ライフサイエンスコーパス: regioselectively

1 entially produce enolate I, were synthesized regioselectively.

2 nes provided the 2-alkylsubstutited products regioselectively.

3 t glycosides and branched sugars stereo- and regioselectively.

4 ylic group by a hydrogen or a deuterium atom regioselectively.

5 nt addition to geminal-disubstituted olefins regioselectively.

6 broad functionalities have been synthesized regioselectively.

7 alkenes and gem-difluoromethlylene compounds regioselectively.

8 Cu(I) afford pyrazolo[5,1-c]-1,2,4-triazoles regioselectively.

9 sfer to alkenes forms vinylsilacyclopropanes regioselectively.

10 ford a 2,4,6-trisubstituted pyridine product regioselectively.

11 p from the C-7 hydroxyl of noreugenin to C-8 regioselectively.

12 1,4-dihydro-3(2H)-isoquinolinone derivatives regioselectively.

13 erature without any metal catalyst to afford regioselectively 1,5-disubstituted triazolylated pyranos

14 These compounds were made in several regioselectively (13)C-labeled forms, and their structur

15 not give [3,2-c]isoxazoles but rather afford regioselectively [2,3-d]isoxazoles in good yields.

16 ere reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles.

17 n this reaction, levansucrase (LS) transfers regioselectively a fructosyl residue to either C6-OH gro

18 n a formal [4 + 2] cycloaddition, the pyrone regioselectively accepts a benzylic anion as a nucleophi

19 lenging isopropenyl side chain oxidation was regioselectively achieved via a newly developed stepwise

20 synthesis that installs two carbon fragments regioselectively across an alkene.

21 the principles of triple radical sorting to regioselectively add N-centered and C-centered radicals

22 with arenes and sulfonamide nucleophiles to regioselectively afford 1-aryl-2-aminopropanes.

23 pha-chloronorbornene at room temperature, to regioselectively afford the 1:1 addition products exo-1-

24 unsaturated diesters, can be efficiently and regioselectively alkylated with very hindered C-electrop

25 These alkyne exchange reactions proceed regioselectively and can tolerate a variety of functiona

26 The reactions occur regioselectively and exhibit a notable endo preference,

27 ry and quaternary stereogenic carbon centers regioselectively and in 78-96% ee.

28 ingly, 2-aryl-substituted systems rearranged regioselectively and in a process whose selectivity prov

29 locolchicinoids 15-19, 23, and 25, with high regioselectively and in moderate to good yields.

30 The polymerization proceeds regioselectively, and the resulting molecular weights ar

31 derivatives to produce 2-quinoxalinol imines regioselectively as one isomer in good yield.

32 onoadducts suggests that the addition occurs regioselectively at a 6,6-ring juncture on the surface o

33 llows subsequent chemistry to be carried out regioselectively at one of the two aldehyde groups.

34 reaction with tetracyanoethene, which occurs regioselectively at only one of the rigidly linked dendr

35 The reactions occur regioselectively at position 8 both in 7 and 9-deazapuri

36 Fourth, subsequent bromination proceeded regioselectively at the 15-position to give a trans-(5,1

37 ility to effect double-strand DNA hydrolysis regioselectively at the 3'-O-P bond.

38 of BN anthracene 1 with Br2, however, occurs regioselectively at the 9-position.

39 ed in six steps from thiophene, was arylated regioselectively at the alpha-position directly with iod

40 Ir-catalyzed C-H borylation occurs regioselectively at the C(6) position of B-substituted 1

41 ne-2-thioxothiochroman-4-one derivatives (3) regioselectively at the C-3 position of 4-hydroxydithioc

42 e functionalization of quinoxalines occurred regioselectively at the C-8 position of quinoxalines.

43 osubstituted N-pyridylcarbazoles takes place regioselectively at the C-8 position.

