ライフサイエンスコーパス: regioselectivity

1 a large set of terpenoids in high yield and regioselectivity.

2 epoxidation of olefins with high stereo- and regioselectivity.

3 n bond with control of stereoselectivity and regioselectivity.

4 d as substrates with complete control of the regioselectivity.

5 ed carbon leads to alcohols with Markovnikov regioselectivity.

6 developed with excellent E/Z selectivity and regioselectivity.

7 ions that reveal the factors controlling the regioselectivity.

8 and to predict the impacts of each factor on regioselectivity.

9 o 96% yield, 100% atom economy, and complete regioselectivity.

10 to alleviate the challenges associated with regioselectivity.

11 ds are mild, proceeding with high chemo- and regioselectivity.

12 alysis to give 3-hydroxyimines with complete regioselectivity.

13 and with high functional group tolerance and regioselectivity.

14 uki and Sonogashira couplings, with complete regioselectivity.

15 zed products with high stereoselectivity and regioselectivity.

16 other in good yield and excellent chemo- and regioselectivity.

17 nism and support the experimentally observed regioselectivity.

18 s of the halogenated products with excellent regioselectivity.

19 acid 2-aminoethyl ester (DPBA) as inducer of regioselectivity.

20 alkyl olefins with complete anti-Markovnikov regioselectivity.

21 tibility, low atom economy, and insufficient regioselectivity.

22 chlorides in excellent yields and with high regioselectivity.

23 te size determines the reaction products and regioselectivity.

24 ive treatment of the cycloaddition site- and regioselectivity.

25 oisomers with high enantio-, diastereo-, and regioselectivity.

26 ording acrylamides with excellent chemo- and regioselectivity.

27 amine derivatives in up to 94% yield and 99% regioselectivity.

28 that the nature of the ligand is key to the regioselectivity.

29 stereocenters with good yield and excellent regioselectivity.

30 oduct is formed in up to 74% yield and >20:1 regioselectivity.

31 eeds rapidly under mild conditions with high regioselectivity.

32 tal control lead to incorrect predictions of regioselectivity.

33 ituted pyrroles in good yields (61-86%) with regioselectivity.

34 n appear to determine the observed divergent regioselectivity.

35 of N-H pyrroles in good yields and with high regioselectivity.

36 midazoline ligand that further increases the regioselectivity.

37 ents also play an important role in reaction regioselectivity.

38 om(s) significantly affecting reactivity and regioselectivity.

39 cated that the reactions proceeded with high regioselectivity.

40 one in good to excellent yield with complete regioselectivity.

41 nd-controlled reversal of the hydrocupration regioselectivity.

42 d 26C acyl-CoAs while maintaining its Delta9-regioselectivity.

43 s of transformations, their versatility, and regioselectivity.

44 od to high chemical yields with an excellent regioselectivity.

45 sp(3) coupled products with moderate-to-good regioselectivity.

46 ons is needed to rationalize and predict the regioselectivity.

47 with complete chemoselectivity and high n/i regioselectivity.

48 oselectivities of up to 99.5:0.5 er and high regioselectivities.

49 ition of terminal alkenes in good yields and regioselectivities.

50 lization effects play a role in the observed regioselectivities.

51 nd tertiary alcohols in excellent yields and regioselectivities.

52 id (palmitic and linoleic, respectively) and regioselectivity (3 and 3', respectively).

53 s C5 isomer b is achieved in almost complete regioselectivity (46:1) and good yield.

54 High regioselectivity (~84%) is also shown by pyridine based

55 of six different steroids with pronounced C7 regioselectivities and beta stereoselectivities, as well

56 0 total turnovers) and selective (up to 25:1 regioselectivity and 97%, please refer to compound 2v en

57 onjugated alkenes, with up to 98% switchable regioselectivity and 98% diastereoselectivity for the pr

58 use of directing group strategies to control regioselectivity and build structural patterns for synth

59 -amino alcohols were obtained with excellent regioselectivity and converted to oxazolidinones and dih

60 model reproduces the experimentally observed regioselectivity and diastereoselectivity of the reactio

61 ile, and how the size of a ligand can impact regioselectivity and efficiency.

