ライフサイエンスコーパス: reparative

1 n the infarct area and exhibits strengthened reparative abilities after MI.

2 The myocardial reparative abilities of EVs derived from induced pluripo

3 Reactivating primitive reparative ability in the mature mammalian heart require

4 failure, especially in older children where reparative ability may be reduced.

5 The strong reparative ability of CPC spheres warrants further inves

6 The reparative ability of the central nervous system varies

7 ibition in CD34(+) cells would improve their reparative ability.

8 on, NO release, and in vivo retinal vascular reparative ability.

9 eling in the ischemically injured heart, the reparative actions of CMCs may be attributed to their im

10 distinct immune cells drive inflammatory and reparative activities after injury.

11 els have diverse pleiotropic effects on hMSC reparative activities, modulating in vitro cytokine secr

12 rophages that are proinflammatory and lacked reparative activities.

13 by directing hMSC survival, engraftment, and reparative activities.

14 ication of specific exosome cargo can rescue reparative activity.

15 r effectors overcomes impediments to enhance reparative activity.

16 in in transgenic (TG) mice would provide any reparative advantage in response to DDC.

17 2-mC mice and cells identified injurious and reparative agents that affect kidney damage.

18 presents with (a) EC shape and proliferative-reparative alterations: ongoing cycles of cellular injur

19 Recent research has shown that reparative (alternatively activated or M2) macrophages p

20 However, these reparative and homeostatic functions can be subverted by

21 ent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them

22 tivates macrophages, endowing them with both reparative and pathological functions.

23 Understanding the mechanisms governing the reparative and pathological properties of activated macr

24 riched for prefibro- and fibro-, regulatory, reparative and prehypertrophic chondrocytes.

25 d neuron survival, suggest that LIF has both reparative and protective activities that make it a prom

26 ion of lymphocyte proliferation, delivery of reparative and protective signals after reperfusion inju

27 The reparative and regenerative capacity of multiple mammali

28 rts the paradigm that stem cells exert their reparative and regenerative effects, in large part, thro

29 ment of human cardiac progenitor cell (hCPC) reparative and regenerative potential by genetic modific

30 ental signaling pathways that regulate their reparative and regenerative potential, and the surroundi

31 We found that CF macrophages had intact reparative and transcriptional responses, suggesting tha

32 can be modulated to mediate cytoprotective, reparative, and even regenerative functions in the infar

33 el therapeutic target for the improvement of reparative angiogenesis after stroke in diabetes.

34 richment for PC that express NK1 and promote reparative angiogenesis after transplantation in a mouse

35 aracterized by microangiopathy with impaired reparative angiogenesis and fibrosis.

36 ntly, pharmacologic Nrf2 activation promotes reparative angiogenesis and suppresses pathologic neovas

37 guidance cue netrin-1 activates a program of reparative angiogenesis in microglia within the ischemic

38 pensity to impact tissue vascularization and reparative angiogenesis.

39 , which are resident stem cells committed to reparative angiomyogenesis.

40 myocardial damage, and suppression of cardio-reparative Angiotensin II receptor 2 (Agtr2).

41 ardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple ce

42 tal role for osteoblast dedifferentiation in reparative bone formation in fish and indicate that adul

43 study characterized mobilization of vascular reparative bone marrow progenitor cells in mouse models

44 esponses (and their potential protective and reparative capabilities) following WNV infection have no

45 on of endogenous stem cells to enhance their reparative capabilities, and transplantation of oligoden

46 To compare the cardiac reparative capacities in vivo, vehicle, iPSCs, and iPSC-

47 ) production in diabetic BMCs improves their reparative capacities.

48 We investigated aging of human endogenous reparative capacity and aimed to clarify whether it is a

49 uced pluripotent-derived cells have the same reparative capacity as physiologically committed CNS-der

50 rs of older patients have significantly less reparative capacity following ischemia and reperfusion (

51 failing heart has a previously unrecognized reparative capacity involving more than cardiomyocyte re

52 ising therapeutic strategy for restoring the reparative capacity of dysfunctional diabetic CD34(+) ce

53 Moreover, NK cells limited the reparative capacity of NSCs following brain inflammation

54 ells (MSCs) has been proposed to augment the reparative capacity of resident cells within the wound b

55 pidermis and control both the functional and reparative capacity of the skin.

