerative capacity to the skeletal muscle after injur

58 leading to decreases in tissue function and regenerative capacity(1-3).

59 tral nervous system (CNS) loses function and regenerative capacity(5-7).

60 This transient regenerative capacity, alongside their close evolutionar

61 unction, diminished pulmonary remodeling and regenerative capacity, and increased susceptibility to a

62 In mammals, hair cells lack regenerative capacity, and their death leads to permanen

63 of cellular senescence can promote impaired regenerative capacity, chronic inflammation, and tumorig

64 The adult mammalian heart has limited regenerative capacity, mostly attributable to postnatal

65 nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent co

66 ae, finding that larval tendons display high regenerative capacity.

67 M) undergoes remodeling, and the heart loses regenerative capacity.

68 nflammatory injury were compromised in their regenerative capacity.

69 The adult mammalian heart has a limited regenerative capacity.

70 l muscle, the heart possesses only a minimal regenerative capacity.

71 that impact stem cell plasticity and impair regenerative capacity.

72 is is paralleled by a progressive decline of regenerative capacity.

73 rates, but should not be to the detriment of regenerative cell populations, primarily mesenchymal ste

74 residual disease (RD) expressed an alveolar-regenerative cell signature suggesting a therapy-induced

75 papillary fibroblasts that form a transient regenerative cell type that promotes healthy skin regene

76 inomas are characterized by the emergence of regenerative cell types, typically seen in response to l

77 d lower tubules comprise a unique, unipotent regenerative compartment.

78 Both conditions demonstrate regenerative components that are just now being identifi

79 otent BSCs can reactivate multipotency under regenerative conditions and upon oncogene expression(3,9

80 iotic molecules as well as a multistep, self-regenerative cycle of iminodiacetic acid were validated

81 scence is a major determinant of age-related regenerative decline in the adult hippocampus.

82 This review presents a model for age-related regenerative decline in the fly intestine and discusses

83 n, O-GlcNAc, as a key molecular regulator of regenerative decline underlying an age-related NSC fate

84 in myogenic cells contributes to aged muscle regenerative decline.

85 cytes, that are hyperproliferative, yet have regenerative deficits and are shifted towards a de-diffe

86 tly counteracts the metabolic, ischemic, and regenerative deficits of fatty liver.

87 ent inflammation is a feature of age-related regenerative deficits, yet the underlying mechanisms are

88 marked variation in tissue architecture and regenerative demands, SCs often follow similar paradigms

89 Perspective, we discuss the rise of the CNS regenerative drugs, the main biological techniques used

90 This study aimed to investigate the regenerative effects of 2,3,5,4'-tetrahydroxystilbene-2-

91 hoinositide-binding properties abrogated the regenerative effects.

92 s between active-site chemical catalysis and regenerative electron transfer.

93 the most critical and difficult concerns for regenerative endodontics therapy (RET).

94 atible constructs for biosensors, tissue and regenerative engineering and bioelectronics.

95 apable of dual drug release are designed for regenerative engineering and drug delivery applications.

96 L-rGO scaffolds are a promising platform for regenerative engineering applications.

97 important technique to develop scaffolds for regenerative engineering incorporated with drug(s).

98 c fields on cellular processes in tissue and regenerative engineering is now easily possible.

99 Here, we identify regenerative factors in neonatal murine skin that transf

100 y increasing the expression of hematopoietic regenerative factors.

101 the cellular and molecular logic behind the regenerative failure of injured RGC axons in adult mamma

102 es the genuine state at a young age, causing regenerative failure of muscle, as occurs in geriatric m

103 egulating myeloid cell cycle, maturation and regenerative function of the epithelial niche in ST2(-/-

104 mes, and is a potent diffusible inhibitor of regenerative growth in NgR1-expressing axons.

105 s as severed axons transition from injury to regenerative growth.

106 -propagating PLCdelta1 activity supported by regenerative H(+) and Ca(2+) .

107 cute tendon injuries, but the driver of this regenerative healing response remains unknown.

108 diac growth, coronary vessel patterning, and regenerative heart repair.

109 been hampered due to concerns about nodular regenerative hyperplasia (NRH) of the liver.

110 rentiation can cause aberrant persistence of regenerative intermediate stem cell states.

111 fect is guided by microchannel size-specific regenerative macrophage polarization with the consequent

112 thesized chaperone ApoM as a circulating pro-regenerative mediator that is deficient in aging and mit

113 bioprinting for tissue engineering (TE) and regenerative medicine (RM).

114 Regenerative medicine aims to repair, replace, or restor

115 These findings have implications for regenerative medicine and anticancer treatments.

116 key components of many biomaterials used for regenerative medicine and drug delivery.

