ライフサイエンスコーパス: regulator gene

1 he cystic fibrosis transmembrane conductance regulator gene.

2 ression in the absence of ydeO, an AraC/XylS regulator gene.

3 8-kb genetic region downstream from the alcR regulator gene.

4 an cystic fibrosis transmembrane conductance regulator gene.

5 utations in the CF transmembrane conductance regulator gene.

6 he cystic fibrosis transmembrane conductance regulator gene.

7 mainly CpG islands (CGIs), of developmental regulator genes.

8 shRNA screen targeting 363 human epigenetic regulator genes.

9 acting promoter motifs in several cell-cycle regulator genes.

10 anscription factor PU.1 to key lymphoid fate regulator genes.

11 y silencing lineage-specifying developmental regulator genes.

12 fications of histone marks at several master regulator genes.

13 ne regulatory network among 87 transcription regulator genes.

14 thought to be controlled by a single 'master regulator' gene.

15 mediately upstream of the fur (ferric uptake regulator) gene.

16 R (cystic fibrosis transmembrane conductance regulator) gene.

17 utophagy, was identified as a hub, or master regulator, gene.

18 n the human interferon-related developmental regulator gene 1 (IFRD1) as a disease-causing candidate.

19 lated AMP kinase; and down-regulated silence regulator gene 1 and PGC-1alpha mRNA/proteins and hepati

20 nthetic genes and down-regulation of silence regulator gene 1, PGC-1alpha, adiponectin, and lipid deg

21 VI secretion-related gene, a transcriptional regulator gene, a guanine deaminase gene, and cviI.

22 mutations of the cystic fibrosis conductance regulator gene account for the chronic pancreatitis note

23 Here, we investigated the role of a UPR regulator gene, activating transcription factor 6 (Atf6)

24 or, VirBR, that binds to the promoter of the regulator gene actX enhancing the transcription of Type

25 Mutations in the staphylococcal virulence regulator gene agr frequently occur during Staphylococcu

26 the function of the staphylococcal virulence regulator gene agr.

27 The human autoimmune regulator gene (AIRE), responsible for autoimmune polygl

28 ted in mature mTEC expressing the autoimmune regulator gene (Aire).

29 Recently, an autoimmune regulator gene (AIRE-1), which is located on chromosome

30 eatured higher basal expression of key PP(i) regulators, genes ALPL, progressive ankylosis protein (A

31 initial change in the expression of a given regulator gene and its potential target gene to estimate

32 nduced induction of a master transcriptional regulator gene and its protein expression critical to ne

33 he cystic fibrosis transmembrane conductance regulator gene and single nucleotide polymorphism in HLA

34 ssion of several type-A ARABIDOPSIS RESPONSE REGULATOR genes and a number of genes involved in cell w

35 Some evidence suggests that a number of regulator genes and gene clusters will likely be found t

36 The timing of transcription of two master regulator genes and two cell division genes is controlle

37 ns in the CFTR (CF transmembrane conductance regulator) gene and is characterized by sustained inflam

38 ssecting cross-interactions among multilevel regulators, genes and biological functions.

39 - targeting SP2020 (putative transcriptional regulator gene) - and compared its performance with the

40 o a mixture of 17 Salmonella mutants lacking regulator genes, and their survival ratios were compared

41 Mutations in lipid regulator genes are a frequent cause of autism spectrum

42 When superrepressed, regulator genes are anticipated either to block programs

43 Subclonal mutations in numerous epigenetic regulator genes are common across cancer types, yet thei

44 In contrast, epigenetic regulator genes are more frequently targeted by somatic

45 c stem cells (mESCs), CpG-rich developmental regulator genes are repressed by the Polycomb complexes

46 riptional activation of ARABIDOPSIS RESPONSE REGULATOR genes, ARR7 and ARR15, feedback repressors of

47 ing that Brachyury is not a notochord master regulator gene as strictly defined.

