ライフサイエンスコーパス: reposition

1 ) to 69% (at 3 weeks after anterior lamellar repositioning).

2 dues in the central Ca(2+)-binding pocket to reposition.

3 le cells away from the niche to be favorably repositioned.

4 nd robust tool for drug development and drug repositioning.

5 exist of successful genomically-driven drug repositioning.

6 l for either approved or novel drugs in drug repositioning.

7 inical use, might lead this strategy of drug repositioning.

8 and the corresponding dynamics of nucleosome repositioning.

9 des new opportunities for drug discovery and repositioning.

10 isassembly, histone exchange, and nucleosome repositioning.

11 raction (DTI) candidates is crucial for drug repositioning.

12 eractions are closely related to the nuclear repositioning.

13 g screening and in applications such as drug repositioning.

14 o use any data inputs for computational drug repositioning.

15 thereby reducing the resources necessary for repositioning.

16 accessibility that resulted from nucleosome repositioning.

17 e brains for at least 8 months without probe repositioning.

18 bstructure-domain interactions based on drug repositioning.

19 o the identification of novel candidates for repositioning.

20 direct target genes by instructing enhancer repositioning.

21 e underlying cellular functions and for drug repositioning.

22 ent, inducing a different type of nucleosome repositioning.

23 ons within the FOXA1 locus, and structurally reposition a conserved regulatory element-herein denoted

24 switch can adopt different conformations to reposition a universally conserved Asp (D) residue invol

25 a NET39 fragment to nucleoli correspondingly repositioned a target gene, indicating a direct tetherin

26 of compounds or modifying, reformulating, or repositioning a known drug.

27 Methylation-sensitive nucleosome repositioning accounted for a significant portion of CTC

28 Patients were repositioned after every capture.

29 Evaluating a repositioning algorithm using indications unknown to inp

30 iously described network-based computational repositioning algorithm, yielding strong results via cro

31 Although SSB binds ssDNA tightly, it can be repositioned along ssDNA to follow the advancement of th

32 rbidity or drug response and to suggest drug repositioning, altogether supporting clinical decisions.

33 Drug repositioning analysis identified several drug classes w

34 bly lines often feature robots that pick up, reposition and connect components in a programmed manner

35 modelers use a helicase-like ATPase motor to reposition and reorganize nucleosomes along genomic DNA.

36 requency was observed in fractures requiring reposition and subperiosteal fractures.

37 lthough adjacent nucleosomes can also become repositioned and occupy at least a subset of start sites

38 Box B, two homogenous domains of HMGB1, are repositioned and packed together by EGCG.

39 he pseudoobscura subgroup through centromere repositioning and a pericentric inversion.

40 reatment prioritization for a patient), drug repositioning and discovery and the study of mechanism/m

41 screening with potential in lead discovery, repositioning and drug safety.

42 Computational drug repositioning and drug-target prediction have become ess

43 isease motivates us to jointly consider drug repositioning and drug-target prediction in drug discove

44 lled iDrug, which seamlessly integrates drug repositioning and drug-target prediction into one cohere

45 On the other hand, both drug repositioning and drug-target prediction involve the sam

46 Centromere repositioning and evolutionary new centromeres (ENCs) we

47 -of-care targeted drugs, candidates for drug repositioning and immunotherapeutic approaches.

48 Drug repositioning and repurposing can enhance traditional dr

49 o the identification of novel candidates for repositioning and repurposing.

50 g the free energy from ATP hydrolysis to the repositioning and restructuring of nucleosomes, but how

51 ibutors to cost were clinical nurse time for repositioning and skin inspection.

52 ferences between the visual acuity using IOL repositioning and that using IOL exchange 2 years after

53 Snf2 plays a fundamental role in nucleosome repositioning and the expression of growth genes.

54 y of tumors, the opportunity for therapeutic repositioning and the rationale for combination therapy

55 ATP-dependent chromatin remodeling, which repositions and restructures nucleosomes, is essential t

56 target image, a template is first oriented, repositioned, and scaled to the target during a scaled r

57 ould be applied to drug combinations or drug repositioning, and be helpful guiding clinical trial des

58 s an effective integrative strategy for drug repositioning, and identified new drugs against the VCP/

59 the orchestration of cell emergence, growth, repositioning, and loss under homeostatic conditions and

60 ntial treatments for PD and 6 hold potential repositioning applications.

