ライフサイエンスコーパス: region-specific

1 hology generated was both time dependent and region specific.

2 hanisms responsible for seizure onset can be region specific.

3 conversion of tau into a prion exist and are region specific.

4 he observed increase in synchrony is cue and region specific.

5 on protein (FMRP) on these pathways is brain region specific.

6 ship was component, neurochemical, and brain region specific.

7 e microbial taxa are sample site rather than region specific.

8 schizophrenia risk features that were brain region-specific.

9 Knowledge about the region-specific absorption profiles from the gastrointes

10 al and evolutionary processes, which promote region-specific accumulation of diversity through time o

11 understood, a prevailing hypothesis is that region-specific accumulation of hyaluronan, a predominan

12 c and hindbrain choroid plexi contributes to region-specific, age-dependent protein secretion in vitr

13 SCA3 knockin mice exhibit region-specific aggregate pathology marked by intranucle

14 d mortality differ among regions, suggesting region-specific air pollution control strategies.

15 heritable component and are associated with region specific alterations in brain anatomy.

16 Surprisingly, we uncovered only modest region-specific alterations in Htr2c RNA editing profile

17 in astrocytes in the adult brain results in region-specific alterations in morphology and physiology

18 increased immobility in the FST and induced region-specific alterations in Oprk1, Oprm1, and PDYN mR

19 Co-expression networks identified region-specific alterations in synaptic signaling and ol

20 The region-specific analysis determined that 81 bases and 10

21 Branch and region-specific analysis revealed that spine volume was

22 A region-specific analysis showed that brain regions impli

23 ional speckle-tracking echocardiography, and region-specific analysis to compare subendocardial and s

24 ly, AUC, sensitivity, and specificity of the region-specific analysis were 0.66 and 0.74 (P = .21), 3

25 ly, AUC, sensitivity, and specificity in the region-specific analysis were 0.67 and 0.75 (P = .07), 2

26 sed tau burden using voxel-based analysis or region-specific analysis.

27 We found the following: (1) region-specific and age-dependent synapse loss in aged W

28 Combining brain region-specific and cell type-specific genetic manipulat

29 land use, and host distributions, suggesting region-specific and cross-sectoral foci for LD risk mana

30 se metabolism deteriorates in a progressive, region-specific and disease-specific manner - a problem

31 These differences were frequency- and region-specific and implicated brain systems thought to

32 on their development of a strategy that uses region-specific and molecularly engineered astrocytes to

33 icity for ordinal and dichotomized data in a region-specific and patient-specific approach.

34 First, we defined region-specific and sexually dimorphic gene expression i

35 es of short bursts of synchrony occurring in region-specific and task-time-specific patterns.

36 eins, successful retrieval correlated with a region-specific and transient upregulation of BCN levels

37 a starting point to categorize GO terms into region-specific and whole-protein terms and select predi

38 ogenesis after stroke is activity-dependent, region-specific, and sensitive to modulation, and the sy

39 These region-specific apparent activation energies suggest tha

40 Interestingly, the synaptic difference is region specific as no differences were found in excitato

41 There are some documented species and brain region-specific astrocyte specializations, but the exten

42 -week-old YY1 (flox/flox) mice to generate a region-specific astrocytic YY1 conditional knockout (cKO

43 GFAP-Cre-GFP vectors into the SN resulted in region-specific astrocytic YY1 deletion and attenuation

44 and important molecular atlas for exploring region-specific astroglial functions.

45 m high-resolution micro-computed tomography, region-specific atrial cell electrophysiology and the ef

46 r stress could account for the transient and region-specific BCN upregulation.

47 ere: for any intervention to have an effect, region-specific biological, therapeutic and implementati

48 of trees in crop and pasture lands based on region-specific biomass distributions.

49 and flaring and four times greater than our region-specific bottom up inventory-based estimate.

50 own measurements were directly compared with region-specific bottom-up inventories that utilized curr

51 rectly reported data but consistent with our region-specific bottom-up inventory-based estimate.