48 pinpoints a small number of master metabolic regulator genes, balancing the relative proportion of do

49 ription from the p1 promoter of the response-regulator gene bldM depended on bldN in vivo, and the bl

50 raembryonic lineages at promoters of lineage regulators, gene bodies, and DNA-methylation valleys.

51 a indicate that aberrations in the chromatin regulator gene BRPF1 cause histone H3 acetylation defici

52 romosomal translocations involving chromatin regulator genes can lead to the formation of fusion onco

53 Deletion of the main transcriptional regulator gene, cbbR, resulted in impaired growth on ben

54 ubisCO) along with a divergently transcribed regulator gene, cbbR.

55 detect gene amplification of the cell cycle regulator gene CCND1 in 88 examples of formalin-fixed, p

56 hepatic expression of the G(1)/S checkpoint regulator genes Ccnd1 and cMyc and increased expression

57 ng the expression of a fission yeast mitotic regulator gene, cdc25, under the control of a tetracycli

58 he cystic fibrosis transmembrane conductance regulator gene CFTR have empirical evidence that they ca

59 kb cystic fibrosis transmembrane conductance regulator gene ( CFTR ) and Escherichia coli lacZ .

60 an cystic fibrosis transmembrane conductance regulator gene ( CFTR ) and its murine homologue ( Cftr

61 he cystic fibrosis transmembrane conductance regulator gene (CFTR) are poorly understood.

62 he cystic fibrosis transmembrane conductance regulator gene (CFTR) encodes a transmembrane protein (C

63 he cystic fibrosis transmembrane conductance regulator gene (CFTR) in 1989 represents a landmark acco

64 ung disease mutation in the CF transmembrane regulator gene (CFTR) led to correction or partial corre

65 or cystic fibrosis transmembrane conductance regulator gene (CFTR) mutations or polymorphisms, were e

66 he cystic fibrosis transmembrane conductance regulator gene (CFTR) shows a tightly regulated pattern

67 he cystic fibrosis transmembrane conductance regulator gene (CFTR) that cause cystic fibrosis have be

68 he cystic fibrosis transmembrane conductance regulator gene (CFTR) that disturbs fluid homeostasis an

69 he cystic fibrosis transmembrane conductance regulator gene (Cftr) to test the hypothesis that SLC26A

70 an cystic fibrosis transmembrane conductance regulator gene (CFTR) transcription is tightly regulated

71 he cystic fibrosis transmembrane conductance regulator gene (CFTR), as well as genes involved in anti

72 an cystic fibrosis transmembrane conductance regulator gene (CFTR), in which an abbreviated polypyrim

73 he cystic fibrosis transmembrane conductance regulator gene (CFTR), the sup-tRNAs re-established expr

74 he cystic fibrosis transmembrane conductance regulator gene (CFTR).

75 he cystic fibrosis transmembrane conductance regulator gene (CFTR).

76 utations in the CF transmembrane conductance regulator gene (CFTR).

77 he cystic fibrosis transmembrane conductance regulator gene, CFTR.

78 , WT1 and TP53 (class III), and 5 epigenetic regulator genes (class IV), were analyzed in 206 childre

79 ependent cohorts, we identified (1) a master regulator gene common to asthma across severity and ages

80 he cystic fibrosis transmembrane conductance regulator gene could be detected simultaneously in inter

81 versity and fewer mutations in two-component regulator genes covRS.

82 entified early driver mutations in chromatin regulator genes (CREBBP, EZH2 and KMT2D (MLL2)), whereas

83 45], P = 4.54 x 10(-5) ), and the complement regulator gene CSMD1 (rs7002001; odds ratio 2.41 [95% co

84 The carbon storage regulator gene, csrA, encodes a factor which negatively

85 t affect expression of eukaryotic cell cycle regulator genes CYCD3;1 and CDC2A but affects expression

86 An insertion mutation of the sensor-regulator gene eliminated the ability of uropathogenic E

87 of neighboring histidine kinase and response regulator genes, encoded on the same strand, was compile

88 The mtrR (multiple transferrable resistance Regulator) gene encodes a putative transcriptional repre

89 mline mutations in the WNT-signaling-pathway-regulator gene encoding APC, and we generated COs that e

90 As effector gene expression increases, regulator gene expression can

91 ce the expression of its own gene, such that regulator gene expression is repressible (like effector

92 in the same direction; uncoupling, in which regulator gene expression remains constant while effecto

93 h widespread homeostatic control of splicing regulator gene expression.

