ライフサイエンスコーパス: repair synthesis

1 acilitate the DNA unwinding required for DNA repair synthesis.

2 ion, to produce a 3'-hydroxyl that can prime repair synthesis.

3 distinguish between true replication and DNA repair synthesis.

4 e inhibited NER at the steps of incision and repair synthesis.

5 ation into DNA, during either replication or repair synthesis.

6 orporation of all nucleosides tested through repair synthesis.

7 (s) used to initiate excision and subsequent repair synthesis.

8 mical inhibitors almost completely abolished repair synthesis.

9 the initial induction of cross-links, not in repair synthesis.

10 cts using an assay that does not require DNA repair synthesis.

11 3'-hydroxyl that serves as a primer for DNA repair synthesis.

12 , and promotes its recruitment to facilitate repair synthesis.

13 to form a synaptic complex (SC) and initiate repair synthesis.

14 gous recombination pathways driven by D-loop repair synthesis.

15 on the undamaged strand is filled in by DNA repair synthesis.

16 sely with MCM8-9 to promote postsynaptic DNA repair synthesis.

17 erase delta (Pol delta), RFC and PCNA in LLR repair synthesis.

18 logous recombination, and stimulation of DNA repair synthesis.

19 utilized to enable lesion bypass during DNA repair synthesis.

20 RFC and PCNA are required for large loop DNA repair synthesis.

21 g in damage recognition, strand excision and repair synthesis.

22 ne copy might participate in error-prone DNA repair synthesis.

23 tinct stages: mismatch-provoked excision and repair synthesis.

24 enhancing repair excision, and facilitating repair synthesis.

25 es, thus initiating long-patch base excision repair synthesis.

26 g a DNA lesion, and residues are replaced by repair synthesis.

27 ne at a position 5' of AP sites to prime DNA repair synthesis.

28 both excision activity and single nucleotide repair synthesis.

29 signatures of template switching during DNA repair synthesis.

30 was inhibited, suggesting a requirement for repair synthesis.

31 g in damage recognition, strand excision and repair synthesis.

32 each strand under conditions of limited DNA repair synthesis.

33 DE-2 or (-)-DE-2 adducts exhibited increased repair synthesis.

34 icipation of polymerase delta in myocyte DNA repair/synthesis.

35 esis, but the (-)-DE-2 adduct experienced no repair synthesis above that of the control.

36 lbeta), which typically contributes both DNA repair synthesis and 5' "trimming" to SP-BER.

37 eta (Polbeta) carries out most base excision repair synthesis and also can excise deoxyribose 5-phosp

38 pendent excision; the second carries out DNA repair synthesis and DNA ligation; and the third provide

39 e Ape1 exonuclease during BER after both DNA repair synthesis and excision of the abasic deoxyribose-

40 and invasion steps, but differ in subsequent repair synthesis and resolution steps, influencing the g

41 Following repair synthesis and second-end capture, de novo DNA syn

42 NA polymerase (pol) beta was used to measure repair synthesis, and DNA ligase I was used to seal the

43 cleases, removal of deoxyribose 5-phosphate, repair synthesis, and ligation.

44 into homologous duplex DNA to form a D loop, repair synthesis, and second-end capture.

45 Here, we have asked how dual incision and repair synthesis are coordinated in human cells to avoid

46 repair activity, as measured by an in vitro repair synthesis assay and an in vivo host-cell reactiva

47 In a repair synthesis assay the toxins gave 70% inhibition of

48 r G1 or G2, were used as substrates in a DNA repair synthesis assay using human whole cell extracts.

49 We used this substrate in an in vitro repair-synthesis assay to study the complete repair of H

50 H3s can be deposited by the RC pathway, DNA repair synthesis associated with meiotic recombination u

51 veloped to assess the error frequency of DNA repair synthesis at a site-specific uracil residue.