52 n peripheral mechanosensory neurons leads to region-specific brain abnormalities, revealing links bet

53 ity in providing non-invasive stimulation of region-specific brain circuits for neuroscientific and t

54 to convert human pluripotent stem cells into region-specific brain organoids that resemble the develo

55 ll (hiPSC)-derived monolayer brain cells and region-specific brain organoids to SARS-CoV-2 infection.

56 ent that antibodies directed against several region-specific cell adhesion molecules, including neuro

57 region played a key role in maintaining the region-specific cell functions and heterogeneity during

58 heir respective regions resulted in enhanced region-specific cell functions and maintained region-spe

59 egion-specific cell functions and maintained region-specific cell heterogeneity compared to supplemen

60 Brain region-specific changes have been demonstrated with a va

61 Region-specific changes in cellular activity correlated

62 Detailed analysis of primary cilia revealed region-specific changes in ciliary morphology accompanie

63 Together with region-specific changes in glutamate acid decarboxylase

64 However, region-specific changes in rhythms across multiple, inte

65 ent protein C3 in mediating aged-related and region-specific changes in synaptic function and plastic

66 demonstrated distinct biochemical profiles, region-specific changes, and distinct subcellular locali

67 den the use of embryonic chimeras, including region-specific chimeras, for basic developmental biolog

68 tructural and molecular evidence for epitope region-specific, chirality-regulated Abeta fragment self

69 in disorders affect I/E dynamics, leading to region-specific circuit dysfunction and behavioral impai

70 ts in GME individuals was corroborated among region-specific, clinical WES cohorts.

71 which is not regionally restricted, requires region-specific cofactors in the form of Hox proteins to

72 Addressing region-specific competition barriers and educational nee

73 KOR expression in CeA neurons, we performed region-specific conditional knockout of these genes and

74 Using novel cell-type- and region-specific conditional knockouts of the GABAA recep

75 t loss of HDAC11 has age dependent and brain-region specific consequences.

76 dividual Bdnf transcripts make differential, region-specific contributions to total BDNF levels.

77 diencephalon, hypothalamus and eyes via the region-specific control of the ratio of activator and re

78 erate growing climate of Louisiana warrant a region-specific core collection that can be used for bas

79 at learning to produce AG sounds resulted in region-specific cortical reorganization within the infer

80 a uniquely human subset of cono-ventricular region-specific CPCs, marked by LGR5.

81 patients), 495 received a letter describing region-specific CRC screening adherence rates (generic r

82 in ex vivo slices from transgenic mice with region-specific Cre recombinase expression.

83 nd endoscopic scanning programs require new, region-specific criteria to diagnose UGI cancers in this

84 These region-specific CSNs terminate in different spinal level

85 in vivo, it remains unknown whether the Pol region-specific CTLs are equally efficient.

86 We utilize region specific data and models to analyze the consumpti

87 Nation- and region-specific data were examined for (1) a composite o

88 the availability and quality of country- and region-specific data.

89 Region-specific deletion of Cul3 leads to distinct pheno

90 Here, through the use of brain region-specific deletion of GABA release in both male an

91 (e.g., dose), topographic distribution, and region-specific delivery in small (rodent) and large (po

92 Accordingly, eFSE provoked region-specific dendritic loss in the hippocampus, and a

93 chronic social defeat stress, we identified region-specific differences in myelination between mice

94 ed DAT internalization and reveal unexpected region-specific differences in PKC-stimulated DAT traffi

95 Region-specific differences were present, with estimated

96 Further, the equiaxial load induced region-specific differentiation of ASCs within the inner

97 ntrolling adult epithelial proliferation and region-specific differentiation, and suggest downstream

98 rds from the health insurance system, and to region-specific disease and death registers.