56 repair by continued proliferation overwhelm reparative capacity, causing loss of specialised cell fu

57 icine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field with

58 mbranes and biogenic cellular membranes with reparative capacity.

59 ential, which contributes to their decreased reparative capacity.

60 elia have limited self-renewal and therefore reparative capacity.

61 ntified a novel population of c-kit-negative reparative cardiac cells (SA CMCs) that can be isolated

62 enous, epicardial-derived factor that drives reparative cardiac lymphangiogenesis and function via Cx

63 The long-term sequelae of many reparative cardiac surgical procedures are not yet fully

64 t and a prolonged effect on inflammatory and reparative cell functions leading to delayed healing and

65 at the hierarchical organization of tracheal reparative cells be revised to include a facultative bas

66 application it would be preferable to obtain reparative cells from an olfactory mucosal biopsy via in

67 P12 administration mediated proliferation of reparative cells in the AMI hearts.

68 be readily extended to the delivery of other reparative cells of interest and used in quantitative st

69 s of T lymphocytes have emerged as important reparative cells with context-specific actions.

70 ry response is associated with activation of reparative cells.

71 ises the reserve or functioning of localized reparative cells.

72 prove cell therapy or mimic the qualities of reparative cells.

73 out c-kit sorting, was sufficient to isolate reparative CMCs.

74 oid response, including higher levels of the reparative cytokine interleukin-22.

75 T cells can resolve inflammation and secrete reparative cytokines and growth factors as well as inter

76 This reparative cytotype was characterized by high expression

77 elease of odontogenic exosomes resulted in a reparative dentin bridge formation, superior to glass-io

78 nds that can potently stimulate and expedite reparative dentin formation is still underexplored.

79 sed from these materials is known to mediate reparative dentin formation.

80 ORAI1 may be a therapeutic target to enhance reparative dentin formation.

81 lphaSMA-tdTomato(+) cells to cells secreting reparative dentin.

82 ies removal to stimulate the regeneration of reparative dentin.

83 s a dental procedure that aims to regenerate reparative dentin.

84 signalling thus has a dual role in promoting reparative dentine formation by activating pulp stem cel

85 this pathway affects the rate and extent of reparative dentine formation in damaged mice molars by t

86 onists that promote the natural processes of reparative dentine formation to completely restore denti

87 ibitor, Tideglusib (TG), can equally enhance reparative dentine formation to fully repair an area of

88 n of reactionary dentine, but in common with reparative dentine formation, exogenous elevation of Wnt

89 ule GSK-3 antagonists, resulting in enhanced reparative dentine formation.

90 l to investigate the role of immune cells in reparative dentine formation.

91 al pulp stem cell activation and appropriate reparative dentine formation.

92 ion that stimulates the natural formation of reparative dentine via the mobilisation of resident stem

93 into new odontoblast-like cells that secrete reparative dentine.

94 lization of primary pulp cultures and during reparative dentinogenesis following pulp exposures.

95 eta-catenin signaling pathway is crucial for reparative dentinogenesis following tooth damage, and th

96 this simple method of enhancement of natural reparative dentinogenesis has the potential to be transl

97 ole of Wnt/beta-catenin signaling pathway in reparative dentinogenesis using an in vivo mouse tooth d

98 use line during odontoblast differentiation, reparative dentinogenesis, and bone.

99 ntal pulp exposure model in molars to induce reparative dentinogenesis, we demonstrate the contributi

100 essential and important roles in primary and reparative dentinogenesis, with conflicting results rega

101 that acts in an autocrine manner to modulate reparative dentinogenesis.

102 o a second generation of odontoblasts during reparative dentinogenesis.

