ライフサイエンスコーパス: regulatory pathway

1 iptional activation by the TGFbeta-SMAD gene regulatory pathway.

2 eric Kv7.4 channels were insensitive to this regulatory pathway.

3 y co-option of the retinoblastoma cell cycle regulatory pathway.

4 C metastasis through the hTERT-miR-29a-ITGB1 regulatory pathway.

5 action of the C-repeat binding factor (CBF) regulatory pathway.

6 s more complex than a simple direct negative regulatory pathway.

7 roRNA (miRNA) is a central component in this regulatory pathway.

8 rate them into the CIF1-mediated cytokinesis regulatory pathway.

9 edgehog (Shh) signaling, a key developmental regulatory pathway.

10 ing mutant, F508del-CFTR, by enhancing other regulatory pathways.

11 ffects of these alterations on signaling and regulatory pathways.

12 the cell, including important signaling and regulatory pathways.

13 e intriguing possibility of undiscovered NMD regulatory pathways.

14 ffects on gene transcription and non-genomic regulatory pathways.

15 ifferentiation are influenced by a number of regulatory pathways.

16 Cancer is a disease of subverted regulatory pathways.

17 Gs/cAMP-dependent and Gs-independent/growth-regulatory pathways.

18 ne selection, and improving understanding of regulatory pathways.

19 known to play a substantial role in various regulatory pathways.

20 d sword" related to interference with immune-regulatory pathways.

21 inth infections can suppress allergy through regulatory pathways.

22 -wide data to form a global picture of these regulatory pathways.

23 n disrupt cell-type-specific transcriptional regulatory pathways.

24 actors but do have a variety of adhesins and regulatory pathways.

25 e involved in a broad range of metabolic and regulatory pathways.

26 l roles in a host of different metabolic and regulatory pathways.

27 cal signaling molecule in diverse biological regulatory pathways.

28 e resource for analyzing plant metabolic and regulatory pathways.

29 94 were involved in three metabolic and four regulatory pathways.

30 Human islets shared many of these regulatory pathways.

31 f-renewing and pluripotent state by multiple regulatory pathways.

32 relocation of proteins forms the mainstay of regulatory pathways.

33 lung cancer through affecting all major cell regulatory pathways.

34 s implicated in an ever-increasing number of regulatory pathways.

35 important for uncovering their function and regulatory pathways.

36 d by altered metabolism of key molecules and regulatory pathways.

37 the melanocyte lineage by targeting diverse regulatory pathways.

38 luding loading highly onto synaptic and gene regulatory pathways.

39 vo, implicating another Ser5 kinase in these regulatory pathways.

40 key to understanding fundamental epigenetic regulatory pathways.

41 pair, and growth factor response, as well as regulatory pathways.

42 o rare variants enriched for gene expression regulatory pathways.

43 ement of both ZmFDL1/MYB94 and abscisic acid regulatory pathways.

44 sue-engineering approaches, and clinical and regulatory pathways.

45 as a link between cellular and systemic iron-regulatory pathways.

46 Here we describe three independent regulatory pathways active in coronary vessels during de

47 a powerful resource for exploring genes and regulatory pathways active in the aortic microenvironmen

48 This novel regulatory pathway allows enhanced induction of regulato

49 This regulatory pathway also operated in human Th17 cells.

50 hich function sequentially in the neurogenic regulatory pathway and are also required for the differe

51 We summarise the regulatory pathway and describe the challenges involved.

52 , by device type, and overall, stratified by regulatory pathway and modification type.

53 However, the regulatory pathway and outcomes remain incompletely unde

54 dentified a new regulator in the cytokinesis regulatory pathway and reiterated that a backup cytokine

55 press these responses by activating negative regulatory pathways and checkpoints such as PD-1/PD-L1 a

56 ignaling hub, receiving signals from various regulatory pathways and decoding them via phosphorylatio

57 tics, engagement of patients in the process, regulatory pathways and digital tools.

