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1 .mol(-1), the DA cycloaddition becoming more regioselective.
4 inoadducts of Gd(3)N@I(h)-C(80), obtained by regioselective 1,3-dipolar cycloadditions, were elucidat
6 l, undergo exclusive or exceptionally highly regioselective 1,4-addition reactions to alpha,beta-gamm
7 le, easy to handle and facilitate direct and regioselective (18) F-labeling to prepare [(18) F]fluoro
9 ly enantioselective, diastereoselective, and regioselective [2,3]-rearrangement of iodonium ylides ha
11 pfb)4 or Rh2 (esp)2 directs the reactants to regioselective [3+2]-cycloaddition generating cyclopenta
12 A Rh(III)-catalyzed cascade C-H activation; regioselective [4 + 2] oxidative annulation; and lactoni
13 functionalized 2-benzyl benzo[b]furans via a regioselective 5-exo-trig intramolecular oxidative cycli
14 opper oxidase (MCO) VdtB responsible for the regioselective 6,6'-coupling of semiviriditoxin (10), wh
17 ign concept is further demonstrated with the regioselective acetylation of the natural product querce
19 eration of a sulfonyl isocyanate followed by regioselective acylation of an indole or pyrrole nucleop
21 m the corresponding dioxinone keto ester via regioselective acylation, Tsuji-Trost allylic decarboxyl
22 chlorobenzoate, which undergoes enantio- and regioselective addition of HBpin catalyzed by DTBM-SEGPH
23 tion of 1,2-dihydropyrimidines involves 100% regioselective addition of the rhodium carbenoid to endo
24 stepwise and concerted mechanisms involving regioselective addition to the keteniminium C-N bond.
26 single electron metalation to Ni complexes, regioselective alkylation and arylation of olefins is po
27 logs based on a pyrazole core through highly regioselective alkyne cycloaddition reactions of sydnone
28 0 enzyme was employed to effect a chemo- and regioselective allylic C-H oxidation in the presence of
33 ted to undergo protonation at C6 followed by regioselective amination at C5 with a variety of primary
35 his approach is a sequence composed of a (1) regioselective and -retentive preparation of allyloxycar
38 gly, the growth processes for NWs on NPs are regioselective and controlled by the chemical compositio
44 thetic transformations used to make multiple regioselective and stereoselective carbon-carbon bonds.
45 obtained from toluene dioxygenase-catalyzed regioselective and stereoselective cis-dihydroxylations
47 oxygenase (12-LOX) can directly catalyze the regioselective and stereospecific oxidation of 2-arachid
48 WCNTs), and demonstrate that the reaction is regioselective and takes place at the perpendicular posi
51 erein, we report a simple, efficient, highly regioselective, and broad-scope hydration method that is
55 LT2 inhibitors, featuring an underexploited, regioselective, and stereospecific palladium-catalyzed a
56 In this reaction, cascade C-H activation, regioselective annulation, and lactonization occur in on
59 r, and ketone were found to be efficient for regioselective anti-Markovnikov cleavage of cyclopropane
63 and base-free conditions and enables a clean regioselective arylation at the N(3) nitrogen atom, whil
69 lpha-d-Glcp-(1<-->1)-alpha-d-Glcp, through a regioselective beta-d-transfructosylation of trehalose (
70 y one metal atom; it also sheds light on the regioselective binding of auxiliary Ph(3) P on the surfa
75 otoredox and nickel catalytic system for the regioselective C(sp(3))-C(sp(3)) coupling of unactivated
76 ed the gamma-amino esters resulting from the regioselective C-C bond formation between the alpha-carb
83 a 2-pyridyl directing group, which undergoes regioselective C-H bond activation, serving as a valuabl
84 -H bonds at different positions resulting in regioselective C-H bond activation; paradoxically, the s
86 tilized to distinguish C-H bonds, undirected regioselective C-H functionalization strategies remain e
88 , we have developed a visible-light-promoted regioselective C3-H trifluoromethylation of 2 H-indazole
89 philus thermophilus) capable of enantio- and regioselective C5 hydroxylation of decanoic acid 1 to (S
96 Their synthesis was enabled by exclusively regioselective catalytic arene-norbornene annulation (CA
97 The transformation involves a stereo- and regioselective chloropalladation of an internal alkyne t
100 An efficient protocol is described for the regioselective construction of polysubstituted functiona
106 this study we report the development of the regioselective Cp*Ir(III)-catalyzed allylic C-H sulfamid
107 A copper-mediated picolinamide directed regioselective cross-coupling of naphthylamines with azo
108 via a palladium-catalyzed auxiliary-directed regioselective Csp(3)-H arylation of the unactivated bet
109 We also showed that NanA-C(T) catalyzes the regioselective cyclization of a surrogate synthetic subs
110 (3)) domains of NanA are responsible for the regioselective cyclization of the tethered Ant-l-Kyn dip
111 ydrofuran (THF) aldehydes, obtained from the regioselective dehydration of biomass-derived sugars, to
114 ing in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hy
115 ron dioxygenase flavonol synthase performs a regioselective desaturation reaction as part of the bios
116 n this study, we explored the consequence of regioselective deuteration of a heroin hapten and its im
119 stituted carbazoles are examined to showcase regioselective discrimination (3,3'- versus 1,3'-bicarba
121 Herein, we report the development of remote regioselective electrophilic aromatic substitution (S(E)
123 was synthesized from phosphatidylcholine via regioselective enzymatic hydrolysis and was reacted with
124 f the approach; this includes diastereo- and regioselective epoxide formation/trichloroacetic acid cl
126 es late-stage conformation-controlled highly regioselective esterification of the glucose diol in the
128 ng annulations of two different alkynes in a regioselective fashion have been demonstrated effectivel
129 omides and indoles is discovered in a highly regioselective fashion to furnish 3,5-diarylcarbazoles.