103 essential and important roles in primary and reparative dentinogenesis.

104 ing pulp exposure in mouse molars results in reparative dentinogenesis.

105 -derived exosome significantly rescued their reparative dysfunction in myocardial repair, improved le

106 le, and choosing stem cells with the highest reparative effects has been a challenge.

107 y phenotype and restricts their survival and reparative effects in a mechanism mediated by TLR4.

108 ich has the potential to induce multifaceted reparative effects in the environment within and surroun

109 The mechanism(s) underlying cardiac reparative effects of bone marrow-derived mesenchymal st

110 The reparative effects of exogenous GFP-BMSCs were investiga

111 We previously demonstrated the age-dependent reparative effects of human c-kit+ progenitor cells (hCP

112 two sources do not differ in terms of their reparative effects or functional efficacy after transpla

113 ti-inflammatory and possibly neuroprotective/reparative effects, may contribute to its efficacy in MS

114 h monocyte infiltration and loss of resident reparative embryonic-derived cardiac macrophages.

115 itable scaffold for use within regenerative (reparative) endodontic techniques.

116 immune response and the generation of a pro-reparative environment.

117 abetic patients demonstrate reduced vascular reparative function due to decreased proliferation and d

118 Recent studies have indicated a reparative function for Tregs and ILC2.

119 r inhibiting NADPH oxidase would restore the reparative function in diabetic EPCs.

120 rdial fluid, supporting the notion that this reparative function is relevant in human disease.

121 Reparative function was evaluated in a mouse model of re

122 that the late inflammatory response serves a reparative function.

123 pathy but may be preempted from carrying out reparative functions if the molecular abnormalities comp

124 enhance the survival, persistence, and osteo-reparative functions of human bone marrow-derived mesenc

125 e as metabolic cues to promote or impair the reparative functions of immune cell populations.

126 d harnessing the mechanisms that promote the reparative functions of these T cells could greatly impr

127 a is a target of miRNA-126 in protective and reparative functions, and suggest that their therapeutic

128 cell to mediate both tissue-destructive and -reparative functions.

129 mal cells (ADSCs) that have regenerative and reparative functions; however, whether DWAT atrophy in f

130 ailure after myocardial infarction induces a reparative genetic program with increased scar border va

131 om moderate COVID-19 were enriched in tissue reparative growth factor signature A, whereas the profil

132 aging abnormalities among infants undergoing reparative heart surgery.

133 a (TNF-alpha) production which then enhances reparative hepatic neutrophil recruitment.

134 n mouse pericardial fluid contributed to the reparative immune response.

135 Reparative inflammation is an important protective respo

136 nd the phased transition from destructive to reparative inflammation.

137 n), have powerful roles in driving acute and reparative inflammatory pathways that affect the spectru

138 r testing the effects of neuroprotective and reparative interventions.

139 This suggests that reparative K14+ progenitor cells may be tumor-initiating

140 owing evidence that alternatively activated, reparative leukocyte subsets and their products can be d

141 Autophagy is a reparative, life-sustaining process by which cytoplasmic

142 e identified suppressed formation of a novel reparative lipid mediator 14S,21R-dihydroxydocosa-4Z,7Z,

143 on Day 1 to Day 4 and digest damaged tissue; reparative Ly-6C(lo) monocytes dominate on Day 5 to Day

144 cumulated Ly-6C(high) monocytes give rise to reparative Ly-6C(low) F4/80(high) macrophages that proli

145 accumulation of inflammatory Ly-6C(high) and reparative Ly-6C(low) monocytes/macrophages.

146 motes cardiac healing after MI by activating reparative Ly6C(low) Mos/Mps, indicating that Ep3 recept

147 (sVegfr-2), that inhibits developmental and reparative lymphangiogenesis by blocking Vegf-c function

148 py significantly increased the percentage of reparative M2 macrophages (F4/80(+)CD206(+)) in the infa

149 ediator Fas, whereas there was a decrease in reparative M2-like CD11b(+) microglia and phosphorylatio

150 tone lactylation and decreased expression of reparative macrophage genes.