58 rmacological inhibitors targeting epigenetic regulatory pathways and discovered that NA activates bet

59 ediated RNA transfer are abundantly studied, regulatory pathways and mechanisms remain poorly defined

60 cing (AS) variants, little is known about AS regulatory pathways and programs involved in anticancer

61 pathways) has elaborated different chromatin regulatory pathways and the involvement of noncoding RNA

62 mathematical descriptions of three necessary regulatory pathways and use these to predict both the ra

63 and glucose homeostasis through a PPARgamma regulatory pathway, and its inhibition could be clinical

64 l conidiation by controlling the conidiation regulatory pathway, and that all three pigmentation gene

65 the proper probiotic strain identification, regulatory pathways, and how healthcare providers can ch

66 urately delineate their identities, origins, regulatory pathways, and relevance to normal vascular st

67 rrelative link between central metabolic and regulatory pathways, and they suggest that the Gac syste

68 Many regulatory pathways are involved in liver regeneration a

69 Herein, we argue that immune regulatory pathways are one key determinant of susceptib

70 iple transcriptional and posttranscriptional regulatory pathways are triggered in response to cardiac

71 cancer include drug alteration of cell cycle regulatory pathways as a useful strategy.

72 n, cytoskeleton organization, and cell-cycle regulatory pathways as major pathways controlled by PEAK

73 Recent advances point to these different regulatory pathways as organizing platforms that allow t

74 ether, these findings identify Trib3 and its regulatory pathways as potential targets to suppress the

75 Lastly, we outline untested regulatory pathways, as well as logistical challenges in

76 and kidney showed marked activation of gene regulatory pathways associated with the immune system an

77 rget of rapamycin complex 1 as the major IEC regulatory pathway, but mechanistic target of rapamycin

78 Collectively, our data reveal a regulatory pathway by which the negative regulator Foxo1

79 The regulatory pathways by which C. difficile initiates spor

80 Today, plant regulatory pathways can be reconstituted in heterologous

81 ring universally, but the upstream flowering regulatory pathways can differ markedly among plants.

82 tes an endogenous antitumor response, immune regulatory pathways can subvert the effector phase and e

83 hat proteins in the nephrin/Nck/N-WASP actin-regulatory pathway cluster into micron-scale domains at

84 n TAF6, which encodes a core transcriptional regulatory pathway component.

85 PilB functions as an intermediary in the EPS regulatory pathway composed of the T4P upstream of the D

86 These findings establish a novel regulatory pathway connecting histone modification and h

87 A conserved conidiation regulatory pathway containing Mr-BrlA, Mr-AbaA and Mr-We

88 ore growing evidence that disruption of this regulatory pathway contributes to neurodevelopmental dis

89 al landscape to identify a context-dependent regulatory pathway controlling APA in the Caenorhabditis

90 methylation of RBP substrates, suggesting a regulatory pathway controlling gene expression and virul

91 d human tissue samples were used to define a regulatory pathway controlling pathological myocyte hype

92 tensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, i

93 of Rcy1 in chromosome regulation and another regulatory pathway controlling the Cse4 level and activi

94 tabase, our results provide insight into the regulatory pathway controlling the REGgamma-proteasome i

95 this appears to be a regulated process, the regulatory pathways controlling cell shape transitions i

96 his review summarizes recent findings on the regulatory pathways controlling ceramide production, the

97 This regulatory pathway controls the transcription of the fox

98 To meet this challenge, a complex set of regulatory pathways controls nearly every aspect of cell

99 matory COX2/PGE2 pathway and the YAP1 growth-regulatory pathway cooperate to recruit the stem cell fa

100 t Cbz-B3A reveals a previously unappreciated regulatory pathway coordinating cytosolic protein qualit

101 he differentiation of MDSC into TAM, and its regulatory pathway could be a potential target for thera

102 us neovascularization is inefficient and the regulatory pathways directing coronary vessel growth are

103 Here, we describe the key chromatin regulatory pathways disrupted in gliomas, delineating th

104 Here, we described a regulatory pathway downstream of p53 in which inhibition

105 experiments support the existence of a novel regulatory pathway: ECs secrete factors that remodel RPE

106 rameters to ideally be incorporated within a regulatory pathway for drug approval.

