ライフサイエンスコーパス: remote memory

1 less is known about the neural mechanisms of remote memory.

2 -like accuracy and hippocampus dependency of remote memory.

3 on and restrains the formation of recent and remote memory.

4 gement of mechanisms specific for processing remote memory.

5 d have important roles in the maintenance of remote memory.

6 cocaine memory, without affecting recall of remote memory.

7 g fear extinction, and for the expression of remote memory.

8 ippocampal neurogenesis in the expression of remote memory.

9 methylation 1 month after learning disrupted remote memory.

10 ential drug target site to improve long-term remote memory.

11 s known about signaling events important for remote memory.

12 orward conclusions about the neuroscience of remote memory.

13 tion of new memory but typically spares very remote memory.

14 by a null alpha-CaMKII mutation that blocks remote memory.

15 ations concerning hippocampal involvement in remote memory.

16 neuropsychological tests of anterograde and remote memory.

17 a learning while providing stable storage of remote memories.

18 pocampus, which was associated with enhanced remote memories.

19 s) as well as for the stable organization of remote memories.

20 the initial aversive conditioning normalized remote memories.

21 n the BLA and animals are unable to retrieve remote memories.

22 e acetylation, such plasticity is absent for remote memories.

23 ingful association with emotionally salient, remote memories.

24 pathway may open the door for modulation of remote memories.

25 evertheless contained more information about remote memories.

26 respected the distinction between recent and remote memories.

27 rers often complain of irretrievable loss of remote memories.

28 tant level of activity during recall of more remote memories.

29 ory persistence (7-day memory retention) and remote memory (30-day memory retention).

30 ion of hippocampal CA1 excitatory neurons to remote memory and find that contextual fear memory recal

31 ling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug tar

32 that the anterior cingulate is activated by remote memory and that this activation is impaired by a

33 given 10 tone-shock pairings in one context (remote memory) and 10 tone-shock pairings in a distinct

34 rest in the organization and neurobiology of remote memory, and the pace of work in this area has acc

35 The retrieval of recent and remote memories are thought to rely on distinct brain ci

36 rn of findings has been that both recent and remote memory are impaired after hippocampal lesions whe

37 ively and reversibly modulated the recall of remote memories as silencing COMT Val overexpression sta

38 C, but not ACC or DH, abolished retrieval of remote memory, as revealed by lack of freezing to the co

39 its within-subjects comparison of recent and remote memory at the same time point; freezing behavior

40 For many tasks and species, remote memory (but not recent memory) is spared after da

41 hibitor (HDACi) during reconsolidation, even remote memories can be persistently attenuated.

42 yed versions of the game, demonstrating that remote memories can influence the images from recent wak

43 er the timing of emergence of persistence or remote memory capabilities during development.

44 ortical mnemonic regions during retrieval of remote memories, coupled with relying more on gist-like

45 Here, we demonstrate age-dependent remote memory decline in APP/PS1 mice, which coincides w

46 Analysis of Fos expression showed that the remote memory deficit is not mirrored by changes in reac

47 ests to clarify the extent and nature of the remote memory deficits in patients with transient epilep

48 activation of these areas produces selective remote memory deficits.

49 Forty participants retrieved recent and remote memories, describing each for approximately 2 min

50 n-spatial, but not for the retrieval of very remote memories, either spatial or non-spatial.

51 f gene expression programmes associated with remote memory engrams adds an important dimension of act

52 ed of 10 tone-shock pairings in one context (remote memory), followed 16 months later by 10 additiona

53 More remote memory for both facts and autobiographical events

54 or cingulate cortex plays a critical role in remote memory for contextual fear conditioning.

55 Remote memory for factual knowledge (from 11-30 years be

56 iation in executive functions, its impact on remote memory formation and recall is still poorly explo

57 T-Val gene (COMT-Val-tg) present exaggerated remote memories (>50 days) while having unaltered recent

58 Accelerated long-term forgetting and remote memory impairment are common amongst patients wit

59 Our data indicate that age-dependent remote memory impairment in APP/PS1 mice is due to incre

60 sturbance: accelerated long-term forgetting, remote memory impairment, especially affecting autobiogr

61 d memories fade over days to weeks and (iii) remote memory impairment, in which there is loss of memo

62 e process underlying the progressive loss of remote memories in AD has remained elusive.

