ライフサイエンスコーパス: renal tubule

1 apical expression in the distal part of the renal tubule.

2 thelial ion flux and fluid generation by the renal tubule.

3 hesis by a genetic approach along the entire renal tubule.

4 of the proximal and the distal parts of the renal tubule.

5 ic transcription factors expressed along the renal tubule.

6 be active urea secretion somewhere along the renal tubule.

7 he paracellular cation barrier of the distal renal tubule.

8 home specifically to injured regions of the renal tubule.

9 xpressed by L. kirschneri that colonized the renal tubule.

10 tumorigenesis especially within the proximal renal tubule.

11 ubject to an active secretory process by the renal tubule.

12 the innate immune response to the distressed renal tubule.

13 channel involved in NaCl reabsorption in the renal tubule.

14 on of calcium transport processes within the renal tubule.

15 vity of different nephron segments along the renal tubule.

16 ized by formation of 2,8-DHA crystals within renal tubules.

17 IHC of kidneys localized FAM20A in the renal tubules.

18 , stellate cells, in Drosophila melanogaster renal tubules.

19 induces phosphaturia through its effects on renal tubules.

20 in SCC diagnosis, we found p53+ cells in the renal tubules.

21 proliferating cell nuclear antigen-positive renal tubules.

22 ion and antiapoptosis during regeneration of renal tubules.

23 opportunity to pursue experiments on single renal tubules.

24 in which fluid-filled cysts displace normal renal tubules.

25 F by increasing local delivery of BNP to the renal tubules.

26 of stem cells and augmenting repopulation of renal tubules.

27 require polarization of epithelia that line renal tubules.

28 or to detect fluid flow through the lumen of renal tubules.

29 is found in greatest abundance in the distal renal tubules.

30 normal G alpha(s) expression in the proximal renal tubules.

31 ejecting kidney biopsies and co-expressed in renal tubules.

32 stitial cells, and macrophages in the distal renal tubules.

33 n rats, where infection is restricted to the renal tubules.

34 ateral membranes of hepatocytes and proximal renal tubules.

35 adult mice, the expression is restricted to renal tubules.

36 d the structural and functional integrity of renal tubules.

37 r of CaOx crystal formation and retention in renal tubules.

38 he nascent nephron that is the progenitor of renal tubules.

39 ystal formation and crystal retention in the renal tubules.

40 alamin and selective protein reabsorption in renal tubules.

41 suggesting defect(s) in Cl- reabsorption in renal tubules.

42 ossum kidney (OK) cells, a model of proximal renal tubules.

43 suggesting a Na+ reabsorption deficiency in renal tubules.

44 to several important transport functions in renal tubules.

45 Ig light chain deposition was evident within renal tubules.

46 nger in isolated membrane vesicles or intact renal tubules.

47 re distinguishable in the tissue surrounding renal tubules.

48 acellular matrix, and displacement of normal renal tubules.

49 ron model revealed hot spots in the proximal renal tubules.

50 of ribosomal protein S6 (rpS6) in activated renal tubules.

51 he preconditioning dose of endotoxin and the renal tubules.

52 e epithelial cells of distal segments of the renal tubules.

53 luid transport by the Drosophila Malpighian (renal) tubule.

54 ed fluid transport by Drosophila Malpighian (renal) tubules.

55 al fluid transport by Drosophila Malpighian (renal) tubules.

56 oxcarbazepine can enhance the sensitivity of renal tubules, a reduction in desmopressin dose might be

57 dney, characterized by cystic enlargement of renal tubules, aberrant epithelial proliferation, and io

58 east 10 mutations that cause severe proximal renal tubule acidosis in humans.

59 omerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified.

60 The highly metabolically active cells of the renal tubule also pair their energetic needs to the regu

61 At the level of renal tubules, ambrisentan treatment prevented the incre

62 membrane protein that is expressed along the renal tubule and exposed to a wide range of concentratio

63 olarity, found that many dividing pre-cystic renal tubule and hepatic bile duct cells from Tsc1, Tsc2

64 ng transcription factor expression along the renal tubule and mapping metabolic pathways.

