ライフサイエンスコーパス: relevance to

1 sive behavior in affective neuroscience with relevance to a broad range of neuropsychiatric condition

2 creasing number of studies demonstrating its relevance to a broad variety of disease states, the bioe

3 by RhoA and regulate synapse maintenance of relevance to AD risk.SIGNIFICANCE STATEMENT Genetic vari

4 human AD patients, indicating its potential relevance to AD.

5 studies carried out in cells and tissues of relevance to AD.

6 ication-related DNA lesions, with particular relevance to adaptive immunity.

7 ulated endothelial function in vivo, and the relevance to adipose tissue function and obesity.

8 copy to particles > ~10 mum, which have less relevance to aerosol health and climate impacts.

9 ned with receptor-binding assays might be of relevance to aid in the diagnosis of total or partial ED

10 pathway, as well as new targets of potential relevance to ALS pathophysiology.

11 CLINICAL RELEVANCE: To analyze vitreoretinal procedural trends, w

12 ies of nanocrystals but also determine their relevance to, and performance in, various applications.

13 of great fundamental interest and of direct relevance to areas that include the de novo design of gr

14 a function of dopaminergic tone and may have relevance to aspects of therapeutic responses.

15 Pathway-level relevance to asthma biology was tested in model systems

16 Ten loci selected based on the relevance to asthma, magnitude of methylation change, an

17 uman cancers and viral infections, but their relevance to bacterial diseases has not been investigate

18 sel-associated gene expression that may have relevance to BBB regulation and drug delivery.

19 l oscillations and more importantly in their relevance to behaviour (initiate versus reset conditione

20 Our unprecedented new mechanism may have relevance to biological and biomimetic chemistry process

21 ion is a rapidly developing study field with relevance to biological, physical and material sciences.

22 include water, alcohols, and solutions with relevance to biology and energy technology.

23 in biological reactions and has considerable relevance to biosynthetic reactions in organic chemistry

24 es for plant lignocellulose degradation with relevance to biotechnological applications as biofuel pr

25 Despite their widespread relevance to both human health and agriculture, the mole

26 3CA activation in a developmental context of relevance to both PROS and cancer, we engineered isogeni

27 OA and BMD, highlight genes with biological relevance to both traits, and establish a robust new OA

28 velopmental trajectories, underscoring their relevance to brain organization and function.

29 research has provided information of direct relevance to bTB management, and a better appreciation o

30 s, we examined the function of Hsp90 and its relevance to BTV replication.

31 ties of oral bacterial communities have more relevance to cancer development.

32 fectious disease, but it also has particular relevance to cancer research.

33 road impact of RNA editing in cancer and its relevance to cancer-related immune pathways.

34 led several functionally-related clusters of relevance to cancer.

35 a fundamental cell-biological question with relevance to cancers, which often exhibit enlarged nucle

36 en based on strength of association with and relevance to cardiogenic shock.

37 ibes these hardware advances in CT and their relevance to cardiovascular imaging.

38 elationship with underlying musculature, and relevance to cat-specific facial action units.

39 ution of inverse design approaches and their relevance to catalysis.

40 lency with the ligand, a feature of possible relevance to catalyst design in synthetic and natural sy

41 benzylic borylation reactions, which are of relevance to catalytic methylarene (di)borylation, are r

42 g insoluble manganese oxides, with practical relevance to chemoorganotrophic mineral bioprocessing ap

43 ived in non-CICU populations, assesses their relevance to CICU practice, and highlights key knowledge

44 ime to examine published studies with direct relevance to clinical care and, more broadly, to examine

45 sity-induced adipose tissue fibrosis and its relevance to clinical manifestations.

46 phage and phage-encoded protein therapies of relevance to clinical microbiology.

47 biotic persistence and for understanding its relevance to clinical outcomes.