94 ime by binding to chromatin of the flowering regulator gene Flowering Locus C (FLC).

95 Comparative analysis of the master regulator genes followed by validation testing in indepe

96 The RPGR (retinitis pigmentosa GTPase regulator) gene for RP3, the most frequent genetic subty

97 the functional role of the master courtship regulator gene fruitless (fru) and show that fru is nece

98 utation in the host's global transcriptional regulator gene fur.

99 Using a Vibrio cholerae iron uptake regulator gene (fur) as a probe, a 2.6-kb SalI/HindIII D

100 pathogenicity island (SPI) 1 transcriptional regulator genes hilA, C, and D and invF.

101 Lrp represses transcription of key virulence regulator genes--hilA, invF, and ssrA--in Salmonella pat

102 sults identify mtrA as an essential response regulator gene in M. tuberculosis which is differentiall

103 categories, 8 molecular networks, and 10 key regulator genes in confluency-induced differentiation of

104 ts provide a rationale for autoregulation of regulator genes in repressible gene circuits and lead to

105 This implicates putative master regulator genes in which multiple independent stop codon

106 ative stress response and pigment production Regulator) gene in Pseudomonas aeruginosa.

107 s several members of the B7 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; O

108 ce of JAK2-V617F and mutations in epigenetic regulator genes, including EZH2 In this study, we show t

109 By disrupting 200 epigenetic regulator genes, individually or in combination, we gene

110 omplish metabolic processes, this network of regulator-gene interactions describes potential pathways

111 ty and coverage of the underlying network of regulator-gene interactions.

112 A regulator gene is adjacent to the operon of the sulfide-

113 By contrast, only the duplicated response regulator gene is present in the sex-linked regions of P

114 Such a subpopulation of regulator genes is expected to include, notably, genes g

115 The HFE (Homeostatic Fe regulator) gene is commonly mutated in hereditary hemoch

116 ion alone, including the iron-sulfur cluster regulator gene, iscR, which was required for oxidative s

117 n the level of expression of the main myelin regulator gene Krox20/Egr2 and the myelin gene P0.

118 ta sets revealed the hematopoietic stem cell regulator gene latexin (LXN) to be commonly downregulate

119 howed that allele replacement of the NMB0595 regulator gene led to loss of virulence, sensitivity to

120 tified and further validated transcriptional regulator genes like MAFB, TFAP2B, and POU6F2 to be diff

121 identified a novel maternal transcriptional regulator gene, lilliputian (lilli), which contains an H

122 Recurrent point mutations were enriched in regulator genes linking unicellular and multicellular su

123 Deletion of the response regulator gene, lovR, results in severe attenuation of c

124 Two new LysR-type symbiosis regulator genes, lsrA and lsrB, were identified in the s

125 ture stop codon in the lysosomal trafficking regulator gene (LYST) that shortens the corresponding pr

126 lelic mutations in the lysosomal trafficking regulator gene (LYST), resulting in formation of giant l

127 Our analyses identified 41 consensus master regulator genes (MRs), the regulons of which comprised b

128 we constructed an flhD (the master flagellar regulator gene) mutant of Salmonella enterica serovar Ty

129 Deletion of the sialic acid regulator gene nanR partially restored IBC formation in

130 homeotic mutation in the co-transcriptional regulator gene NODULE ROOT1 (MtNOOT1) converts legume-ty