65 effects of acid on calcium transport in the renal tubule and then discuss why not all gene defects t

66 The cysts arise from renal tubules and are lined by abnormally functioning an

67 ized to epithelial cells, including proximal renal tubules and biliary epithelial cells.

68 atopoietic cell niche in proximal and distal renal tubules and collecting ducts.

69 hedgehog (Shh), which was rapidly induced in renal tubules and could target interstitial fibroblasts.

70 Animals that overexpress soluble Crry in renal tubules and elsewhere are protected from the acute

71 ic kidney disease (ADPKD) cysts develop from renal tubules and enlarge independently, in a process th

72 Detection of viral gene products in renal tubules and excretion of JC virions in the urine s

73 rfamily of cytokines, is highly expressed in renal tubules and generally promotes maintenance of epit

74 itin to visualize the interleaved pattern of renal tubules and glomeruli.

75 xperiments were conducted in isolated canine renal tubules and in a canine autotransplant model of hy

76 cialized epithelia of the choroid plexus and renal tubules and in connective tissues of the eye, ovar

77 AC3 and G(olf) colocalize in renal tubules and in macula densa (MD) cells which modul

78 tion, uPAR mRNA transcripts were detected in renal tubules and interstitial cells of the obstructed u

79 Morphometric analysis of renal tubules and interstitium revealed a marked attenua

80 iation that are essential for the control of renal tubules and kidney morphogenesis.

81 autophagic flux in glomerular podocytes and renal tubules and markedly increasing their susceptibili

82 es derived from it, one of which deposits in renal tubules and one of which displays no renal pathoge

83 y intravital microscopy revealed dilation of renal tubules and peritubular capillaries within 20 minu

84 ost animals that harbor leptospires in their renal tubules and shed the bacteria in their urine.

85 e can lead to PTH resistance in the proximal renal tubules and thus lead to impaired regulation of mi

86 s during cold storage preservation injury in renal tubules and to determine whether these changes con

87 tically attenuated CD8 infiltration into the renal tubules and tubular injury.

88 show that BMDC can respond by engrafting the renal tubules and undergo DNA synthesis after acute rena

89 cell types, including endothelial, neuronal, renal tubule, and cardiac cells.

90 omarker of increased oxidative stress in the renal tubule, and demonstrate that antioxidants can atte

91 d microcephaly, decreased convolution of the renal tubules, and abnormal craniofacial morphology.

92 munoglobulin peak, immunoglobulin deposit in renal tubules, and highly characteristic bone lytic lesi

93 ntetate dimeglumine enabled visualization of renal tubules, and hypointensity from cationic ferritin

94 Epac1 is expressed in heart, renal tubules, and in the HK-2 cell line.

95 hemistry, UbA52 was exclusively localized to renal tubules, and its expression was markedly increased

96 spiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their applicatio

97 tor expression was specifically increased in renal tubules, and myofibroblastically phenotypic transi

98 , miRNAs are essential for the maturation of renal tubules, and Pkd1 is a target of miR-200.

99 se in the branching ureteric bud, developing renal tubules, and sex ducts.

100 ss were obtained within 3.2 minutes to image renal tubules, and T2*-weighted images of the same resol

101 eactive nitrogen species (RNS) generation by renal tubules, and the inducible nitric oxide synthase i

102 d convergent extension (CE) shape developing renal tubules, and their disruption has been associated

103 uptake of the fusion protein in the proximal renal tubules, and, therefore, could significantly reduc

104 ic beta-cells, small intestine, and proximal renal tubule are encoded by the 12 exons of the PKLR gen

105 c permeabilities in the Ildr1 knockout mouse renal tubules are not affected.

106 appear in PKD kidneys and that PKD-deficient renal tubules are predisposed to abnormally increased cy

107 e, decreased mtDNA levels were visualized in renal tubules as a function of aging, which was prevente

108 crystal adhesion to the luminal membrane of renal tubules as a fundamental initiating mechanism of o

109 ciated with increased delivery of BNP to the renal tubules as evident by a greater urinary BNP excret

110 nsult, associated with enhanced autophagy in renal tubules, as assessed by measuring microtubule-asso

111 sis directly causes synchronized necrosis of renal tubules, as demonstrated by intravital microscopy

112 al hemofiltration cartridge in series with a renal tubule assist device (RAD) containing 10(9) porcin

113 al hemofiltration cartridge in series with a renal tubule assist device (RAD) containing 109 renal pr

114 The renal tubule assist device (RAD) is composed of a conven

115 colonizing the lumen of proximal convoluted renal tubules at both 10 and 28 days postinfection.