61 on of the obtained models, an in silico drug repositioning approach allowed for the identification of

62 Accordingly, we adopted a targeted repositioning approach to screen for candidate FDA-appro

63 Computation-based drug-repurposing/repositioning approaches can greatly speed up the tradit

64 allenges of the hindered gene target in drug repositioning approaches to date.

65 opportunities for developing in silico drug repositioning approaches.

66 utperforms several recent computational drug repositioning approaches.

67 Repositioning approved drug and small molecules in novel

68 litude, low signal-to-noise ratio, and voxel repositioning are major sources of error.

69 al ISR and suggest that the HIV-PIs could be repositioned as therapeutics in human diseases to modula

70 Our data demonstrate the power of targeted repositioning as a method to identify existing drugs tha

71 ween TADs and LADs was observed with the TAD repositioning as a unit.

72 thelmintics exhibit desirable properties for repositioning as anti-C. difficile agents.

73 we show that the unaltered array is rapidly repositioned at the cell center.

74 was reintervention rate for band removal or repositioning at 3 years.

75 prevents supercoil diffusion and nucleosome repositioning at coding regions.

76 Nucleosome repositioning at gene promoters is a fundamental aspect

77 We present evidence of extensive nucleosome repositioning at thousands of gene promoters as genes ar

78 Mef2c is specifically repositioned away from the nuclear periphery during earl

79 First, chromatin is repositioned away from the nuclear periphery in response

80 Novel drugs are also proposed for repositioning based on their mechanism of action to trea

81 ng-and-sliding mechanism for nucleosomal DNA repositioning, bearing unexpected similarities to chroma

82 ligand must be endocytosed to be modified or repositioned before it binds Notch and (2) pulling model

83 l modeling and molecular docking show that a repositioned beta6alpha6 loop allows sKlotho to bind alp

84 et prediction is a promising avenue for drug repositioning, but performance is wanting.

85 s packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to contro

86 by the amino acid side chain, because it is repositioned by linker torsion.

87 Here we propose a framework for drug repositioning by comparing transcriptomes imputed from G

88 of DNA translocation and promoter nucleosome repositioning by RSC.

89 atients (eyes) were randomly assigned to IOL repositioning by scleral suturing (n = 54) or IOL exchan

90 s (104 eyes) were assigned one group for IOL repositioning by scleral suturing (n = 54) or one group

91 signed 104 patients (104 eyes) either to IOL repositioning by scleral suturing (n = 54) or to IOL exc

92 Nucleosome placement and repositioning can direct transcription of individual gen

93 uided to the synaptic membrane by centrosome repositioning, can facilitate the extraction of immobili

94 e applied TargetPredict in identifying novel repositioned candidate drugs for Alzheimer's disease (AD

95 k, PUDTI, is then designed to infer new drug repositioning candidates by integrating NDTISE, probabil

96 Repositioning candidates for a number of disorders were

97 sed approaches to identify and validate drug-repositioning candidates for epithelial ovarian cancer (

98 We found a number of repositioning candidates, many supported by preclinical

99 very strategies including computational drug repositioning, cell and gene-therapy, clustered regularl

100 genes at borders into a tandem configuration repositions cohesin, enlarges the pericentromere and imp

101 caused by ATP6V1A deficit were improved by a repositioned compound, NCH-51.

102 her changes in differentiation revealed that repositioning contributes (1/3) to (2/3) of a gene's nor

103 Thus, centrosome repositioning coupled to changes in microtubule stabilit

104 sed for drug repurposing (also known as drug repositioning), discuss the challenges faced by the repu

105 We evaluated the clinical efficiency of top repositioned drug candidates using EHRs of over 72 milli

106 anisms, identify new disease biomarkers, and reposition drugs for diseases with unmet needs.