107 Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissu

108 This study describes a regulatory pathway for IL-27 expression and cytotoxic T

109 with previous findings implicate a dual PIP2 regulatory pathway for NBCe1 involving both PIP2 itself

110 B3, through the CHOP pathway, which is a key regulatory pathway for TRIB3 expression.

111 In summary, we describe here a novel regulatory pathway for vitamin B3 that could provide a n

112 on from multiple systems to identify a novel regulatory pathway for Wnt signaling and potential thera

113 NBCn2 and the IRBITs are at the nexus of the regulatory pathways for multiple renal transport process

114 Although recent studies have identified regulatory pathways for the control of growth during veg

115 to the complexity of SMC biology and reveals regulatory pathways for therapeutic targeting of SMC tra

116 The disruption of these regulatory pathways forms the basis of chronic inflammat

117 The extent to which this branch of m(6)A RNA-regulatory pathway functions in vivo and contributes to

118 that Vst50 lies downstream of VdSho1 in the regulatory pathway governing penetration and melanin bio

119 ectinib for those harbouring NTRK fusions, a regulatory pathway has been created to facilitate the ap

120 Reestablishment of competent regulatory pathways has emerged as a strategy to reduce

121 The identification of aging-regulatory pathways has enabled scrutiny of this hypothe

122 A variety of feedback regulatory pathways have evolved to prevent an inappropr

123 Multiple regulatory pathways impact RB function, including the ub

124 factor (IGF) system is a well-studied growth regulatory pathway implicated in breast cancer biology.

125 Despite this, the regulatory pathways implicated in the HSC DNA damage res

126 a physical link at the crossroads of various regulatory pathways important for the growth and virulen

127 current study, we identify the role of a key regulatory pathway in alcohol-induced persistent molecul

128 Thus, we identify a new regulatory pathway in autoimmunity and elucidate upstrea

129 phagy-lysosome" axis represents an intrinsic regulatory pathway in BRAF-mutant melanoma, coupling BRA

130 pposing reactions of PptT and PptH uncover a regulatory pathway in CoA physiology.

131 study demonstrates a previously unidentified regulatory pathway in fibrogenesis in which a macrophage

132 Our findings reveal a novel regulatory pathway in ILC2-mediated pulmonary inflammati

133 al role for neurotrophins and identify a new regulatory pathway in insulin secretion that can be targ

134 Our results define a novel regulatory pathway in KRAS-driven cancers, which offers

135 Autophagy is a regulatory pathway in liver fibrosis.

136 to provide insight into an epigenetic-miRNA regulatory pathway in pressure overload-induced cardiac

137 he present study, we characterized the FOSL1 regulatory pathway in rat trophoblast cells.

138 optotic form of cell death, represents a new regulatory pathway in suppressing tumor development.

139 e existence of a novel B7-H1-mediated immune-regulatory pathway in T cells, which selectively limits

140 hypothalamic-pituitary-adrenal axis is a key regulatory pathway in the maintenance of these homeostat

141 matory cytokine, IL-6, thus characterizing a regulatory pathway in which a microRNA acts as a feedbac

142 ew study by Murakami et al. uncovers a novel regulatory pathway in which an N-terminal di-proline mot

143 In this work, we describe a novel regulatory pathway in which reduced translational fideli

144 We propose a regulatory pathway in which spermatogenic leucine zipper

145 Collectively, our findings reveal a novel regulatory pathway in which the REGgamma-proteasome cont

146 infection stimulates unique transcriptional regulatory pathways in A. fumigatus.

147 Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consist

148 segment formation - is directed by alternate regulatory pathways in diverse species.

149 aceae-specific FIS-PRC2 complex modified the regulatory pathways in female gametophyte and seed devel

150 in levels, and functional assays for calcium regulatory pathways in human HCM surgical samples with (

151 and murine ILC2s confirms the activation of regulatory pathways in ILC2s by IFN-alpha.

152 ronal cells indicate that actin cytoskeletal regulatory pathways in nuclei have a direct role in the

153 c proteolytic complex involved in nearly all regulatory pathways in plant cells.

