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1 ligand in anaerobic cobamide biosynthesis is regiospecific.
2 alG4), whose catalytic functions are clearly regiospecific.
3 SCSC) polymerization at room temperature via regiospecific 1,3-dipolar cycloaddition, yielding the co
4 thase (ISPS), enzymes that catalyze a formal regiospecific 1,4-conjugate elimination of hydrogen diph
5 combinant proteins revealed that NnOMT1 is a regiospecific 1-benzylisoquinoline 6-O-methyltransferase
6 ka mask and dibenzyl-bromomalonate, a single regiospecific 2 o'clock bis-isomer is obtained, owing to
7 uccess of our strategy is a highly efficient regiospecific 7-mono- and 7,12-di-phenoxy bay substituti
8 a functionalized arylstannane gave expedient regiospecific access to a wide range of functionally div
9 ence of substituted pyridine N-oxides offers regiospecific access to acyl/aryl, acyl/alkenyl, and acy
11 ediacy of 2,3-bridged-2H-azirine followed by regiospecific addition of an amine to C=N/ring opening/c
12 trate enolate, not vindoline, and subsequent regiospecific addition of the resulting electrophilic ra
14 ring, we unravel structural contributions to regiospecific aldol condensations and show that reshapin
15 report that the cleavage products vary from regiospecific alkyl cleavage to predominant aryl cleavag
17 iliverdin IXalpha by heme oxygenase involves regiospecific alpha-meso-hydroxylation followed by extru
18 tion of proteins entails forming two or more regiospecific amide bonds of multiple free peptide segme
22 ic information explaining how OhyAs catalyze regiospecific and stereospecific hydration is required t
23 dies revealed that SRPK1 phosphorylates RS1, regiospecific and temporal-specific control within the l
24 dies reveal CalE10-catalyzed oxidation to be regiospecific and to present trace amounts of the corres
27 adily available building blocks, including a regiospecific approach to N-substituted benzimidazoles a
28 stal cavity where substrate must bind during regiospecific aromatic ring hydroxylation catalysis.
30 lts show that the process was not completely regiospecific at sn-1,3 positions, due to the spontaneou
32 Mechanistic studies are consistent with a regiospecific bimolecular homolytic substitution (S(H)2'
33 our unprotected segments forming two or more regiospecific bonds consecutively without a deprotection
35 s good functional-group compatibility and is regiospecific, both of which can be issues with traditio
39 a homodimer whose enzyme activity is highly regiospecific by producing N-gamma-ADABA but not the ect
41 such as 1c,f,g are mild, regioselective, and regiospecific C-acylating agents of particular utility w
42 quinoxalines) and methylbenzenes leading to regiospecific C-aroylation has been accomplished using A
43 Using this strategy, we demonstrate ortho-regiospecific C-H activation of pyridines and an example
49 ith olivetol under silver catalysis provided regiospecific (-)-CBD, contrary to reported ones which g
50 studies provide insight into the origins of regiospecific changes in potency of siRNAs and the incre
52 controlled on microfabricated substrata with regiospecific chemistry by confining attachment and spre
53 hydrolyzed products was consistent with the regiospecific chlorination at position 5 and then positi
54 oramine likely plays a key role in directing regiospecific chlorination of substrate in this importan
55 sis of these compounds, a novel tin-mediated regiospecific cleavage reaction of the dioxole intermedi
56 specific effects, the present study analyzed regiospecific conformational changes of heated native be
57 son-Khand reaction has been explored for the regiospecific construction of [5.5.5.5]- and [5.6.6.5]te
58 ings are presented as a new strategy for the regiospecific construction of diaryl and alkyl aryl ethe
59 for the mechanistic and structural study of regiospecific control of the substrate hydroxylation by
60 Interestingly, both the stereoselective and regiospecific control over phenoxy radical-radical coupl
61 The reaction proceeds smoothly in absolute regiospecific control when symmetrical diynes are applie
64 with unique chemical reactivity that allows regiospecific covalent conjugation in the presence of th
66 t in aromatic polyketide biosynthesis is the regiospecific cyclization of a linear, preassembled poly
69 is a bifunctional protein that catalyzes the regiospecific cyclization of the Tcm PKS-bound linear de
70 nthases (NR-PKS group of IPKSs) results from regiospecific cyclizations of reactive poly-beta-keto in
73 tutive monoterpenes that is conferred by two regiospecific cytochrome P450 limonene-3- and limonene-6
75 ups) and its d4-analogue provide evidence of regiospecific decompositions after attachment of fluorid
81 te localization to the base of the heart and regiospecific distributions of nucleoside derivatives an
82 eal that the CT exerts both multifaceted and regiospecific effects on catalytic activities and relate