44 ization steps were very rapid and took place regioselectively at the C-atoms of the C=N bonds, by 5-e

45 can be difunctionalized site-selectively and regioselectively at the C4 and C5 positions in good yiel

46 the intermolecular alkylation to take place regioselectively at the indole C3 position over the othe

47 2]-cycloaddition reactions with arylallenes regioselectively at the styrenyl olefin to furnish the c

48 uCl4, metallic particles and sheaths deposit regioselectively at the SWNT tips, yielding novel SWNT-m

49 (Z)-1-alkene-1,2-diboronic esters proceeded regioselectively at the terminal C-B bond to afford (E)-

50 The alkylation occurred regioselectively at the terminal oxygen, leading to a si

51 lkyloxy- and dihydroxyoctahydroperylenes are regioselectively available via a new tandem Friedel-Craf

52 ido) hosts (in particular 3a) are capable of regioselectively binding dicarboxylates and pyrophosphat

53 ta-functionalization of BODIPY, resulting in regioselectively branched beta,beta'-disubstituted alken

54 2-hydroxyphenyl)pyridines have been prepared regioselectively by a transition-metal-free, mild, one-s

55 nt C-acylimine electrophile could be trapped regioselectively by a variety of arenes, on which the mo

56 5,8-hydroborated products could be obtained regioselectively by modifying the phosphine ligand.

57 Regioselectively C5-alkylated imidazoheterocycles were s

58 Three types of ligands regioselectively cap on the surface of the Ag(78) NC, fo

59 Alternately, mono-functionalization was regioselectively carried out with trimethylsilyl azide a

60 recombinant enzyme assays, SbSOMT and COMTs regioselectively catalyze O-methylation of stilbene A-ri

61 The P450s stereoselectively and regioselectively catalyzed the metabolism of (R)- and (S

62 rent flavin-dependent tryptophan halogenases regioselectively chlorinate or brominate trypto-phan's i

63 ion of tryptophan 7-halogenase (PrnA), which regioselectively chlorinates tryptophan.

64 deed, each of the three SAM S-C bonds can be regioselectively cleaved in an RS enzyme.

65 total synthesis of chlorocyclinone A (1) is regioselectively completed in 28 steps.

66 hich flavin-dependent tryptophan halogenases regioselectively control chlorine addition to tryptophan

67 - and diastereoselective process allowing to regioselectively control the functionalization of NH-tri

68 The regioselectively controlled introduction of chlorine int

69 mall molecules and complex natural products, regioselectively controlled libraries, novel one-pot lib

70 A simple and regioselectively controlled method for the preparation o

71 on alkane hydroxylase (alkB) was applied to regioselectively convert heptane to 1-heptanol.

72 alyzed water-oxidation process is capable of regioselectively converting antibody-bound benzoic acid

73 The deprotected guanidines were subsequently regioselectively cyclized with beta-keto esters yielding

74 ique with (13)C NMR detection was applied to regioselectively deuterated pyridine complexes to invest

75 Various dienes and a triene can be regioselectively diaminated at the internal double bond

76 The investigated catalytic system could regioselectively differentiate the enantiotopic hydroxy

77 demonstrated by the possibility to displace regioselectively each aromatic chloride to introduce div

78 These reactions are regioselectively favoring the 5-exo-dig cyclizations in

79 fluorine into complex structures to produce regioselectively fluorinated full-length polyketides.

80 d a thermal Huisgen cycloaddition to proceed regioselectively for the first time using geometric cont

81 ylenes into propargylic CO bonds of epoxides regioselectively form 1,2-silaoxetanes, which add to ald

82 on of a wide range of substituted alkynes to regioselectively form polycycles containing syntheticall

83 alkyne cycloaddition reactions, the products regioselectively formed, the components sufficiently sta

84 nd electron-acceptor groups were synthesized regioselectively from 2,3,5,6,8-pentachloro-BODIPY, and

85 ers that allow for the growth of each branch regioselectively from any of the hydroxyl positions (5',

86 iacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a

87 imer, -tetramer, and -pentamer were obtained regioselectively from their lower homologues, albeit in

88 gh alpha-lithiation, bringing easy access to regioselectively functionalized dearomatized benzochrome

89 or internal alkynes in the presence of TiCl4 regioselectively generates substituted naphthalene deriv

90 anide-mediated intermolecular hydroamination regioselectively generates the anti-Markovnikov addition

91 oallylic alkenes cyclize with modest to high regioselectively, generating tetrahydropyrans 40-45, Tab

92 romethylphenyl ether eliminates neutral ArOH regioselectively, giving ionized 2-hexenes rather than i

93 tuent as the substrates, the reaction occurs regioselectively, giving rise to vinyl carbene complexes

94 6-Chloropurine and 2,6-dichloropurine were regioselectively glycosylated at position 7 to give the

95 Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of biosynthe

96 ow the fungal halogenase RadH can be used to regioselectively halogenate a range of bioactive aromati

97 ly available disubstituted cyclobutenes were regioselectively halogenated at the allylic position by

98 roxide species of this porphyrin is found to regioselectively hydroxylate the meso carbon adjacent to

99 Cytochrome P450cam (CYP101Fe(3+)) regioselectively hydroxylates camphor.

100 id into para-hydroxy benzoic acid as well as regioselectively hydroxylating the 4-position of the phe

101 to introduce four phosphates on nucleosides regioselectively in a one-flask key transformation.