48 RELEVANCE TO CLINICAL PRACTICE: This paper highlights th

49 We discuss their relevance to clinical transplantation and highlight pote

50 cteristics of Deltatau314 proteins and their relevance to cognitive dysfunction and shed light on the

51 tion within hippocampal neuronal circuits of relevance to cognitive processing in male mice at 6, 24,

52 These results have relevance to conservation policy formulation and to impr

53 demic and endemic cholera, and are of direct relevance to controlling current and future cholera epid

54 sms that regulate AID expression are of much relevance to CSR and genomic integrity; however, effecto

55 The study has particular relevance to cultural heritage, where heterogeneous laye

56 W state remains inconclusive and its broader relevance to cuprate physics is an open question.

57 R) spectroscopy, which are all techniques of relevance to current and future space missions.

58 ansformed by OFC to emphasize information of relevance to current goals.

59 The results are of direct relevance to current policies, which promote tree planti

60 ng of the conditions that led to the ETE has relevance to current rising CO(2) levels.

61 Despite its broad relevance to daily life, including in many naturalistic

62 with age, it is of fundamental and clinical relevance to decipher new determinants that control TEC

63 y of outcomes reported in research and their relevance to decision making is uncertain.

64 temic inflammation can impair cognition with relevance to dementia, delirium and post-operative cogni

65 r more times and examined evidence for their relevance to depression phenotypes.

66 directly on the podocyte, with translational relevance to designing new selective synthetic Gc molecu

67 utaneous wound healing that is of particular relevance to diabetic wound complication.

68 on study on plasma metabolism and microbiome relevance to diet, inflammation, CVD risk, and cardiomet

69 etween normal-weight and obese persons is of relevance to dietary recommendations for obese populatio

70 factors for simvastatin-related myopathy and relevance to different types of muscle symptom.

71 all cases, their functional consequences and relevance to disease are unknown.

72 ere, we discuss the molecular mechanisms and relevance to disease of necroptosis.

73 ated as biomarkers of disease, with no clear relevance to disease pathogenesis.

74 ges and neural correlates may have potential relevance to disease progression and prognosis.

75 diagnostic platform requires assessing their relevance to disease progression.

76 ent, and individuals with AD to assess their relevance to disease.

77 l methods developed here may have particular relevance to disorders of attention, such as unilateral

78 Modulation of Fbxl2 activity may have relevance to disorders of muscle wasting associated with

79 This topic is of practical relevance to diverse fields, ranging from neuroscience t

80 ation of gene expression and for elucidating relevance to diverse physiological processes.

81 ssible link to underlying pathways and their relevance to DME prognosis.

82 the agonists used, which should be of broad relevance to drug discovery and disease treatment.

83 A transient peptide-protein interaction of relevance to drug discovery was analyzed thermodynamical

84 tide hydrolysis, a prototypical HTS assay of relevance to drug discovery.

85 among tumor cells at low cell densities with relevance to early stage growth patterns of emerging and

86 lion, a structure with empirically supported relevance to echolocation.

87 ake progress in this critical area of direct relevance to ecology and plant performance in a changing

88 teria and biomarker, which would be of great relevance to either outcome evaluation or study design.

89 omments were manually reviewed to assess for relevance to elective surgery in the United States durin

90 ne vapor self-administration in rodents with relevance to electronic cigarette use in humans and high

91 This material system has relevance to emerging classes of biologically and enviro

92 tter in the design of compounds of potential relevance to energetic formulators.

93 reduction reaction is a coveted objective of relevance to energy research.

94 ovides valuable results that confirm the PLE relevance to enhance the value of this neglected materia

95 ), and citizen science, and to explore TEK's relevance to environmental health research.

96 A toxicity, including effects with potential relevance to exposed sensitive human populations.

97 such a level that polyatomic reactions with relevance to extreme astrochemical and combustion chemis

98 neutralization in chickens, which has direct relevance to field protection and virus evolution.

99 olic and acidic compounds, including many of relevance to firefighting or breast cancer etiology.

100 g the odorant-receptor dissociation rates of relevance to flies.