116 In the renal tubule, ATP is an important regulator of salt and

117 nsgene recapitulated Gata3 expression in the renal tubules but failed to direct sufficient GATA3 acti

118 e kidney glomerulus and is reabsorbed in the renal tubule by the action of the apical sodium-dependen

119 uired for efficient destruction of the graft renal tubules by CD8 effectors directed to donor MHC I a

120 absorbed from the lumen of the intestine and renal tubules by, respectively, enterocytes and renal ep

121 of the renal Ca receptor (CaR) may decrease renal tubule Ca reabsorption and cause hypercalciuria th

122 (GHS) rats is due, in part, to a decrease in renal tubule Ca reabsorption.

123 ts demonstrate that loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive

124 dent amino acid transporters in the proximal renal tubule, causing a reduction in amino acid resorpti

125 90 may play a role as an adapter molecule in renal tubule cell death.

126 Renal tubule cell injury occurs early in septic shock bu

127 ), a major physiologic regulator of proximal renal tubule cell sodium-phosphate cotransport, stimulat

128 Earlier work identified renal tubule cell synthesis of C3, rather than hepatic s

129 n of a synthetic hemofiltration device and a renal tubule cell therapy device containing porcine rena

130 abnormal pattern of L-fucose on postischemic renal tubule cells and activates a destructive inflammat

131 nt injuries induce cholesterol increments in renal tubule cells and that statins sensitize these cell

132 Since renal tubule cells appear to play a critical role in the

133 ubule cell therapy device containing porcine renal tubule cells in an extracorporeal perfusion circui

134 ve effector on the fate of cisplatin-exposed renal tubule cells in vivo and in vitro; adenoviral tran

135 Renal tubule cells produce BNP.

136 Ex vivo renal tubule cells showed a marked capacity for CL-11 bi

137 its sodium-phosphate cotransport in proximal renal tubule cells through activation of several kinases

138 eins to the same subcellular regions such as renal tubule cells where the proteins are associated wit

139 hat cisplatin causes apoptotic cell death in renal tubule cells, but the underlying molecular mechani

140 rs of dUTP-biotin nick end labeling-positive renal tubule cells, suggesting that increased lethality

141 her pyruvate-to-lactate flux than the normal renal tubule cells.

142 docrine, and immunologic functions of normal renal tubule cells.

143 n vitro binding of CL-11 on hypoxia-stressed renal tubule cells.

144 cially in bile duct epithelial cells, and in renal tubule cells.

145 n the inherited germline mutation within the renal tubule cells.

146 nterferon-gamma up-regulate C3 production in renal tubule cells.

147 rformed on whole-kidney samples and isolated renal tubule cells.

148 uppressor) and present in lower abundance in renal tubule cells.

149 In renal tubules, cilium-associated PKD2 appears to mediate

150 hat connected to host vasculature, alongside renal tubules comprising tubular epithelia of different

151 Haufen originated from renal tubules containing virally lysed cells, and the de

152 quired for the maintenance of the Drosophila renal tubule could provide new insights into the molecul

153 ng manba expression in zebrafish resulted in renal tubule defects and pericardial edema, phenotypes t

154 including glomerular crescent formation and renal tubule defects in early disease, which progressed

155 Isolated renal tubules demonstrated progressive loss of membrane

156 eotypic positioning of outgrowing Drosophila renal tubules depends on signaling in a subset of tubule

157 inositide 3-kinase-C2alpha (PI3K-C2alpha) in renal tubule-derived inner medullary collecting duct 3 c

158 cAMP can stimulate fluid secretion early in renal tubule development during the time when renal cyst

159 PKD1 gene product, plays a critical role in renal tubule diameter control and disruption of its func

160 Renal tubules did not demonstrate any evidence of peroxy

161 riptional target, MIM, resulted in extensive renal tubule dilation and cysts, whereas Hdac5 heterozyg

162 disease, including biliary epithelial cysts, renal tubule dilation, organ fibrosis, and basement memb

163 of active morphogenesis and, except for some renal tubules, disappeared from the adult kidney.

