ライフサイエンスコーパス: remodelling

1 inflammation and extracellular matrix (ECM) remodelling.

2 enome doubling, indicating ongoing karyotype remodelling.

3 role of LD-transpeptidases in peptidoglycan remodelling.

4 he novel idea that RMH pacing causes reverse-remodelling.

5 t more often promote inflammation and airway remodelling.

6 ss strengthening, stress sensing and network remodelling.

7 nded our understanding of ATP-driven protein remodelling.

8 ocytes growth, a hallmark of adverse cardiac remodelling.

9 nipulate MGC-associated pathologies and bone remodelling.

10 absorption, gluconeogenesis and cytoskeletal remodelling.

11 Pseudogenes are ideal markers of genome remodelling.

12 ab's effect on eosinophilic inflammation and remodelling.

13 iated with extensive inflammation and airway remodelling.

14 oration of fatigue resistance via angiogenic remodelling.

15 arly during states of new bone formation and remodelling.

16 ol and sphingolipids that undergo continuous remodelling.

17 inflammation and extracellular matrix (ECM) remodelling.

18 lay of transcriptional control and chromatin remodelling.

19 ivity of DnaD is redundant for this filament remodelling.

20 idence for roles of apoptosis and epithelial remodelling.

21 ization of IL-13 may reduce asthmatic airway remodelling.

22 chanical stimulation induces the desired ECM remodelling.

23 biomarkers related to disease-induced tissue remodelling.

24 he second cluster included markers of tissue remodelling.

25 are required for row formation and membrane remodelling.

26 transcriptional regulation to cell junction remodelling.

27 y by signal transduction and transcriptional remodelling.

28 ediated by a reduction in pulmonary vascular remodelling.

29 vivo and their relation to regional myocyte remodelling.

30 role of reprogramming factors and chromatin remodelling.

31 etabolism, membrane biogenesis and organelle remodelling.

32 role in osteoblast differentiation and bone remodelling.

33 y single-cells involves complex cytoskeletal remodelling.

34 associated biomarkers and measures of airway remodelling.

35 and other diseases associated with vascular remodelling.

36 CM) through cell-matrix interactions and ECM remodelling.

37 est that FASN can mediate actin cytoskeletal remodelling; a process known to be downstream of Rho fam

38 ent transcript recruits repressive chromatin remodelling activities and the de novo methylation appar

39 gy and demonstrates that different chromatin remodelling activities are required for efficient repair

40 nscription-factor binding reveals that these remodelling activities have specific effects on binding

41 nd fiber alignment resulting from fibroblast remodelling activities or chemotactic signals are neithe

42 owever, our mechanistic understanding of the remodelling activity is hindered by the lack of a high-r

43 n a subset of bone marrow cavities with bone-remodelling activity.

44 Motor unit (MU) remodelling acts to minimise loss of muscle fibres follo

45 airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide.

46 us recovery of function as a result of brain remodelling after stroke or injury does occur, and cell-

47 helpful in identifying patients with better remodelling after TEVAR.

48 Indicators of MU remodelling also progressively increased with age to a s

49 single generation induced limited methylome remodelling (an order of magnitude fewer differential me

50 he combined action of HF-induced ion channel remodelling and a decrease in cell-to-cell coupling due

51 entiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility(1-3).

52 echanisms leading to myocardial destruction, remodelling and arrhythmic predisposition remain poorly

53 TS5(+) cells were present in areas of matrix remodelling and associated with ECM proteins lumican, ve

54 rowth and division by most bacteria requires remodelling and cleavage of their cell wall.

55 of proteins within the mammalian Nucleosome Remodelling and Deacetylation (NuRD) complex: Mta1, Mta2

56 that interacts directly with the nucleosome remodelling and deacetylation complex (NuRD) and polycom

57 CHD4, an ATPase and member of the nucleosome remodelling and deactetylase (NuRD) complex, drives a co

58 ed LV stiffness was related to LV concentric remodelling and diastolic dysfunction, and associated wi

59 myocyte loss after injury results in adverse remodelling and fibrosis, inevitably leading to heart fa

60 n and subsequent airway and lung parenchymal remodelling and fibrosis.