101 e detected from fingerprints is of potential relevance to forensic science and as well as toxicology

102 ycan impairs IgG effector functions, but its relevance to GAS infection in vivo is unclear.

103 unt importance to MS clinicians, but also of relevance to general neurologists and radiologists.

104 on and initially were investigated for their relevance to genetic recombination.

105 we highlight 15 emerging issues of potential relevance to global conservation in 2020.

106 Their relevance to governing the energetics and the photo(elec

107 ary nature of this field of research and its relevance to grand challenges in the treatment of neurol

108 n intestinal barrier integrity/function with relevance to gut permeability and the development of dis

109 brain have attracted attention for possible relevance to HD pathology, potential as therapeutic targ

110 diazepine-resistant status epilepticus, with relevance to how this life-threatening condition should

111 (lineage, phenotype, and plasticity) and its relevance to human biology remain unclear.

112 blic datasets suggest that our data may have relevance to human cancers.

113 early postimplantation period, with possible relevance to human development.

114 , compelling genetic demonstrations of their relevance to human disease are lacking.

115 ids are a class of molecules that have shown relevance to human disease risk and cardiovascular outco

116 n present in P. gingivalis-induced FGR, with relevance to human disease since dysregulation of placen

117 sms of the model, particularly regarding its relevance to human disease, how this model might be repu

118 Establishing relevance to human disease, we find high activation of s

119 d embryonic survival, with important broader relevance to human female infertility and mitochondrial

120 levels of several POP congeners of potential relevance to human health.

121 ed by an important compendium of agents with relevance to human health.

122 eral clocks, their synchronization and their relevance to human health.

123 glucose metabolism and lipid oxidation, with relevance to human physiology and type 2 diabetes.

124 Next, we tested these gene sets on their relevance to human tumors of brain and non-brain origin.

125 himurium is used as a typhoid model, but its relevance to human typhoid is limited.

126 c lipogenic transactivation event with broad relevance to human viral infections and represents SREBP

127 ion in the taiep rat model and determine its relevance to human white matter disease.

128 ion highlighted 20 proteins of possibly high relevance to IgAN and/or kidney disease.

129 2 kinases has not been examined despite its relevance to immune-based therapies.

130 spatial analysis are all areas of particular relevance to immuno-oncology.

131 dy this parasite and that have physiological relevance to in vivo infection remain suboptimal.

132 Relevance to in vivo Treg biology was established by int

133 l bacterial entry into host cells, but their relevance to infection in vivo is undefined.

134 EBi3-independent activities; however, their relevance to infection is unclear.

135 against 5 different microbial pathogens with relevance to infectious keratitis.

136 acrophage immune responses and discuss their relevance to inflammation-related diseases.

137 ite immunoprophylaxis may have translational relevance to instances of RhIg failure that occur in hum

138 e retromer complex and its neurobiology, its relevance to key molecules involved in neurodegeneration

139 s framework can be used to examine SDGs with relevance to kidney health that require attention and re

140 fects of gestation on ion channels and their relevance to labor.

141 The mechanisms we uncover have relevance to learning in the cerebellum, hippocampus, an

142 oncerning epigenetic aging and discuss their relevance to life history evolution and their potential

143 ing capacity for surveillance of diseases of relevance to local populations can provide a mechanism f

144 macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.

145 Sexual conflict is a vast topic with relevance to many areas of biology and so here we restri

146 ficial receptors is important because of its relevance to many biological and environmental applicati

147 of the most studied biological systems, with relevance to many fields including the development and u

148 es with their submicron features have direct relevance to many geoenergy applications.

149 etter than specialist performance, has broad relevance to many other applications in medical imaging.

