ライフサイエンスコーパス: relevance

1 er strengthening the case for its biological relevance.

2 ome using prostate cancer models of clinical relevance.

3 vity independently of consciousness and task relevance.

4 in their natural host for maximal biological relevance.

5 ll-molecule RyR1 modulators towards clinical relevance.

6 and tumour suppression, and its therapeutic relevance.

7 infectious disease research of public health relevance.

8 to determine genomic variation with clinical relevance.

9 ssion, in vivo responses and social behavior relevance.

10 le underlying mechanisms and pharmacological relevance.

11 merit further study for possible therapeutic relevance.

12 vey PET-based radiomics research to clinical relevance.

13 ge repetitive proteins with biotechnological relevance.

14 s loss of MSC functionality and its clinical relevance.

15 monas-phages that have increasing biomedical relevance.

16 We identified 1,832 articles of potential relevance.

17 involve visual signals that carry behavioral relevance.

18 sms, which hints at an underlying functional relevance.

19 gains in predictive confidence and societal relevance.

20 clinical scores supported pathophysiological relevance.

21 ons that may have prognostic and therapeutic relevance.

22 quality studies that have high translational relevance.

23 array of microbes of ecological and medical relevance.

24 o chromatin organization of great biological relevance.

25 al tumor samples, suggesting a translational relevance.

26 omal mutations to infer their likely disease relevance.

27 vironmental stimuli regardless of their task relevance.

28 ious studies that have analyzed its clinical relevance.

29 onnectivity changes of potential therapeutic relevance.

30 etection of deadly toxins with high clinical relevance.

31 development is of public health and clinical relevance.

32 ty, and luminescence), often with biological relevance, allowing for direct application in CNS focuse

33 Improved translational relevance also requires increased focus on volitional dr

34 g for more informed assessment of biological relevance and criticality of the attributes.

35 omic, structural, regulatory or evolutionary relevance and integrate them into a single functional sc

36 The functional relevance and mechanistic basis of the effects of the ne

37 inical correlation to determine its clinical relevance and need for treatment.

38 ls are often a compromise between biological relevance and scalability.

39 The clinical relevance and the potential prognostic role of persisten

40 To demonstrate the relevance and validity of the new test system, known and

41 tissue microenvironment might have clinical relevance and warrants further investigation.

42 optimize the MMS for biological and clinical relevance and yield a patient Weighted Multiparametric M

43 sign and recent infectious disease trials of relevance are discussed in this viewpoint.

44 biota-brain signalling and its physiological relevance are largely unknown.

45 Despite its relevance as a disease-causing serotype, the associated

46 Potential lack of tropospheric relevance associated with these chemistries, as well as

47 harge disproportionation lacks technological relevance because it occurs only under specific physical

48 olved mysteries and has significant clinical relevance because preterm birth is the leading cause of

49 These results have broad clinical relevance beyond HNSCC to other HPV-associated malignanc

50 ECG waveforms identified CRT subgroups with relevance beyond LBBB and QRSd.

51 nowledge of the CMC is not only of practical relevance but also of theoretical interest because it pr

52 rate that targeting neoantigens has clinical relevance even in low-mutational frequency cancers like

53 gard to disease prevalence and public health relevance, evidence of clinical efficacy, and safety, as

54 s, which is an important indication of their relevance for antiviral defense.

55 These novel results are of relevance for breeding programs, and for predicting the

56 al and cytosolic proteostasis are of central relevance for cellular stress resistance and organismal

57 sulin-like growth factor-1 that are of major relevance for children's development and growth.

58 panel also provides general guidelines with relevance for ctDNA-related research efforts, irrespecti

59 o an aquatic species and imply toxicological relevance for dissipated tire rubber residues.

60 cells (hNSC)-particularly for genes of high-relevance for DMN circuitry.

61 eatures of T cell memory and their potential relevance for effective immunity to SARS-CoV-2.

62 range of crucial cell functions, and are of relevance for efforts to develop artificial or minimal c

63 Our findings further suggest a relevance for functional network trajectories as a possi

64 imer-induced aggregation mechanism may be of relevance for human amyloid diseases in which oxidative

65 ed therapy in amblyopia and may have broader relevance for improving treatment outcomes in additional

66 ms of impulsivity with broader translational relevance for impulsivity-related disorders in humans.

67 These findings are of relevance for managing parent flocks and eggs at the hat

68 duced inhibitory synaptic plasticity and its relevance for neuropsychiatric disease.

69 potential therapeutic targets with clinical relevance for patients with DSRCT.

