ライフサイエンスコーパス: repurpose

1 g compound differentiation, combination, and repurposing.

2 at may guide disease gene discovery and drug repurposing.

3 s been characterized by different 'waves' of repurposing.

4 for clinically relevant, evidence-based drug repurposing.

5 trials to improve drug efficacy, safety and repurposing.

6 and gene and cell therapies, as well as drug repurposing.

7 oach to identify a few strong candidates for repurposing.

8 n use, thus represents an ideal molecule for repurposing.

9 ent-expired and currently neglected for PrEP repurposing.

10 host-directed therapeutics as candidates for repurposing.

11 novel drug targets and possibilities of drug repurposing.

12 braries facilitating both drug discovery and repurposing.

13 y different disease, a concept known as drug repurposing.

14 on of novel candidates for repositioning and repurposing.

15 enotype-based diagnosis of disease, and drug repurposing.

16 ssue of Molecular Cell, Layton et al. (2019) repurpose a common next-generation DNA sequencer to enab

17 his article reviews the published methods to repurpose a PGM to detect analytes other than glucose, a

18 Here, we investigate and repurpose a ubiquitous, indirect gene regulation mechani

19 Thus, S. aureus repurposes a metabolic regulator to directly control the

20 tion and growth of phospholipid membranes by repurposing a soluble enzyme FadD10 to form fatty acyl a

21 Phase II trials assessing repurposed agents must consider the best target populati

22 s to block this calcium interaction and also repurpose already approved drugs for this use for a fast

23 Here, we have repurposed an isothermal calorimeter to measure heat flo

24 assay is fast, broadly useful, practical and repurposes an inexpensive reagent known for more than 10

25 ution of blood feeding in Anopheles involves repurposing an ancestral thermoreceptor from non-blood-f

26 These data suggest the possibility of repurposing an approved class of drugs for prevention of

27 oral cancer patients, using gene therapy and repurposing an available drug to effectively treat both

28 s were identified through bioinformatic drug repurposing analyses (such as pioglitazone, levonorgestr

29 d natural compounds upon bioinformatics drug repurposing analyses, such as calcium folinate and betul

30 signatures were used for bioinformatic drug repurposing analyses, yielding leads for possible new dr

31 A network-based drug repurposing analysis further revealed that everolimus, t

32 neuro-oncological clinical trials to deliver repurposed and experimental therapeutics, aimed at achie

33 broadens our view of how genetic systems are repurposed and provides potentially exciting new tools f

34 of the current approach to early-stage drug repurposing and consider the issues contributing to inco

35 eatment from multiple angles, including drug repurposing and de novo discovery efforts, and discusses

36 nsidered for the treatment in the concept of repurposing and off-label use.

37 ies and highlight the opportunities for drug repurposing and pharmacogenomics for the treatment of hy

38 known drugs plays an essential role in drug repurposing and understanding of their unexpected side e

39 data on the therapeutic efficacy of various repurposed antimicrobials undergoing testing against the

40 f infant ALL and test EIF4E targeting by the repurposed antiviral agent ribavirin, which has anticanc

41 groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroqu

42 en tumor models, respectively, identifying a repurposing approach for cotargeting stress-adaptive res

43 ngs provide preclinical evidence that a drug repurposing approach to prevent metastatic disease in TN

44 sible to identify new targets rapidly and to repurpose approved drugs for treating heterogeneous dise

45 The CRISPR-Cas9 nuclease has been widely repurposed as a molecular and cell biology tool for its

46 erful biological signal that scientists have repurposed as a reporter for gene expression in plants a

47 imalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug.

48 t enzyme, protein phosphatase 2 A (PP2A), is repurposed as an integral component of the intasome to m

49 y and therefore could potentially be rapidly repurposed as antivirals.

50 ISPR-Cas antiviral defence systems have been repurposed as genome editing tools.

51 nucleotide-based signaling mechanisms can be repurposed as TA modules during evolution, potentially m

52 tors that enhanced drug sensitivity could be repurposed as therapeutics and provide leads for drug de

53 e utilized for both infection prevention and repurposing as a cancer immunotherapy.

54 significant implications for potential drug repurposing, as baseline renal disease must be considere

55 esting of some compounds represents compound repurposing at scale rather than drug discovery.