150 g multiple stereogenic axes is of increasing relevance to materials science, pharmaceuticals, and cat

151 tudy and understand fundamental questions of relevance to materials science, such as how the size and

152 evaluated using patterns of correlations and relevance to medical decision making to create a 5-item

153 ain and skull marrow, a finding of potential relevance to migraine and other neuroinflammatory brain

154 ization: prediction and analysis of clinical relevance to minimize the RISK) conducted a clinical and

155 n their efficiency, accuracy and statistical relevance to model angiogenesis patterns of Human Umbili

156 ions for endogenous targeted mRNAs and their relevance to modulation of in vivo tissue dynamics remai

157 Relevance to MS was corroborated by the strong expressio

158 complex yet poorly understood process, with relevance to multiple diseases, including biliary atresi

159 gely unexplored and, more importantly, their relevance to naturally acquired immunity in longitudinal

160 tif found in over 1000 natural products with relevance to neurodegenerative disease, bacterial and pa

161 models of HD pathogenesis, validating their relevance to neuronal dysfunction in vivo.

162 roduced two biophysical changes in models of relevance to neuronal excitability: 1) enhanced action p

163 Our work has direct relevance to nonequilibrium assembly in mixtures of chem

164 nflammation affects DA neurotransmission and relevance to novel therapeutic strategies to treat reduc

165 To test the relevance to nuclear proteins expressed in skeletal musc

166 Our findings have primary relevance to obese individuals who are at an increased r

167 ins and 76 lipids, selected because of their relevance to obesity-associated diseases, in plasma and

168 clinical studies reveal outcomes with direct relevance to ongoing clinical trials that explore the us

169 ays for replicator formation has significant relevance to ongoing efforts to design programmable and

170 omising way to explore new chemical space of relevance to opioid addiction.

171 of this class of peptides and discusses the relevance to organismal metabolism.

172 ction step, may constitute concepts of broad relevance to organometallic chemistry.

173 y, they were selected because of their broad relevance to other areas.

174 he effect of E3 ligase binding affinity with relevance to other drug discovery efforts in targeted pr

175 to impact on tissue homeostasis, has direct relevance to other mechano-sensitive physiological syste

176 These insights might have broader relevance to other neurodegenerative conditions and are

177 lenging nature of the Hop TPR2A target, with relevance to other TPR domain interactors.

178 infection, but the underlying mechanism and relevance to other viruses or in vivo infections remaine

179 s of regulated innate immunity, and may have relevance to our understanding of the responses of ecolo

180 uced greater changes in gene expression with relevance to oxidative stress, apoptosis, and ion transp

181 ribbon and a dispersed Golgi, a pathway with relevance to pathophysiological conditions.

182 ecular determinants of outcome with clinical relevance to patients with AML receiving venetoclax-base

183 ational status of NPM1 has strong prognostic relevance to patients with point mutations of the FLT3 t

184 Of significant relevance to pediatrics, in utero and perinatal stressor

185 With its particular relevance to pharmacogenetic GWAS, SurvivalGWAS_SV will

186 hips between biological components and their relevance to phenotype, environmental conditions or othe

187 This regulatory mechanism may be of direct relevance to phenotypic variability of tauopathies, as t

188 rker-based approach that provides biological relevance to positive genotoxicity assay data, particula

189 n mechanically ventilated patients and their relevance to practice, as perceived by key ICU clinician

190 al foundations of machine learning and their relevance to practitioners.

191 commercial MCPH1 antibodies, with potential relevance to previously published data.

192 eligibility criteria based primarily on the relevance to prioritizing ECs in groundwater.

193 evelopment is partly driven by its potential relevance to prostate cancer, in particular the apparent

194 It's relevance to proteinopathies and drug delivery is discus

195 s Prx1 hyperoxidation and inactivation bears relevance to Prx1 functions beyond its antioxidant activ

196 for NRG2 in the modulation of behaviors with relevance to psychiatric disorders.

197 DA modulation of cognitive performances with relevance to psychiatric disorders.

198 n brain and highlight findings of particular relevance to psychiatric genetics.

199 ifferences in individual cell responses with relevance to putative therapeutic applications.

200 stems, including up to 58 electrons, showing relevance to realistic polyatomic molecules.