107 GWAS and gene expression microarray data to reposition drugs for PD.

108 identified that the prescriptions top-ranked repositioned drugs are significantly associated with low

109 that this modular approach is promising for repositioning drugs for use in polygenic diseases such a

110 This change repositions DSB hotspots and completely restores fertili

111 perimentally observed biphasic nature of the repositioning due to an interplay between MT cytoskeleto

112 Myocd is specifically repositioned during early cardiogenic differentiation, b

113 ting approximately 50% of the genes that are repositioned during WT development.

114 These analyses demonstrate active nucleosome repositioning during Dictyostelium multicellular develop

115 ane proteins (NETs) that direct their normal repositioning during myogenesis.

116 ng the clustering of lytic granules and MTOC repositioning during the development of NK cell-mediated

117 repurposing could alleviate this problem by repositioning effective and safe small-molecule drugs fr

118 Features of specific repositioning events were then tested by fluorescence in

119 approved drugs, suggesting opportunities to reposition existing drugs for SCZ.

120 before extrapolating from these preliminary repositioning experiments to clinical use, particularly

121 The Drug ReposER (DRug REPOSitioning Exploration Resource) web server is design

122 The repositioning feature of the THV was applied in 25.8% of

123 cleosomes where it binds and destabilizes or repositions flanking nucleosomes.

124 macological properties that can lead to drug repositioning for the 15% drugs which seem to be inconsi

125 Computational drug repositioning framework via incorporating drug-gene sign

126 Concomitantly, recombination complexes reposition from on-axis association to the SC central re

127 t in developing T cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior.

128 the domain of pathway and network-based drug repositioning from genetic associations.

129 RM3) and describe targets for potential drug repositioning from other clinical indications.

130 a S2 cells leads to chromatin compaction and repositioning from the nuclear envelope.

131 anged by -1.2 +/- 5.8 mm Hg (P = .18) in the Repositioning group and -3.8 +/- 6.4 mm Hg (P < .001) in

132 (logMAR) units (range, -0.18 to 1.10) in the repositioning group and 0.22 +/- 0.30 logMAR (range, -0.

133 ) units (range, -0.18 to 1.16 logMAR) in the repositioning group and 0.35+/-0.54 logMAR (range, -0.20

134 eyes (12%) had cystoid macular edema in the repositioning group compared with 5 eyes (15%) in the ex

135 ior ischemic optic neuropathy (n = 1) in the repositioning group, and IOP increase (n = 9), pupillary

136 ystem included a cutting guide and a pair of repositioning guides.

137 Repositioning had a longer mean surgical time than excha

138 uctures by most existing approaches for drug repositioning has been challenging.

139 Computational compound repositioning has the potential for identifying new uses

140 Many computational strategies for drug repositioning have been proposed, which are based on sim

141 ntemplated for optimizing current therapies, repositioning histaminergic ligands for new therapeutic

142 nal techniques have been developed to aid in repositioning, however, the majority of available method

143 ue and prostate hyperplasia, whereas MMP2 is repositioned in both prostate cancer and hyperplasia.

144 a humanized mAb (leronlimab)], are now being repositioned in clinical trials as cancer therapeutics.

145 ntenna guidance reduces the need for antenna repositioning in microwave ablation to accurately target

146 centricity may diminish the effect of tendon repositioning in moderate to highly myopic patients, wit

147 gether, our findings reveal a role for Golgi repositioning in regulating the initial integration of a

148 rite growth and maintenance, was dynamically repositioning in the soma of newborn cells during this i

149 Computer-aided drug repositioning is a cheaper and faster alternative to tra

150 Computational drug repositioning is a cost-effective strategy to identify n

151 ivocally demonstrates that NET-directed gene repositioning is critical for developmental gene regulat