117 oaches to direct cellular behaviour for many regenerative medicine applications including those for p

118 e tissue-engineered cartilage constructs for regenerative medicine applications.

119 d as a novel tool for cellular and acellular regenerative medicine approaches for osteoarthritis (OA)

120 nant of RPE phenotype, with implications for regenerative medicine approaches that utilise stem cell-

121 Regenerative medicine approaches to enhancing beta cell

122 hould be used to inform ongoing integrative, regenerative medicine approaches to HSCR.

123 vitro tissue models, tissue engineering, and regenerative medicine are provided to further motivate f

124 caffolds unveils great potential not only in regenerative medicine but also in drug testing and disea

125 n induced pluripotent stem cell (iPSC)-based regenerative medicine can be applied; however, mass prod

126 n of Wnt signaling has untapped potential in regenerative medicine due to its essential functions in

127 efficacy of mesenchymal stem cells (MSCs) in regenerative medicine has been documented in many clinic

128 The field of tissue engineering and regenerative medicine has made numerous advances in rece

129 tors the location of SPIO-labelled cells for regenerative medicine of the knee with MRI, histology, a

130 e further exploited to devise strategies for regenerative medicine purposes.

131 her development, this approach may provide a regenerative medicine solution to uterine factor inferti

132 f non-collagenous matrix and suggesting that regenerative medicine strategies should change focus fro

133 f applications including neural engineering, regenerative medicine, multi-functional sensors and actu

134 mmes has been proposed as a new paradigm for regenerative medicine, therefore, a complete understandi

135 genome editing easier, and may be useful in regenerative medicine, unravelling heterogeneity in dise

136 edical application such as drug delivery and regenerative medicine.

137 ity in the efficient production of cells for regenerative medicine.

138 e implications for harnessing Wnt agonism in regenerative medicine.

139 ding tissue SCs has led to major advances in regenerative medicine.

140 ramming, which has important implications in regenerative medicine.

141 and appendage regeneration is a key goal of regenerative medicine.

142 safety of PSC-derived cellular therapies for regenerative medicine.

143 r in vitro tissue models and applications in regenerative medicine.

144 otential use of viscoelastic biomaterials in regenerative medicine.

145 esis in the context of blood pathologies and regenerative medicine.

146 tic framework to evaluate future research on regenerative medicine.

147 ditions is emerging as a promising option in regenerative medicine.

148 2 as a therapeutic target in stem cell-based regenerative medicine.

149 ns for the generation of bona fide hPSCs for regenerative medicine.

150 delivers a powerful technique to facilitate regenerative medicine.

151 in PSCs, and improve their effectiveness in regenerative medicine.

152 as the foundation of tissue engineering and regenerative medicine.

153 ) would have broad reaching implications for regenerative medicine.

154 tional applications in skeletal muscle-based regenerative medicine.

155 EVs and their cargo as therapeutic agents in regenerative medicine.

156 regeneration with potential implications in regenerative medicine.

157 ards informing the design of therapeutics in regenerative medicine.

158 votal advancements in tissue engineering and regenerative medicine.

159 ations, especially in tissue engineering and regenerative medicine.

160 ue engineering processes for applications in regenerative medicine.

161 more mature cardiomyocytes for research and regenerative medicine.

162 tuned spatiotemporal manner for personalized regenerative medicine.

163 ease modeling, toxicology, cell therapy, and regenerative medicine.

164 nsplantation, graft versus host disease, and regenerative medicine.

165 ructs in the field of tissue engineering and regenerative medicine.

166 tems have impeded their use in translational regenerative medicine.

167 s has important potential in biomedicine and regenerative medicine; however, it often requires comple

168 m cells as a prerequisite for harnessing the regenerative-medicine potential of these cells in the cl

169 Regenerative medicines that promote remyelination in mul

170 without reducing the development of the pro-regenerative microenvironment required for ductular rege

171 educe scar formation while maintaining a pro-regenerative microenvironment will be essential in devel

172 neurons offering a potential redox-dependent regenerative model for mechanistic and therapeutic disco

173 cues and modulating secretion of instructive regenerative molecules in response to dynamic signaling

174 A better understanding of the regenerative nature of hantavirus-induced glomerulopathy

175 which is normally found at low levels in non-regenerative neurons.

176 This pro-regenerative neutrophil promoted repair in the optic ner

177 ter mechanistic models in planaria and other regenerative organisms.

178 ivation in the progenitor niche to determine regenerative outcome in fibrosis.