201 ecies coordinated to a metal ion of possible relevance to reductive elimination/oxidation addition re

202 at call into question the findings and their relevance to regional wildfire risk.

203 The associated impact on P-body dynamics has relevance to regulation of stem cell differentiation, st

204 pathway) medium spiny neurons (MSNs) and its relevance to repetitive grooming behavior in Shank3B mut

205 is enriched in testicular tissue, but their relevance to reproductive processes is unknown.

206 rnative to surgery for tumor treatment, with relevance to resource-limited settings.

207 ated mudstone via analytical techniques with relevance to robotic missions.

208 This is of special relevance to safeguard human health considering Palythoa

209 ets demonstrated UClncR's accuracy and their relevance to sample clinical phenotypes.

210 nge of behavioral changes with translational relevance to schizophrenia.

211 odulating this coexpression module and their relevance to SCZ.

212 les were chosen for inclusion based on their relevance to sepsis, acute inflammation, sepsis-related

213 These findings provide immediate clinical relevance to serology results that can be equated to NAb

214 evaluated for underlying pathophysiology and relevance to sex-specific prevention strategies.

215 ic plasticity mechanisms and their potential relevance to shaping motivated behaviors is poorly under

216 er define sHSP/client interactions and their relevance to sHSP chaperone function, we implemented mul

217 ts this energy wasting reaction is of direct relevance to solar energy conversion.

218 er distribution in worldwide samples and its relevance to sperm parameters in an Estonian cohort of i

219 , an epigenetic deficiency in psoriasis with relevance to stem cell dysregulation has not been previo

220 tal thymus development, and are thus of high relevance to strategies aimed at generating/regenerating

221 golipid receptors as important substrates of relevance to stress-related psychiatric disorders.

222 ting that this process could have biological relevance to stroke pathogenesis.

223 independence of magnetic fields, and a close relevance to structural disorder.

224 embling key aspects of ALS, highlighting its relevance to study disease pathogenesis.

225 ntify the patterns of SERT pathology and the relevance to symptoms.

226 alance is controlled in neurons and may bear relevance to synaptic dysfunction in autism.

227 in the glymphatic system and it has obvious relevance to TBI.

228 Because of its relevance to the ASCO membership, ASCO reviewed the guid

229 and biomechanics of the knee could also have relevance to the assessment of early OA.

230 ecular reactions under thermal conditions of relevance to the atmosphere.

231 es relative to saturation values, has little relevance to the atmospheric N(2) pool due to its large

232 These interrelationships may have relevance to the biological actions of retinol, includin

233 h discriminative power and strong functional relevance to the biological phenotype.

234 of high-throughput screening applications of relevance to the biomedical and pharmaceutical sectors.

235 observed among lactococci and may also have relevance to the biosynthesis of complex rhamnose-contai

236 , these findings are of direct translational relevance to the comorbidity between opioid dependence a

237 indings provide key clinical and preclinical relevance to the conformational immunoassay, and provide

238 y deleterious genetic variations in genes of relevance to the cornification process.

239 These observations will be of particular relevance to the crystal engineering community, whose go

240 e saliency of sensory percepts against their relevance to the current behavioral goal.

241 tures is currently of great interest due its relevance to the design of novel mechanical metamaterial

242 ritical Care Medicine was included given the relevance to the discussion and was referenced according

243 atus to MIA are still unclear, despite their relevance to the etiology of NDD.

244 overy that permeate all ecosystems, and with relevance to the evolving Society of Critical Care Medic

245 iology and disease, as well as their general relevance to the field of cell biology.

246 s on the biology of memory T cells and their relevance to the field of transplantation.

247 Which is a key biological endpoint of relevance to the fields of cancer therapy (radiotherapy)

248 and the electron-phonon interaction and its relevance to the formation of the ordered phases have al

249 ing resonator is employed in this work, with relevance to the gyroscopic lateral modes of vibration.

250 y of the targeted modification and potential relevance to the human condition.

251 and neurobiological mechanisms of potential relevance to the increased risk for disorder.