152 The evolutionary significance of centromere repositioning is discussed in the context of possible ad

153 We speculate that this repositioning is incompatible with higher-order nucleoso

154 The dramatic repositioning is influenced by a differential ability to

155 One popular method of drug repositioning is network-based DTI prediction, which use

156 Locus repositioning is not always associated with transcriptio

157 Drug repositioning is often modeled as a recommendation syste

158 Centromere repositioning is proposed as the key mechanism different

159 The mechanism of nucleosome repositioning is shown to be strongly linked to DNA sequ

160 However, the extent to which nucleosome repositioning is used within eukaryotic genomes is poorl

161 Drug repurposing (or repositioning) is a cost-effective approach for finding

162 cts were strongly frequency-dependent and we repositioned it for treatment of atrial fibrillation and

163 In the field of drug repositioning, it is assumed that similar drugs may trea

164 tions and recent studies that have sought to reposition ivermectin for the treatment of other disease

165 rch strategy to identify compounds in a drug-repositioning library (Prestwick library) that block lig

166 by increasing the expression of Arl8b, which repositions lysosomes and prevents their fusion with aut

167 onses to the site of vulnerability by glycan repositioning may be a step towards achieving cross-grou

168 Such motif repositioning may serve as a conformational switch that

169 s, and achieved specificity similar to other repositioning methods.

170 Schizophrenia working group to build a drug repositioning model for schizophrenia.

171 g (motion of >0.5 mm within 3 s) and general repositioning (motion of >0.3 mm over 15 s or more).

172 ient motion patterns were considered: sudden repositioning (motion of >0.5 mm within 3 s) and general

173 tated version of KAHRP, with the PEXEL motif repositioned near the signal sequence, prevented PMV cle

174 ler, belonging to ISWI family, only produces repositioned nucleosomes and no evidence for particles a

175 zymes that are critical for reorganizing and repositioning nucleosomes in concert with many basic cel

176 icase DNA-binding protein 1 (Chd1) remodeler repositions nucleosomes by altering DNA topology at its

177 While nucleosome repositioning occurs pervasively, we found that a class

178 5a resulted in the conformational change and reposition of the activation loop, alphaC-helix, and jux

179 ed toolbox, we demonstrate robust reversible repositioning of (endogenously tagged) organelles within

180 be identified with eRepo-ORP, we discuss the repositioning of a kinase inhibitor for Ras-associated a

181 ream or downstream gene by a fusion-mediated repositioning of a regulatory sequence is much more comm

182 However, repositioning of AD2-adjoining degrons (i.e. DSGLS-conta

183 Repurposing/repositioning of approved drugs offers a relatively low-

184 failed to demonstrate the benefit of routine repositioning of at-risk patients for the prevention of

185 Supercontraction was accompanied by the repositioning of centromeres, pericentromeres, and long

186 Importantly, we found significant repositioning of chromosomes X and Y towards the nuclear

187 Tisseel fibrin glue for the repositioning of conjunctival autografts in pterygium su

188 we employed an integrative strategy for the repositioning of drugs as novel inhibitors of the VCP/p9

189 regarding the repercussions, interplay, and repositioning of drugs in the context of disease.

190 Repositioning of drugs towards new indications is an att

191 PVR might be treated by rational repositioning of existing drugs that target mTOR and IL-

192 ensive resource constructed by a large-scale repositioning of existing drugs to orphan diseases with

193 Loss of EZH2 expression leads to repositioning of EZH1 to EZH2 targets.

194 Spatial repositioning of genes in nuclear space has been extensi

195 We show that the repositioning of genes was closely associated with the s

196 This is associated with spatial repositioning of genomic loci away from the nuclear peri

197 offer a preclinical rationale to explore the repositioning of GSK3 inhibitors to enhance differentiat

198 timulation of hDot1L activity and leads to a repositioning of hDot1L on the nucleosomal surface, whic

199 g efficacy, avoidance of adverse effects, or repositioning of histaminergic ligands.

200 We further identify local dynamic repositioning of individual RSS-associated nucleosomes a

201 his Viewpoint, we report evidence supporting repositioning of intravenous iron to the frontline in mu

202 slocation, which was subsequently for proper repositioning of IOL.

203 r37, now H-bonded to l-Lys47, resulting from repositioning of l-Lys47.