131 The global nitrogen regulator gene ntcA encodes a DNA-binding protein, NtcA,

132 The SKN7 two-component response regulator gene of Candida albicans was deleted, and the

133 Regulator gene of glucosyltransferase (Rgg) family prote

134 The identified master regulator genes of asthma provide a novel path forward t

135 EM231, CAPS, PTPRC, and FYB); and (3) master regulator genes of mild/moderate persistent asthma in ch

136 across severity and ages (FOXJ1); (2) master regulator genes of severe persistent asthma in children

137 osaC is linked to the response regulator gene osaB; expression analysis of the latter r

138 The independently transcribed response regulator gene, osaB, is essential for osmoadaptation; w

139 n rare and novel variants only in complement regulator genes (P<0.01), a distinction consistent with

140 pothesized that modulation of the epigenetic regulator gene p63 could improve the efficiency of human

141 A putative Lrp/AsnC-type transcriptional regulator (gene PA2082, here called kynR), is divergentl

142 is of a hybrid histidine kinase and response regulator gene pair, osaAB, involved in osmoadaptation i

143 ity of a divergent histidine kinase-response regulator gene pair.

144 Conducting univariate test for each possible regulator-gene pair is subject to serious multiple compa

145 defined two histidine kinase sensor-response regulator gene pairs important for S. aureus in vivo sur

146 lication of regularization methods to select regulator-gene pairs is computationally infeasible.

147 at both node (regulators or genes) and edge (regulator-gene pairs) levels.

148 A putative LysR-type transcriptional regulator gene, pcpM, and a maleylacetate reductase gene

149 Two hypothetical LysR-type regulator genes, pcpM and pcpR, have been identified; pc

150 decreased 5mC methylation in transcriptional regulator genes (pcrA and rpsD), compared to strains wit

151 phe (MR) neurons expressing the serotonergic regulator gene Pet1 send collateralized projections to f

152 sociated only with mutations in the response regulator gene pleD that block the loss of motility.

153 operon with the TetR-family transcriptional regulator gene pnbX, implying that it has a distinct reg

154 tion is effected through control of both the regulator gene prpR and the prpBCDE operon itself.

155 These prophage-encoded secretion regulator genes (psr) are found exclusively on prophages

156 e gene (cph1) and its cotranscribed response regulator gene (rcp1) were significantly reduced and its

157 Mutation of the cognate response regulator gene rcsB restored full virulence to the rcsC

158 The transposon interrupted a response regulator gene (referred to as aoxR), which encodes an n

159 he cystic fibrosis transmembrane conductance regulator gene region across nine eutherian mammals reve

160 els, which lead to improved understanding of regulator-gene relationships, discovery of transcription

161 cence/immortalization and found that the key regulator genes represented six pathways: the cell cycle

162 se range of functions, including a number of regulators, genes required for glutamine synthesis, NADH

163 on efflux transporter gene and a PbrR family regulator gene, respectively.

164 aling molecules, including the redox-sensing regulator gene rex.

165 etected a GA insertion in the quorum-sensing regulator gene rhlR and, in addition, identified a novel

166 in R800, inactivation of the orphan response regulator gene ritR by allele replacement reduced pathog

167 associated with retinitis pigmentosa GTPase regulator gene (RPGR) mutations.

168 ular symmetry in retinitis pigmentosa GTPase regulator gene (RPGR)-associated retinopathy using spect

169 r of iron transport) for the orphan response regulator gene, rr489, is proposed.

170 l activating mutation in the known virulence regulator gene saeS (Ala106Thr).

171 ltogether, 18 molecular networks, and 39 key regulator genes, several of which were associated with e

172 In contrast, the flowering negative regulator gene SHORT VEGETATIVE PHASE (SVP) was up-regul

173 function sequence variants in the epigenomic regulator gene SIN3A in two patients with complex CDH.

174 L and HMR) depends on the silent information regulator genes, SIR1, SIR2, SIR3, and SIR4.

175 fied a null allele of the silent information regulator gene SIR4 as a host mutant that allows for tra

176 ases (HDACs) 1 and 9, and Silent information regulator genes (sirtuins [SIRTs]) 6 and 7 were signific

177 d beta-cells activated expression of the EMT regulator gene Snail in a SMAD3/Stat3-dependent manner.