179 We also examine the spectrum of regenerative outcomes, including preclinical and clinica

180 Regenerative pain medicine, which seeks to harness the b

181 Here we report a regenerative paradigm that we call enriched conditioning

182 populations, with no adverse effects on key regenerative parameters.

183 fs adjacent to genes that regulate essential regenerative pathways.

184 lutionized DPSCs significantly shortened the regenerative period of periodontal defects by enhancing

185 rated that chick fetal wound healing shows a regenerative phenotype regarding the cellular and molecu

186 nipulated to adopt a neuroprotective and pro-regenerative phenotype that can aid repair and alleviate

187 ology, as well as comparison of scarring and regenerative phenotypes to uncover master regulators of

188 type to exploit the physics governing spinal regenerative plasticity.

189 ponse and enables intestinal epithelial cell regenerative plasticity.

190 A key question is whether cells with regenerative potential contribute to brain health and ev

191 However, this regenerative potential declines with age due to unknown

192 ous axon growth through the injury, but this regenerative potential diminishes with maturity until it

193 in zebrafish may provide cues to unlock the regenerative potential in the mammalian nervous system.

194 We investigated the vasculoprotective and regenerative potential of a newly identified PPARgamma-p

195 an shed significant light on the quality and regenerative potential of cultivated human corneal epith

196 In order to harness the regenerative potential of growth factors and stimulate b

197 acing in BAC-transgenic mice, we confirm the regenerative potential of intestinal stem cells (ISCs) b

198 Humans have limited regenerative potential of musculoskeletal tissues follow

199 rogenic progenitors is key to harnessing the regenerative potential of the retina.

200 The study thus revealed an unappreciated regenerative potential of the young DG and suggests hipp

201 faithfully maintaining genomic integrity and regenerative potential remains elusive.

202 (ER) cell survival, exit from quiescence and regenerative potential upon gamma radiation-induced inju

203 that inactivation of Drp1 causes loss of HSC regenerative potential while maintaining HSC quiescence.

204 e arrest, resulting in impaired homeostasis, regenerative potential, and gradual functional decline i

205 to a pro-fibrotic phenotype, expanding their regenerative potential, and improving healing in a compl

206 regulation can directly affect the zebrafish regenerative potential.

207 The adult human heart is an organ with low regenerative potential.

208 1, and recombinant IL-11 enhances crypt cell regenerative potential.

209 rate in capturing the overall benefit of the regenerative procedure and (2) to better identify which

210 e defects and may be a promising adjuvant in regenerative procedures.

211 Membrane durability is critical for regenerative procedures.

212 This regenerative process is critical for the re-establishmen

213 However, the regenerative process is highly complex, and premature cl

214 Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone induction in resp

215 es to study lung development, infection, and regenerative processes in vitro.

216 Regenerative processes that maintain the function of the

217 reactivate nerve-dependent developmental and regenerative processes to promote their growth and survi

218 and plays chief roles in carcinogenesis and regenerative processes.

219 We identify two regenerative progenitor populations, sox10(+) perichondr

220 raising the hypothesis as to the presence of regenerative progenitor-like populations in the adult pa

221 terocytes show basal induction of the Clu(+) regenerative program and a fetal gene expression signatu

222 To better understand how a regenerative program is fulfilled by neural progenitor c

223 ablished an inducible PPARgamma-p53 mediated regenerative program regulating 19 genes involved in lun

224 s inhibitory Hippo signaling and facilitates regenerative proliferation in nonmammalian utricles, whe

225 cell nuclei in chicken utricles and promoted regenerative proliferation, but YAP remained cytoplasmic

226 elops as repair Schwann cells lose their pro-regenerative properties and inhibitory factors such as C

227 heterogeneity is critical to understand its regenerative properties and malignancies.

228 ulation and maturation of NGF, improving the regenerative properties of dASCs.

229 rovskite lattice, which explains the unusual regenerative properties of these materials.

230 el blood-derived embolic material (BEM) with regenerative properties, that can achieve instant and du

231 teady network structure yet shows remarkable regenerative properties.

232 anscriptional programs spanning stem-like to regenerative pulmonary epithelial progenitor states.

233 able various biomedical applications such as regenerative repair in medicine and biosensing in bioeng

234 atricellular proteins SMOC2 was required for regenerative repair.

235 ssibly be a suitable scaffold for use within regenerative (reparative) endodontic techniques.