99 w V i statistic was proposed to estimate the region-specific divergence in CNVR for each group based

100 operties of adult hippocampal astrocytes via region-specific DNA binding, thereby modulating the plas

101 ion in the brain hinders an understanding of region-specific ECM functions and the role of ECM in hea

102 re based on evidence-based clinical data and region-specific economic data acquired from direct field

103 ain-penetrant TrkB antagonist leads to brain region-specific effects and may be a potential pharmacol

104 Interestingly, Scn2b deletion resulted in region-specific effects in the heart.

105 In addition, we found region-specific effects of each drug, suggesting both co

106 e we describe a new syndrome with remarkably region-specific effects on neuronal migration in the pos

107 These region-specific effects were corroborated by a separate

108 repeated exposure, and found age- and brain region-specific effects.

109 updated emission estimates for Ghana using a region specific emissions inventory.

110 s are sensitive enough to detect lamina- and region-specific encoding of different subtypes of affere

111 Region-specific endocardial Notch activity regulates hea

112 Here, we report region-specific engagement of the DYN/KOR system and sub

113 ted novel molecular mechanisms that regulate region-specific enhancer activity in the developing brai

114 ity to traumatic stress in adulthood through region-specific epigenetic activity and catecholamine le

115 uation, University of Washington, to develop region-specific estimates of premature cardiovascular mo

116 ied a conserved cell-type set containing two region-specific excitatory neuron classes and three regi

117 er supported by transcriptome evidences from region-specific expression analysis.

118 tion, and post-endocytic sorting, as well as region-specific expression at the mRNA level.

119 in humans, allowing mapping of cell-type and region-specific expression of >190 genes associated with

120 12 distinct cell types were identified, and region-specific expression of candidate genes was mapped

121 First, we assessed the association of region-specific expression of the serotonin transporter

122 This region-specific expression pattern of genes, such as syn

123 One of these methods, region-specific extraction (RSE) is characterized by the

124 l activation by microglia occurs in a highly region-specific fashion and depends on the ability of mi

125 rm progenitors specifically contributed in a region-specific fashion to endodermal tissues.

126 tein-level annotations and multiple types of region-specific features.

127 , spectral karyotyping (SKY), and locus- and region-specific fluorescence in situ hybridization (FISH

128 We describe here a novel, region-specific focal seizure pattern that mimics seizur

129 e provided an optimized paradigm to generate region-specific forebrain neurons from hPSCs under a def

130 tion of FOXP2 biochemically and analyzed the region-specific function and sumoylation of FOXP2 in the

131 However, neither the region-specific function of FOXP2 in the brain, in parti

132 The global function of RNase H2 and the region-specific function of RNase H1 provide insight int

133 fiber targeting thalamic nuclei and map the region-specific functional connectivity with whole-brain

134 unity to investigate the molecular basis for region-specific functions in mucosa physiology and patho

135 nt and independent mechanisms that also show region-specific gating.

136 Using the expression profiles of brain region-specific GCN edges, we determined how well the br

137 es proof-of-concept that a cell-specific and region-specific gene expression approach can provide pot

138 Many examples of region-specific gene expression in the adult intestine a

139 several signaling pathways that orchestrate region-specific gene expression.

140 , South Carolina and South Dakota using nine region specific genotypes.

141 ed HK, for capturing the large-scale and yet region-specific glacier changes taking place over the HK

142 mice, acidified drinking water caused brain region-specific glial activation and significant changes

143 uple for the first time, to our knowledge, a region-specific global health model based on dietary and

144 To test the impact of cell- and region-specific GR knockdown on physiology and behavior,

145 ology (illness burden) have implications for region specific health policy.