164 Here, we demonstrate that renal tubules do not undergo sensitization to necroptosi

165 Infiltrating lymphocytes and the renal tubules drove the miRNA tissue pertubations in rej

166 Hypertension and renal tubule dysfunction, including hyperkalemia, hyperc

167 ine chemistry panels demonstrated pronounced renal tubule dysfunction, which was confirmed histologic

168 a skin cancer and nonprogressive, reversible renal tubule effects were observed with avagacestat.

169 r1.1, encoded by KCNJ1) critically regulates renal tubule electrolyte and water transport and hence b

170 Renal tubule epithelia represent the primary site of dam

171 implicated in hyperproliferative diseases of renal tubule epithelia.

172 Renal tubule epithelial cells express the insulin recept

173 ed along the entire nephron, its function in renal tubule epithelial cells remains unclear, as no spe

174 In primary renal tubule epithelial cells, overexpression of AATF me

175 age-associated ligand exposed by ischemia on renal tubule epithelial cells, which after recognition b

176 ally involved in cold preservation injury in renal tubule epithelial cells.

177 mal tubule (HK-2) cells and in mouse primary renal tubule epithelial cells.

178 ey; increases proliferation and apoptosis of renal tubule epithelial cells; elevates protein kinase A

179 ic cells is an important mechanism mediating renal tubule epithelial regeneration after AKI.

180 NRP could mediate attachment of CaOx to the renal tubule epithelium, thereby causing retention of cr

181 transgenic mice expressed Cre recombinase in renal tubules, especially collecting ducts and thick asc

182 helial resistance than other segments of the renal tubule exhibit.

183 with conditional inactivation of Xpr1 in the renal tubule exhibited generalized proximal tubular dysf

184 Protein abundance along the renal tubule for many commonly studied water and solute

185 ells and cooperate to enhance and accelerate renal tubule formation in uninduced rat metanephric mese

186 ned cell therapy of vessel-forming cells and renal tubule-forming cells aimed at alleviating renal hy

187 Notably, after renal injury, renal tubule-forming cells and vessel-forming cells infu

188 We administered renal tubule-forming cells derived from human adult and

189 Directly injecting vessel-forming cells and renal tubule-forming cells into the subcutaneous and sub

190 ed with mesenchymal-epithelial transition in renal tubule-forming cells, indicating paracrine effects

191 ECFCs augmented in vivo tubulogenesis by the renal tubule-forming cells.

192 The paradigm for recovery of the renal tubule from acute tubular necrosis is that survivi

193 ) expression has been shown to be altered in renal tubules from diabetic mice.

194 formoterol restored renal function, rescued renal tubules from injury, and diminished necrosis after

195 Furthermore, compared with renal tubules from kidney samples of normal controls, cy

196 -smooth muscle actin (SMA) were increased in renal tubules from kidney transplant recipients on calci

197 ring the looped morphology characteristic of renal tubules from worms to humans.

198 layers in mammalian microvessels of choroid, renal tubules, glomerulus, and psoas muscle all showed s

199 shing out" crystals by purposefully dilating renal tubules has not previously been recognized.

200 lateral Na+/H+ exchange in the regulation of renal tubule HCO3- absorption.

201 to interstitial fibrosis and atrophy of the renal tubules if not appropriately treated.

202 long the basolateral surface of the proximal renal tubule in association with L-fucose, the potential

203 that conditional inactivation of Xpr1 in the renal tubule in mice resulted in impaired renal Pi reabs

204 of gestation, and it was confined mainly to renal tubules in 1-week-old mice.

205 Glomerular epithelium and renal tubules in the kidneys are entirely composed of mo

206 increasing the cold storage time of isolated renal tubules in University of Wisconsin solution caused

207 ch resulted in significantly more dysplastic renal tubules in zebrafish larvae.

208 to assess whether vitamin Ds directly affect renal tubule injury responses.