62 gistically to direct the sense and extent of regioselectivity and enantioinduction.

63 liphatic esters were obtained with excellent regioselectivity and enantioselectivity.

64 have proceeded in high yields with complete regioselectivity and excellent geometric selectivity.

65 ally hindered alkenes experience a change in regioselectivity and form unconjugated carboxylic acids.

66 e for alkyne annulations with high levels of regioselectivity and functional group tolerance, viable

67 hols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98%

68 are formed with complete levels of branched regioselectivity and high levels of anti-diastereo- and

69 the allylic position of alkenes with unique regioselectivity and no allylic transposition.

70 etal catalysts to control stereoselectivity, regioselectivity and periselectivity (selectivity among

71 , and mutational studies illustrate how high regioselectivity and periselectivity are achieved in nea

72 Mechanistic studies suggest that the regioselectivity and reactivity observed under these con

73 group appended to the alkene to control the regioselectivity and stabilize the nucleopalladated alky

74 ntate directing group is used to control the regioselectivity and stabilize the putative alkylpalladi

75 ful C-H borylation and the factors effecting regioselectivity and substrate scope to be identified, d

76 ubstituent effects on reactivity, chemo- and regioselectivity and the effects of oxidant in the inter

77 olated in good to excellent yields with high regioselectivity and under mild reaction conditions (25-

78 e oxides leads to cycloadducts with complete regioselectivity and with cis/trans selectivity up to 19

79 This allows achieving superior degrees of regioselectivity and yields in the desaturation of alcoh

80 trategy proceeded efficiently with excellent regioselectivity and yields.

81 ible mechanism was proposed for the observed regioselectivity and Z-selective arylation of N-allylpic

82 which of the two sulfur atoms was attacked (regioselectivity), and found that disulfide interchange

83 xcellent functional group tolerance, yields, regioselectivities, and stereochemical fidelities are ob

84 looctadiene products were obtained with high regioselectivity, and catalyst-controlled access to eith

85 enables the binding of substrate, guides the regioselectivity, and expels product efficiently.

86 udies of its cycloaddition reactivity, mode, regioselectivity, and scope illustrate that it participa

87 c aliphatic ketones with notable efficiency, regioselectivity, and stereocontrol.

88 ternal nucleophiles are introduced with high regioselectivity applying this substrate-directing conce

89 The observed chemoselectivity and regioselectivity are explained via an acid-catalyzed mec

90 Good levels of regioselectivity are observed for a wide range of electr

91 ls of N versus C3 and branched versus linear regioselectivity are observed.

92 tional group diversity, substrate scope, and regioselectivity are the important practical features.

93 , achieving supramolecular catalyst-directed regioselectivity as opposed to directing-group selectivi

94 strategies developed to date lack chemo- and regioselectivity as well as result in non-native linkage

95 nerated with the same high ortho-to-fluorine regioselectivity associated with the overall catalytic t

96 The reaction afforded regioselectivity at the 2,2'-positions of indole in an o

97 ction and in situ monitor its unconventional regioselectivity at the molecular level.

98 od provided 23 examples with high chemo- and regioselectivity at yields up to 96%.

99 We demonstrate the regioselectivity between reactions of sodium thiomethoxi

100 Fmoc-protected amino alcohols with excellent regioselectivity but in low to moderate yields.

101 amolecular mechanism allows for a control of regioselectivity by a metalation procedure.

102 The titanocene enforces the anti-Markovnikov regioselectivity by forming the more highly substituted

103 pairing to a SbF6(-) counterion changes the regioselectivity by up to a factor of 12 depending on th

104 y more demanding than at C2 due to issues of regioselectivity (C3 versus C2), and the requirement of

105 The regioselectivity can be explained in terms of computed e

106 e alpha-functionalization of amines in which regioselectivity can be tuned with minor changes to the

107 substrate binding and specificity, oxidative regioselectivity, catalytic efficiency, and stability.