151 ssue injury and promoting the development of reparative macrophage responses.

152 Here, we find that the reparative macrophage transition is dictated by B-cell a

153 es transition of inflammatory macrophages to reparative macrophages by imprinting epigenetic changes.

154 Endogenous and exogenous reparative mechanisms serve to reverse vascular damage a

155 g hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/

156 ocytes known to mediate tissue repair, their reparative mechanisms, and the diseases in which they ha

157 mediators as the emerging factor for post-MI reparative mechanisms-translational leukocyte modifiers,

158 helial cells, antagonizing NO production and reparative mechanisms.

159 cement after injury via stem cells and other reparative mechanisms.

160 future priorities in cardiac regenerative or reparative medicine.

161 nto microglia, and both Mt and HN promote a "reparative" microglia phenotype characterized by enhance

162 pathways that drive oligodendrocytes into a reparative mode contributing to remyelination following

163 s used to explore the regenerative effect of reparative monocyte recruitment.

164 s regeneration competency is associated with reparative myeloid cells.

165 othelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms th

166 us ECs-derived H2O2 plays a critical role in reparative neovascularization in response to ischemia by

167 Our data highlight the role of SP in reparative neovascularization.

168 pport a model in which IL-6, produced in the reparative niche, functions to enhance the differentiati

169 rophages from an inflammatory phenotype to a reparative one in normal wound healing.

170 Although these reparative options have proven successful, they are tech

171 ost-MI pro-inflammatory response followed by reparative or anti-inflammatory response is essential fo

172 ry or classical monocytes (Ly6c(Hi)) and pro-reparative or non-classical monocytes (Ly6c(Lo)).

173 Advancement of reparative or regenerative means to treat damaged or deg

174 Great variability in reparative outcomes was found, attributed to patient fac

175 ad cells and matrix debris, while activating reparative pathways necessary for scar formation.

176 ased cardiomyocytes by using the classic and reparative pathways.

177 In the second, reparative phase, accumulated Ly-6C(high) monocytes give

178 During the later, reparative phase, infarcts of bmLp-PLA2 (-/-) mice conta

179 iferative cytokines IL-6 and IFNgamma at the reparative phase.

180 f bone morphogenetic protein 2 at a critical reparative phase.

181 monocytes orchestrate both inflammatory and reparative phases during myocardial infarction and depen

182 3CR1(-/-)) microglia and macrophages adopt a reparative phenotype and increase expression of genes th

183 n macrophages undergoing pro-inflammatory or reparative phenotype changes.

184 phage polarization from an inflammatory to a reparative phenotype in peritonitis and skin wound heali

185 This reparative phenotype in Vim(-/-) corneas is strikingly r

186 eting GM-CSF, leading to a unique macrophage reparative phenotype that supports tubular proliferation

187 duced a shift in macrophage profile toward a reparative phenotype, which secondarily stimulated colla

188 orresponding to an "M2"-like homeostatic and reparative phenotype.

189 phage activation from a proinflammatory to a reparative phenotype.

190 r trigger of macrophage skewing toward a pro-reparative phenotype.

191 to microglia, where it promotes a phagocytic/reparative phenotype.

192 ating myeloid cells into an antiinflammatory/reparative phenotype.

193 ophage polarization toward a pro-angiogenic, reparative phenotype.

194 d injury in two mouse strains with different reparative phenotypes following virus-induced demyelinat

195 r as they can adopt both pro-inflammatory or reparative phenotypes to modulate inflammatory and repar

196 HIV-related inflammation may impair vascular reparative potential and consequently increase the risk

197 of demyelinating disorders, this spontaneous reparative potential fails at later stages.

198 migratory capabilities, which impair overall reparative potential for injured myocardium.