56 Our results provide a mechanistic basis for repurposing ATO to target p53 mutations for widely appli

57 Drug repurposing attempts to determine new indications for pr

58 this study, we investigated the potential of repurposing auranofin to treat pressure ulcers infected

59 In addition, some phages may repurpose bacterial CRISPR-Cas systems to eliminate comp

60 igned to identify potential targets for drug repurposing based on sub-structural similarity to the bi

61 methylidene penicillin-based sulfones 1-7 to repurpose beta-lactam antibiotics activity with bacteria

62 irections, dealing with such aspects as drug repurposing, biologicals, multispecific drugs, the targe

63 For these reasons, drug repurposing - both a less expensive and time-efficient p

64 acterized as functional, they can be readily repurposed by delivering an engineered synthetic CRISPR

65 w in the present study that IFIT2 is instead repurposed by influenza virus to promote viral gene expr

66 The general anesthetic ketamine has been repurposed by physicians as an anti-depressant and by th

67 Yet the same terminology has been repurposed by subsequent researchers to promote the very

68 Drug repositioning and repurposing can enhance traditional drug development eff

69 evidence of safety and efficacy of novel or repurposed candidate drugs.

70 network, we identified literature-supported repurposing candidates, such as the use of systemic horm

71 ol photons.m(-2).s(-1)) while simultaneously repurposing captured ultraviolet and short-wave radiatio

72 we present a computational approach to drug repurposing, CATNIP, that requires only biological and c

73 gies of several pathogenic bacteria, and for repurposing CDCs to kill new cellular targets.

74 The past two decades have seen data-driven repurposing characterized by signature-based approaches

75 s study represent an important first step in repurposing class I PI3K inhibitors to modulate CMA in v

76 mune evasion, highlighting the potential for repurposing copper chelators as enhancers of antitumor i

77 es have greatly expanded our capabilities to repurpose CRISPR for the development of biomolecular sen

78 Repurposed CRISPR-Cas molecules provide a useful tool se

79 tiple instances where Tn7-like elements have repurposed CRISPR/Cas systems.

80 ome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to dev

81 humans, a search that could be expedited by repurposing currently approved drugs.

82 However, most repurposing discoveries have been led by anecdotal obser

83 in the downstream applications such as drug repurposing, disease modeling and gene function predicti

84 antiparasitic mechanisms of DOX and suggest repurposing DOX as a faster acting antimalarial at highe

85 are essential for developing in silico drug repurposing (DR) methods and understanding underlying bi

86 s of BMPR2 modifiers in vitro and tested the repurposed drug enzastaurin for its propensity to improv

87 This trial design may be useful for other GA repurposing drug trials.

88 n have immediate impact particularly if they repurpose drugs with additional cancer-unrelated benefit

89 ributed to the emergence of novel compounds, repurposed drugs and new technologies.

90 While many investigational, approved, and repurposed drugs have been suggested as potential treatm

91 sis, data on increased efficacy with new and repurposed drugs have led WHO to recommend all-oral ther

92 Optimized treatment using available and repurposed drugs may have an increased impact when prior

93 therapy using conventional therapeutics and repurposed drugs or phytochemicals for an enhanced anti-

94 Repurposed drugs targeting CPH-mediated metabolic pertur

95 tion models has led to clinical trials using repurposed drugs without preclinical evidence of their i

96 ed understanding of their aetiology has made repurposing drugs for RAIDs challenging.

97 Repurposing drugs from autoimmunity and cancer immunothe

98 work providing the opportunity to infer drug repurposing due to transitivity, (viii) remove compounds

99 mitotic prophase-analogous stage of G2/M is repurposed during meiosis prophase to promote interactio

100 tion sites on clathrin heavy chain (CHC) are repurposed during mitosis to directly recruit the microt

101 Here we repurposed DXR as a targeted inhibitor rather than a bro

102 rt a new approach, called DREAM-in-CDM (Drug Repurposing Effort Applying Integrated Modeling-in vitro

103 ry, innovative, informed, and cost-effective repurposing efforts using big data ("omics") have been d

104 These results also provide a framework for repurposing endogenous CRISPR-Cas systems for flexible g

105 cell development emerged as a consequence of repurposing evolutionarily ancient constitutive cytokine

106 onse to COVID-19 can help to identify new or repurpose existing drugs targeting those proteins.