102 ons or N-acyloxyiminium ions to be generated regioselectively in a subsequent step.

103 Arrays with the antibodies attached regioselectively in a uniform orientation are typically

104 The reaction proceeds chemo- and regioselectively in an atom-economic way, generating a l

105 ess to a variety of substituted benzosultams regioselectively in excellent yields.

106 ne-1,4-dicarboxylate ester afforded adduct 6 regioselectively in good yields.

107 ers to give tetrahydrofuran ring stereo- and regioselectively in good yields.

108 5,6-dihydro-2H-pyran-2-acetates stereo- and regioselectively in good yields.

109 o generate spiroindenes chemoselectively and regioselectively in moderate to high yields.

110 ursor and, more importantly, it is installed regioselectively in native aromatic compounds by C-H sul

111 e corresponding dianion, which reacts highly regioselectively in the presence of 0.25 equiv of tetram

112 gave 6,6'-dialkoxy-2,2'-bipyridines (6g-k), regioselectively, in excellent isolated yields.

113 allowing a third type of functionality to be regioselectively incorporated during the macrocyclizatio

114 n by N-methyl-N-nitrosourea at N7-guanine is regioselectively inhibited by point substitutions of the

115 tem (ABEHCS) and a plug-and-play strategy to regioselectively introduce histone acetylation and deoxy

116 e formyl and 2-formylvinyl substituents were regioselectively introduced at positions 3 and 20 of Ni(

117 onalization, substituents can be rapidly and regioselectively introduced at the alkaloid C13 position

118 etic polypeptides to be chemoselectively and regioselectively joined together.

119 none substrates, the cyclization takes place regioselectively, leading to either dibenzocyclohepten-5

120 inone (6PPD-Q) was recently discovered to be regioselectively metabolized to alkyl hydroxylated metab

121 aceae O-methyltransferase and its ability to regioselectively methylate norbelladine in the heterolog

122 ferases used, which were found to be able to regioselectively methylate two different catechols in a

123 ified to be the C-6 C-methyltransferase that regioselectively methylates pretetramid to yield 6-methy

124 These regioselectively modified particles were desorbed by app

125 cause Gibbs' reagent reacting with different regioselectively modified phenolics displays different c

126 ith heterologous elongation modules afforded regioselectively modified polyketides containing alterna

127 A dearomative strategy to regioselectively modify arenes using a "diene" synthon w

128 Specifically, NXPE1 utilizes acetyl-CoA to regioselectively modify the mucus sialic acid, 5-N-acety

129 useful precursors for further preparation of regioselectively monosubstituted derivatives of gamma-cy

130 kably, internal homoallyl alcohols delivered regioselectively nonconjugated unsaturated carbonyl comp

131 bility of two Saccharinae grasses to produce regioselectively O-methylated stilbenes is reported.

132 By this, a series of allyl arenes can be regioselectively obtained from readily available benzoic

133 enyl-6-(aryl-benzyl)amino-benzimidazoles are regioselectively obtained using N,N'-dibenzyl-phenylened

134 dition of the N-ethylazomethine ylide occurs regioselectively on a [5,6] double bond on the surface o

135 ogenation conditions, the NH-aziridines were regioselectively opened to the corresponding enantiopure

136 P3A4 adjusts and reshapes the active site to regioselectively oxidize chemically diverse compounds is

137 assessment because it is preferentially and regioselectively oxidized by CYP3A4.

138 ic nature of the reagents, it is possible to regioselectively prepare monoisotopically labeled produc

139 Three series of analogs were regioselectively prepared from a protected forskolin pre

140 ihydroisoquinolone cyclization precursor was regioselectively prepared via a Rh(III)-catalyzed C-H ac

141 The methods reported herein diastereo- and regioselectively proceed under straightforward and mild

142 TAZ(-) regioselectively promotes the degradation of DEDNPP via

143 Indazoles are regioselectively protected at N-2 by a 2-(trimethylsilyl

144 Both require regioselectively protected building blocks that are main

145 The trehalose core was regioselectively protected using a tandem procedure with

146 P-Nitrosophosphate (9) regioselectively reacts with 1-methoxy-1,3-butadiene to

147 the boron trifluoride etherate treatment of regioselectively reduced N-homoallyl imides.