108 insertion pathway, explaining the change in regioselectivity caused by steric effects and distinguis

109 ium phosphoramidite catalyst, which controls regioselectivity, chemoselectivity and enantioselectivit

110 3-diazooxindoles and styrenes with exclusive regioselectivity, chemoselectivity, and E-stereoselectiv

111 he yield of an amino alcohol product and the regioselectivity could be altered by the addition of a c

112 The reaction proceeded with high regioselectivity (crossed product) and perfect diastereo

113 allenyl-type were employed, giving different regioselectivities, depending on its nature; the regiose

114 degrees versus 2 degrees ) in the rate- and regioselectivity-determining transmetalation transition

115 hts into the reaction mechanism and observed regioselectivity/diastereoselectivity.

116 dition observed), proceed with a predictable regioselectivity (dienophile most electron-rich atom att

117 This strict regioselectivity differentiates the sophora biocatalyst

118 ontrol) play essential roles in the observed regioselectivity during N-alkylation.

119 trate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and room

120 the result of exquisite catalyst controlled regioselectivity enabling use of electronically unbiased

121 acid selectivity (palmitic vs. linoleic) and regioselectivity (esterification at positions 3 vs. 3').

122 The regioselectivity favoring binding to the terminal C atom

123 ein, we demonstrate a reversal of the native regioselectivity for alkene halofunctionalization throug

124 ituted alkynes, thus demonstrating divergent regioselectivity for alkyne hydrostannylation controlled

125 nd how the acceptor site of UGT76G1 achieves regioselectivity for branched-glucoside synthesis.

126 yridine can play a key role in enabling high regioselectivity for difficult reactions.

127 Preliminary results indicate high regioselectivity for primary amide formation in the diol

128 of phosphoric acid to enhance efficiency and regioselectivity for problematic cyclopentanone substrat

129 electivity, as well as pronounced ortho/meta regioselectivity for reactions performed with dienophile

130 catalysts have low linear-to-branched (L:B) regioselectivity for simple linear alkenes.

131 efforts to develop biocatalysts that confer regioselectivity for site-specific modification, thereby

132 ith unactivated arenes that occurs with high regioselectivity for the anti-Markovnikov product.

133 llyl intermediate and demonstrates exclusive regioselectivity for the branched position of the pai-al

134 reported examples in 42-68% yield and modest regioselectivity for the desired regioisomer.

135 High regioselectivity for the glycosylation on the equatorial

136 , pyrazoles, and purines with typically high regioselectivity for the less-hindered alpha-position.

137 irected or occur with low reactivity and low regioselectivity for the n-alkylarene.

138 xtremely general and proceeds with excellent regioselectivity for the ortho over para isomer.

139 nes and ketones, where it exhibits excellent regioselectivity for the tertiary carbon.

140 ds diagnostic (1)H/(13)C NMR adduct signals, regioselectivity for various dye/nucleophile combination

141 pha-d-pyranosides, which provide a change in regioselectivity from 2:1 (E) to 1:5 (Z) for the monoace

142 nocatalyst provokes a dramatic change in the regioselectivity, from the 1,5- to the 1,3-functionaliza

143 Herein, we demonstrate that the regioselectivity (gamma-selectivity vs. delta-selectivit

144 e primary cross-metathesis product with high regioselectivity (>98%) along with a molybdenum metallac

145 Herein, we report that excellent regioselectivity (>99%) can be achieved keeping an ortho

146 A change in regioselectivity has been observed in the hydrogen atom

147 This acid-induced change in regioselectivity has been successfully applied for selec

148 The factors controlling the observed regioselectivity have been quantitatively rationalized b

149 ptional and tunable diastereoselectivity and regioselectivity (head-to-head versus head-to-tail adduc

150 an be used to gain control of diastereo- and regioselectivities in the formation of this important mo

151 In addition, we evaluated the regioselectivity in a series of nucleopalladation reacti

152 center is determinant for the control of the regioselectivity in favor of the 6-endo process.