146 We show how myocardial region-specific heterogeneity in cell function emerges d

147 Here, we take advantage of a region-specific heterogeneity in luminal progenitors to

148 These region-specific histological changes corresponded with M

149 areas during prolonged wakefulness lead to a region-specific homeostatic increase in theta activity (

150 Vibrio cholerae revealed infection-stage and region-specific host barriers to infection and showed un

151 Finally, there are region-specific hotspots of future changes in precipitat

152 fic transcriptome impairment in MeCP2 mutant region-specific human brain organoids that were rescued

153 and South Africa to test the hypothesis that region-specific immune alterations directly correlate to

154 2 expression, Foxf2(-/-) embryos a exhibited region-specific increase in sulfated keratan sulfate and

155 A significant region-specific increase of GluA2 AMPAR subunit expressi

156 racking of such data may serve as a valuable region-specific influenza indicator and predictor to gui

157 degradation (e.g. REDD+) require country- or region-specific information on temporal changes in fores

158 Using in vivo optogenetics, the brain region-specific inputs to the NAc that mediate these nuc

159 indicate that this non-canonical feedback is region specific: it is most prominent in lobules that re

160 nd that beta-catenin interacts directly with region-specific LEF/TCF factors, and with KLF4 in differ

161 We quantified brain region-specific levels of Oxtr messenger RNA and oxytoci

162 sets of input and output neurons as well as region-specific local interneurons.

163 of in situ mapping of biomolecules and their region-specific localizations, matrix-assisted laser des

164 Despite the identification of multiple region-specific lung progenitor cells, the identity of m

165 Region-specific manipulations indicate that CSNs from ca

166 roach, using genetic animal models and brain region-specific manipulations of oxytocin activity.

167 oteomes differently from U50,488H in a brain-region specific manner after 30-min treatment.

168 otein levels and astroglial cell marker in a region specific manner.

169 inuously function in the adult skeleton in a region-specific manner by regulating differentiation of

170 nesis in two models of neurodevelopment in a region-specific manner has significant mechanistic impli

171 either MGE- or CGE-derived interneurons in a region-specific manner in mouse neonatal hippocampus in

172 tified several genes that are expressed in a region-specific manner in the developing human intestine

173 ent data showing that TCF4 is expressed in a region-specific manner in the radial glia and stem cells

174 ults show that tau pathology is related in a region-specific manner to cognitive impairment in Alzhei

175 their influence on excitatory signaling in a region-specific manner, and suggests that these NMDARs m

176 n was upregulated in CASP4/APP/PS1 mice in a region-specific manner, including hippocampus and prefro

177 eep-wake regulatory systems exist in a brain region-specific manner, which can be modulated independe

178 leads to ciliary morphology disruptions in a region-specific manner, which may explain the complex mu

179 ffects transcriptome in the vasculature in a region-specific manner, which may help to identify genes

180 rexpression affects IEC differentiation in a region-specific manner, with ileum tissue being influenc

181 t the mouse retina encodes visual space in a region-specific manner.

182 he recruitment of these factors by Meth in a region-specific manner.

183 n "master clock," which is DNA methylated in region-specific manner.

184 ulation of embryonic RGCs, in a temporal and region-specific manner.

185 ved with high efficiency in a cell-type- and region-specific manner.

186 , was differentially affected by stroke in a region-specific manner.

187 ling the presentation of growth factors in a region-specific manner.

188 stress (CUS) paradigm on the rat brain in a region-specific manner.

189 for the treatment of FXS may vary in a brain-region-specific manner.

190 identity, and synaptic-support capacity in a region-specific manner.

191 pocampal glycerophospholipid metabolism in a region-specific manner.

192 nd in either male or female mouse brain in a region-specific manner.

193 editing can recode genetic information in a region-specific manner.

194 s associated with changes in NPY and OX in a region-specific manner.

195 l and extrinsic synaptic input in a nuanced, region-specific manner.SIGNIFICANCE STATEMENT All sensor

196 gions of interests, of which whole-brain and region-specific means were compared by using a general l

197 les, microbial metabolites, medications, and region-specific metabolism of medications and placed it

198 entative database of visits to PAs and built region-specific models predicting visit rates from PA si

199 cis-proline-specific regulatory factors and region-specific modulation of the CTD code that may augm

200 ary cilia in forebrain morphogenesis through region-specific modulation of the Hh pathway.