86 e by heme oxygenase (HO-1) results in highly regiospecific extrusion of the alpha-meso-carbon as CO a
88 crete aromatase/cyclase enzymes in bacteria, regiospecific first-ring aldol cyclizations result in ch
89 this paper, we synthesized and purified two regiospecific fluoro- and bromo- substituted end groups
90 benzoyl-CoA, respectively, and is apparently regiospecific for acylation of the 2alpha-hydroxyl group
91 tructure of a ligase ribozyme that catalyzes regiospecific formation of a 5' to 3' phosphodiester bon
92 pecies acts as an autocatalyst to prompt the regiospecific formation of N-substituted pyrazoles in go
93 , the formation of six stereocenters and the regiospecific formation of six rings in A-74528 appear t
95 ification has been demonstrated to be highly regiospecific, forming proteinogenic para-Tyr (p-Tyr) ex
96 oducts to photodissociation in solution with regiospecific fragmentation of the core cyclobutane ring
97 tC is a geranyl transferase that catalyzes a regiospecific Friedel-Crafts alkylation of the naphthace
99 n chemistry, the latter enabling the direct, regiospecific functionalization of the unsubstituted thi
100 blish the second core quaternary center, and regiospecific functionalizations of the resultant comple
101 ping approach to explore the determinants of regiospecific glycosylation of two GTs of Arabidopsis th
102 cosubstrates, purified RebH displays robust regiospecific halogenating activity to generate 7-chloro
105 A key step employed the chemospecific and regiospecific hydroboration/oxidation at C(16)-C(17); th
106 dihydroxybenzoyl)serine (DHB-Ser) moiety and regiospecific hydrolysis of an ester linkage in the tril
107 iron enzymes, which catalyze the stereo- and regiospecific hydroperoxidation of unsaturated fatty aci
108 distinct cytochrome P450s that catalyze the regiospecific hydroxylation of (-)-4S-limonene at C3 or
111 enantiofacial errors, and is 3.5 times less regiospecific in propylene polymerizations at the same c
112 differentiate block-hybrid dendrons and was regiospecific in the retro-aldol reaction of dendron 21.
113 These features are consistent with rapid and regiospecific inactivation of pSAMHD1 dNTPase at RFs or
114 enyl)naphthalene in CH(3)CN-D(2)O, whereupon regiospecific incorporation of deuterium takes place at
116 anamidyl/arylcyanamidyl radical, followed by regiospecific interaction of its nitrile-N center with b
118 so been extended to deuterodeboronations for regiospecific ipso-deuterations of aryls and heteroaryls
119 addition with a 3-furyl-benzoate followed by regiospecific lactonization provided rapid, large-scale
120 pagation within a highly stereoselective and regiospecific living coordination polymerization of 1,6-
121 into the imidazole moiety was achieved in a regiospecific manner to establish both C-N bonds to C(6)
122 on metal catalysis, the reaction occurs in a regiospecific manner, leading exclusively to the product
126 nt O-methyltransferase; (ii) NcsB1 catalyzes regiospecific methylation at the 7-hydroxy group of its
127 c pathway, revealing that (i) TnmH catalyzes regiospecific methylation at the C-7 hydroxyl group, (ii
128 -induced cytokine secretion was dependent on regiospecific methylation of the flavonol scaffold with
129 level of control of scaffold bioactivity by regiospecific methylation, with important implications f
130 xpected to further enhance the potential for regiospecific modification of bacterial aromatic polyket
131 structural determinants for the stereo- and regiospecific modification of their tetrapyrrole substra
132 aerobic, transition-metal-free, direct, and regiospecific mono-alpha-arylation of ketones to yield a
135 sol and o-methoxyphenol as model substrates, regiospecific mutants of T4MO were created; for example,
136 a four-component complex that catalyzes the regiospecific, NADH-dependent hydroxylation of toluene t
137 bstrates for C4-prenylation and also acts as regiospecific O-dimethylallyltransferase (DMAT) on a tyr
138 ynaphthoic acids as substrates and catalyzes regiospecific O-methylation; and (iv) the carboxylate an
140 id-mediated conditions, the model under went regiospecific oxa-conjugate addition producing a stable
141 ethionine salvage pathway that catalyzes the regiospecific oxidation of 1,2-dihydroxy-3-oxo-(S)-methy
143 e, an enzyme has been engineered so that its regiospecific oxidation of a substrate can be controlled
145 oluene-o-xylene monooxygenase influences the regiospecific oxidation of aromatics (e.g., from o-creso
147 alpha-sulfonamide carbanion is possible and regiospecific oxidation with chromyl acetate has been ac
148 thod was further optimized by analysis of 18 regiospecific pairs of AAB type TGs and five triplets of
149 owed for the description of a broad-spectrum regiospecific peptidyl tryptophan-6-brominase which poss
150 que 'grab-and-pull' mechanism to control the regiospecific phosphorylation of its protein substrate.