178 premature stop codon in the transcriptional regulator gene SNF2 in the mutant.

179 HIF-2alpha to a specific site in the master-regulator gene SOX9.

180 ation patterns in MPN patients at the master regulator gene SPI1 and its distal binding sites, which

181 f target cell cytokine receptors, cell death regulator genes such as bcl-2 family members, Fas recept

182 ncreased expressions of hard keratin and its regulator genes such as HOXC13.

183 enhancer loops regulate expression of master regulator genes (such as Bcl6), the T cell receptor locu

184 We assayed histone modifications at key regulator genes (such as Nanog, Pou5f1 (also known as Oc

185 comitant changes in the expression of floral regulator genes suggest that these processes are a prere

186 These include the cell growth regulator gene TGFbetaRII and the proapoptotic gene BAX.

187 often controlled by the protein product of a regulator gene that is directly involved in the control

188 Through an integrative analysis of the regulator genes that are responsible for the activation

189 gene signatures of asthma to identify master regulator genes that causally regulate genes associated

190 transcriptional repression of developmental regulator genes that is drastically perturbed upon genet

191 interrogated the network to identify master regulator genes that mechanistically regulate brain regi

192 R (cystic fibrosis transmembrane conductance regulator) gene that encodes a cAMP-dependent anion chan

193 has been renamed the motility quorum-sensing regulator gene (the mqsR gene).

194 The lung lineage master regulator gene, Thyroid Transcription Factor-1 (TTF-1, a

195 he cystic fibrosis transmembrane conductance regulator gene to human airway epithelia.

196 twork connecting loci enriched in cell cycle regulator genes to nuclear lamina that mediates the CTCF

197 cis-trans-regulated target genes, from trans-regulator genes to target genes, and from trans-eQTL to

198 A putative His-Asp response regulator gene (trg1: transcriptional regulatory gene 1)

199 isclosed a RPGR (Retinitis Pigmentosa GTPase Regulator) gene truncating variant segregating with the

200 model, an insertion mutation in the response regulator gene, trxR, led to a significant reduction in

201 he cystic fibrosis transmembrane conductance regulator gene using SERRS active primers in an ARMS ass

202 charide synthesis and of the transcriptional regulator genes vpsR, vpsT, and hapR.

203 ctly binds to the chromatin of the flowering regulator genes VRN1 and ID1 and affects their transcrip

204 Transcription of the response regulator gene was induced by the presence of ethanolami

205 ions in the human hematopoietic cytoskeletal regulator gene WAS.

206 these results, expression of several cambial regulator genes was downregulated in the stems of the tr

207 that ybbI (designated cueR for copper export regulator gene) was required for copper tolerance during

208 OPSIS RESPONSE REGULATOR5, a type-A response regulator gene, was upregulated at the time of shoot com

209 oxidative mitochondrial and differentiation regulator genes were downregulated in differentiating ce

210 s containing unique DNA barcodes in place of regulator genes were mixed with the parental control, an

211 While regulator genes were under positive selection, others ev

212 -rich CIM, and cytokinin-responsive response regulator genes were upregulated during incubation on cy

213 The hurIR (heme uptake regulator) genes were previously identified upstream of

214 he cystic fibrosis transmembrane conductance regulator gene, which codes for a chloride channel, but

215 ing of the RPGR (retinitis pigmentosa GTPase regulator) gene, which has been shown to be mutated in 1

216 mutation that inactivates the etaR response regulator gene, while M7 is a wild-type revertant for et

217 in alginate production genes and a c-di-GMP regulator gene; while PA01 acquired mutations in PilT an

218 he cystic fibrosis transmembrane conductance regulator gene with respect to pancreatitis.

219 rs of Tfap2a, Pax3 and other transcriptional regulator genes with transient function at earlier devel

220 in F. tularensis a heterologous chain-length regulator gene (wzz) from the related species Francisell