153 The decisive step in the determining regioselectivity in fluorine functionalization is fluori

154 e of sulfoximine and alkynoates and displays regioselectivity in forming single regioisomers in good

155 enzobicycloheptanone products with excellent regioselectivity in high yields (up to 96%).

156 )/N-C exhibits superior chemoselectivity and regioselectivity in hydrogenation.

157 l/catalyst-free approach for the reversal of regioselectivity in nucleophilic fluorination of a wide

158 eeded with excellent efficacy and high ortho-regioselectivity in proximity to the weakly coordinating

159 s, as well as insight into the source of the regioselectivity in reactions of internal alkynes.

160 fluorinated sites are the origin of the high regioselectivity in the catalytic borylation reaction.

161 An unprecedented regioselectivity in the cycloaddition step toward the mo

162 This reaction involves a reverse regioselectivity in the cyclopropene opening than with g

163 omposition analysis shows that the change of regioselectivity in the DA reaction of hollow fullerenes

164 an ion pair-directed approach to controlling regioselectivity in the iridium-catalyzed borylation of

165 This is presumably related to the high regioselectivity in the Prato addition reaction driven b

166 ioselectivities, but also provides exclusive regioselectivity in the presence of two methylene groups

167 regiodivergent reactions allow control over regioselectivity in the synthesis of a wide range of org

168 The alpha-angelica lactone displays unusual regioselectivity in this reaction, acting as a nucleophi

169 ltaneous control of diastereoselectivity and regioselectivity in Zn-catalyzed allenylation reactions

170 bonding, will accelerate reactions, control regioselectivity, induce spin-state selectivity, and eli

171 echanistic study sheds light on the observed regioselectivity involving a Cu-vinylidene complex, and

172 A high level of regioselectivity is achieved in 37 examples, where (E,E)

173 Additionally, the regioselectivity is also influenced for such interaction

174 Furthermore, the regioselectivity is complementary to conventional method

175 Notably, the observed regioselectivity is complementary to conventional radica

176 oselectivities, depending on its nature; the regioselectivity is complete with alkyl azides and pheny

177 The regioselectivity is controlled by the electron-donating

178 The regioselectivity is controlled by the electronically tun

179 The regioselectivity is directed by the substituent at the C

180 This regioselectivity is distinct from that of the classical

181 Here, regioselectivity is governed for 10 of the 11 active sub

182 The strict regioselectivity is guided by the pyridyl substituent at

183 n the other hand, achieving a high degree of regioselectivity is important as that will make the reac

184 ding these key factors affecting the product regioselectivity is important to the development of cata

185 The regioselectivity is justified by the DFT calculations at

186 The reaction regioselectivity is supported by the data of quantum-che

187 or elongation, but the mechanistic basis for regioselectivity is unknown.

188 ing computational rationale for the observed regioselectivity, is also described.

189 s dimerization points to a certain degree of regioselectivity, leading to a low sheet homogeneity (Hs

190 The regioselectivities observed computationally allowed the

191 underpins the high enantioselectivities and regioselectivities observed.

192 The high chemo- and regioselectivity observed for these reactions is attribu

193 The regioselectivity observed in alkyl azides and phenyldiaz

194 igins of the uniquely high ortho-to-fluorine regioselectivity observed in these reactions.

195 ered radicals, although the magnitude of the regioselectivity observed is greater for hydroxyl.

196 Prompted by the observation that the regioselectivities of phenolate reactions (C versus O at

197 Thus, the regioselectivities of reactions of five-membered heteroa

198 e effects of the organoboron catalyst on the regioselectivities of the epoxide ring-opening and acyla

199 arbon-carbon bond formation and controls the regioselectivities of the pair of subsequent aminal bond

200 uning of the reaction system, which provided regioselectivities of up to 98:2.

201 via the cis/syn form of nitroso oxide with a regioselectivity of 91%.