151 earch for more efficient catalysts, enabling regiospecific phosphorylations and oligonucleotide forma
152 This is consistent with their formation by a regiospecific polymerization of C(1) species derived fro
153 differential activity has drawn attention to regiospecific preparation of the C-2, C-5, and C-6 preny
156 ted that methionine oxidation can direct the regiospecific proteolysis of peptides by cathepsin G.
157 tion is generated by anchimerically assisted regiospecific protonation of a double bond adjacent to t
158 proved this novel technique by capturing the regiospecific reaction between a thiol and a vicinal dis
159 an-1-amine isomer (b) occurred, leading to a regiospecific reaction in the radiolabeling of [(18)F]-f
161 ay are a valuable resource for understanding regiospecific reactions and substrate selectivities and
162 from vinorelbine by means of an original and regiospecific rearrangement and subsequent diastereosele
163 The target N9-H analogues were obtained via regiospecific reductive amination of the appropriate ben
164 The N9-CH3 analogues were synthesized via a regiospecific reductive methylation of the corresponding
165 MS analyses proved unequivocally the highly regiospecific regular prenylation at C-5 of the indole n
167 ed by means of quaternization and subsequent regiospecific ring opening at C4 of the azetidinium inte
169 of triethylamine hydrobromide, enabled their regiospecific ring-opening at C6 position by organometal
170 hese indole alkaloids and provides the first regiospecific route to 11-methoxy-substituted ajmaline/v
172 [FAC], [Cl(-)]) permitted quantification of regiospecific second-order rate constants for formation
173 ide, bromide, and chlorine) were varied, and regiospecific second-order rate constants were calculate
175 An efficient synthetic strategy for the regiospecific silylvinylation of internal alkynes is des
176 a and para dibenzyl pyromellitates served as regiospecific sources of other diesters, by further este
177 inal bronchioles and support the notion that regiospecific stem cell niches function to maintain epit
178 This ester was then employed in the first regiospecific, stereospecific total synthesis of (+)-12-
181 tive L-dCs are introduced into a D-template, regiospecific synthesis of 3'-5' oligo(G)s proceeds to t
182 promoted the mild and efficient stereo- and regiospecific synthesis of biologically important vinyl
185 col provides the facile and highly efficient regiospecific synthesis of various 1,2,4-thiadiazole der
187 , on mild heating of its crystals, undergoes regiospecific TAAC polymerization to yield a 1,4-disubst
188 uV, none of which are shell proteins, allows regiospecific targeting of the reporter group to the emp
189 rmer is the more stereospecific and the less regiospecific, the sum of these two enantioface errors i
191 Type A photorearrangements of 9a-g were regiospecific to give mixtures of two diastereomers of t
192 dative [3 + 2] annulation strategy is highly regiospecific to proceed a selective C-N bond formation
193 also maintained crystallinity and underwent regiospecific topochemical polymerization as in the case
194 ut 10-fold more efficiently than (2S)-1, and regiospecific toward both substrates with exclusive atta
195 acetyl CoA, respectively, and is apparently regiospecific toward the 10-hydroxyl group of the taxane
196 a molecular mass of 54 kDa and catalyzed the regiospecific transfer of a glucuronosyl unit from UDP-g
197 fucosyltransferase 1 (AtFUT1) catalyzes the regiospecific transfer of terminal 1,2-fucosyl residues
198 Small size and minimal requirements for regiospecific translational activity strongly support th
199 hyll a biosynthesis requires the stereo- and regiospecific two electron reduction of the C7-C8 double
200 pha-arylated ketones, which are converted to regiospecific vinyl triflates and cyclized by a palladiu
201 ctions involving aldoxime ethers) as well as regiospecific when using 2'-aryl groups with meta-substi