52 C1-dependent short-patch repair increase DNA repair synthesis at neuronal enhancers, whereas defects

53 of repaired M13mp2 DNA, the fidelity of DNA repair synthesis at the target was determined to be abou

54 ereoisomers exhibited significant amounts of repair synthesis, but the (-)-DE-2 adduct experienced no

55 sions per plasmid is substrate for efficient repair synthesis by cell extracts.

56 nic (AP) endonuclease family that primes DNA repair synthesis by cleaving the DNA backbone 5' of AP s

57 se to this 8-oxoguanine residue inhibits DNA repair synthesis by DNA polymerase beta, thus delaying r

58 to the 5' side of abasic sites to facilitate repair synthesis by DNA polymerase beta.

59 s considered 'dirty' because it cannot prime repair synthesis by DNA polymerases or sealing by classi

60 s are highly defective in the stimulation of repair synthesis by N:-acetoxy-N:- acetylaminofluorene,

61 ng tandem mutations during in vivo short-gap repair synthesis by pol beta.

62 h the latter should represent the product of repair synthesis by polymerase beta.

63 orm, which is intimately associated with the repair synthesis by polymerases delta and epsilon.

64 he complete removal of tandem lesions before repair synthesis can be efficiently performed by DNA pol

65 Repair synthesis carried out by repair-proficient ung, r

66 Repair synthesis catalysed by DNA polymerase beta at 1 n

67 alizing antibody to Polbeta, which inhibited repair synthesis catalyzed by pure Polbeta by approximat

68 We show that DNA repair synthesis, catalyzed by human DNA polymerase eta

69 complements the oligonucleotide excision and repair synthesis defects in rad7 and rad16 mutant extrac

70 CNA foci (40-45%) co-localized with sites of repair synthesis detected by bromodeoxyuridine labeling.

71 ' incision by XPG and that the initiation of repair synthesis does not require the catalytic activity

72 on stress-dominated response, highlighted by repair synthesis-driven DNA damage tolerance signalling

73 including Prim-PolC that performs short gap repair synthesis during excision repair.

74 me of the yeast proteins responsible for DNA repair synthesis during LLR.

75 varepsilon (pol2-16) also led to a deficient repair synthesis during NER, which was complemented by p

76 the low fidelity Poleta is not accessible to repair synthesis during NER.

77 mical system, we show that PARI inhibits DNA repair synthesis during recombination events in a PCNA i

78 e overall HR and in terminating the extended repair synthesis during sister chromatid recombination (

79 se that a defined order of dual incision and repair synthesis exists in human cells in the form of a

80 e nick supported mismatch excision, although repair synthesis failed using 5'-nicked templates.

81 hrough "induced fit") and hence maintain DNA repair synthesis fidelity.

82 earby sequences, suggesting an origin by DNA repair synthesis followed by microhomology-mediated end

83 cells complemented with XPA protein restored repair synthesis for both of these adducts.

84 Such repair synthesis for UV damage or HNE-dG adducts did not

85 ne, is functionally compartmentalized toward repair synthesis in a process regulated by ribonucleotid

86 ara-C nucleotide in DNA was incorporated by repair synthesis in CCRF-CEM cells; the remainder was in

87 patch size distribution associated with DNA repair synthesis in cell-free extracts showed that the p

88 eal fundamental strategies of polymerase DNA repair synthesis in genomic instability.

89 As expected, there is little or no repair synthesis in homozygous spn-A mutants after P exc

90 ex formation was also found to stimulate DNA repair synthesis in human cell extracts, in a pattern co

91 ce of the second plasmid strongly stimulates repair synthesis in the cross-linked plasmid.

92 ducts and double-strand breaks do not induce repair synthesis in the unmodified plasmid, indicating t

93 ciency correlates with reduced levels of DNA repair synthesis in these cells and is not due to reduce

94 erase beta (Pol beta) is responsible for the repair synthesis in this pathway and also removes a 5'-s

95 PCNA and RFC seem to act in LLR only during repair synthesis, in contrast to their roles at both pre

96 may participate in mtBER by stimulating the repair synthesis incorporation step.

