ライフサイエンスコーパス: renal clearance

1 ) progression, implicating mechanisms beyond renal clearance.

2 y dipeptidyl peptidase-4 (DPP-4) and through renal clearance.

3 l imaging may increase the size too much for renal clearance.

4 ted fast in vivo pharmacokinetics with major renal clearance.

5 albumin-binding peptide to prevent its rapid renal clearance.

6 s a dangling carboxylate to facilitate rapid renal clearance.

7 er limit of 5-10 ligands per quantum dot for renal clearance.

8 escriptors show a positive relationship with renal clearance.

9 nd to be the physicochemical determinants of renal clearance.

10 utic plasma levels of drugs with predominant renal clearance.

11 nother serum protein that protects RBP4 from renal clearance.

12 rse cholesterol transport or, alternatively, renal clearance.

13 a-BBN(7-14) exhibited both hepatobiliary and renal clearance.

14 ropriate prescribing, in view of compromised renal clearance.

15 by its short biological half-life and rapid renal clearance.

16 onsidered when measuring Hcy plasma flux and renal clearance.

17 dney and liver uptake with equal biliary and renal clearance.

18 atively high kidney uptake and predominantly renal clearance.

19 (PF-4) and a lysine-rich sequence for rapid renal clearance.

20 axel using a dose formula based on projected renal clearance.

21 llular distribution with predominantly rapid renal clearance.

22 hich was improved by a targeted reduction in renal clearance.

23 tumour retention, insignificant toxicity and renal clearance.

24 the PDC in receptor-positive tumors and high renal clearance.

25 d signal enhancement in the kidneys and fast renal clearance.

26 Biodistribution showed fast renal clearance.

27 etic properties, good tumor penetration, and renal clearance.

28 0.5 - 1 hour postinjection followed by rapid renal clearance.

29 ide, however, was rapidly eliminated through renal clearance.

30 difications, peptides are rapidly removed by renal clearance.

31 ction site to peripheral tissues by reducing renal clearance.

32 n protects against enzymatic degradation and renal clearance.

33 th that of two existing models for augmented renal clearance.

34 es (carboxylates) on the chelator, promoting renal clearance.

35 esult from increased formation and decreased renal clearance.

36 tion by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

37 tion by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

38 al accumulation in normal tissues, and rapid renal clearance.

39 ave low kidney retention and relatively fast renal clearance.

40 ed the highest tumor accumulation and little renal clearance.

41 all tracers, and they all showed predominant renal clearance.

42 le gastrointestinal absorption and nonlinear renal clearance act additively to produce the ceiling ef

43 robe showed selective tumor uptake and rapid renal clearance, affirming that the pepa-pic(2) chelator

44 Rosuvastatin renal clearance, although still minor, was increased app

45 was also found in vivo, with a predominantly renal clearance and a specific uptake in the PD-L1-overe

46 and metabolite analysis in mice showed rapid renal clearance and acceptable in vivo stability.

47 can be valuable in early prediction of human renal clearance and can aid the chemist in structural mo

48 8)Ga-PNT6555 and (68)Ga-PNT6952 showed rapid renal clearance and continuous accumulation in tumors, r

49 Renal clearance and enzymatic inactivation control the e

50 predicts that a GCSF analog that eliminates renal clearance and has reduced endosomal binding affini

51 The efficient renal clearance and high compatibility can be translated

52 labeled C2Am derivative showed predominantly renal clearance and high specificity and sensitivity for

53 biodistribution profiles, with predominantly renal clearance and low nonspecific retention in the liv

54 n mouse blood for 5 h and demonstrated rapid renal clearance and lower blood levels in vivo compared

55 However, slow renal clearance and persistent activity predominately in

56 Renal clearance and recollection micro-puncture experime

57 d antibody recycling, thereby evading ligand renal clearance and requiring increasingly high antibody

58 ulant activity; however, problems with rapid renal clearance and short circulation half-life have pre

59 The present study aimed to predict renal clearance and systemic disposition of morphine and

60 mathematical modeling successfully predicted renal clearance and systemic disposition of opioids in C

61 With renal clearance and tubule perfusion techniques, we show

62 rating near infrared emission with efficient renal clearance and ultralow background interference, th

63 Evaluation in vivo demonstrated primarily renal clearance and uptake of approximately 8 percentage

64 Measured renal clearance and whole body total clearance data for

65 s reduction may be attributable to defective renal clearance and/or extrarenal clearance and metaboli

66 in vivo by reducing nuclease hydrolysis and renal clearance, and achieved high and sustained inhibit

67 lyzed correlations between changes in ANRIL, renal clearance, and CIMT.