61 haemodynamic measurements determined cardiac remodelling and function.

62 differences explained differential chromatin remodelling and gene activation.

63 endothelin-1 drives many features of airway remodelling and inflammation elicited by A fumigatus.

64 In addition, they can modulate extracellular remodelling and intracellular pathways related to cell a

65 rtic dissection is linked to improved aortic remodelling and is associated with a lower re-interventi

66 ify Blimp1 as a critical regulator of tissue remodelling and maternal tolerance during early stages o

67 luding protein quality control, cytoskeleton remodelling and membrane dynamics.

68 dothelial cells as important players in lung remodelling and metastatic progression.

69 genes, subunit loss or fusions in chromatin remodelling and modifying complexes, and disruption of h

70 ethylation, histone modification, nucleosome remodelling and modulation of the 3D chromatin structure

71 LV stiffness was associated with concentric remodelling and more severe diastolic dysfunction, espec

72 sses including gene transcription, chromatin remodelling and mRNA processing.

73 engineered heart valves (TEHVs) with repair, remodelling and regenerative capacity can address these

74 We propose a role for Gdf5 in tissue remodelling and repair after injury, which may partly un

75 actions is preceded by asymptomatic cervical remodelling and ripening, which can be seen on trans-vag

76 environmental factors involved in cell wall remodelling and sporulation are the main drivers of adap

77 n opening, and thereby facilitate nucleosome remodelling and subsequent transcription.

78 act together to attenuate pulmonary vascular remodelling and that their actions are mediated by Notch

79 roenvironment and instigates aberrant tissue remodelling and the adoption of atypical cellular phenot

80 However, how ATP powers substrate remodelling and whether a shared mechanism underlies the

81 3SA) mouse) are causally linked to metabolic remodelling and whether the failing heart shares a commo

82 ifferentiation (proliferation and epigenetic remodelling) and function are orchestrated coordinately

83 lial cells, mucus hypersecretion, and airway remodelling, and consequently might impact asthma sympto

84 d extracellular injury, pathological cardiac remodelling, and diastolic and systolic dysfunction.

85 mulate elastin and collagen for bladder wall remodelling, and hAFSC transplantation improved these ch

86 hylation, histone modification and chromatin remodelling, and non-coding RNAs, the manipulation of th

87 prevent atherosclerosis progression, cardiac remodelling, and the resulting ischaemic heart disease a

88 g experimental data on AF-induced electrical remodelling, and then integrated actions of drugs into t

89 ptosis levels, which in turn promotes tissue remodelling, and ultimately leads to the relocalization

90 playing at least two different roles in bone remodelling: apoptotic trigger of the repair protocol, a

91 interact with fibroblasts and promote tissue remodelling are beginning to be understood and will be a

92 een IgA deposition, inflammation, and matrix remodelling are not well characterized.

93 Other properties of post-MI remodelling are present in both peri-infarct and remote

94 , but its effects on airway inflammation and remodelling are unknown.

95 ed to WT, accompanied by extensive metabolic remodelling as demonstrated by metabolomics-fluxomics co

96 a plasma membrane that is itself subject to remodelling as division progresses.

97 subepithelial fibrosis, a feature of airway remodelling, as well as improved lung function and reduc

98 t heart under substrate excess the metabolic remodelling associated with cardiac function in diabetic

99 rgeting OPG can attenuate pulmonary vascular remodelling associated with PAH in multiple rodent model

100 the implementation of AF-induced electrical remodelling associated with SND agreed with the clinical

101 sthma in mice with females developing airway remodelling at a much earlier stage than males.

102 epair but which also contributes to vascular remodelling, atherogenesis and restenosis.

103 local proteomes that facilitate the synaptic remodelling attributed to normal cellular function.

