ライフサイエンスコーパス: replicative

1 These variants showed replicative abilities and pathogenicity that is similar

2 mal-adapting mutations that may increase the replicative ability and/or organ tropism of the virus; o

3 utations and deletions occurred with loss of replicative ability in most mammalian cells.

4 l abnormality, decreased infectivity, and no replicative ability, which correlated with levels of CA

5 We did not detect evidence of a replicative advantage for smaller mtDNA molecules in the

6 terminants that provide these viruses with a replicative advantage in human cells.

7 dy in ferrets indicated that 195K provides a replicative advantage over 195R in H1N1/2009 viruses.

8 t the stem-cell level generates a clone with replicative advantage.

9 tive selection for 'selfish' traits, such as replicative advantage.

10 G, or Q350L and T397S, conferred substantial replicative advantages in mosquito and primate cells, re

11 Here we show that C. auris undergoes replicative aging (RA) that results from asymmetric cell

12 ays lead to an epigenetic landscape of yeast replicative aging with multiple equilibrium states that

13 ose in the growth medium, which extends both replicative and chronological life span (CLS).

14 lations and how this diversity may shape the replicative and evolutionary dynamics of these viruses.

15 llular transit, assembly, and disassembly of replicative and non-replicative forms of the histone H3.

16 Cellular senescence is due to replicative and stress-related senescence with activatio

17 We conclude that both replicative and TLS polymerases can bypass this DpC lesi

18 ely 0.01-0.40%) that are in concordance with replicative and translational errors.

19 that in contrast to the toolbelt model, the replicative and translesion polymerases do not form a st

20 y the biochemical and structural analyses of replicative and translesion synthesis (TLS) DNA polymera

21 te, beta-cells in adult humans are minimally replicative, and therefore fail to execute the second pr

22 Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is

23 genes from cellular hosts, achieving partial replicative autonomy and becoming parasitic genetic elem

24 n, we systematically assessed the repair and replicative bypass of a series of O (6)-alkyl-dG lesions

25 DNA damage followed by inefficient repair or replicative bypass.

26 nu and Pol theta were dispensable for their replicative bypass.

27 Viruses transmitted to females have lower replicative capacity (p = 0.0005) and are more type I in

28 here, RI8; Gag residues 275 to 282) on viral replicative capacity (VRC) since HLA-mediated reduction

29 d RMs, where progeny SHIV-A showed increased replicative capacity and caused AIDS.

30 nd SHIV-325cH demonstrated markedly enhanced replicative capacity compared with the parental virus.

31 eir cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner

32 Each of these variants reduced viral replicative capacity in C clade viruses, particularly th

33 rSADS-CoV demonstrated little, if any, replicative capacity in either immune-competent or immun

34 We identified clones with high replicative capacity in pigtail peripheral blood mononuc

35 e repopulation is at the most modest, unless replicative capacity of hepatocytes is abrogated.

36 Telomere length determines the replicative capacity of mammalian cells.

37 urthermore, we propose that the poorer viral replicative capacity of subtypes A and C may paradoxical

38 SHIV-AE16W exhibited a similar replicative capacity to the parental SHIV-AE16 stock.

39 old higher than for wild-type virus, and the replicative capacity was lower.

40 ank" of ovarian cancer models with extensive replicative capacity, derived from both ascites and soli

41 sults in an extraordinary attenuation of IAV replicative capacity.

42 ithout incurring a significant loss to viral replicative capacity.

43 with this Env retained good infectivity and replicative capacity; however, analysis of recombinant v

44 Expansion by continuous passaging induced replicative cell senescence.

45 of H4K20me0 present on new histones in post-replicative chromatin(6).

46 proteolysis-dependent eviction of CHK1 from replicative chromatin.

47 The eukaryotic replicative CMG (Cdc45, Mcm2-7, GINS) helicase contains

48 phase egg extracts into a mitotic state, the replicative CMG (CDC45/MCM2-7/GINS) helicase undergoes u

49 anonical CDK motifs of components in the pre-replicative complex and is essential for DNA replication

50 ates that translesion synthesis occurs under replicative conditions.