63 tructed and overtly elaborated on recent and remote memories in response to picture cues in the fMRI

64 We propose that the hippocampus reconstructs remote memories in the absence of the original trace.

65 dorsal hippocampus activity, while recall of remote memory in both contexts requires the medial prefr

66 ring SWS selectively impaired recent but not remote memory in the absence of effects on error rate an

67 h features normally observed in consolidated remote memories, including higher engagement of neocorti

68 t overtraining and were tested at recent and remote memory intervals.

69 recalled in the observer's context only, but remote memory is recalled in both observer and demonstra

70 slowly and shows substantial forgetting when remote memory is tested.

71 n teasing apart neural mechanisms underlying remote memory loss.

72 arge medial temporal lobe lesions had intact remote memory, markedly impaired recent memory, and also

73 ion task, but exhibit impairments during the remote memory phase of testing.

74 her, our findings suggest a role for PNNs in remote memory processing by stabilizing the neural netwo

75 formation with clemastine fumarate improves remote memory recall and promotes fear generalization.

76 ntage of time Te2 theta leads the BLA during remote memory recall correlates with a faster latency to

77 ns in Arc expression modulated by recent and remote memory recall could guide future inactivation and

78 ceptors was sufficient to rescue the altered remote memory recall in COMT-Val-tg mice and increased P

79 s in neuronal activity underlying recent and remote memory recall is unknown but essential for deciph

80 isms through which they interact to underlie remote memory recall remain unexplored.

81 ds to deficits in synaptic plasticity and in remote memory recall using conditional knockout of Cdc42

82 An effective remote memory recall was accompanied by fewer strengthen

83 ctive during learning and reactivated during remote memory recall, whereas the extinction of remote m

84 nected to other PFC neurons recruited during remote memory recall.

85 ion, from fear memory encoding to recent and remote memory recall.

86 nt fear memory, while its knockdown impaired remote memory recall.

87 eurons, which contribute to the capacity for remote memory recall.

88 uisition, but instead significantly impaired remote memory recall.

89 isms through which they interact to retrieve remote memories remain unexplored.

90 ir interactions during learning and tests of remote memory retention for whisker-signaled trace eyebl

91 ty during the trace interval during tests of remote memory retention, suggesting its involvement in r

92 and make larger behavioral contributions to remote memory retrieval compared to those TRAPed during

93 ygdala of stress-susceptible male mice after remote memory retrieval.

94 critical contribution of the hippocampus to remote memory retrieval.

95 increases in activity specifically following remote memory retrieval.

96 s using flies trained to have both early and remote memories showed that the alpha'/beta' MBNs have a

97 Moreover, bexarotene treatment improved remote memory stabilization in fear conditioned mice and

98 ell gene expression landscape that underlies remote memory storage in the medial prefrontal cortex.

99 cise HPC circuits and mechanisms involved in remote memory storage remain poorly understood.

100 ), was traditionally found to be involved in remote memory storage, but recent evidence points toward

101 and sheds light on the elusive mechanisms of remote memory storage.

102 t to occur weeks to months later to subserve remote memory storage.

103 ression signatures that were associated with remote memory, suggesting that they actively contribute

104 n healthy older adults taking a famous faces remote memory test.

105 rating novel associations between recent and remote memories that are then instantiated during non-RE

106 genetic variations modulate the retrieval of remote memories through the dysregulation of the endocan

107 dal cells blocked extinction learning at the remote memory time-point.

108 ity associated with the recall of recent and remote memories was then compared.

109 Remote memory was present at P23, but expression was not

110 ote memory recall, whereas the extinction of remote memories weakened those synapses.

111 stingly, we also found that while recent and remote memories were both represented within anterior an

112 d remote autobiographical memories, although remote memories were more readily detected there, indica

113 this study, we demonstrated that recent and remote memories were susceptible to a loss of episodic d

114 s, fewer functional disabilities, and intact remote memory were associated with unrecognized dementia

115 ocampal volume with recall, recognition, and remote memory were fully mediated by wider network abnor

116 pocampus is not involved in the retrieval of remote memories, whereas others assert that it is necess

117 ed extensively(1-3), but less is known about remote memories, which can persist for a lifetime(4).

118 on of this structure in normal mice disrupts remote memory without affecting recent memory.

119 of pyramidal cells facilitated extinction of remote memory, without affecting recent memory, inhibiti