104 ve collagen metabolism, extracellular matrix remodelling, beta-cell differentiation and non-beta-cell

105 k on specialized functions such as chromatin remodelling, biomarker potential and the recently discov

106 ar function, arterial stiffness and vascular remodelling by improving central and local blood flow co

107 n 1 and 2 regulate angiogenesis and vascular remodelling by interacting with the tyrosine kinase rece

108 l stimulation; prevention of adverse cardiac remodelling by interatrial shunts; and finally targeting

109 xis(8,9) further regulates basement membrane remodelling by localizing Nodal signalling-and therefore

110 -to-cell coupling caused by atrial fibrosis) remodelling can have an effect on the generation of atri

111 -catenin is dispensable for CAF-mediated ECM remodelling, cancer cell growth and invasion, DKK3-drive

112 ng metabolic pathways, DNA repair, chromatin remodelling, cellular senescence and immune cell functio

113 LV geometric patterns, such as concentric LV remodelling (cLVR), concentric LVH (cLVH), and eccentric

114 ence for germ layer formation by extensively remodelling compacted chromatin before the onset of indu

115 The chromatin-remodelling complex SWI/SNF is highly conserved and has

116 cently described non-canonical BAF chromatin-remodelling complex that also contains GLTSCR1 and GLTSC

117 ered by heterogeneities in the BAF chromatin-remodelling complex.

118 and the non-canonical BAF (ncBAF) chromatin remodelling complex.

119 sferases and the SWI/SNF family of chromatin remodelling complexes - regulate gene expression and dev

120 Chromatin remodelling complexes evict, slide, insert or replace nu

121 Multiprotein chromatin remodelling complexes show remarkable conservation of fu

122 f designated chaperone systems and chromatin remodelling complexes that regulate their localization i

123 ost-translational modification and chromatin remodelling complexes, histone variants contribute to th

124 s encoding subunits of the SWI/SNF chromatin-remodelling complexes, with nearly 25% of all cancers ha

125 h constituents of the NURD and BAF chromatin remodelling complexes.

126 spatiotemporally regulated basement membrane remodelling contributes to the coordination of embryo gr

127 can lead to the development of mild chamber remodelling, diffuse fibrosis and loss of diastolic func

128 and degradation are necessary for junctional remodelling during cell migration and angiogenesis.

129 n sdk mutants, suggesting a defect in tissue remodelling during convergence and extension.

130 spatiotemporally regulated basement membrane remodelling during early embryonic development.

131 program has been implicated in pathological remodelling during heart failure (HF), we examined wheth

132 modification, DNA methylation and nucleosome remodelling, dynamically regulate the gene expression re

133 ates needed for proliferation and epigenetic remodelling early during T cell activation, whereas comp

134 ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibi

135 ATP-dependent chromatin remodelling enzymes facilitate different DNA repair path

136 ental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gl

137 By producing ECM-remodelling enzymes-in particular the ECM protease ADAMT

138 ilage include Ctgf, Cyr61 and several matrix remodelling enzymes.

139 Through chromatin remodelling, ETV2 induces tubulogenic pathways, includin

140 of their effects on endogenous neurovascular remodelling events.

141 e functions, including matrix deposition and remodelling, extensive reciprocal signalling interaction

142 This basement membrane remodelling facilitates embryo growth before gastrulatio

143 ssociated protein POT1B and on the chromatin remodelling factor BRD2.

144 rase II transcriptional machinery (chromatin remodelling factors and Mediator Complex), punctate nucl

145 nounced suggesting the presence of chromatin remodelling factors that stimulate THF accessibility to

146 The contribution of remodelling factors to double-strand break repair within

147 omyocyte c-Kit signalling in pathological LV remodelling following pressure overload.

148 ed mutations in genes involved in chromosome remodelling (for example, PBRM1, BAP1 and SETD2), DNA me

149 om the tibialis anterior show indications of remodelling from middle into older age and which does no

150 Our findings indicate motor unit remodelling from middle to older age occurs to a similar

151 d in mechanotransduction (Cx43, AKT), tissue remodelling (GAGs, elastin, collagen) and inflammation (

152 s in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the o

153 ional proteins, the mechanisms of junctional remodelling have yet to be determined.