199 However, the reparative potential is diminished in certain chronic cl

200 20) demonstrate an equitable homeostatic and reparative potential of all hepatocytes, irrespective of

201 This model system demonstrates the robust reparative potential of myelin in the central nervous sy

202 HCA attenuates the inflammatory response and reparative potential of primary human small airway epith

203 Compare the reparative potential of saphenous vein-derived pericytes

204 effects of HCA on inflammatory response and reparative potential of the primary human small airway e

205 hCPCeP exhibited augmentation of reparative potential relative to hCPCe control cells, as

206 duced pluripotent stem (iPS) cells harbour a reparative potential, and were here bioengineered from s

207 or as a promising approach for restoring the reparative potential, thereby preventing the development

208 ration of progenitor cells with vasculogenic/reparative potential.

209 agnosis to maximize opportunity to perform a reparative procedure.

210 iodontitis and through TNF limits the normal reparative process by negatively modulating factors that

211 ositive effect on MSCs in conditions where a reparative process has been initiated.

212 Cardiac lymphangiogenesis contributes to the reparative process post-myocardial infarction, but the f

213 Medium-sized crystals induced a particular reparative process that we term extratubulation.

214 notypes after injury, suggesting a potential reparative process to preserve connectivity and the b-wa

215 portant contributor to this inflammatory and reparative process, mainly through TNF-alpha receptor 1.

216 ns suggests that spermatogenesis is a highly reparative process, with the mutational load of germ cel

217 damage but is also essential for the tissue reparative process.

218 in myeloid cells displayed a defect in this reparative process.

219 of macrophages is critical for activation of reparative processes during the midstage of cutaneous re

220 ults show that propofol may prevent or limit reparative processes in the early-phase postinjury.

221 heart has been tempered by realizations that reparative processes in the heart are insufficient to re

222 (MS) correlates with disease progression and reparative processes may be triggered.

223 man skin injected with PDGF-BB and in tissue reparative processes PDGF beta-receptors colocalize with

224 Reparative processes such as gliosis and fibrosis also c

225 lls and pathways during acute injury and the reparative processes that are subsequently activated.

226 oduce matrix, regulate inflammation, mediate reparative processes, and serve as pluripotent mesenchym

227 luding the orchestration of inflammatory and reparative processes, as well as the pathogenesis of adv

228 Through efficient anti-inflammatory and reparative processes, inflammation may resolve without a

229 Cerebral ischemia can activate endogenous reparative processes, such as proliferation of endogenou

230 phin receptor expression, probably to foster reparative processes, which in turn could render the bra

231 subsets are active in both inflammatory and reparative processes, yet our understanding of the causa

232 y lung is opposed by reactive, adaptive, and reparative processes.

233 endothelial dysfunction and promote vascular reparative processes.

234 car formation, in the course of reactive and reparative processes.

235 keys, suggesting ongoing, albeit inadequate, reparative processes.

236 text of ongoing destructive, protective, and reparative processes.

237 P expression and secretion may influence the reparative proficiency of APC therapy.

238 om inflamed gut acquire an anti-inflammatory/reparative profile.

239 rtantly, mice treated with IL233 displayed a reparative program in the kidneys, as evidenced by incre

240 rminant of initial tubular cell survival and reparative proliferation after ischemic injury.

241 activity to restrain cell growth during the reparative, proliferative state induced by vascular inju

242 SA CMCs exhibited robust reparative properties and offered numerous advantages, a

243 zed, the components that regulate macrophage reparative properties are less well understood.

244 onale: Systemic inflammation compromises the reparative properties of endothelial progenitor cell (EP

245 EK1/2 inhibition is capable of promoting the reparative properties of murine and human macrophages.

246 r, parallel advances in understanding of the reparative properties of stem cells--including their dis

247 d in the cardiac tissue and maintained their reparative properties, reduced infarct size, increased s

248 1/2 pathway as a key regulator of macrophage reparative properties.

249 damental questions about the universality of reparative regeneration and whether mammals share any pr

250 Impaired CPC-dependent reparative remodeling ultimately leads to continuous dec

251 eep cerebellar stimulation may guide plastic reparative reorganization after nonprogressive brain inj

252 y for new therapeutic strategies to regulate reparative reprogramming in ageing and cancer.