134 We have explored the synthetic routes for regioselective formation of 2-pyridone[ a]- and 2-pyrido
136 zed dihalogenation processes allowing highly regioselective formation of different carbon-halogen bon
137 ure in the presence of oxygen results in the regioselective formation of ethyl 5,7-difluoro-4-azaspir
138 table process conditions for the stereo- and regioselective formation of mono- or bis-silylated adduc
139 yingly, this protocol draws attention to the regioselective formation of monohydroxymethylated beta-c
140 -bis(dimethylaminovinyl)-BODIPY leads to the regioselective formation of the 2-pyridone[ a]-fused BOD
142 an electrophilic halogen source and leads to regioselective formation of the halofunctionalized adduc
145 reaction system was designed that allows for regioselective functional group transformation, efficien
147 A picolinamide directing group enables the regioselective functionalization of a wide array of olef
150 ic <-> kinetic enolates furnished the highly regioselective functionally rich 1,2,3-triazoles by disc
151 the presence of dimethyl substituent 1(Me), regioselective gamma-arylation is favored by 3.4 kcal/mo
157 rom H-terminated carbon surfaces, initiating regioselective grafting of terminal alkenes to surfaces
158 N-centered radical while also directing its regioselective H atom transfer (HAT) to the beta carbon
159 Here we demonstrate that integration of regioselective halogenase enzymes with Pd-catalysed cros
160 this viral halogenase reveals it capable of regioselective halogenation of a diverse range of substr
161 eliable, facile, and cleaner methods for the regioselective halogenation of organic compounds are the
163 ogenases (2ODHs) have been found to catalyze regioselective halogenation of unactivated C-H bonds in
166 enerating an R(3)S(0) radical that undergoes regioselective homolytic reductive cleavage of the S-C5'
167 longstanding central question: what controls regioselective homolytic S-C bond cleavage upon SAM redu
168 were successfully implemented to direct the regioselective hydration for various functionalized delt
171 ent of simple and scalable protocols for the regioselective hydrofluorination of alkynes to access bo
172 ling up of the catalytic reaction as well as regioselective hydrogenation and double condensation to
174 of the fatty acid substrate and its enantio/regioselective hydroxylation by the active species of th
175 zed to create the C4 stereogenic center, and regioselective hydrozirconation/iodine quench afforded a
176 n at an sp(2) carbon atom, allows the direct regioselective incorporation of mono-, di-, tri-, and te
177 he Ox group also facilitates the stereo- and regioselective incorporation of nucleophiles (Nu) and di
178 succinctly summarized, with emphasis on the (regioselective) incorporation of various types of cataly
180 loxycarbamates as nitrene precursors towards regioselective intramolecular C-H oxygenations to provid
185 ted triazole anions but, by virtue of highly regioselective ion pairing, exhibit alkylation selectivi
186 pment of the first enantio-, diastereo-, and regioselective iridium-catalyzed allylic alkylation reac
188 ivated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodinatio
189 ntal results of ligation at Gly junction and regioselective ligation at Glu junction were theoretical
190 subsequent C-C reductive elimination of the regioselective linear product is facilitated by the ster
191 olo[3,4-b]pyridines 4 has been prepared in a regioselective manner by the microwave-assisted reaction
192 disubstituted derivatives were obtained in a regioselective manner in good to excellent yield on up t
194 er, the introduction of an electrophile in a regioselective manner on a drug-like molecule is a chall
195 se strategies allow C-C bond formations in a regioselective manner to synthesize large molecular libr
196 ,2,4-trisubstituted pyrrole core in a highly regioselective manner via a one-pot [3+2] cycloaddition/
198 a-ketodihydroporphyrin isomers, generally in regioselective manner, and sets of separable stereoisome
201 Herein, we report on manganese-catalyzed regioselective Markovnikov addition and [2+2+2] cycloadd
203 d with different nucleophiles for performing regioselective metal-free C-O and C-N bond-cleaving to a
205 highly functionalized benzene derivatives by regioselective metalation of ester-, amide-, carbamate-,
209 base [(dioxane)0.5 NaFe(HMDS)3 ] (1) enables regioselective mono and di-ferration (via direct Fe-H ex
210 The Pd-catalyzed quinazolinone-directed regioselective monoarylation of aromatic rings by C-H bo
211 of gem-difluorocyclopropanes and subsequent regioselective monoepoxidation of the products were demo
215 copper-catalyzed tandem process integrating regioselective N-arylation, followed by aza-Michael addi
217 nazolines via a two-step N1 dealkylation and regioselective N3 functionalization protocol, including
218 to selective chemical modifications such as regioselective O- and N-sulfation and selective de-sulfa
219 a quite strong sterically nondemanding base, regioselective O-acylations should be possible at low te
222 on-coupled electron transfer (PCET) mediated regioselective ortho-specific nitration of aromatic C(sp
223 yzed reaction, thus leading to complementary regioselective outcomes and addressing the limitations o
226 with just traces of oxygen is shown to yield regioselective oxidation, dehydrogenation, and fragmenta
228 e cleavage products is complex, initiated by regioselective oxygen radical addition to the carbon-car
230 disclose a template-assisted method for the regioselective para silylation of toluene derivatives.