154 F has been associated with aberrant vascular remodelling, however the role of vascular remodelling in

155 ments associated with cell mechanics and ECM remodelling, implicating a reciprocal crosstalk between

156 ing training, vascular function and arterial remodelling improved, and arterial stiffness decreased i

157 In the present study, ECM remodelling improves contractile force in a short time,

158 is a feature of asthma whereas evidence for remodelling in allergic rhinitis (AR) is conflicting.

159 etween allergic inflammation and features of remodelling in AR.

160 t Th2-inflammation and development of airway remodelling in AR.

161 recursors that contributed to postnatal bone remodelling in both physiological and pathological setti

162 rgic HFD female mice presented a robust lung remodelling in comparison with HFD males, evidenced by h

163 chanisms to r-protein abundance and proteome remodelling in conditions of nutrient stress.

164 ork has revealed roles for basement membrane remodelling in global tissue morphogenesis(3-5).

165 Mechanisms leading to pulmonary vascular remodelling in HFpEF, a summary of pre-clinical models o

166 role of transcription factors and epigenetic remodelling in macrophages in the context of atheroscler

167 important role in extracellular matrix (ECM) remodelling in order to dictate the timing of birth.

168 This probably reflects the effects of remodelling in PAH and possibly in Fontan physiology.

169 This probably reflects vascular remodelling in PAH and possibly in Fontan physiology.

170 Translation remodelling in persister cells coincides with an increas

171 ar remodelling, however the role of vascular remodelling in pulmonary fibrosis is poorly understood.

172 ut also on shorter timescales via structural remodelling in relation to water availability and temper

173 These axonal branches undergo synaptic remodelling in response to changes in their internal ene

174 re, we investigated the implications of this remodelling in the downstream vascular organization, in

175 s hypotheses on the effects of spiral artery remodelling in utero and also indicates rapid venous dra

176 This remodelling includes the opening and marking of thousand

177 xpression of markers of activation of airway remodelling including alpha-SMA, HSP-47, extracellular m

178 disease (CKD), reverse left ventricular (LV) remodelling, including reduction in LV mass, can be obse

179 monstrated that HF-induced atrial electrical remodelling increased susceptibility to atrial alternans

180 Remodelling increases intercellular coupling and cellula

181 ere we show that the ATP-dependent chromatin remodelling INO80 complex promotes resolution of R-loops

182 presence of palmitate, there is a metabolic remodelling involving tricarboxylic acid cycle, polyol a

183 Airway remodelling is a feature of asthma whereas evidence for

184 ether, our results suggest that 3D epigenome remodelling is a key mechanism underlying endocrine resi

185 rs, we have begun to understand how membrane remodelling is coordinated during division; however, the

186 he underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatm

187 ing, which demonstrates that heterochromatin remodelling is essential for natural reprogramming at fe

188 esis pathway, NAMPT, as a result of enhancer remodelling is subject to resistance by NMRK1-dependent

189 nerative response manifested by cytoskeletal remodelling, junction dissolution, migration and extrace

190 ctural and functional changes in the intact, remodelling lymphatic vessel over a 42-day period.

191 helial and submucosal inflammatory cells and remodelling markers were evaluated by computed image ana

192 be reduced secondary to high pressures, but remodelling may increase perfusion heterogeneity.

193 an unexpectedly high conservation of nuclear remodelling mechanisms across diverse eukaryotes.

194 y driving angiogenesis, extracellular matrix remodelling, metastasis and immunosuppression.

195 variability) and biomarkers of peripheral MU remodelling (MUP size, complexity, stability).

196 targets including infarct repair and reverse remodelling, must be considered to improve patient outco

197 hich prevents the basal extracellular matrix remodelling necessary for wing morphogenesis.

198 This result suggests that remodelling occurs independently from the onset of syste

199 ogies where both acute and chronic metabolic remodelling occurs.