70 ng early cell-type specification, with broad relevance for pluripotent stem cell differentiation and

71 RNAs in lymphoma cells and reinforce PRMT5's relevance for promoting lymphoma cell growth and surviva

72 cholesterol-sensing mechanism; however, its relevance for protein function is thus far unknown.

73 glutamate receptor gene expression and their relevance for schizophrenia (SCZ) and bipolar disorder (

74 insights into these key intermediates, their relevance for the catalytic cycle of [FeFe] hydrogenase,

75 nterventional targets with direct functional relevance for the treatment of human disease.

76 Despite their relevance for understanding aging and cancer, the proces

77 ing range (1 ng/mL - 100 mug/mL) of clinical relevance has been also achieved.

78 Of particular relevance here are Piaget's last studies.

79 de a model system for polyploid research, of relevance here because polyploidy was suggested to be as

80 consensus when evaluating variants and their relevance in a clinical setting.

81 nd glucose homeostasis regulation, with high relevance in Alzheimers disease and type 2 diabetes inte

82 an oncogene with prognostic and therapeutic relevance in breast cancer.

83 onsistent with their potential physiological relevance in control of voltage-gated calcium influx and

84 topic of wide-ranging interest owing to its relevance in fields spanning from biomineralization to t

85 is largely uncharted thus questioning their relevance in human circuit function.

86 distinct subpopulations and their functional relevance in human satellite cells is lacking.

87 play a key role in gene regulation but their relevance in senescence remains elusive.

88 atterns of AML, and highlight their clinical relevance in the era of precision medicine.

89 heritable microbes having potential clinical relevance, including Escherichia-Shigella linked to urin

90 compares and contrasts topics of functional relevance, including Golgi outpost heterogeneity, format

91 overed recently in E. coli Its physiological relevance is not yet understood, because MK and DMK are

92 toring; however, the biomedical and clinical relevance is still controversial due to the complexity o

93 Because anti-CCD IgE has limited clinical relevance, it may impact ARD phenotyping and assessment

94 a complex range of isoforms whose biological relevance largely remains to be determined.

95 Of direct cancer relevance, MYC and UBR5 genes were coamplified in MYC-dr

96 ustering of OMP occurrence data revealed the relevance of 11 most frequently detected OMPs for classi

97 eased susceptibility to F brachygibbosum The relevance of AGO4, RdR1, RdR2, and DCL3 in a natural set

98 ew years regarding the causes and functional relevance of alternative splicing in cancer.

99 Background Relevance of antiangiogenic treatment with bevacizumab i

100 ent, little is known about the physiological relevance of AOX enzymes in humans and their additional

101 The role and relevance of autoantibodies to FceRIalpha in CSU can and

102 mbly has led some ecologists to question the relevance of biodiversity experiments to real-world ecos

103 cacy, possibly due to the lack of functional relevance of biomarker genes to cancer progression.

104 tia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic archite

105 Finally, we discuss the increasing medical relevance of CB dysfunction and its potential impact on

106 le to S aureus infections, demonstrating the relevance of CD163 for antimicrobial defense as well.

107 Functional relevance of CD163 was investigated in models of inflamm

108 Recent findings have shown the relevance of cellular hierarchy in islets from multiple

109 r of osteoblast metabolism and highlight the relevance of cellular metabolic rewiring during osteobla

110 rk reveals for the first time the biological relevance of COASY as a predictive rectal cancer biomark

111 the first high"), little is known about the relevance of cognitive processes governing memory retrie

112 However, the clinical relevance of complement-binding anti-HLA antibodies rema

113 at CP-mediated Zn limitation and the in vivo relevance of CP-GAS interactions to bacterial pathogenes

114 is knowledge is fundamental for studying the relevance of cuticular strain information within the com

115 Translational relevance of DDR1 is supported by its marked elevation i

116 consistent data collection approach and the relevance of defining specific metrics and answer scales

117 Despite the ecological relevance of diatoms, many aspects of their photosynthet

118 The analysis of clinical relevance of differences between pairs (Passing-Bablok)

119 (Passing-Bablok) only confirmed the clinical relevance of differences between the first and second re

120 Our study identifies the relevance of disorder in the stabilization of QSLs.

121 Many studies have investigated the clinical relevance of drug resistant minority variants, but the l

122 We also discuss the disease relevance of each of these steps of telomerase biogenesi

123 is an important tool to elucidate the causal relevance of environmental and biological risk factors f

124 seased and healthy prostates, supporting the relevance of ex vivo activity assays to in vivo translat