154 Blocking epigenetic regulatory pathways in specific regions of the spinal co

155 Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immu

156 to therapeutic agents designed to block the regulatory pathways in T cells, such as programmed death

157 This study highlights gene regulatory pathways in the developing brain that may con

158 NA decay (NMD), an RNA surveillance and gene-regulatory pathway, in noncycling cells.

159 Negative regulatory pathways include extrinsic suppression mechan

160 changes in multiple cell density and growth regulatory pathways including hypoxia, apoptosis, cell c

161 the role of tRNAs in biosynthesis and other regulatory pathways, including nutrient sensing, splicin

162 neural pathway separate from the sleep-wake regulatory pathway induce behavioral quiescence and rest

163 indings, comprising of innate signalling and regulatory pathways, inflammatory mediators, cellular me

164 "Orbital-deconvolution" elucidated upstream, regulatory pathways interconnecting human susceptibility

165 general framework for integrating known gene regulatory pathways into a differential network analysis

166 or GWAS hits and important insights into the regulatory pathways involved in many diseases.

167 The proteins and regulatory pathways involved in Plasmodium sexual develo

168 Alterations in the regulatory pathways involved in the establishment, perpe

169 esponses to pathogens and the utilization of regulatory pathways involved in the sustained tolerance

170 information about these effects or about the regulatory pathways involved.

171 lating GATA4 expression through a cell-cycle regulatory pathway involving CDKN2a.

172 Therefore, we have identified a gene regulatory pathway involving CsCLV3, CsWUS, CsFUL1(A) an

173 Our study uncovers a new regulatory pathway involving miR-19a that is critical to

174 enal glucose transporter, uncovering a novel regulatory pathway involving Olfr1393 and Sglt1.

175 (CTD) to citrulline, uncovering a potential regulatory pathway involving opposing arginine modificat

176 Here, we describe a novel insulin signalling regulatory pathway involving TAZ.

177 proteomic datasets identified potential ECM regulatory pathways involving inhibition of matrix metal

178 Here, we summarize elaborate regulatory pathways involving this transcription factor

179 sume glucose before galactose, the galactose regulatory pathway is activated in a fraction of the cel

180 Given that the regulatory pathway is open, and migrastatic candidates h

181 The angiogenic VEGFA-MEF2 regulatory pathway is predominantly active in endocardia

182 The mechanism of this regulatory pathway is proposed to entail a displacement

183 Identification of key regulators and regulatory pathways is an important step in the discover

184 se circuits, but identifying associated gene regulatory pathways is complicated by the molecular comp

185 t mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tu

186 o make explicit predictions for the types of regulatory pathways likely to underlie each type of exag

187 i identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood p

188 esults from rodents into primates, where the regulatory pathway may be different to that in mice.

189 ibrillary degeneration and suggest that this regulatory pathway may be useful for developing therapeu

190 Potential manipulation of this regulatory pathway may have significant clinical potenti

191 This regulatory pathway may represent an unexplored opportuni

192 strate that manipulating posttranscriptional regulatory pathways may be a potential strategy to rever

193 We recently identified a new beige fat regulatory pathway mediated via the nicotinic acetylchol

194 Bacterial Nod factors (NFs) and plant regulatory pathways modulating NF signalling control rhi

195 Here we show that the regulatory pathways modulating seed oil content, which i

196 le suggests that extensive crosstalk between regulatory pathways must exist.

197 volved in a previously undescribed virulence regulatory pathway of an important human pathogen and su

198 t recruited human monocyte subsets trigger a regulatory pathway of cytokine-mediated signaling at the

199 ptional elongation, thus deciphering a novel regulatory pathway of gene expression.

200 Our study unravels a novel centrosomal regulatory pathway of inflammasome activation and may pr

201 These findings reveal a regulatory pathway of protein quality control that is im

202 We recently uncovered a regulatory pathway of the muscle isoform of glycogen pho

203 Thus, our findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and sugge

204 maintain vascular homeostasis; however, the regulatory pathways of DDAHs remain unclear.