200 t Exl1 acts on the plant tissue, probably by remodelling of a cell wall component or altering the bar

201 It is hypothesized that HF-induced remodelling of atrial cellular and tissue properties pro

202 Consequently, remodelling of bone marrow niches can facilitate immune

203 Here we examined whether pathological remodelling of cardiomyocyte substructure and function d

204 preimplantation development is the dramatic remodelling of constitutive heterochromatin, although th

205 metalloproteinases, enzymes involved in the remodelling of ECM proteins, and noted that the proteogl

206 food intake, and preventing the post-mating remodelling of enteric neurons reduces both reproductive

207 ER-regulated genes, consistent with dynamic remodelling of ER pathways accompanying the development

208 ntain osmotic and protein homeostasis during remodelling of eukaryotic proteomes, and that bioenerget

209 for the excessive synthesis, deposition and remodelling of extracellular matrix proteins in fibrosis

210 Our results argue in favour of the remodelling of genomic methylome/hydroxymethylome landsc

211 In IBD, we observe a positional remodelling of goblet cells that coincides with downregu

212 Using calibrated ChIP-seq, we show that remodelling of histones during spermiogenesis results in

213 One important feature of this condition is remodelling of intramural small coronary arteries and ar

214 Remodelling of junctions is an essential process during

215 ion reveal the stoichiometric and structural remodelling of metabolically functional Pdu MCPs.

216 AF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel

217 Local structural remodelling of NEDD8 and large-scale movements of CRL do

218 e associated with defective learning-related remodelling of postsynaptic dendritic spines and reduced

219 cardiovascular disorder characterized by the remodelling of pre-capillary pulmonary arteries.

220 dorsal collapse that involves attrition and remodelling of pseudostratified ventricular layer (VL) c

221 er mechanism by which RAD52 limits excessive remodelling of stalled replication forks, thus indirectl

222 pithelial repair responses may contribute to remodelling of the airway wall.

223 is characterized by chronic inflammation and remodelling of the airways, associated with dysregulated

224 epidermis, meanwhile, softening and enhanced remodelling of the basement membrane promote tumour budd

225 rogression as a result of tissue healing and remodelling of the blood vasculature, causing cancer cel

226 Thus, substantial remodelling of the BSL and displacement of BSL-interacti

227 In SHRs, we found significant remodelling of the capillary network density and dispers

228 e of aneurysm plays an important role in the remodelling of the carotid arteries.

229 ptidoglycan hydrolases that are required for remodelling of the cell wall during growth.

230 n response to CRE, whereas the brain-sparing remodelling of the fetal circulation resulting from plac

231 function results in a profound architectural remodelling of the genome, which is characterized by lar

232 Remodelling of the IL-11 locus facilitates p65 access to

233 Remodelling of the immune system with age - immunosenesc

234 Our results demonstrate that large-scale remodelling of the intestinal wall and cell-fate specifi

235 s indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in th

236 abolic pathways linked to the early and late remodelling of the left and right ventricle over the cou

237 Remodelling of the myocardium is regulated by a combinat

238 ertension and aortic valve disease, promotes remodelling of the myocardium that can progress to heart

239 During cell division, remodelling of the nuclear envelope enables chromosome s

240 atiotemporal regulation of the synthesis and remodelling of the peptidoglycan layer that surrounds th

241 erial hypertension (PAH) is characterized by remodelling of the pulmonary arteries and right ventricl

242 t SA binding involves a major conformational remodelling of the SA-binding core of NPR4, which we val

243 ve initiation of brain hyperexcitability and remodelling of the synaptic constituency.

244 rgence coinciding precisely with large-scale remodelling of the transcriptome shared by prestalk and

245 the interaction between tumour genomics and remodelling of the tumour microenvironment provide impor

246 undergo a dramatic, complex and coordinated remodelling of their cytoskeleton and membranes.

247 of fatty acid oxidation, and undergo marked remodelling of their lipidome, particularly a reduction

248 acterised in resting state acquisitions, the remodelling of these state transitions by engagement in

249 due to steady state blood pressure or due to remodelling of vagal efferent function.

250 rdial Infarction through Reversal of Cardiac Remodelling]) of 223 patients post-MI, of which 33 patie

251 Fibrotic tissue remodelling often leads to organ malfunction and is comm

252 athophysiology leading to Fontan palliation, remodelling, or increased gravitational gradients from l

253 years, molecular processes underlying heart remodelling over the course of PAH are still insufficien

254 ignificance of this signal-mediated membrane remodelling pathway probably extends beyond host defence

255 that transcription factors rely on specific remodelling pathways for correct genomic binding.