125 To determine the clinical relevance of fusion events, we detect gene fusions from

126 The functions and relevance of genes that share essentiality in multiple d

127 In addition, the clinical relevance of genetic mutations in human disease and pote

128 We discuss here the relevance of glia for maintaining circadian rhythms and

129 Our results support the relevance of high-affinity binding of ARF transcription

130 To investigate the functional relevance of histone-binding activity of Pygo2 in malign

131 To test the relevance of HMP-PG to the fab1 phenotype, we used trans

132 hanistic details of their formation, and the relevance of hotspots to evolution and disease are likel

133 lated from its congeners and to evaluate the relevance of hybridization and interspecific gene flow f

134 To assess functional relevance of identified CpGs, association of DNAm with g

135 isoform-selective probes with a focus on the relevance of isoform differentiation, design strategies

136 Furthermore, we demonstrated the functional relevance of Kv1.3 in augmenting the neuroinflammatory r

137 We demonstrate the causative relevance of locally rewired as well as compensatory ret

138 se is highly correlated with locomotion, the relevance of locomotion-related VIP neuron activity to v

139 omenon associated with (1) higher ecological relevance of low-spatial frequency (SF) components in en

140 The existence, nature and biological relevance of mechanoradicals in proteins, instead, are u

141 However, the ecological relevance of microbiome-mediated behavioural plasticity

142 lection systems, we attempt to establish the relevance of mid-distance land transport patterns to reg

143 Although the relevance of MLIs during fear memory formation is curren

144 on was performed to determine the prognostic relevance of MRI-derived myocardial strain for a combine

145 s facing extinction threats, identifying the relevance of natural mating patterns for conservation ma

146 ociation" approach to unravel the biological relevance of NDUFB9 and C1qL2 in the context of CD.

147 We validate the clinical relevance of new putative tumor suppressors by showing t

148 medicine by inferring the potential disease relevance of newly discovered mutations.

149 Recently, the relevance of non-HLA antibodies has become more prominen

150 nal eQTL discovery and provide insights into relevance of noncoding variants for cell-specific gene r

151 n mathematical modeling has demonstrated the relevance of nonlinear reaction-diffusion type equations

152 reover, the data point towards an increasing relevance of object-bound information with increasing ag

153 These results question the ecological relevance of OCLTT for Tigriopus and raise the possibili

154 over, even when a high concordance about the relevance of one parameter was evident, thresholds for t

155 The observed relevance of open conformations resolves the debate abou

156 ardiac hypertrophy and heart failure but the relevance of Orai1 is still unclear.

157 The biological relevance of our finding and its consequences for child

158 spinal cord, underscoring the translational relevance of our findings in mice.

159 Exploring the relevance of our observations to other brain structures

160 As such, the relevance of OXPHOS status and role of CI mutations in c

161 Our data shed light on the relevance of p73 alternative splicing and show that the

162 , we unveil the magnitude and macro-economic relevance of parallel nature-based contributions to prod

163 each approach are presented to document the relevance of peptidomimetics in drug discovery.

164 ults support the existence and physiological relevance of pGpp as a third alarmone, with functions th

165 In defining the functional relevance of PHOPSPHO1 in BAT thermogenesis and energy m

166 The processing proteases and the relevance of posttranslational modifications for peptide

167 the DMN, putatively improving translational relevance of preclinical models of neuropsychiatric dise

168 Our findings highlight the relevance of prioritizing public health measures targeti

169 Our data support the pathological relevance of protein encoded by FAM222A in AD.

170 However, there was no consensus on the relevance of REA, including how each of these measures s

171 Clinical relevance of rodent models of 2,8-DHA crystal nephropath

172 g increasingly complex samples heightens the relevance of single-molecule results to industrial appli

173 havior, we finally reveal how the behavioral relevance of such anticipatory brain states is similarly

174 and the mechanisms and (patho)physiological relevance of such signaling modes are actively investiga

175 These findings underscore the behavioral relevance of temporally delayed coordination between ant

176 0 provided further support for the catalytic relevance of the "extended" model of a PKS module.

177 y developments are briefly analyzed, and the relevance of the advance to efficient and enantioselecti

178 The relevance of the CA/COL ratio for the antioxidant activi

179 The practical relevance of the capabilities is demonstrated by mapping

180 de cross-linking validates the physiological relevance of the closed conformation, while electron mic

181 The relevance of the cooperation between NPM1 and other muta

182 on architectures, this study highlights the relevance of the deemed-of-low-importance process of pad

183 Our results highlight both the continued relevance of the EPIC technique, and the value of meta-a

184 ypassing and further enhance appreciation of relevance of the extent of ribosome loading for recoding

185 re life history, highlighting the ecological relevance of the gut microbiota.