68 mor uptake and high retention, predominantly renal clearance, and fast wash-out from blood and other

69 antly decreased urinary carnitine excretion, renal clearance, and fractional clearance of NEC.

70 ion of myocardial radioactivity, substantial renal clearance, and high metabolic stability in plasma.

71 We used electrophysiology, renal clearance, and immunoblotting to study Kir4.1 in t

72 ity to degradation in the circulation, rapid renal clearance, and immunostimulatory adverse effects g

73 CKD and determined by intestinal uptake and renal clearance, and it is not fully accounted for by di

74 aled rapid and persistent tumor uptake, fast renal clearance, and low retention in normal tissues.

75 e bloodstream with a 5.7 min half-life, high renal clearance, and low, transient liver enhancement in

76 Renal clearance appeared to be the major route of elimin

77 Augmented renal clearance appears to be a common finding in this p

78 (IRDye 800CW) in physiological stability and renal clearance but exhibit a much longer tumor retentio

79 le fluorescence in xenograft MCF7 tumors and renal clearance by MR imaging.

80 irculation half-life of 5.6 h and to undergo renal clearance-characteristics needed for nanomedicines

81 methods that provide accurate prediction of renal clearance (CL(r)) and systemic disposition of opio

82 showed 64Cu-DOTA-knottin 2.5F to have a fast renal clearance combined with low nonspecific accumulati

83 in chronic kidney disease because decreased renal clearance contributes to cardiovascular and liver

84 ibutions were also assayed in the absence of renal clearance (e.g., in mice rendered surgically aneph

85 By virtue of their ideal renal clearance efficiency (60% injected doses at 24 h p

86 ze result in four- to ninefold reductions in renal clearance efficiency in the early elimination stag

87 y but different densities, we found that the renal-clearance efficiency exponentially increased in th

88 h solute/regimen combination, the equivalent renal clearance (EKR: ml/min) was calculated as a dimens

89 lysis and hemodialysis? (2) Are dialytic and renal clearances equivalent? and (3) Will survival impro

90 odified Brenner method, in which (99m)Tc-MDP renal clearance estimated from the whole-body counts was

91 The overall median estimated total renal clearance (eTRCL) was 50 mL/minute (interquartile

92 First, renal clearance experiments were used to assess the impa

93 Unbound tracer underwent rapid renal clearance followed by high renal reabsorption.

94 ion, urinary fluoride excretion and fluoride renal clearance following no exercise and three exercise

95 of physicochemical properties and the human renal clearance for a data set of 391 drugs or compounds

96 MA-targeting, minimal off-target uptake, and renal clearance for all picaga-Met-hex-KuE systems.

97 c residues with smaller dimensions to ensure renal clearance for better biocompatibility of the funct

98 e daily or valganciclovir (dose-adjusted for renal clearance) for 8 weeks with 12 weeks of follow-up.

99 y large size, can be efficiently excreted by renal clearance from the host after systemic injection.

100 While methods for metabolic and passive renal clearance have proven reasonably robust, there is

101 en the scFv were evaluated in the absence of renal clearance in anephric mice, indicating that the ra

102 y the deleterious systemic effects of absent renal clearance in ARF without the confounding effects t

103 o plasma proteins in vitro and exhibit rapid renal clearance in naive mice.

104 clearance (29-min half-life) and predominant renal clearance in nonhuman primates.

105 redox properties, hypertensive response, and renal clearance in rats.

106 l nervous system partitioning, and decreased renal clearance in vivo.

107 d pharmaceuticals in patients with augmented renal clearance, in addition to the potential impact on

108 y, increased blood circulation time, reduced renal clearance, increased tumor biodistribution, and gr

109 Renal clearance is a major pathway for regulating the le

110 ghtly longer than that of ShK, implying that renal clearance is the major determinant of its plasma l

111 Renal clearance is traditionally viewed as a passive fil

112 Optimized for efficient renal clearance, it concurrently achieved specific tumor

113 ent was subtracted from the total (bone plus renal) clearance (K(total)) measured from the free (99m)

114 iopharmaceuticals; however, both agents have renal clearances less than that of (131)I-orthoiodohippu

115 all excellent renal imaging agents but have renal clearances lower than that of (131)I-orthoiodohipp

116 Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-base

117 Enhanced renal clearance may lead to increased renal solute elimi

118 plasma half-life was 27.3 min with primarily renal clearance (mean 25.7% +/- 5.4% of injected dose 4

119 Renal clearance measurements and histologic assessments

120 Renal clearance measurements showed that uroguanylin def

121 Augmented renal clearance might lead to subtherapeutic plasma leve

122 a-pic(2) as the lead scaffold, showing rapid renal clearance, minimal nontarget retention, and high i

123 ands and small bowel, with hepatobiliary and renal clearance noted, whereas (68)Ga-RM2 had the highes

124 est physiologic uptake in the pancreas, with renal clearance noted.