209 tion of miRNAs in CDs spontaneously evokes a renal tubule injury-like response, which culminates in p

210 e of cleaving hBD1, a component of the human renal tubule innate immune response.

211 the human sickle kidney, HO-1 is induced in renal tubules, interstitial cells, and in the vasculatur

212 hether mTOR contributes to the regulation of renal tubule ion transport.

213 The renal tubule is a major route of clearance of uric acid,

214 neuroendocrine stimulation of the Drosophila renal tubule is an extensive remodeling of the mitochond

215 Chloride transport by the renal tubule is critical for blood pressure (BP), acid-b

216 communication between different parts of the renal tubule is increasingly recognized as an important

217 Immune destruction of the graft renal tubules is an important barrier to the long-term f

218 widely studied; however, mTORC2 function in renal tubules is poorly characterized.

219 alcium oxalate monohydrate (COM) crystals to renal tubules is thought to be one of the critical steps

220 PTHrP, and PTHrP expression in rat proximal renal tubules is upregulated in response to ischemic inj

221 peptide signaling in the insect Malpighian (renal) tubules is a key physiological mechanism during r

222 Diabetic kidneys contained renal tubules laden with communities of E. coli UTI89 ba

223 rized by the growth of fluid-filled cysts in renal tubules leading to end-stage renal disease.

224 such as the kidneys (epithelial cells in the renal tubules), lungs (bronchial epithelia), thymus (epi

225 ajor role is played by the kidney, where the renal tubule matches the urinary magnesium excretion and

226 pment, but their role during later stages of renal tubule maturation is not well understood.

227 sgenic progeny expressed lacZ exclusively in renal tubules, mesonephric tubules, ureteric bud, develo

228 Here, we used RNA-seq coupled with classic renal tubule microdissection to comprehensively profile

229 Through live analysis of Drosophila renal tubule morphogenesis we show that tissue elongatio

230 Renal tubules normally show no lymphocyte infiltration,

231 rk demonstrates that repopulation of damaged renal tubules occurs primarily from proliferation of tub

232 sured intraluminal ATP concentrations in the renal tubules of anesthetized rats.

233 Cell proliferation in the developing renal tubules of Drosophila is strikingly patterned, occ

234 Using the renal tubules of Drosophila, we show that a specific dis

235 is essential to brush border maintenance in renal tubules of Drosophila.

236 ed expression of TLR4 but not of TLR2 in the renal tubules of human kidneys with diabetic nephropathy

237 o epithelial cell surfaces under flow in the renal tubules of the kidney.

238 in many cell types in the kidney, including renal tubules of the outer stripe of the medulla, glomer

239 alactosidase-positive cells were detected in renal tubules of the recipients by X-Gal staining.

240 ssion via freshwater and colonization of the renal tubules of their reservoir hosts.

241 long with greater cell proliferation, in the renal tubules of Tsc1 and rpS6 double-mutant mice.

242 In the Malpighian (renal) tubule of Drosophila melanogaster, TA activates a

243 helial ion and water flux in the Malpighian (renal) tubules of the fly, which are in direct contact w

244 tered gadopentetate dimeglumine to visualize renal tubules on T1-weighted gradient-refocused echo (GR

245 the sodium transporters expressed along the renal tubule, only the 70 kDa form of the y-subunit of t

246 within the tight junction of cultured canine renal tubule or human intestinal epithelial monolayers.

247 ach combining two-photon imaging of isolated renal tubules, physiological studies, and genetically en

248 omponents of salt reabsorption in the distal renal tubule), possibly through adenylate cyclase and cy

249 In renal tubules, preconditioning prevented peroxisomal dam

250 lized to the basolateral membranes of normal renal tubules, predominantly thick ascending limbs of He

251 in Solution and reperfused in vitro to model renal tubule preservation injury, which was assessed by

252 ynitrite (1 mM) directly to freshly isolated renal tubules produced strong nitrotyrosine signals but

253 miRNA-processing enzyme Dicer from maturing renal tubules produces tubular and glomerular cysts in m

254 produce a nitrotyrosine signal in extracted renal tubule proteins but significantly impaired transpo