148 the ferric-reductase-like enzyme RbtH, which regioselectively reduces one of the maleic anhydride moi

149 Specifically, AtyD regioselectively reduces the C4-keto group on 6 but cann

150 The DMAP unit was shown to regioselectively relay 1,1'-carbonyldiimidazole (but not

151 sformations proceed with stereoretention and regioselectively, responding to bond strength, as well a

152 h copper iodide.TMEDA then allylation occurs regioselectively (S(N)2 mechanism).

153 introduced at the alkene C1 and C2 positions regioselectively simply by changing the coupling partner

154 sformation forms the basis of an approach to regioselectively synthesize substituted isoquinolines vi

155 ed by the 6(I)-O-yl radical, which abstracts regioselectively the hydrogen at C5(II) of the contiguou

156 in we report a domino protocol able to reach regioselectively thiazolylidene systems by combining the

157 pi-Addition proceeds regioselectively through a single transition state to xy

158 lfonyl azides, creating four different bonds regioselectively through N-sulfonyltriazole intermediate

159 hich all reported derivatives add completely regioselectively to [5,6] double bonds.

160 iodomethyl-1,3-dioxanes proceeds rapidly and regioselectively to afford enol ether alcohols by prefer

161 Dihalocarbenes add regioselectively to aryl-substituted benzocyclopropenes

162 MBH acetates with tosyliminoindolines occurs regioselectively to form various a-carbolines with a wid

163 , such as Bronsted acid to protonate ynamide regioselectively to generate the reactive keteniminium i

164 IroD hydrolyzes apo MGE (and DGE) regioselectively to give a single linear trimer product

165 moiety embedded in fuscimiditide hydrolyses regioselectively to isoaspartate.

166 ormed in situ to iminium ions formed in situ regioselectively to produce the corresponding propargyla

167 The NO2* radical adds regioselectively to the 4- over the 2-vinyl group but do

168 riments confirm oxidative addition of Pt(II) regioselectively to the least substituted carbon-carbon

169 C-H bond with intermediate A, in some cases regioselectively, to form the neopentylidene-aryl deriva

170 Allylsilanes can be regioselectively transformed into the corresponding 3-si

171 y this application, we developed a method to regioselectively transmute the nitrogen atom from pyridi

172 Herein we provide the first series of regioselectively tunable conditions for a Cope rearrange

173 ubstituted naphthalenes are readily prepared regioselectively under mild reaction conditions by the 6

174 ocyclic scaffolds can also be functionalized regioselectively under the developed conditions.

175 mation of propargylamine intermediate, which regioselectively undergoes 6-endo-dig cyclization throug

176 these salts induces ring closure cleanly and regioselectively via formal "exo" addition of the nitrog

177 F gave 2-formyl-4-chloro-3-fluoropyridine 10 regioselectively, which was converted to 2-aminomethyl a

178 ,7-diamino-3,6-dibromo-NDI isomer was formed regioselectively, while in DMF under similar reaction co

179 thout TBAF the 2,7-diamino isomer was formed regioselectively, while without TBAF the 2,3-diamino iso

180 robust approach that combines various amines regioselectively with 4,6-dichloropyrone to create subst

181 to give XCF(2)CF(2)CFXY, c-C(3)F(5)Br reacts regioselectively with Br(2) to give a 16.7:1 mixture of

182 h a charge-transfer radical form that reacts regioselectively with O(2) as prescribed by resonance.

183 ted and unactivated aryl chlorides to couple regioselectively with olefins has been developed.

184 ng cyclic sulfamidate, which was ring opened regioselectively with representative nucleophiles to yie

185 The polymerization reaction proceeds regioselectively with the addition of the aryl bromide t

186 )methyl)quinoxalin-2-ones, reactions proceed regioselectively with the formation of only rearrangemen

187 sed from the molecule, the reaction proceeds regioselectively without perturbation of the remainder o

188 iliotoxins was formed stereospecifically and regioselectively, without the use of a directing group o

189 cryogenic photoinduced S-C bond cleavage has regioselectively yielded either 5'-dAdo. or .CH(3), and