202 The same unusual regioselectivity of addition was observed with monoaryl

203 Controlling the regioselectivity of ambident nucleophiles toward alkylat

204 ntate directing group is used to control the regioselectivity of aminopalladation and stabilize the r

205 The regioselectivity of C-H activation is correlated to the

206 The regioselectivity of C-H activation is dominated by steri

207 To achieve full control on the regioselectivity of chemical additions to fullerenes is

208 5 variant resembled that of WT Thal, but its regioselectivity of chlorination and bromination was alm

209 However, controlling the regioselectivity of disubstituted epoxide transformation

210 The regioselectivity of hydroxyl radical addition to arenes

211 The regioselectivity of hydroxylation was broken when the re

212 ation complement those of earlier studies on regioselectivity of IPR fullerenes and endohedral metall

213 f substituents demonstrates the efficacy and regioselectivity of metalation.

214 ic insights into the surface selectivity and regioselectivity of molecular grafting.

215 leophile-substrate interaction affecting the regioselectivity of nucleopalladations with different Pd

216 The data rule out a bifurcation based on the regioselectivity of protonation of the hydroperoxide, as

217 It was found that the regioselectivity of reaction depends dramatically on the

218 alculations were utilized to rationalize the regioselectivity of the addition reaction.

219 eactivity descriptors were used to study the regioselectivity of the addition steps.

220 In addition, the regioselectivity of the addition was probed using both D

221 ures was achieved via a simple switch in the regioselectivity of the alkyne insertion thanks to a pro

222 Products distribution shows that the regioselectivity of the anchimerically driven alkylation

223 Evidence obtained from the resulting regioselectivity of the annulation reactions and DFT stu

224 ocated hydrogen bond to transcend the normal regioselectivity of the C-F functionalization event.

225 rol the rate of the alkene insertion and the regioselectivity of the catalytic reactions of vinylaren

226 ate directing groups are used to control the regioselectivity of the chloropalladation step and stabi

227 to develop a general analysis to predict the regioselectivity of the cross-coupling reaction.

228 prior to reaction could greatly enhance the regioselectivity of the dehydrocyclization reaction and

229 required by Nature: the chemo-, stereo-, and regioselectivity of the desaturation of stearic acid.

230 Mechanistic studies reveal that the apparent regioselectivity of the desired bond-forming event is a

231 The regioselectivity of the diamination is controlled by the

232 In this work, we computationally analyze the regioselectivity of the Diels-Alder (DA) reaction of cyc

233 nvestigate the effects of ion pairing on the regioselectivity of the hydroarylation of 3-substituted

234 nsition state theory incorrectly predict the regioselectivity of the hydroboration of propene with BH

235 The complete shift of the regioselectivity of the intermediate enolate from a C-C

236 The observed regioselectivity of the ortho-cyclization of nitroso oxi

237 the Wacker oxidation suggested that the high regioselectivity of the oxidation in these lactam alkene

238 The regioselectivity of the process and the factors controll

239 The regioselectivity of the protocol has been confirmed by p

240 The scope and regioselectivity of the reaction are presented here, and

241 n as a major problem, the causes of the poor regioselectivity of the reaction are unknown.

242 intermediates in a reaction mixture, and the regioselectivity of the reaction have been demonstrated

243 In addition, the regioselectivity of the reaction was studied and rationa

244 The regioselectivity of the reaction with unactivated termin

245 This study allowed a deep knowledge of the regioselectivity of the reaction, which can be tuned thr

246 at we expected to be crucial for guiding the regioselectivity of the reaction.

247 bridged intermediate lower both the rate and regioselectivity of the reaction.

248 The structures of the products and regioselectivity of the reactions were determined on the

249 The regioselectivity of the second annulation reaction was r

250 The regioselectivity of the transannular cyclization was inf

251 lenoate was found to exclusively control the regioselectivity of the transformation.