252 These observations are of likely relevance to the influence of ketamine upon mood and its

253 s the dynamic behaviour of E2 and has direct relevance to the interaction of HCV with cell-surface re

254 r and involved in lipid homeostasis, but its relevance to the long-term risk of developing metabolic

255 hormone, sclerostin, or vitamin D and their relevance to the management of different pathologies in

256 articular areas of focus that are of current relevance to the MGBA during the last decade (2009-2018)

257 rm consequences of opioid exposure and their relevance to the negative affect of OUD remains scarce.

258 P leads to epigenetic changes in pathways of relevance to the offspring phenotype.

259 This review discusses metabolic pathways of relevance to the origin of life in a manner accessible t

260 Modulation of this pathway has direct relevance to the pathogenesis and treatment of autoimmun

261 and innate immunity in T cells and may have relevance to the pathogenesis of human disease caused by

262 when telomeres are short and underscore its relevance to the pathophysiology and interventions of hu

263 cecraft components and will also have direct relevance to the pharmaceutical and medical industries.

264 atin, which is a model organic compound with relevance to the physiology of malaria parasites(10,11).

265 ugs for stabilizing the MT lattice and is of relevance to the possible use of combinations of MSAs to

266 taneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both

267 um rings remain obscure despite their utmost relevance to the quantum photonic applications of quantu

268 umerical content of the dataset to determine relevance to the query entity.

269 most difficult professional esports and its relevance to the real world in terms of its raw complexi

270 nockout screens assigned putative functional relevance to the RNA-protein interactions observed by Ch

271 ere may be regulatory pathways of particular relevance to the salivary metabolome.

272 describing these responses and discuss their relevance to the SARS-CoV-2 immune response.

273 s following 14 experimental perturbations of relevance to the striatum, we discovered that striatal a

274 This information is of especial relevance to the structure analysis of insoluble polysac

275 ly identified that were of direct biological relevance to the study.

276 ded because of poor study design and lack of relevance to the topic under evaluation.

277 n discoveries that have direct translational relevance to the treatment of allergic diseases.

278 These findings may have considerable relevance to the treatment of B cell-associated autoimmu

279 earch findings and observations are of broad relevance to the understanding of plastic flow behavior

280 gy of opioid receptors and discuss potential relevance to therapeutics.

281 the absence of CO in the gas effluent confer relevance to these catalysts for the Sabatier reaction,

282 se to a compound, and then rank pathways for relevance to these response-correlated genes using PACER

283 patients, summarize previous publications of relevance to this field, and discuss future directions.

284 Of particular relevance to this study, is the antibiotic abuse in pig

285 y large-effect regulatory variants and their relevance to traits.

286 or nociceptive processing in SSDHN with high relevance to transcriptional changes and the development

287 o a GAM-specific phenotype, showing clinical relevance to transcriptomic and patient survival data.

288 al immunomodulation that may have particular relevance to transplant-associated immunobiology.

289 iated with respiratory infections has direct relevance to treatment.

290 g and cellular iron deficiency that may have relevance to type 2 diabetes in humans.

291 not recent threat memories and have clinical relevance to understanding overgeneralization characteri

292 rmation, influx and efflux transporters with relevance to understanding peripheral nerve homeostasis

293 the genetics of neurocognitive function with relevance to understanding the pathophysiology of neurop

294 ny eukaryotic parasites and is also of great relevance to vaccine design.

295 y represent a novel homeostatic mechanism of relevance to vascular health and disease.

296 t for cardiomyocyte cell cycle reentry, with relevance to ventricular noncompaction cardiomyopathy an

297 res reported here for protein C have general relevance to vitamin K-dependent clotting factors contai

298 intaining autocrine/paracrine signaling with relevance to wound healing and cellular transformation.

299 ing of innate and adaptive immune cells with relevance to wound pathologies.

300 loimmunity and alloantibodies will also have relevance to xenotransplantation where the xenoantibodie