186 in pea protein samples confirmed the sensory relevance of the identified compounds and indicated lipi

187 Finally, the physiological relevance of the intermediate state KCNQ1 conductance is

188 skeletal muscle cells (SKMCs) confirmed the relevance of the key driver candidate genes for insulin

189 e findings underscore the pathophysiological relevance of the LAPTM4B-24 isoform and identify it as a

190 with COPD and then to determine the clinical relevance of the LV(EV) in multivariable models, includi

191 We also discuss the relevance of the malaria parasite's intravacuolar lifest

192 The relevance of the parameters is demonstrated using result

193 the disease, which highlights the biological relevance of the partitions found.

194 Despite the relevance of the peripheral nervous system for normal se

195 sed people; however, the source and clinical relevance of the reactivity remains unknown.

196 ral and functional alterations emphasize the relevance of the visual association cortex for visual sn

197 ide a better understanding of the biological relevance of these allosteric sites and the way forward

198 the biological significance and the in vivo relevance of these events has remained unclear.

199 Further studies to understand the clinical relevance of these findings are warranted.

200 ence synaptic plasticity, and we discuss the relevance of these findings to neurodegenerative disease

201 Emphasizing the translational relevance of these findings, the expression profile of M

202 on for 24-48 h after events, but what is the relevance of these findings?

203 records to begin to understand the clinical relevance of these inhibitors.

204 To validate the clinical relevance of these methods, we quantified the prediction

205 However, impact and functional relevance of these modifications are poorly understood.

206 ene families in most species, the functional relevance of these multigene families remains largely un

207 in pediatric OCD, highlighting the clinical relevance of these networks as potential circuit-based t

208 histone code', emphasizing the physiological relevance of these PTMs in metabolism, development, and

209 To understand the biological relevance of these regulations, we showed that GCN5 part

210 plorations in order to better understand the relevance of these signatures in pancreatic neoplasms.

211 However, the relevance of this "caliper" model, and the mechanisms un

212 The physiological relevance of this cleavage event remains unclear, althou

213 We confirmed the relevance of this glial barrier system in human multiple

214 However, the comparability and relevance of this information is limited by methodology

215 yet to be understood how awareness and task relevance of this input interact with deviance processin

216 KU also binds to RNA, but the relevance of this interaction in mammals is unclear.

217 However, the clinical relevance of this interaction is controversial.

218 eract with UL69 and UL48, but the functional relevance of this interaction is unknown.

219 The relevance of this mechanism in health and during patholo

220 g the biological and potential translational relevance of this mechanism.

221 However, the ecological relevance of this microbiome-gut-brain (MGB) axis outsid

222 swapping, investigations into the biological relevance of this octameric M(pro) have stalled.

223 human hepatoblast cell line, indicating the relevance of this pathway for human liver development.

224 of TCGA and GEO public datasets supports the relevance of this pathway in human breast cancer, demons

225 The physiological relevance of this phenotype is supported by decreased av

226 accelerated by thrombolytic therapy, but the relevance of this risk factor remains controversial.

227 n mycotoxin occurrence in crops increase the relevance of this study for risk assessment of nanoparti

228 The relevance of this transport system was verified in trans

229 ription, yet the functional and evolutionary relevance of this variation remains unclear.

230 ompensatory mutations to test the functional relevance of viral RNA secondary structures.

231 C and D are linked to tumor growth, but the relevance of vitamin B6 remains uncertain.

232 obank participants were used to estimate the relevance of waist-to-hip ratio and body mass index (BMI

233 ination assay and omission tests, showed the relevance of Z-3-hexenal, linalool and methyl benzoate a

234 g behavioural effects with little ecological relevance, or conversely mismanaging situations in which

235 icability in risk assessment, and ecological relevance), propose a protocol for future effect studies

236 and function has gained significant clinical relevance recently.

237 Their prognostic relevance regarding disease conversion was determined us

238 Measures were assessed for relevance, relationship to disease and therapy, sensitiv

239 , the plant Nat machinery and its biological relevance remain poorly understood, although NTA has gai

240 ied into molecular subtypes whose functional relevance remains to be comprehensively established.

241 his review, we aim to analyze the biological relevance, reported modulators, and structural features

242 stands on this spectrum may have therapeutic relevance.See related commentary by Wang and Wulf, p.