125 Renal clearance of (11)C-metformin was approximately 3 t

126 metformin PET/CT in 6 anesthetized pigs, and renal clearance of (11)C-metformin was compared with ren

127 ation in the kidneys, indicating substantial renal clearance of (18)F-FCP.

128 11)C-metformin was approximately 3 times the renal clearance of (51)Cr-EDTA.

129 earance of (11)C-metformin was compared with renal clearance of (51)Cr-ethylenediaminetetraacetic aci

130 No appreciable renal clearance of (64)Cu-DOTA-VEGF(121) was observed, a

131 These methods were compared with renal clearance of 125I-iothalamate GFR (GFR1) in 193 hy

132 idneys and urinary bladder, indicating rapid renal clearance of 18F-annexin V metabolites.

133 Renal clearance of 4-pyridoxic acid was 232 +/- 94 mL/mi

134 Hepatobiliary and renal clearance of 99mTc-sestamibi are Pgp-mediated, and

135 modal imaging studies in mice to investigate renal clearance of a single-walled carbon nanotube (SWCN

136 Alterations in renal clearance of anticancer drugs can affect the occur

137 This analysis is based on the renal clearance of ascorbic acid, which rises sharply wi

138 he blood retention, kidney accumulation, and renal clearance of Au25(SG)18 in a doxorubicin-induced a

139 , increased kidney accumulation, and reduced renal clearance of Au25(SG)18.

140 her transplacental transfer efficiencies and renal clearance of branched PFOS and PFOA isomers, compa

141 The renal clearance of cobalt increased with the serum conce

142 Renal clearance of creatinine was found significantly be

143 ction, and fluid balance and related this to renal clearance of diuretics.

144 Renal clearance of DMSO was 14.1 +/- 3.4 mL/min.

145 'bandpass' filter to significantly slow down renal clearance of few-atom gold nanoclusters (AuNCs) wi

146 We used microperfusion, micropuncture, and renal clearance of FITC-inulin to examine the effects of

147 he indocyanine-green or both, methods and by renal clearance of inulin and para-aminohippurate (PAH),

148 Reduced renal clearance of inulin, resulting from gentamicin or

149 e, were examined against GFR measured by the renal clearance of iothalamate in 1286 individuals with

150 on exchange (ionic etching), and facilitates renal clearance of metal ions released from the quantum

151 on of the urea cycle independent of impaired renal clearance of nitrogenous waste.

152 can be employed to evaluate the mechanism of renal clearance of organic anions, to assess potential d

153 Impaired renal clearance of parathyroid hormone may contribute to

154 We determined the single-pass renal clearance of parathyroid hormone, fibroblast growt

155 Overall, the rapid renal clearance of peptides can be exploited to direct c

156 a surrogate of intestinal uptake as well as renal clearance of phenylacetylglutamine.

157 pport a role of the intestine in stimulating renal clearance of Pi.

158 Since lowering TTR levels increases renal clearance of RBP4, we determined whether decreasin

159 Dynamic gamma imaging demonstrated rapid renal clearance of RP748.

160 Because the rapid renal clearance of scFv may blunt the impact of improved

161 34 hemodialysis patients (with no meaningful renal clearance of sodium), and 31 patients with chronic

162 Rapid renal clearance of the 50-kDa antibody fragment enables

163 We speculated that the impaired renal clearance of the intrinsic purine metabolite solub

164 rasmall size of Cu(5.4)O USNPs enables rapid renal clearance of the nanomaterial, guaranteeing the bi

165 Baseline levels as well as renal clearance of the NNK metabolites correlated with n

166 in anephric mice, indicating that the rapid renal clearance of the scFv was not responsible for thes

167 take in the kidneys and bladder due to rapid renal clearance of the tracer.

168 r of QD-Cys ( approximately 6 nm) allows for renal clearance of these nanoparticles in rat models.

169 modifier to improve the water solubility and renal clearance of three hydrophilic analogues of 1.

170 In two patients, the renal clearance of thymidine was approximately 20% that

171 serve immune defenses and the breakdown and renal clearance of toxic substances.