51 Replicative crisis is a senescence-independent process t

52 diated proliferative lifespan barrier called replicative crisis.

53 ebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could alread

54 hich PfAP2-G-expressing parasites complete a replicative cycle as committed forms before converting i

55 cell cholesterol is important for the HSV-1 replicative cycle at a stage(s) beyond entry, after the

56 inciding with longer circulation within each replicative cycle of parasitized erythrocytes without ad

57 esses that are critical to the intracellular replicative cycle of T. gondii including secretion of ad

58 f viruses on the host cell to complete their replicative cycle renders cellular functions potential t

59 We describe herein its structure and replicative cycle, along with genomic analysis and genom

60 One approach to better understand the viral replicative cycle, and potential therapies to target it,

61 During a replicative cycle, CRK5 stably interacts with a single P

62 7 hijacks the E3 ligase to promote the viral replicative cycle.

63 for elucidating the early events of the PRV replicative cycle.

64 otein SM, whose expression is limited to the replicative cycle.

65 tives, 22 and 30, inhibit early steps of the replicative cycles of HIV-1 and EV-A71 by interacting wi

66 both the host response to infection and the replicative cycles of several viruses.

67 s neoformans, which require no host in their replicative cycles.

68 vely with the DDR during the course of their replicative cycles.

69 ary tumor cells become highly susceptible to replicative DNA damage following NS depletion and are pr

70 cessing of BER intermediates results in post-replicative DNA gaps and a critical dependence on HR for

71 re that when DPC proteolysis is blocked, the replicative DNA helicase CMG (CDC45, MCM2-7, GINS), whic

72 terstrand crosslink, TRAIP ubiquitylates the replicative DNA helicase CMG (the complex of CDC45, MCM2

73 Activation of the Mcm2-7 replicative DNA helicase is the committed step in eukary

74 merases cause excessive DNA unwinding by the replicative DNA helicase, CMG, demonstrating that buddin

75 n origins are licensed by the loading of the replicative DNA helicase, Mcm2-7, in inactive double hex

76 tion initiation and the expression levels of replicative DNA helicases, which ensure maintenance of p

77 as gamma-H2A, so it can tether Smc5-Smc6 at replicative DNA lesions to promote survival.

78 Although the enzymatic activities of the replicative DNA Pol III are well understood, its dynamic

79 Amongst replicative DNA Pols, translesion DNA Pols play a partic

80 Here we identify subunits of the replicative DNA polymerase delta (Pol delta) as promoter

81 The replicative DNA polymerase epsilon (Pol epsilon) was sho

82 The proofreading exonuclease activity of replicative DNA polymerase excises misincorporated nucle

83 ily D DNA polymerase (PolD) is the essential replicative DNA polymerase for duplication of most archa

84 Thus, multi-subunit replicative DNA polymerase holoenzymes are present in al

85 ion raises the interesting question of how a replicative DNA polymerase is able to recognize template

86 omponent of the mtDNA replisome and the only replicative DNA polymerase localized to mitochondria.

87 merization and exonuclease states of E. coli replicative DNA polymerase Pol III.

88 oSMoS) to follow the exchange of the E. coli replicative DNA polymerase Pol IIIcore with the transles

89 c data, we show that the response of a model replicative DNA polymerase to variously structured DNA i

90 lian cells) and two subunits shared with the replicative DNA polymerase, pol delta.

91 epsilon holoenzyme an efficient and faithful replicative DNA polymerase.

92 sured mutation frequencies in genes encoding replicative DNA polymerases and in genes frequently muta

93 overview of the chemistry and properties of replicative DNA polymerases and their evolved variants,

94 Replicative DNA polymerases are highly efficient enzymes

95 High fidelity replicative DNA polymerases are unable to synthesize pas

96 visiae mispair recognition proteins with the replicative DNA polymerases during DNA replication has s

97 icient cells, we examined a possible role of replicative DNA polymerases in their bypass and determin

98 Proofreading by replicative DNA polymerases is a fundamental mechanism e

99 During DNA replication, replicative DNA polymerases may encounter DNA lesions, w

100 Replicative DNA polymerases misincorporate ribonucleosid

101 of leading and lagging strands by the three replicative DNA polymerases Pol alpha, Pol delta, and Po

102 By using alleles of the replicative DNA polymerases that are permissive for ribo

103 ins in live Bacillus subtilis cells: the two replicative DNA polymerases, PolC and DnaE, and a proces

104 of the RNA primers that are elongated by the replicative DNA polymerases.

105 idelity of RNA synthesis resembling those of replicative DNA polymerases.

106 to guide any future rational engineering of replicative DNA polymerases.

107 s a crucial event during the reinitiation of replicative DNA synthesis.

108 of microRNA-126 and HIF-1alpha in a model of replicative endothelial senescence and the interrelation

109 R-90) and endothelial cells (HUVEC, HAEC) by replicative exhaustion, exposure to ionizing radiation o

110 an fibroblasts rendered senescent by stress, replicative exhaustion, or oncogene activation, mTORC1 i

111 egies: high virion pp71 levels enhance viral replicative fitness but, strikingly, impede silencing, w

112 e of ClO2 resistance resulted in an enhanced replicative fitness compared to the less resistant start

113 to nucleotide analogs, and displayed reduced replicative fitness compared to the parental virus.

114 ons that resulted from optimization of viral replicative fitness either in the absence of adaptive im

115 Moreover, these changes impaired replicative fitness in a reassortant background.

116 bilizing HA mutations that do not compromise replicative fitness in cell culture.

117 dditional mutation(s) can compensate for the replicative fitness loss of IAV escape variants.

118 Information on replicative fitness of PA-I38-substituted viruses remain

119 ity are unclear but could be due to impaired replicative fitness of pH1N1 A/California/07/2009-like (

120 We did not observe much difference in replicative fitness of the TF viruses in cultures treate

121 itional heterogeneity and whether it affects replicative fitness remains unclear.

122 r data highlight the importance of assessing replicative fitness, in addition to antigenicity, when s

123 s heat resistance, disassembly kinetics, and replicative fitness.

124 A1, causing a deficit in Vif expression and replicative fitness.

125 bility (9- to 116-fold) but also on in vitro replicative fitness.

126 mbly, and disassembly of replicative and non-replicative forms of the histone H3.

127 lky adducts in mammalian cells involves post-replicative gap repair and define a role for PrimPol in

128 mammalian cells predominantly occurs at post-replicative gaps formed by the DNA/RNA primase PrimPol.

129 Through this process, replicative H3 maintains cell fate while, in contrast, t

130 The deposition of the replicative H3 variant following DNA replication is esse

131 Increasing the levels of post-replicative H3K27me3 or preventing S phase entry inhibit

132 All 4 biomarkers in both, low and high-replicative HBV demonstrate modest accuracy for fibrosis

133 negative, low-replicative (n = 213) and high-replicative (HBV DNA >/=20,000 IU/mL, n = 153) patients

134 NA replication by phosphorylating the Mcm2-7 replicative helicase [5-7].

135 together with GINS and Cdc45 form the active replicative helicase Cdc45/Mcm2-7/GINS (CMG).

136 The 11-subunit eukaryotic replicative helicase CMG (Cdc45, Mcm2-7, GINS) tightly b

137 The eukaryotic replicative helicase CMG is a closed ring around double-

138 Here, we show that the replicative helicase component Cdc45 targets the checkpo

139 c minichromosome maintenance complex-the DNA replicative helicase comprising MCM2 to MCM7(3,4)-that c

140 DNA replication origins serve as sites of replicative helicase loading.

141 DNA unwinding by the replicative helicase may continue during such pauses, bu

142 recognize DNA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize new

143 DNA, recruiting CDC6, and assembling the MCM replicative helicase on DNA.

144 dc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin.

145 building a step-wise complex that loads the replicative helicase onto chromosomal DNA.

146 , a DNA-binding ATPase that loads the Mcm2-7 replicative helicase onto replication origins.

147 ng the Ctf4-interacting peptide (CIP) of the replicative helicase subunit Sld5.

148 an MCM complex, the inactive form of the DNA replicative helicase that is assembled onto DNA in G1-ph

149 ires DNA loading of two copies of the Mcm2-7 replicative helicase to form a head-to-head double-hexam

150 on between the polymerase holoenzyme and the replicative helicase upon association of the primase wit

151 oned DNA replication forks and reloading the replicative helicase with the help of protein partners t

152 inase 2 (CDK2)-dependent reactivation of the replicative helicase, but did not reinitiate DNA synthes

153 d CDK2- and CDC7-dependent activation of the replicative helicase.

154 o inhibit the assembly and activation of the replicative helicase.

155 9 complex, which is paralogous to the MCM2-7 replicative helicase.

156 es cohesion through interaction with the MCM replicative helicase.

157 mcm4 mutants, affecting a subunit of the MCM replicative helicase.

158 asis for relatively slow duplex unwinding by replicative helicases and explains how replisome compone

159 r, the origin of slow DNA unwinding rates by replicative helicases and the mechanism by which other r

160 Most replicative helicases are hexameric, ring-shaped motor p

161 lution structures have not been reported for replicative helicases at a replication fork at atomic re

162 Replicative helicases generally unwind duplex DNA an ord

163 lance and DNA replication, including the Mcm replicative helicases.

164 Replicative hexameric helicases are thought to unwind du

165 Other non-replicative histone variants deposited throughout the ce

166 During S phase, specialized replicative histone variants ensure the bulk of the chro

167 Replicative immortality is a hallmark of cancer cells go

168 owth suppressors, resist cell death, promote replicative immortality, induce angiogenesis, support in

169 ersal hallmark of cancer cells which enables replicative immortality.

170 A range of replicative impairments could be demonstrated in lymphob

171 SMT-null mutants were fully viable and replicative in culture but showed increased sensitivity

172 stablish a nonreactivating, latent-like or a replicative infection in CD34(+) hematopoietic progenito

173 Asn/Gln residues may act in concert along a replicative interface to promote prion conversion.

174 se interacts with vRNA and the complementary replicative intermediate cRNA using several specific bin

175 s essential for the accumulation of the cRNA replicative intermediate in infected cells.

176 proceeds through a complementary RNA (cRNA) replicative intermediate, and requires oligomerization o

177 acilitates HBV infection in vitro, where all replicative intermediates including covalently closed ci

178 oluminescent imaging (BLI) to determine oHSV replicative kinetics in the injected tumor mass.

179 coni anaemia pathway, inhibiting error-prone replicative lesion bypass and interstrand crosslink repa

180 sive account of metabolic changes during the replicative life of Saccharomyces cerevisiae.

181 hondrial quantity causes a severe decline of replicative life span of daughter cells.

182 e response to loss of mtDNA is a decrease in replicative lifespan (RLS).

183 histones in response to DNA damage increases replicative lifespan and reduces genomic missegregations

184 mains technically challenging to measure the replicative lifespan of individual mammalian cells.

185 metic effect of extracellular H2O2 stress on replicative longevity.

186 must periodically switch from a latent to a replicative/lytic phase.

187 Such a simple replicative mechanism may have led to the accumulation o

188 The post-replicative mismatch repair (MMR) system has anti-recomb

189 uclear gene encodes the catalytic subunit of replicative mitochondrial DNA polymerase gamma.

190 copious numbers, these TEs may have evolved replicative mobilization strategies that circumvented ho

191 eristic curve (AUROC) of HBeAg-negative, low-replicative (n = 213) and high-replicative (HBV DNA >/=2

192 ng of interleukin-18, thereby destroying the replicative niche for intracellular bacteria and alertin

193 thereby, allows the bacteria access to their replicative niche in the cytosol.

194 een developed which mimics the intracellular replicative niche of C. burnetii and allows axenic growt

195 e span of infected cells, which serve as the replicative niche of intracellular pathogens.

196 thogens form an intracellular membrane-bound replicative niche termed the inclusion, which is enriche

197 rder to establish a productive intracellular replicative niche.

198 facilitates Y. pestis access to a protected replicative niche.

199 late host cellular processes and establish a replicative niche.

200 d strategies to establish and maintain their replicative niche.

201 To establish these replicative niches, intracellular pathogens secrete vari

202 o block apoptosis and to safeguard bacterial replicative niches.

203 irus, exploits inflammasomes to activate its replicative or lytic phase.

204 man VSMCs derived from plaques or undergoing replicative or palmitate-induced senescence versus healt

205 l strand orientation is essential for such a replicative organization of DNA, given our premises, the

206 Overexpression of a GFP-tagged TcUBP1 in replicative parasites resulted in >10 times up-regulated

207 s can be resolved by disparate repair and/or replicative pathways, resulting in an assortment of sign

208 and AAR identified it more frequently in low-replicative patients (37.5% vs. 19.4%, P = 0.037).

209 tly identified F2-4 fibrosis in low vs. high-replicative patients (48.7% vs. 69.6%, P = 0.032) and AA

210 Of the low and high-replicative patients, 40 (18.8%) and 73 (47.7%) had F2-4

211 or identifying F2-4 fibrosis in low and high-replicative patients.

212 Meanwhile, no replicative PGCs or prophase I meiocytes could be found.

213 Periodic activation into the lytic/replicative phase allows such viruses to propagate and s

214 nflammasome sensors to actually activate its replicative phase from quiescence/latency.

215 /reactivation switch protein on to enter the replicative phase.

216 RER-deficient, and harbor an rNTP-permissive replicative Pol mutant, excessive accumulation of single

217 on, limited dNTP pools slow DNA synthesis by replicative Pols and provoke the incorporation of high l

218 s by the replicative polymerases (Pols); the replicative Pols can insert AraCTP at the 3' terminus of

219 tion between the proofreading subunit of the replicative polymerase and the processivity clamp, which

220 Using purified proteins, we show that the replicative polymerase DnaE is mutagenic within the sequ

221 that cytosine deamination encountered by the replicative polymerase has a prominent role in melanoma

222 We show here that whereas the high-fidelity replicative polymerase Poldelta is blocked in the replic

223 d DNA, allowing stringent DNA synthesis by a replicative polymerase to resume beyond the offending da

224 its ability to inhibit DNA synthesis by the replicative polymerases (Pols); the replicative Pols can

225 or AP sites in ssDNA at junctions found when replicative polymerases encounter the AP lesion.

226 is contrasts with the multi-subunit B-family replicative polymerases of eukaryotes.

227 elongs to the same B-family as high-fidelity replicative polymerases, yet is specialized for the exte

228 ne of the most common DNA lesions that block replicative polymerases.

229 ploidy to replication mode and nature of the replicative polymerases.

230 elomere maintenance mechanisms for unlimited replicative potential.

231 in nature; (ii) recombination is primarily a replicative process mediated by the RNA-dependent RNA po

232 d biomolecules in metabolic, structural, and replicative processes, it is highly likely that such non

233 r chromatid cohesion and possibly other post-replicative processes.

234 te that the RdRp plays a central role in SVA replicative recombination.

235 d, a short pulse of nucleoside analog labels replicative regions in the cells of interest.

236 mbination (HR), but HR can also perform post-replicative repair after bypass of the obstacle.

237 e RAD51 axis, stimulates RAD51-mediated post-replicative repair and engagement of the MUS81 complex t

238 ents caused by a telomere crisis arise via a replicative repair process involving template switching.

239 breakpoint junction features reminiscent of replicative repair, and show increased de novo point mut

240 age in S phase, suggesting it acts as a post-replicative resolvase.

241 It is not clear how this replicative ring helicase translocates on, and unwinds,

242 hroat was confirmed by the presence of viral replicative RNA intermediates in the throat samples.

243 gene expression profiles from cells entering replicative senescence (RS) or upon oncogene-induced sen

244 to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompani

245 corneal epithelial stem/progenitor cells to replicative senescence and apoptosis.

246 ic model, based on cell population dynamics, replicative senescence and functionality loss.

247 ays a causative role in the establishment of replicative senescence in HMECs.

248 rofile in human endothelial cells undergoing replicative senescence in presence of metformin.

249 ey candidates whose downregulation can delay replicative senescence of primary human cells.

250 Insofar as telomere shortening and replicative senescence prevent genomic instability and c

251 encoding proteins involved in OPC function, replicative senescence, and inflammation.

252 We show that, in a mouse model of replicative senescence, decline in muscle satellite cell

253 investigate how metabolic pathways regulate replicative senescence, we used LC-MS-based metabolomics

254 ts were recapitulated in a cellular model of replicative senescence, whereby we exposed replicating h

255 herefore can be used to predict the onset of replicative senescence.

256 a limited number of cell divisions, known as replicative senescence.

257 arkers for DPSC populations with accelerated replicative senescence.

258 leads to a DNA damage response that signals replicative senescence.

259 netic screens to identify genes required for replicative senescence.

260 pectroscopy, following their transition into replicative senescence.

261 genome conformation akin to that of cells in replicative senescence.

262 re shortening ensures a measured approach to replicative senescence.

263 and the population of cells start to undergo replicative senescence.

264 ctin-dependent coalescence of multiple early replicative sites.

265 ICP8 is a classical replicative SSB and interacts physically and/or function

266 e role of ICP8 as an SSAP from its role as a replicative SSB during viral replication.

267 able to separate the activities of ICP8 as a replicative SSB from its annealing activity.

268 tains many other functions characteristic of replicative SSBs.

269 ycle stages, such as the transition from its replicative stage (tachyzoite) to the latent stage (brad

270 rmed that TcHTE is predominantly detected in replicative stages (epimastigote and amastigote), in whi

271 , this reveals that BRCA1-BARD1 monitors the replicative state of the genome to oppose 53BP1 function

272 of HBeAg-negative patients can achieve a low-replicative state within a short duration of follow-up.

273 t are differentially regulated in latent vs. replicative states of infection.

274 decomplexation cells return to their normal replicative states.

275 nian tegument variability promoted alternate replicative strategies: high virion pp71 levels enhance

276 Like other types of DNA damage, replicative stress activates the DNA damage response, a

277 , impairs cellular response to genotoxic and replicative stress and could identify patients at higher

278 sed cancer cell resistance to DNA damage and replicative stress and increased tumor cell killing and

279 sts or mouse liver tissue is associated with replicative stress and mitochondrial dysfunction.

280 ression of the DNA replication fork, causing replicative stress and/or cell cycle arrest.

281 understanding of how mitochondria cope with replicative stress but can also explain some controversi

282 The combination of replicative stress caused by defects in the ATRX-histone

283 demonstrate that the role of Pol epsilon in replicative stress sensing is conserved in plants, and p

284 omatin that fosters cycles of DNA damage and replicative stress that activate homology-directed repai

285 e S-phase checkpoint in yeast in response to replicative stress, but whether this mechanism functions

286 This treatment also increased replicative stress, cytoplasmic DNA, and signals related

287 n autosomal-recessive syndrome that combines replicative stress, neurodevelopmental abnormalities, an

288 t mitotic chromosome abnormalities following replicative stress.

289 silencing genome-wide, likely by preventing replicative stress.

290 reactive-oxygen species generation, and DNA-replicative stress.

291 leading-strand synthesis under conditions of replicative stress.

292 ed, and genomic instability increased during replicative stress.

293 We show that pregnancy triggers replicative stresses leading to genetic instability in m

294 s; positive-sense genomic and negative-sense replicative, template viral RNA; essential viral replica

295 TL in skeletal muscle represents a minimally replicative tissue.

296 The Tn3 family is a widespread group of replicative transposons that are notorious for their con

297 in for the absolute quantification of single replicative units, propagons.

298 stems using known and previously undescribed replicative vectors.

299 WNV-DeltaNS1 appeared to be safe, as no replicative virus was found in naive Vero cells after co

300 ndpoint geometric mean titer of ~415 against replicative virus, comparing favorably with several vacc