201 However, their region-specific molecular features are presently unknown

202 al analyses, we identified hundreds of novel region-specific molecular markers, which may serve as to

203 rly and sclera posteriorly, are regulated by region-specific molecular mechanism remains unclear.

204 onal burden, we used country-specific or WHO region-specific morbidity and mortality estimates and di

205 Using region-specific mouse reporter strains, we performed an

206 nses in each brain region as trajectories in region-specific multidimensional spaces, and models the

207 We examined mice with constitutive and brain region-specific mutations in Neurexin1alpha, a neuropsyc

208 ral primary tumour specimens reveals various region-specific mutations.

209 ptibility, at least in part, originates from region-specific myoepithelial progenitors.

210 Recent studies using region-specific netrin1 deletion suggested that FP-netri

211 Here we identify a brain-region-specific neural progenitor-based signaling pathwa

212 ory elements and represses the expression of region-specific neuronal differentiation genes, thereby

213 g deficits in value-based decision-making to region-specific Nrxn1alpha disruption and changes in val

214 strating that they are orientation- and skin-region-specific, occur even when just one hand is adapte

215 of a result-set containing an optimal set of region-specific oligos.

216 The results revealed dose-dependent and region-specific opioid effects on the control of both re

217 sed the approach to generate astrocytes with region-specific or reactive features.

218 r, these results challenge recent reports of region-specific organizations in the mouse SC and reveal

219 Together, our brain-region-specific organoids and SpinOmega provide an acces

220 viously developed approach to generate brain-region-specific organoids called cortical spheroids and,

221 Finally, fusing region-specific organoids followed by live imaging enabl

222 objective of this study is to engineer brain region-specific organoids from hiPSCs incorporated with

223 alamus and cortex by fusing the two distinct region-specific organoids representing the developing th

224 Here we used human three-dimensional brain-region-specific organoids to study the effect of oxygen

225 When region-specific organoids were transplanted into immunoc

226 ing organic carbon, ecosystem structure, and region-specific parameterizations of e-ratio are key fac

227 all-animal PET/MRI enables tracking of brain region-specific pathology in mouse models, which may pro

228 h lowest cerebral substrate delivery, show a region-specific pattern of small brain volumes and impai

229 id not show biofluid-characteristic or brain region-specific pattern.

230 delivery impacts the brain globally, or in a region-specific pattern.

231 ry genome of epidemic clones partly reflects region-specific patterns of antibiotic usage, which may

232 expressed in striking cell class-, type-, or region-specific patterns.

233 n effect was subsequently investigated using region-specific pharmacological blockade of dopamine D1-

234 Region-specific phenotypes of BG microglia emerged durin

235 s and visualization, opening new options for region-specific phenotypic screening of complex physiolo

236 We show here that region-specific PMCA in part reproduces the specific bra

237 The Midwest had the lowest region-specific prevalence (1.14% [95% CI, 1.04%-1.30%])

238 The West census region had the highest region-specific prevalence (2.14% [95% CI, 1.96-2.48]);

239 nces is an important prerequisite for better region-specific prevention and treatment of this devasta

240 oups and we observed striking enrichment for region-specific processes.

241 By enrichment for region-specific progenitors, we identify bipotent and mu

242 findings support developing both global and region-specific programmes to prevent stroke.

243 of the duct, and incorporates morphometrics, region-specific proliferation and apoptosis rates.

244 , providing a foundation for determining how region-specific properties contribute to both chromosoma

245 f the 55 regions (22%), the most significant region-specific, prostate-cancer associated variant repr

246 microproteomics (STOMP) is a method to study region-specific protein complexity in primary cells and

247 attery of behavioral assessments followed by region-specific quantification of brain cytokines using

248 Cumulative doses of chemotherapy and body region-specific radiotherapy (RT) were abstracted from m

249 that enables reliable identification of RNA-region-specific RBPs and is applicable to any RNA of int

250 s of a tolerant ideotype over sensitive were region specific reaching up to 44% greater yields for to

251 In this study, we demonstrate that region-specific receptor fragmentation modifies channel

252 nsic cues that regulate stem cells, enabling region-specific regeneration in this parasite.