97 been shown to carry out damage-specific DNA repair synthesis induced by a variety of lesions, includ

98 This induced repair synthesis is consistent with previous evidence in

99 one H2AX does not become phosphorylated, and repair synthesis is not detectable in response to total

100 However, repair synthesis is often incomplete, resulting in inter

101 rporation during replication or DNA excision repair synthesis, leading to stalled replication forks a

102 ould also participate in strand displacement repair synthesis (long patch repair (LP-BER)) mediated b

103 Repair synthesis, measured by the incorporation of [(32)

104 In human cancer cells, mitotic DNA repair synthesis (MiDAS) is described as a final mechani

105 y mitosis via a process known as mitotic DNA repair synthesis (MiDAS), but little is known about how

106 tion of endogenous DNA damage by short-patch repair synthesis might lead to a high spontaneous mutati

107 d mutation assay revealed that errors in DNA repair synthesis occurred predominantly at the position

108 ective, in both oligonucleotide excision and repair synthesis of damaged plasmid DNA.

109 Repair synthesis of NER was not affected by thermal inac

110 These results suggest that efficient repair synthesis of yeast NER requires both Poldelta and

111 polymerase-delta to execute conservative DNA repair synthesis over many kilobases.

112 ractionation, we show that the length of the repair synthesis patch differs in the soluble and the pa

113 s were omitted from the reaction to suppress repair synthesis, PCNA was required for the formation of

114 We find that, when repair synthesis proceeds through a Pol beta-dependent s

115 bling nucleotide excision repair factors and repair synthesis proteins around damage-stalled RNAPII,

116 of nucleotide excision repair and in a full repair synthesis reaction, with either UV-damaged or cis

117 of homology search, DNA strand invasion, and repair synthesis remain to be determined.

118 ibonucleotides and promote RNA-templated DNA repair synthesis remains unknown.

119 How this long-tract homologous recombination repair synthesis responds to complex secondary DNA struc

120 rome promotes homologous strand invasion and repair synthesis, similar to mitotic break repair events

121 ell-free repair system, we have analyzed the repair synthesis step of NER.

122 tudies have suggested a role for PCNA-in the repair synthesis step of nucleotide excision repair, and

123 a single nucleotide at the AP site, based on repair synthesis studies using oligonucleotide substrate

124 endent on XPC, with entry of DDB2 only after repair synthesis that completes the first repair cycle.

125 s (CFSs) during early mitosis to trigger DNA-repair synthesis that ensures faithful chromosome segreg

126 f a mechanistic linkage between excision and repair synthesis that is mediated by PCNA.

127 bination indicates that aRPA can support DNA repair synthesis that requires polymerase delta, PCNA, a

128 model of slip mispairing during error-prone repair synthesis to explain the formation of state II Ds

129 Heterologous DNAs also stimulate repair synthesis to variable extents.

130 air products from DmBlm mutants have shorter repair synthesis tract lengths compared to wild type and

131 In wild-type males, repair synthesis tracts are usually long, resulting in f

132 thways of D-loop disassembly result in short repair synthesis tracts or flanking deletions.

133 ted in dramatic reductions in the lengths of repair synthesis tracts.

134 rginal effect, determined by measurements of repair synthesis (unscheduled DNA synthesis), by immunoa

135 s are required to reconstitute base excision repair synthesis using a uracil-containing DNA as a mode

136 plex structure under conditions conducive to repair synthesis, using cell extracts from wild-type and

137 tract before addition of PCNA, inhibition of repair synthesis was gradually relieved with time.

138 In the in vitro studies, DNA repair synthesis was measured in extracts from normal hu

139 Residual repair synthesis was observed in pol3-1 and pol2-18 muta

140 volved in DNA replication, recombination and repair synthesis, we suggest that MDM2 binding to DNA po

141 ular factors activated during S phase or DNA repair synthesis were required for efficient retroviral

142 and on both sides of the lesion, followed by repair synthesis, which fills the gap using the intact s