204 organelles 1 subunit 1 (Blos1) leads to the repositioning of late endosomes (LEs)/lysosomes to the m

205 ch as elongation of stem-like structures and repositioning of leaves, elicited by shade cues, includi

206 n by bound TFs and TF regulation via dynamic repositioning of nucleosomes.

207 gation of Arp2/3 interferes with haptotactic repositioning of platelets to microlesions, thus impairi

208 Translational frameshifting involves the repositioning of ribosomes on their messages into decodi

209 X-ray data at pHs of 4.5-6 reveal the repositioning of side chains along one side of the FeMo-

210 opic versus isotropic substrates resulted in repositioning of specific chromosomes, which contained g

211 lled by neuronal activity and suggest mutual repositioning of synaptic components as a potential nove

212 cription factor IRX-1/Iroquois, allowing the repositioning of synaptic inputs to the ventral side.

213 channels, opening of the pore is due to the repositioning of tethered pore-lining helices within a s

214 a kinked and untwisted conformation to allow repositioning of the 'activated' SRP-SR complex on the r

215 loops of the receptor enable the rigid-body repositioning of the 7-transmembrane domains, which come

216 usion of its AIIS is the capstone event in a repositioning of the anterior gluteals that maximizes co

217 Repositioning of the beta H-NOX domain leads to a straig

218 Conversely, experimental repositioning of the bulbous arteriosus by tissue recomb

219 op dispensing in an array, without requiring repositioning of the chip between dispensing steps, can

220 Fashioning and repositioning of the conjunctival autograft (flap time)

221 includes the relocation of a beta-strand and repositioning of the functionally important "BB-loop" re

222 mers that have different activities owing to repositioning of the K145 sidechain.

223 opensity for Na2 release, which leads to the repositioning of the N terminus and transition to an inw

224 binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that

225 rapid pacing used during valvuloplasty, and repositioning of the prosthesis.

226 impairment of DM is the combined result of a repositioning of the reactive carbon of linoleic acid su

227 ing of large-scale chromatin structure and a repositioning of the region within the nucleus.

228 Phe-mediated allosteric activation induces a repositioning of the regulatory domains.

229 ) loss due to Sirt1 S-nitrosation results in repositioning of the tetrathiolate subdomain away from t

230 irus homolog pM50 but reveals a considerable repositioning of the very C-terminal alpha-helix of pUL5

231 predicted per-millimeter effect of surgical repositioning of their insertions.

232 mutants, in spite of a dramatic rostrocaudal repositioning of these neurons in hindbrain.

233 Repositioning of these vessels to lie in contact with th

234 the Dictyostelium IQGAP family and call for repositioning of this genuine RasGAP outside of the IQGA

235 d to occluded from the membrane involves the repositioning of transmembrane helix 4 (TM4) following i

236 Importantly, we found that restructuring and repositioning of two C-terminal helices enable MapZ to d

237 plexed with the portal, which is achieved by repositioning of two consecutive repeats of a conserved

238 DrugPredict exploited unique repositioning opportunities rendered by a vast amount of

239 ies of active compounds and can provide drug repositioning opportunities.

240 linical observations and suggesting new drug repositioning opportunities.

241 the rate of catheter misplacement requiring repositioning or replacement was 1.0% (95% CI, 0.6-1.7%)

242 evaluation that more accurately reflect the repositioning potential of a compound could provide a be

243 etic architecture of telomere length and the repositioning potential of lithium as an anti-ageing med

244 d paradigm may further improve computational repositioning predictions.

245 hich could serve as start point for CNS drug repositioning research.

246 lation, impedance was modulated by adding or repositioning return patches in an attempt to decrease t

247 Differentiating neutrophils also repositioned ribosomal DNA and mininucleoli to the lamin

248 A drug-repositioning screen identified the HIV1-protease inhibi

249 lusive sub-categories, the data-driven model repositions semantics, language, social behaviour and fa

250 Many remodellers reposition (slide) nucleosomes, however, how DNA is prop

251 g loop to an even greater degree, as well as reposition specific CBL-binding residues, bringing them

252 uman cells, we found that slow transcription repositioned specific co-transcriptionally deposited chr

253 We here use a drug repositioning strategy and identify a promising anticryp

254 A common drug repositioning strategy is the re-application of an exist

255 This study utilized a drug repositioning strategy to investigate FDA-approved gold-

256 A drug-repositioning strategy was employed to identify suitable

257 novel drug therapies, taking advantage of a repositioning strategy, the small teleost zebrafish (Dan

258 tcome measures were previous IOL exchange or repositioning surgery, significant IOL dislocation, degr

259 ia within a single theoretical framework and repositions synaesthesia not as some quirk of aberrant c

260 strategy that combines a computational drug-repositioning system (DrugPredict) with biological testi

261 We propose a method for drug repositioning that uses the clinical signatures extracte

262 e hTR RNA using circular permutations, which reposition the 5' and 3' ends.

263 /lysine-mediated hydrogen-bonding network to reposition the asparagine in the McrB signature motif fo

264 s and activated cohesin-dependent looping to reposition the Bcl11b enhancer from the lamina to the nu

265 plana vitrectomy may be required in order to reposition the dislocated IOL-CB complex in the presence

266 rearrangements within the S4-S5 linker that reposition the S1-S4 and pore domains relative to the TR

267 A structural rearrangement in AAV2-R432A repositioned the betaA strand region under the icosahedr

268 e, however, human neutrophils rapidly (<3 h) repositioned the ensemble of proinflammatory genes towar

269 template system provides greater accuracy in repositioning the chin than traditional intraoperative m

270 n with Asp or phosphorylation) "undocks" and repositions the cofilin N terminus away from the filamen

271 We hypothesized that cTnT-Delta160E repositions the flexible linker, altering weak actomyosi

272 In the context of drug discovery or drug repositioning, the methods presented here could help ass

273 I) prediction plays an integral role in drug repositioning: the discovery of new uses for existing dr

274 l treatment, with a mechanistic rationale to reposition this drug to improve the management of colore

275 ) to Eallo or an S121P substitution in Eallo repositions this region to increase Ecat activity; and (

276 eral optogenetic approaches enable organelle repositioning through light-inducible recruitment of mot

277 extracellular portion of TM2 and TM3, which repositions TM6 in the cytoplasmic region of muOR, hinde

278 system in cancer immunotherapy, is now being repositioned to treat inflammatory and autoimmune disord

279 heir trapping, retrieving, transporting, and repositioning to a desired microwell on the array.

280 ted mitochondrial dynamics and mitochondrial repositioning to the cortical cytoskeleton.

281 Furthermore, we observed telomere repositioning to the nuclear periphery driven by nuclear

282 Whether gene repositioning to the nuclear periphery during differenti

283 that are necessary and sufficient to induce repositioning to the nuclear periphery.

284 A ring of phenylalanine residues repositions to expose previously shielded glycine residu

285 vation of such genes is often accompanied by repositioning toward the nuclear interior.

286 rmation of myosin motors, resulting in their repositioning toward the thin filament before activation

287 n, our findings provide a rationale for drug repositioning trials investigating combinations of agent

288 nd, once created, that they can be moved and repositioned using applied electric fields.

289 Drug repositioning, using known drugs for treating conditions

290 vances, the number of compounds successfully repositioned via computational screening remains low.

291 within 3 degrees in both eyes, therefore IOL repositioning was not necessary.

292 In the freehand arm, a median of one repositioning was required (range, zero to seven reposit

293 In the robotic arm, no antenna repositioning was required.

294 rotubule dynamics, confirmed that centrosome repositioning was responsible for further cell disengage

295 he reintervention rate for band retrieval or repositioning was significantly higher in the absence of

296 Drug repositioning, which aims to identify new indications fo

297 It is distinct from drug repositioning, which identifies new uses for existing dr

298 target genes provide an opportunity for drug repositioning, while for 36 genes CpG methylation was fo

299 and promoted SATB1 nuclear translocation and repositioning within the somatostatin gene promoter.

300 ar incisions with minimal flap elevation and repositioning without advancement.