172 ive, better tolerated agents to increase the renal clearance of uric acid and thereby control hyperur

173 The renal clearances of (99m)Tc(CO)(3)(rac-ASMA) and (131)I-

174 The renal clearances of inulin and para-aminohippurate were

175 Out of 33,258 ICU days, we found augmented renal clearance on 19.6% of all ICU days in the developm

176 ubarachnoid hemorrhage experienced augmented renal clearance on at least 1 day.

177 tracerebral hemorrhage experienced augmented renal clearance on at least 1 day.

178 Overall, 65.1% manifested augmented renal clearance on at least one occasion during the firs

179 xed-effects model, the presence of augmented renal clearance on study day 1 strongly predicted (p = 0

180 Augmented renal clearance on the next day can be predicted with go

181 r, a clinical prediction model for augmented renal clearance on the next day during ICU stay, and mad

182 ht (6.8 kDa) of the ProGel-Dex ensures rapid renal clearance once it escapes the joint, limiting syst

183 that predonation GFR as measured by isotopic renal clearance or any of the creatinine-based estimatio

184 d by several drug delivery hurdles including renal clearance, phagocytosis, enzymatic degradation, pr

185 We developed and validated our augmented renal clearance predictor, a clinical prediction model f

186 ined six clinical variables in our augmented renal clearance predictor: day from ICU admission, age,

187 ficantly to its enhanced tumor-targeting and renal clearance properties and makes DOTAReCCMSH an exce

188 etection that leverages the fluorescence and renal clearance properties of carbon quantum dots (CQDs)

189 xceptional tumour accumulation and efficient renal clearance properties.

190 The renal clearance property was assessed using the correspo

191 embrane-water distribution coefficients, and renal clearance rate are among the most important model

192 G6 dendrimers also showed decreased renal clearance rate, slightly increased liver and splee

193 Early identification of augmented renal clearance remains challenging for the ICU physicia

194 Renal clearance represented only a small portion of tota

195 es demonstrated conjugate safety profile and renal clearance route of the selected PGA-doxy candidate

196 antly decreased from A to V, consistent with renal clearance, several were found to increase, the mos

197 h a modification that effectively eliminates renal clearance should have a significantly longer half-

198 3-fold, tumor retention of CGT prolonged and renal clearance significantly reduced when compared with

199 Renal clearance studies in mice failed to show a diureti

200 Renal clearance studies were conducted in normal rats wi

201 A range of techniques were used including renal clearance studies, in situ microperfusion, RT-PCR

202 We used electrophysiology, renal clearance techniques, and immunoblotting to examin

203 (95% CI, 1.23-1.71) adjustment when relating renal clearance to creatinine-based estimated glomerular

204 studies, immunoblotting, immunostaining, and renal clearance to examine Kir4.1/Kir5.1 activity in the

205 Because iodine uses predominantly renal clearance, treatment management in hemodialysis pa

206 and 36(17) mug/h; and iii) rate of fluoride renal clearance was 26.5(9.0), 27.2(30.4), 13.1(20.4) an

207 Enhanced renal clearance was defined as a measured creatinine cle

208 Augmented renal clearance was defined by a creatinine clearance mo

209 Augmented renal clearance was defined by a measured creatinine cle

210 safe systemic administration and systematic renal clearance was demonstrated in both tested species.

211 No significant effect on renal clearance was observed.

212 oxaban, an oral factor Xa inhibitor with 50% renal clearance, was noninferior to well-managed warfari

213 The physicochemical space and renal clearance were also statistically analyzed by ther

214 stance to degradation and presumably reduced renal clearance were obtained by introducing a 1,4-disub

215 ntracerebral hemorrhage experienced enhanced renal clearance, which may be otherwise unknown to clini

216 egree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted

217 tudies in the Fabry mouse model showed quick renal clearance with high radioactive uptake in the hear

218 oncentration and decline in rate of fluoride renal clearance with increasing exercise intensity needs

219 biodistribution study showed rapid blood and renal clearance with low retention in all major organs a

220 aqueous and organic solvents, thus improving renal clearance with minimal binding to serum proteins d

221 t decline in urinary carnitine excretion and renal clearance with nonesterfied carnitine (NEC) declin

222 a blood half-life of 25.8 +/- 4.6 min, rapid renal clearance with only 26.2 +/- 6.1 percentage inject

223 bited high kidney-to-blood contrast and slow renal clearance, with an SUV of 14.1 +/- 6.2.

224 The tracer exhibited predominantly renal clearance, with some activity in the liver and spl

225 melanoma show receptor-specific imaging and renal clearance within 4 h post-injection.