253 Our results reveal region-specific regulation of stem cell quiescence.

254 define the transcription factor PRDM16 as a region-specific regulator of intestinal metabolism and e

255 ovides the first in vivo evidence of genomic region-specific repair in mammals.

256 Adolescent-stress also conferred region-specific resilience to norepinephrine changes.

257 We hypothesize that region-specific resolution of N-glycans isolated from th

258 Region-specific RICS analysis remains very challenging b

259 r (AVPV) and arcuate (ARC) nuclei, while the region-specific role of progesterone receptors in these

260 novel plasticity mechanism in the LIPN and a region-specific role of substance P in fear extinction.

261 s, suggesting that IFNAR signaling has brain region-specific roles in CNS immune responses.

262 s, making it difficult to delineate time- or region-specific roles of PIP2.

263 ro- and antioxidant systems that orchestrate region-specific ROS production and removal.

264 Interestingly, we observed that region-specific rules govern the induction of IEGs in SP

265 rol comparisons in specific disorders, using region-specific seed-based analyses.

266 omeostatic functions but could also underlie region-specific sensitivities to microglial dysregulatio

267 ortex and MGE, which utilize both common and region-specific sets of genes to control the proliferati

268 in the limbic system of adult animals, in a region-specific, sexually-dimorphic and experience-depen

269 We also demonstrated a region-specific shift in power of cortical oscillations

270 Markers at 55 regions passed a region-specific significance threshold (P-value cutoff r

271 identified a strong association between one region-specific SNP (rs10509852), 400 kb upstream of SOR

272 These findings provide insights into region-specific specialization of neurovascular communic

273 In addition to region-specific specialization of principal cells, we fi

274 ered likely causal variants underlying brain region-specific sQTLs.

275 Site- and region-specific studies suggest that large trees, which

276 However, designing region-specific sustainable diets that are culturally ac

277 g AMPAR/TARP complexes promising targets for region-specific therapeutic intervention.

278 se findings stimulate further exploration of region-specific therapies targeting myocytes and autonom

279 nical stroke studies, especially those using region-specific therapies, such as transcranial magnetic

280 Laser capture microdissection (LCM)-enabled region-specific tissue analyses are critical to better u

281 ay upregulate neuronal excitability in brain regions specific to the limb, in this study the right ha

282 Together, our studies reveal region-specific transcriptional dependencies for astrocy

283 d ventral poles, producing a cell-class- and region-specific transcriptional description for these po

284 Intersection of region-specific transcriptomes with expression changes i

285 Our findings indicate lineage- and region-specific transcriptomic changes associated with s

286 Here, a cell-specific and region-specific transcriptomics approach was used to det

287 ay of breakpoints responsible for locus- and region-specific translocations.

288 ially varying coefficient models to quantify region-specific trends in trait coordination and trait r

289 aques and patients diagnosed with HIV, brain region-specific up-regulation of amyloid precursor prote

290 d over the same time period, demonstrating a region-specific uptake based on the progression of the i

291 To understand the molecular basis of this region-specific variability we analyzed gene expression

292 ll, our findings support the conclusion that region specific vascular and haemodynamic changes occur

293 After region-specific viral injections of AAV-GFP or AAV-CRE i

294 Linking our region-specific visit estimates to valuation studies ind

295 rons) or the hippocampus, suggesting a brain region-specific vulnerability to the G2019S mutation.

296 The increase in permeability was region specific (white matter, midbrain peduncles, red n

297 nockout mouse lines, that this regulation is region-specific, with the 5-HT4 receptor upregulated in

298 Our data show the substantial nation- and region-specific yield and monetary effects of adjusting

299 At age 4, we calculated the age-, sex-, and region-specific z-scores for cholesterol, triglycerides

300 as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs.