ライフサイエンスコーパス: replicative intermediate

1 genome may involve the generation of a dsRNA replicative intermediate.

2 ntrol their replication via the synthesis of replicative intermediates.

3 and restriction to synthesis of specific DNA replicative intermediates.

4 of UvsW protein results in the loss of these replicative intermediates.

5 ulate viral replication via the formation of replicative intermediates.

6 s undetectable in HCCs which did not contain replicative intermediates.

7 2 are a mixture of partially single-stranded replicative intermediates and double-stranded replicativ

8 the presence of high levels of intracellular replicative intermediates and protected HBV DNA in the m

9 mc6(ts) mutants, the nucleus remains intact; replicative intermediates and sheared DNA are not detect

10 proceeds through a complementary RNA (cRNA) replicative intermediate, and requires oligomerization o

11 e to measure secreted virions, intracellular replicative intermediates, and nuclear non-protein-bound

12 in the production of viral transcripts, DNA replicative intermediates, and secreted virions at level

13 the current study, both genomic (sense) and replicative-intermediate (antisense) HCV RNAs were detec

14 ircular form and no detectable linear duplex replicative intermediates are generated, suggesting that

15 er, dimer, and other higher-molecular-weight replicative intermediates are generated.

16 uble-stranded monomer replicative form (mRF) replicative intermediate but reduced levels of virus, co

17 polymerase copies the viral RNA (vRNA) via a replicative intermediate, called the cRNA, and subsequen

18 se interacts with vRNA and the complementary replicative intermediate cRNA using several specific bin

19 thesis and incorporation of [3H]uridine into replicative intermediates differed among PI replicons, d

20 of Rep78 is consistent with the mechanism of replicative intermediate dimer resolution proposed for t

21 HBV transcripts and replicative intermediates disappeared from the liver by

22 uch intrahepatic markers of WHV infection as replicative intermediate DNA, covalently closed circular

23 owth characteristics, or processing of viral replicative intermediate DNA, including both telomeric a

24 y examines the mechanisms by which the viral replicative intermediate, double-stranded (ds) RNA impai

25 In this study, the effects of the viral replicative intermediate, double-stranded RNA (dsRNA) (i

26 The viral replicative intermediate dsRNA stimulates beta-cell prod

27 gene expression may be induced by the viral replicative intermediate dsRNA through the dsRNA-activat

28 Two-dimensional gel analyses show that the replicative intermediates formed at ori(uvsY) persist lo

29 In this study, we have analyzed the origin-replicative intermediates formed during infections that

30 ense, single-stranded RNA viruses with dsRNA replicative intermediates found within lipid vesicles.

31 s revealed the complete disappearance of HBV replicative intermediates from liver and kidney tissues

32 We have examined mtDNA replicative intermediates from mouse liver using atomic

33 during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalen

34 clearance of HBV capsids and their cargo of replicative intermediates from the cytoplasm of the hepa

35 s essential for the accumulation of the cRNA replicative intermediate in infected cells.

36 y more than 90% and the level of the HBV DNA replicative intermediate in the mouse liver to an almost

37 can be applied to inhibit production of HBV replicative intermediates in cell culture and in immunoc

38 genome integrity and to control the level of replicative intermediates in infected cells.

39 able cell lines expressing viral antigens or replicative intermediates; in addition, cotransfection o

40 acilitates HBV infection in vitro, where all replicative intermediates including covalently closed ci

41 A full spectrum of HBV replicative intermediates, including covalently closed c

42 rand viral genome in the double-stranded RNA replicative intermediate is represented by a single-stra

43 The replicative intermediate is thought to exist as a comple

44 s as well as the early accumulation of these replicative intermediates is equivalent for wild-type an

45 M204I mutation reduced the production of HBV replicative intermediates, no effect on the level of cov

46 ion status based on the presence of dsRNA, a replicative intermediate of all Orthornavirae infections

47 e or if the covalently closed circular (CCC) replicative intermediate of HBV DNA can still be detecte

48 gion of the HBV genome indicative of the CCC replicative intermediate of HBV DNA.

49 Replicative intermediates of HSV-1 DNA from both wild-ty

50 tic HBV transcription may be associated with replicative intermediates of persistent HBV DNA in patie

51 were derived either from different forms of replicative intermediates or from different RCs.

52 dsRNA, as genomic fragment, replicative intermediate, or stem and loop structure in

53 to a previously identified structure in the replicative intermediate (RI) RNA and a panhandle domain

54 ventional dot-blot analysis, hepatic WHV-DNA replicative intermediates (RI) had decreased 100-fold, a

55 Replicative forms (RFs) and replicative intermediates (RIs) were synthesized from th

56 nally truncated analog of RSV positive-sense replicative intermediate RNA (antigenome) bearing the ch

57 s early as day 3 after exposure, Ebola virus replicative intermediate RNA was detected in Kupffer cel

58 onfirmed in 50% of cases by detection of HCV replicative intermediate RNA.

59 he percentage of cells staining positive for replicative-intermediate RNA and the degree of hepatic i

60 The distribution pattern for HCV replicative-intermediate RNA in liver was different from

61 However, HCV replicative-intermediate RNA showed a more focal pattern

62 f liver cells harboring HCV genomes (%G) and replicative-intermediate RNAs (%RI) were evaluated using

63 The maximal concentrations of genomic and replicative-intermediate RNAs at the single cell level w

64 antify signal intensities of HCV genomic and replicative-intermediate RNAs in infected human liver ti

65 onstitute between 7 and 20% of all viral DNA replicative intermediates synthesized in the liver.

66 us DNA replication proceeds via concatemeric replicative intermediates that are comprised of head-to-

67 us DNA replication proceeds via concatemeric replicative intermediates that are comprised of head-to-

68 the ratio of cells staining positive for HCV replicative-intermediate versus genomic RNA correlated w

69 Production of replicative intermediates via this plasmid substrate wer

70 SEN-V-specific RNA (a possible replicative intermediate) was recovered from liver tissu

71 tive-strand HCV RNA, presumably representing replicative intermediates, was confirmed by ribonuclease

72 We also found that all origin-replicative intermediates were absent in infections defi

73 ength, linear HBV genome, viral antigens and replicative intermediates were synthesized and virus was

74 ingle-stranded regions in recombinational or replicative intermediates, which occur at nearly random