252 The regioselectivity of this C-C bond-forming event can be r

253 The regioselectivity of this CDC reaction was confirmed by d

254 The study focuses on the regioselectivity of this reaction on unsymmetrically sub

255 ons on the reaction mechanism to account for regioselectivity on the addition of indoles to unsymmetr

256 hat offer orthogonal chemoselectivity and/or regioselectivity patterns to processes promoted by late

257 Excellent regioselectivity, readily available starting materials,

258 at high resolution to explain this exquisite regioselectivity remains unfulfilled.

259 that have the ability to influence reaction regioselectivity remote to their local chemical environm

260 tion and supramolecular masks-the control of regioselectivity requires multi-step synthetic procedure

261 erns that do not conform to classical S(E)Ar regioselectivity rules can be readily accessed.

262 The method provides excellent regioselectivity, scalability to the gram scale, and a b

263 The reaction gives an unusual regioselectivity switch from aliphatic to aldehyde hydro

264 ogen atom abstraction barriers and enables a regioselectivity switch to a competitive pathway that is

265 incorporating the Ampaphos ligand triggers a regioselectivity switch, allowing both linear and branch

266 alkynes and Bu(3)SnH in high yield and good regioselectivity; these products are challenging to acce

267 and with excellent enantio-, diastereo-, and regioselectivity through catalytic asymmetric fluoroenol

268 f the loop sequence suggests a mechanism for regioselectivity through Dio type-specific loop conforma

269 Excellent chemo- and regioselectivities to five-membered cyclic ureas have be

270 by DFT calculations, which show the observed regioselectivity to arise from steric effects in the B-C

271 an oxygen atom transfer reagent reverses the regioselectivity to give 5-amino-1,3-oxazoles, in compar

272 cycles, including the factors that drive the regioselectivity toward both possible sites.

273 than a minute at room temperature with total regioselectivity toward indolizine C3 carbon.

274 The observed regioselectivity towards primary C(sp(3) )-H activation

275 The rearrangement occurs with high regioselectivity under mild and open-air conditions.

276 ano anions, react with unexpected stereo- or regioselectivity under standard glycosylation conditions

277 and -alkylated benzothiophenes with complete regioselectivity, under metal-free and mild conditions.

278 occurs with high enantio- (up to 96% ee) and regioselectivity (up to >50:1 rr) by applying a novel Ha

279 ivatives were efficiently obtained with high regioselectivity (up to >95:5) and high enantioselectivi

280 are shown to undergo each reaction mode with regioselectivity values reaching greater than 20:1 and e

281 nt yield, practically simple execution, high regioselectivity, very good atom economy, low E-factor,

282 High regioselectivity was achieved in the case of unsymmetric

283 This change in the regioselectivity was attributed to the electronic and, p

284 Regioselectivity was established through the isolation a

285 In addition, reversed regioselectivity was observed for aryl-substituted alkyn

286 High regioselectivity was observed for naturally derived poly

287 High regioselectivity was observed with 1-substituted and 1,2

288 Additionally, in all cases with high 3'-5' regioselectivity, Watson-Crick base pairing between the

289 Experimentally determined regioselectivities were consistent with predictions made

290 Moderate to excellent yields and excellent regioselectivities were obtained for electron-withdrawin

291 Their specific activity and regioselectivity were studied in the synthesis of conjug

292 The reaction mechanism and regioselectivity were then systematically explored by qu

293 roarenes occurs with high sterically derived regioselectivity when catalyzed by the combination of [I

294 ons are distinguished by excellent levels of regioselectivity when unsymmetrical alkynes are used tha

295 ty, high functional group compatibility, and regioselectivity while relying on FeCl3 as an environmen

296 The ligand identity is key to achieving high regioselectivity, while the mild reaction conditions min

297 Atom-economy and high regioselectivity with good to excellent yields of the al

298 owever, the ability to precisely control its regioselectivity with well-established Rh- or Co-catalys

299 This process presented high regioselectivity, with approximately 80mol% of concentra

300 h chemical yields, (ix) excellent chemo- and regioselectivity, (x) short reaction time, (xi) gram-sca