205 ed epigenetic mechanisms presents additional regulatory pathways of genes involved in maintaining chr

206 the context of atherosclerosis and possible regulatory pathways of MC1-R beyond anti-inflammation.

207 Our study suggests that there may be regulatory pathways of particular relevance to the saliv

208 sting that CLEC16A may be involved in immune regulatory pathways of relevance to CVID.

209 Helminths exploit intrinsic regulatory pathways of the mammalian immune system to da

210 lopmental trajectories and identification of regulatory pathways of tissue-specific fibroblasts among

211 al alleles that specifically abrogate either regulatory pathway or both, we demonstrate that tight co

212 The interplay between inflammatory and regulatory pathways orchestrates an effective immune res

213 ses leading to irregular gene expression and regulatory pathway perturbations, in the cells, resultin

214 oration of this manifold enabled ordering of regulatory pathways, principled classification of GIs (e

215 Here, we report that the miR156/SPL2 regulatory pathway regulates pollen production, fertilit

216 The key steps in cellular signaling and regulatory pathways rely on reversible noncovalent prote

217 bal chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood.

218 ailed molecular mechanisms coordinating such regulatory pathways remain poorly understood.

219 The regulatory pathway(s) that links oxygen limitation to in

220 Rubylation is a conserved regulatory pathway similar to ubiquitination and essenti

221 e/protease signaling protein SltB comprise a regulatory pathway specific to filamentous fungi.

222 e re-expression, and changes in key cellular regulatory pathways such as STAT3 signaling.

223 and anti-apoptotic factor BCL-2, among other regulatory pathways such as Wnt, TGF-beta, and Notch sig

224 lled through key microenvironmental cues and regulatory pathways, such as Wnt signaling.

225 ogether, our study reveals a trans-chromatin regulatory pathway that connects aberrant intergenic CpG

226 , our data define a distinct GR-induced gene regulatory pathway that contributes to therapeutic effec

227 es incidence and led to the development of a regulatory pathway that controlled autoimmune progressio

228 Here, we report a miRNA-based autocrine regulatory pathway that controls differentiation of prea

229 Overall, our results revealed a novel regulatory pathway that controls genes involved in phosp

230 also provide evidence of a newly identified regulatory pathway that could promote angiogenesis.

231 These findings highlight a novel regulatory pathway that creates a critical period in bra

232 These findings uncover a feed-forward regulatory pathway that involves distinctive mechanisms

233 Despite being the only RNA regulatory pathway that is associated with multiple ment

234 Overall, these results demonstrate a novel regulatory pathway that links CaN, RCAN1, and Kv3.4 in D

235 common BRAF(V600E)-directed transcriptional regulatory pathway that mediates epigenetic silencing in

236 ssential role for HMMR in the PLK1-dependent regulatory pathway that orients progenitor cell division

237 Here, we identify a regulatory pathway that promotes stalled forks recovery

238 In this study, we uncovered an immune-regulatory pathway that tempers the intensity of the hos

239 rom the canonical cell cycle, endocycles use regulatory pathways that also function in diploid cells,

240 Rather than reinforcing or replacing regulatory pathways that are conserved between organisms

241 ration of external and internal signals into regulatory pathways that control cellular responses to c

242 Moreover, key regulatory pathways that control IRF3 are discussed.

243 the T6SS as well as the diverse signals and regulatory pathways that control its activation in V. ch

244 We describe the regulatory pathways that control metabolism of the cell

245 Regulatory pathways that control responses to changes in

246 ial biofilm formation involves signaling and regulatory pathways that control the transition from mot

247 lar features that enable condensates and the regulatory pathways that control them are dysregulated i

248 groups were discussed in the context of the regulatory pathways that could accelerate the translatio

249 To further our knowledge of novel regulatory pathways that could contribute to gliomagenes

250 ut unlike animals, little is known about the regulatory pathways that determine the sex of plants.