253 ular signals regulating the inflammatory and reparative response after myocardial infarction.

254 e of IP-10 resulted in a hypercellular early reparative response and delayed contraction of the scar.

255 ng interleukin 6 (IL6) expression and impede reparative response by decreasing Arginase-I (Arg1) expr

256 stroke induces an initial proliferative and reparative response in OPCs, but this is blocked by a lo

257 flammatory signaling affects this endogenous reparative response is unclear.

258 erapeutic modulation of the inflammatory and reparative response may hold promise for the prevention

259 e propose that CTGF is a part of the limited reparative response of the degenerated disc.

260 on during a dynamic and complex inflammatory/reparative response remain to be clearly defined.

261 like 1 gene, as a critical component of this reparative response that serves to limit tubular cell ap

262 now recognized as the result of an aberrant reparative response to both antenatal injury and repetit

263 Neovascularization is a reparative response to ischemia, and includes 3 processe

264 degree of injury, a critical mediator of the reparative response, and a possible biomarker to identif

265 ime a sex-specific difference in the corneal reparative response, which is mediated by ERbeta and ERa

266 o the spatial and temporal regulation of the reparative response.

267 the execution of an ordered inflammatory and reparative response.

268 n and aligned electrospun fibres to induce a reparative response.

269 ation enhanced pro-inflammatory and impaired reparative response.

270 ds to impaired pro-inflammatory and enhanced reparative response.

271 ve to distant tissues to influence the local reparative response.

272 t studies suggest that diabetes also impairs reparative responses after cell therapy.

273 the role of estradiol in ocular inflammatory-reparative responses are not well understood.

274 bioligands can be harnessed to direct tissue reparative responses associated with implanted biomateri

275 related receptor can dramatically change the reparative responses of multiple cellular constituents i

276 and how the sum of initial inflammatory and reparative responses only sets the trajectory for diseas

277 s of macrophage-mediated pro-inflammatory or reparative responses post-MI.

278 -edged sword, balancing the inflammatory and reparative responses that arise during injury and diseas

279 tive phenotypes to modulate inflammatory and reparative responses, respectively.

280 of therapeutic approaches to activate innate reparative responses.

281 inducer of neoangiogenesis that can promote reparative revascularization.

282 stroke brains and suggests that CD36 plays a reparative role during the resolution of inflammation in

283 fic macrophage functions that underlie their reparative role in injured tissues, including the regula

284 acute period but serves a protective and/or reparative role in the post-acute phase of SCI.

285 g chambers to determine the inflammatory and reparative role of IL-6.

286 nalysis indicates they are primed to receive reparative signals from alveolar type I cells.

287 om an early inflammatory signature to a late reparative signature, a process that is hampered in BCAP

288 acrophages from a proinflammatory state to a reparative state, however, is vital for resolution of in

289 issue is critical for the rational design of reparative strategies.

290 sses will aid the development of better bone reparative strategies.

291 rategies that modulate the fate/phenotype of reparative structural cells, including epithelial, endot

292 mes and survival to next-stage palliative or reparative surgery between patients undergoing a modifie

293 yocardial infarction seems to be a promising reparative therapeutic approach, (2) HGF and VEGF are ca

294 trials, spurred by the immense need to find reparative therapeutics for central nervous system (CNS)

295 y mediates the expression of the endothelial reparative transcription factor Forkhead box M1 (FoxM1).

296 ession of forkhead box protein M1 (Foxm1), a reparative transcription factor.

297 tor amphiregulin, but whether similar tissue-reparative Tregs exist in humans remains unclear.

298 as CPC exosomes from older children were not reparative unless subjected to hypoxic conditions.

299 the recruitment of hematopoietic stem cells, reparative vascularization, and reperfusion of the ische

300 flammation in either hindering or supporting reparative wound healing and regeneration, this inverteb