256 ytes, which then undergo extensive chromatin remodelling post-meiosis, thus acquiring an active chrom

257 No female animal models of early stage remodelling (pre-HFpEF) have examined the effects that t

258 But when remodelling proceeds abnormally it can contribute to pre

259 After a single tooth extraction, remodelling processes are initiated and morphological ch

260 to varying water content but also to tissue remodelling processes due to the sarcoma.

261 ntact heart undergoes complex and multiscale remodelling processes in response to altered mechanical

262 improve the understanding of the multiscale remodelling processes occurring in CVDs, and the compreh

263 with Bsg highly expressed, and the chromatin remodelling program initialised to establish an early na

264 Fibrotic remodelling programmes with shared fibrotic signalling r

265 ient, and MI can often result in ventricular remodelling, progression to heart failure and premature

266 lts showed that HF-induced atrial electrical remodelling prolonged AP duration, which was accompanied

267 sults show how H3.3K27M-driven transcriptome remodelling promotes tumorigenesis and will be critical

268 IgAN transcriptomics, indicating that tissue remodelling rather than increased expression might contr

269 ng as the central checkpoint of multiple ECM remodelling-related signalling pathways to modulate tumo

270 nt was performed at 3-4 months to assess the remodelling response.

271 blication, we also clarify that the junction-remodelling role of Mpp5a is not specific to dividing ce

272 creased cell-cell coupling due to structural remodelling slow electrical propagation and provide obst

273 osine triphosphate (ATP)-dependent chromatin remodelling (Snf2) enzyme, can alter Top2 chromatin bind

274 nite-element simulations of left ventricular remodelling so as to balance the fluid and solid propert

275 , they can secrete pro-angiogenic and matrix-remodelling soluble mediators that could promote tumour

276 impact on the progressive pulmonary vascular remodelling that drives PAH.

277 rinary tract obstruction triggers urothelial remodelling that stabilizes the obstructed kidney and li

278 ncy between different ER-phagy 'pathways' in remodelling the ER proteome.

279 proteins required for growing, repairing or remodelling the nacreous shell layer, whereas the second

280 es, revealing the importance of apoptosis in remodelling the primmorphs to initiate re-development.

281 For determining aortic remodelling, the degree of true lumen (TL) expansion was

282 s athletes are more successful at motor unit remodelling, the reinnervation of denervated fibres acti

283 Senicapoc treatment attenuated vascular remodelling through inhibition of capillary endothelial

284 n coleorhiza reinforcement through cell wall remodelling to confer coat dormancy.

285 Tumours leverage ECM remodelling to create a microenvironment that promotes t

286 tner recognition triggers reciprocal genetic remodelling to enable colonisation.

287 Remodelling Top2 binding is thus an important new means

288 gous and homozygous regions causes crossover remodelling towards the heterozygous regions in wild typ

289 volved in calcific disease, including matrix remodelling, transcriptional regulation, mitochondrial d

290 hat lead to altered gene expression and cell remodelling under physiological and pathophysiological c

291 ivity occur due to electrical and structural remodelling under Pitx2 deficiency conditions.

292 Pathological LV remodelling was evident by the re-expression of fetal ge

293 05), confirming that the capacity for muscle remodelling was retained following chronic distributed i

294 ar function, arterial stiffness and vascular remodelling were evaluated before and after 12 weeks of

295 alterations in genes associated with matrix remodelling were observed at a transcript level.

296 lop PH in the presence of pulmonary vascular remodelling with a high transpulmonary pressure gradient

297 Notably, they also display features of MU remodelling with advancing age, probably acting to reduc

298 Echocardiography only detected mild chamber remodelling with ageing while intraventricular pressure-

299 characterised by focal abnormalities of bone remodelling, with increased osteoclastic resorption the

300 ain with epithelial cells leads to chromatin remodelling within the IL-11 promoter in a KDM6B-depende