251 Triggers and regulatory pathways that effectively link human cytomega

252 of different maize transcription factors and regulatory pathways that employ REL2 repression to contr

253 The differentiation state and regulatory pathways that enable continuous natural antib

254 ged as key components of the transcriptional regulatory pathways that govern cardiac development as w

255 nd up-regulation of genes involved in cancer regulatory pathways that include apoptosis (p53, Fas, an

256 verting control over and dominating cellular regulatory pathways that influence translation initiatio

257 ing are orchestrated by a complex network of regulatory pathways that involve both the innate and ada

258 r studies are needed to elucidate the common regulatory pathways that may lead to MR irrespective of

259 discuss the overlapping post-transcriptional regulatory pathways that mediate muscle development, how

260 However, the regulatory pathways that mediate these effects are unkno

261 To devise novel approaches to treatment, regulatory pathways that modulate these aggregation-pron

262 -negative bacteria involves highly conserved regulatory pathways that optimize gene expression by tra

263 Mammary epithelial cells engage regulatory pathways that permit dynamic responses to mec

264 The cell cycle-regulatory pathways that produce specific temporal TE pa

265 nscripts, but facilitates the remodelling of regulatory pathways that restore the transcription of ke

266 To further elucidate regulatory pathways that safeguard the somatic state, we

267 with a platform to interrogate the molecular regulatory pathways that shape APA profiles in different

268 chanistic link between Zbtb7b and the lncRNA regulatory pathway through which Zbtb7b recruits the bro

269 ose, play important roles in many of the RNA regulatory pathways through multiple mechanisms.

270 w stem cells couple metabolic inputs to gene regulatory pathways through O-GlcNAc-mediated epigenetic

271 nal framework for delineating B. burgdorferi regulatory pathways throughout the enzootic cycle as wel

272 Finally, we extend this in vivo regulatory pathway to lysosomes and mitochondria.

273 al contribution of this Qa-1/HLA-E-dependent regulatory pathway to maintenance of transplanted organs

274 The available regulatory pathways to accelerate next-generation neuroi

275 known about activation of intrinsic negative regulatory pathways to attenuate excessive inflammatory

276 re-responsive organisms that utilize unknown regulatory pathways to couple their cell shape and assoc

277 use of monoclonal antibodies to block immune regulatory pathways to enhance tumor-specific immune res

278 elopment and homeostasis rely upon concerted regulatory pathways to establish the specialized cell ty

279 o provide insight into manipulation of these regulatory pathways to improve stomatal behavior and ide

280 es to demonstrate vaccine effectiveness, and regulatory pathways to licensure.

281 Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumor-initiating c

282 Cells employ a vast network of regulatory pathways to manage intracellular levels of re

283 The circadian clock interacts with other regulatory pathways to tune physiology to predictable da

284 Several regulatory pathways, typically involved in immune cell h

285 Here, we characterize the regulatory pathway underlying nucellus and endosperm tis

286 an in vivo model of learning and a conserved regulatory pathway underlying the modulation.

287 To understand the regulatory pathways underlying diseases, studies often i

288 view, the structural plasticity of HEVs, the regulatory pathways underpinning this plasticity, and th

289 Altogether, our results reveal a novel regulatory pathway, underscoring a previously unknown an

290 data uncover a novel Bcl11a/Sema3c-dependent regulatory pathway used by migrating cortical neurons.

291 Conservation of this regulatory pathway was confirmed in human psoriasis usin

292 For a global view of IFN signatures and regulatory pathways, we performed gene expression and ch

293 y gut luminal microbiota plays in triggering regulatory pathways, which are critical for the anabolic

294 ng genes that participate in critical immune regulatory pathways, while plasma cells have uniquely hi

295 Our data delineate a post-transcriptional regulatory pathway with a conserved role in regenerative

296 We reasoned that we could uncover regulatory pathways with new roles in hepatocyte differe

297 , LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture amo

298 tion of the complement system and respective regulatory pathways, with concordant findings at the pro

299 rpha exhibits low genetic redundancy in most regulatory pathways, with this portion of its genome res

300 tors, and that multiple post-transcriptional regulatory pathways work dependently and independently o