231 novel and efficient metal- and solvent-free regioselective para-C-H cyanation of hydroxy-, alkoxy-,
235 eatures the following three key steps: (a) a regioselective Pictet-Spengler reaction of tryptamine wi
237 etimes fail to predict reactivity trends and regioselective preferences, e.g., in the case of ambiden
239 S preparation OM-RML brings forth an optimal regioselective preparation of sn-1 mono and sn-1,3 diacy
240 the case of unsymmetrical alkynes, a highly regioselective product was obtained, which was confirmed
246 ene functionalizations, including C(2)/ C(3) regioselective pyrrole alkylation, enantioselective indo
247 s and homologation of aryl boronic esters by regioselective radical C(sp(3))-H activation in boron-at
248 anism where aryl halide reduction triggers a regioselective radical cyclization event, followed by an
249 ydroxyphthalimide (NHPI)-mediated chemo- and regioselective radical cyclization of yne-dienone with t
250 um ylide (SCIDY) precursors for one-step and regioselective radiofluorination, as well as proof-of-co
251 nylthio acids were usually made by the known regioselective reaction of alpha,beta-epoxy acids with P
252 yclooctadiene) as a more robust catalyst for regioselective reductive coupling of ynoates and aldehyd
253 a-F eliminations and fluorine effect-induced regioselective reductive elimination are independently i
254 geometry-based differentiation approach for regioselective remote C-H functionalization reactions ma
255 This family of directing groups enables regioselective remote hydrocarbofunctionalization of sev
257 The mechanochemical, solvent-free, highly regioselective, rhodium-catalyzed C-H methylation of (he
258 approach involves 1,3-dipolar cycloaddition, regioselective ring expansion, followed by the eliminati
260 otocycloaddition reactions followed by fully regioselective ring opening/Hofmann rearrangement/nitrog
262 s was possible, thus enabling diamination by regioselective ring-opening with primary or secondary am
264 This method offers an efficient and highly regioselective route for the synthesis of 1-hydroxymethy
266 ic OMe traceless directing groups (TDGs) for regioselective Sn-radical attack at the triple bonds.
267 thesis of the tetrahydropyran (A-ring) and a regioselective spiroketalization for the efficient gener
268 allowed the first experimental report on the regioselective Steglich rearrangement of isoxazolones, a
269 as it guides the reactivity to a chemo- and regioselective substrate desaturation from the C(2)-H gr
270 -pot, three-component, transition-metal-free regioselective sulfenylation of 2-iminothiazoline throug
272 rones, a straightforward approach toward the regioselective synthesis of 1,2,4,5-tetrasubstituted imi
273 ase-free domino process is developed for the regioselective synthesis of 1,2,4-trisubstituted pyrrole
274 rect and operationally simple method for the regioselective synthesis of 2-aryl-substituted 2H-indazo
275 lkyl) hydrazines was performed, aimed to the regioselective synthesis of 3- or 5-trifluoromethylated
282 elective conventional cross-coupling for the regioselective synthesis of potential pharmacophores.
283 en and simple approach was developed for the regioselective synthesis of structurally diverse chromen
285 f furan/pyrrole/thiophene and PhINTs for the regioselective synthesis of tetrahydropyridine (THP) der
287 s been developed, enabling highly chemo- and regioselective synthesis of unsymmetrical dialkyl ketone
290 mation of ynamine to thiophene and the first regioselective transformation of a longer polyynes to bu
291 he oxidation with hypervalent iodine shows a regioselective transformation of an amino acid chain cha
292 In this Perspective, we highlight various regioselective transformations of disubstituted epoxides
295 fluoroalkenes, we present a cobalt-catalyzed regioselective unsymmetrical dioxygenation of gem-difluo
298 alpha-amino acid is described using a highly regioselective, ytterbium-catalyzed hetero-Diels-Alder r
300 A practical, straightforward, and highly regioselective Zn(OAc)2-mediated method toward propargyl