243 shape their functional roles and behavioral relevance.SIGNIFICANCE STATEMENT Dopamine signals in the

244 eas higher levels require attention and task relevance.SIGNIFICANCE STATEMENT To react to potentially

245 s') or 3D structures with less physiological relevance ('spheroids').

246 Despite their potential therapeutic relevance, the biosynthesis of serrulatane diterpenoids

247 ds have an important biological and chemical relevance, the lack of methods for their production has

248 Despite its biomedical relevance, the origin of the phenomenon is still unknown

249 ased on Shapley value to rank genes by their relevance-the individual gene's synergistic influence in

250 enerally stable during periods of behavioral relevance, then transition abruptly at key task events a

251 pathway, as well as new targets of potential relevance to ALS pathophysiology.

252 uman cancers and viral infections, but their relevance to bacterial diseases has not been investigate

253 sel-associated gene expression that may have relevance to BBB regulation and drug delivery.

254 ties of oral bacterial communities have more relevance to cancer development.

255 ibes these hardware advances in CT and their relevance to cardiovascular imaging.

256 demic and endemic cholera, and are of direct relevance to controlling current and future cholera epid

257 W state remains inconclusive and its broader relevance to cuprate physics is an open question.

258 The results are of direct relevance to current policies, which promote tree planti

259 Modulation of Fbxl2 activity may have relevance to disorders of muscle wasting associated with

260 omments were manually reviewed to assess for relevance to elective surgery in the United States durin

261 ne vapor self-administration in rodents with relevance to electronic cigarette use in humans and high

262 A toxicity, including effects with potential relevance to exposed sensitive human populations.

263 g the odorant-receptor dissociation rates of relevance to flies.

264 unt importance to MS clinicians, but also of relevance to general neurologists and radiologists.

265 ary nature of this field of research and its relevance to grand challenges in the treatment of neurol

266 brain have attracted attention for possible relevance to HD pathology, potential as therapeutic targ

267 (lineage, phenotype, and plasticity) and its relevance to human biology remain unclear.

268 n present in P. gingivalis-induced FGR, with relevance to human disease since dysregulation of placen

269 Establishing relevance to human disease, we find high activation of s

270 ed by an important compendium of agents with relevance to human health.

271 Next, we tested these gene sets on their relevance to human tumors of brain and non-brain origin.

272 spatial analysis are all areas of particular relevance to immuno-oncology.

273 l bacterial entry into host cells, but their relevance to infection in vivo is undefined.

274 s framework can be used to examine SDGs with relevance to kidney health that require attention and re

275 etter than specialist performance, has broad relevance to many other applications in medical imaging.

276 evaluated using patterns of correlations and relevance to medical decision making to create a 5-item

277 ization: prediction and analysis of clinical relevance to minimize the RISK) conducted a clinical and

278 n their efficiency, accuracy and statistical relevance to model angiogenesis patterns of Human Umbili

279 ions for endogenous targeted mRNAs and their relevance to modulation of in vivo tissue dynamics remai

280 Our work has direct relevance to nonequilibrium assembly in mixtures of chem

281 y, they were selected because of their broad relevance to other areas.

282 s of regulated innate immunity, and may have relevance to our understanding of the responses of ecolo

283 Of significant relevance to pediatrics, in utero and perinatal stressor

284 The associated impact on P-body dynamics has relevance to regulation of stem cell differentiation, st

285 les were chosen for inclusion based on their relevance to sepsis, acute inflammation, sepsis-related

286 , an epigenetic deficiency in psoriasis with relevance to stem cell dysregulation has not been previo

287 of high-throughput screening applications of relevance to the biomedical and pharmaceutical sectors.

288 These observations will be of particular relevance to the crystal engineering community, whose go

289 and the electron-phonon interaction and its relevance to the formation of the ordered phases have al

290 s the dynamic behaviour of E2 and has direct relevance to the interaction of HCV with cell-surface re

291 when telomeres are short and underscore its relevance to the pathophysiology and interventions of hu

292 atin, which is a model organic compound with relevance to the physiology of malaria parasites(10,11).

293 taneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both

294 s following 14 experimental perturbations of relevance to the striatum, we discovered that striatal a

295 These findings may have considerable relevance to the treatment of B cell-associated autoimmu

296 gy of opioid receptors and discuss potential relevance to therapeutics.

297 iated with respiratory infections has direct relevance to treatment.

298 ts frequency, underlying causes, and disease relevance vary across different cancers.

299 Clinical relevance was demonstrated by the spatial distribution o

300 t of HCs, and recapitulated their functional relevance with a post hoc meta-analysis on task-based fM