255 ine renal tubular cells and freshly isolated renal tubules rapidly absorbed RCM, plasma membrane inte

256 ithelium is key to renal physiology, but how renal tubules regulate capillary development remains unc

257 owever, delivery of protein nanocages to the renal tubules remains a major challenge because of the g

258 red in vivo for a Wnt response to injury and renal tubule repair, the absence of which triggers cysto

259 cient method for the genetic manipulation of renal tubules, representing a quick and versatile altern

260 d blood pressure (BP) that was normalized by renal tubule-restricted rescue with D(1) R-wild-type but

261 Excision of Vegfa from renal tubules resulted in the formation of a smaller kid

262 roximal tubular cells or in freshly isolated renal tubules revealed that this Xpr1 deficiency signifi

263 median depth of 8261 genes in microdissected renal tubule samples (105 replicates in total) and glome

264 Fly renal tubules secrete a KCl-rich fluid.

265 with a 2100 Da PEG molecule (ICG-PEG45) as a renal-tubule-secreted near-infrared-emitting fluorophore

266 The function of each renal tubule segment depends on the genes expressed ther

267 e proteins expressed in each of 14 different renal tubule segments from rat.

268 sively profile gene expression in each of 14 renal tubule segments from the proximal tubule through t

269 Global miRNA profiling of microdissected renal tubules showed that miRNAs exhibit segmental distr

270 endogenous SLC41A1 specifically localized to renal tubules situated at the corticomedullary boundary,

271 e that parathyroid hormone inhibits proximal renal tubule sodium-phosphate cotransport through a sign

272 unction of these noncoding RNAs in postnatal renal tubules still remains unclear.

273 rfaces of lipids and proteins that may mimic renal tubule surfaces while allowing direct visualizatio

274 produces a specific pattern of injury to the renal tubule that alters uptake of DMSA.

275 accumulation of hemoglobin and lipofuscin in renal tubules that account for the pigmentation.

276 an kidney is composed of roughly 1.2-million renal tubules that must maintain their tubular structure

277 absorption of filtered phosphate in proximal renal tubules, thereby critically contributing to phosph

278 required for lumen continuity in developing renal tubules, though its mechanism of action remains un

279 we show that selective activation of HIF in renal tubules, through Pax8-rtTA-based inducible knockou

280 Renal tubules thus represent a tissue that is not sensit

281 idney relies on abundant mitochondria in the renal tubule to generate sufficient ATP to provide the e

282 roliferative stages, PCP signaling polarizes renal tubules to control OCD.

283 transgene, a predominant isoform of PHDs in renal tubules, to reduce HIF-1alpha level significantly

284 exes, which are expressed most abundantly in renal tubules, to regulate mineral metabolism.

285 ing a simulated (1)H NMR data set to emulate renal tubule toxicity and further exemplified this metho

286 iltration rate (eGFR) owing to inhibition of renal tubule transport of creatinine.

287 Developmental changes in the renal tubule transport systems and their regulation have

288 ncludes characterization of a urate-specific renal tubule transporter explaining many aspects of rena

289 In fly embryonic renal tubules, Tsh is expressed in mesodermally derived

290 that endotoxin toxicity to nonpreconditioned renal tubules was direct and independent of immune cells

291 g content of HTL in chronically infected rat renal tubules was indistinguishable from that of IVCL.

292 Of interest, C3 deposition around renal tubules was significantly less in animals with IRI

293 ehind the ability of BMP-7 to repair damaged renal tubules, we hypothesized that systemic treatment w

294 The cells can differentiate into renal tubules when injected under the capsule of an unin

295 -MAG3) is excreted almost exclusively by the renal tubules, whereas (99m)Tc-diethylenetriamine pentaa

296 Claudin-8 is expressed in the distal renal tubule, which has a characteristically low passive

297 tably, albumin overload induced apoptosis in renal tubules, which was less severe in PKC-delta-knocko

298 teomics' approach, which profiles the entire renal tubule with regard to changes in Na+ transporter a

299 It also limits diameters of differentiating renal tubules, with mutation of certain components of th

300 mice, demonstrating the utility of the Kim-1 renal tubule zebrafish models.