236 -specific ablation of Ptger4 misdirected the regenerative reprogramming of stem cells and prevented S

237 The molecular mechanisms that mediate the regenerative response and its blockade in later life are

238 In turn, the dysbiotic microbiome triggers a regenerative response and stimulates tumor growth.

239 We showed that LOXL2 is elevated in the regenerative response during fracture healing in mice an

240 intestinal (GI) syndrome, elucidation of the regenerative response following radiation-induced gut in

241 In summary, the regenerative response in FSHD muscle biopsies correlates

242 ed P2RX7 and P1R participation in the retina regenerative response induced by photoreceptor damage ca

243 While a regenerative response is often provoked in many muscular

244 dystrophies, little is known about whether a regenerative response is regularly elicited in FSHD musc

245 in debris after injury and tailor a specific regenerative response is unclear.

246 epithelial-mesenchymal transition (EMT)-like regenerative response manifested by cytoskeletal remodel

247 Our findings suggest that Runx1 controls the regenerative response of multiple cardiac cell types and

248 in chondrocytes, and restoration of youthful regenerative response to aged, human muscle stem cells,

249 h1 intracellular domain (N1ICD) and impaired regenerative response to injury in comparison to young (

250 Regenerative response to skeletal muscle injury in Speg-

251 f adult limb joints in mice by stimulating a regenerative response using microfracture (MF) surgery.

252 roliferation in vitro, possibly reflecting a regenerative response, but is dispensable for chondrocyt

253 al processes into the execution of a correct regenerative response.

254 tive role of KLF4 during the postirradiation regenerative response.

255 dative stress and senescence and an impaired regenerative response.

256 yte polarity, canalicular structure, and the regenerative response.

257 nd knee joint, induces chondroprotective and regenerative responses, and attenuates NF-kB signaling.

258 amplify WNT signaling during development and regenerative responses.

259 improved cognitive outcome without affecting regenerative responses.

260 d routinely undergo reductive mitoses during regenerative responses.

261 turation, (d) recent insights related to the regenerative role of the subpopulation of CMs that are n

262 esults suggest that GM may serve as a viable regenerative scaffold for pulp regeneration.

263 small molecules is described to localize pro-regenerative signaling at the injury site.

264 While regenerative signaling by reactive oxygen species (ROS)-

265 Identification of molecular signatures and regenerative signaling pathways for each surgical proced

266 "niche" to transition between quiescent and regenerative states.

267 rentiation, marking the coming-of-age of the regenerative stem cell plasticity model.

268 Regenerative stem cell-like memory (T(SCM)) CD8(+) T cel

269 has limited the search for otoprotective and regenerative strategies.

270 nale for considering endocardial function in regenerative strategies.

271 s(1) and inhibition of apoptosis with tissue-regenerative strategies.

272 studies provide encouraging evidence that a regenerative strategy for patients will be available in

273 racing strategies and experimental models of regenerative stress have revealed a degree of plasticity

274 Cs) have been the focus of developmental and regenerative studies, yet our understanding of the signa

275 ive benefits of Er:YAG laser irradiation for regenerative surgical therapy of peri-implantitis-associ

276 ound-healing responses may ultimately affect regenerative therapies for patients.

277 ther distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacemen

278 therapeutic options are urgently needed, but regenerative therapies have remained an unfulfilled prom

279 e development of characterization assays for regenerative therapies that could be integrated into a g

280 ) metabolism may be a target for periodontal regenerative therapies.

281 inical application in myocardial disease and regenerative therapies.

282 sis holds promise as the basis for new renal regenerative therapies.

283 for disease modelling, drug development and regenerative therapies.

284 Ongoing advances in gene therapy, regenerative therapy and cell augmentation therapy may e

285 ng laser irradiation during peri-implantitis regenerative therapy may aid in better probing PD reduct

286 ealth with a reduced support, whereas, after regenerative therapy, a successful outcome was described

287 eveal a reciprocal interdependence between a regenerative tissue and its niche at different stages an

288 ation underlies proportional growth in adult regenerative tissue.

289 testinal tract is a highly proliferative and regenerative tissue.

290 s osteochondral defect model, the quality of regenerative tissues in both chondral and subchondral la

291 ophic myofibers and uncover degenerative and regenerative transcriptional pathways underlying DMD pat

292 However, in mice with injury alone this regenerative transcriptome is downregulated after two we

293 The regenerative transcriptome represents a reversion to an

294 T) motor neurons in mice, to identify their 'regenerative transcriptome' after spinal cord injury and

295 After regenerative treatment for peri-implantitis, the peri-im

296 posite outcome measure (COM) for periodontal regenerative treatment of intraosseous defects.

297 papilla preservation (EPP) technique in the regenerative treatment of isolated deep intrabony defect

298 The effect of the different regenerative treatments was both collectively and separa

299 These express a strong regenerative/tumorigenic program, driven by the Hippo pa

300 vergent cellular activities that distinguish regenerative vs fibrotic healing.