107 -19 has focused the efforts of scientists on repurposing existing Food and Drug Administration-approv

108 d EIF-4A may be targeted for intervention by repurposing existing therapeutics to reduce the risk of

109 Connectivity Map analysis and drug repurposing experiments identified pyroxamide as a new p

110 at the DREAM-in-CDM approach will be used to repurpose FDA-approved drugs for various new therapeutic

111 To repurpose FDA-approved drugs potentially toxic for CSCs,

112 Two repurposed FDA-approved VCP inhibitors abrogated VCP-med

113 Until an effective vaccine is available, repurposing FDA approved drugs could significantly short

114 es behind magnetocaloric heat pumps could be repurposed for better performance without bulky and expe

115 servoir of biochemical diversity that can be repurposed for biomedical applications.

116 (DSF) is an FDA-approved drug that has been repurposed for cancer treatment.

117 1-nucleotide guide CRISPR RNA (crRNA) can be repurposed for efficient chromosomal targeting and genom

118 SPR-Cas anti-phage immune system that can be repurposed for genome editing.

119 pseudokinases in which the kinase domain is repurposed for noncanonical nucleotide binding or to sta

120 They are also well placed to be repurposed for point-of-care testing of other analytes a

121 icient type I systems lacking Cas3 have been repurposed for RNA-guided transposition by bacterial Tn7

122 ac scintigraphy (i.e., Tc-PYP scan) has been repurposed for the diagnosis of transthyretin amyloid ca

123 rototypic Tn7 element are fused or otherwise repurposed for the new dual activities.

124 thway analysis supports that Apatinib can be repurposed for the treatment of LA.

125 , used for type 2 diabetes, was successfully repurposed for treating neutropenia and neutrophil dysfu

126 This drug might be repurposed for treatment of TTC7A deficiency.

127 (4,5)), that was repurposed for use against severe acute respiratory synd

128 nsidered for sepsis and might be amenable to repurposing for COVID-19.

129 a that await functional characterization and repurposing for genome editing applications in prokaryot

130 PSnet offers a network-based, in silico drug repurposing framework for more efficacious therapeutic s

131 available breath shields and 1 breath shield repurposed from a plastic container lid were tested.

132 This interaction is repurposed from an actin-recruiting and -remodeling comp

133 vation, we propose that the delta-HXTXs were repurposed from an initial insecticidal predatory functi

134 haea and that T2SSs were relatively recently repurposed from type IV pili.

135 nct fields: modeling predicted phenotypes in repurposed gene expression data and modeling predicted c

136 Overall, the current study suggests that repurposing gold-containing drugs, like auranofin, for t

137 Transcriptome-based computational drug repurposing has attracted considerable interest by bring

138 While empirical drug-repurposing has been a routine practice in clinical psyc

139 This methodological framework for drug repurposing has broad applicability to other diseases.

140 Computational drug repurposing has the ability to remarkably reduce drug de

141 Most cardiomyopathy treatments repurpose heart failure drugs to manage these symptoms a

142 is operon induces a protective response that repurposes heme to counteract antimicrobial oxidative st

143 Provision of a repurposed hemodialyzer membrane filtration device marke

144 The compound series was discovered by repurposing hits from a screen against the related paras

145 Repurposing host-targeted drugs approved by the FDA in t

146 ries and discovered a molecule from the Drug Repurposing Hub-halicin-that is structurally divergent f

147 Drug repurposing, identifying novel indications for drugs, by

148 e-dependent conformational change, have been repurposed in septins to play a fundamental role in mole

149 or the identification of candidate drugs for repurposing in the treatment of progressive MS.

150 target- and ligand-based designs emphasizing repurposing inhibitors from one cysteine protease to oth

151 Drug repurposing is a more cost-effective measure.

152 Drug repurposing is potentially the fastest available option

153 ichia coli ribosome has attracted efforts to repurpose it for novel functions, such as the synthesis

154 evice from Oxford Nanopore Technologies, and repurposed it to detect any DNA/RNA oligo (target) in a

155 signature-based in silico approaches to drug repurposing, its integration with multiple omics platfor

156 Overall, this systematic approach to drug repurposing lays the groundwork to streamline future dru

157 of 12,000 molecules that make up the ReFRAME repurposing library, comprising nearly all the small mol

158 the COVID-19 global response was to consider repurposing licensed drugs.

159 cal decision making, medical diagnosis, drug repurposing, literature-based discovery and hypothesis g

160 is therefore critical for understanding and repurposing living systems but has been hindered by comp

161 Here we repurposed mastoparan-L, the toxic active principle deri

162 scratch, however, it's sometimes possible to repurpose materials that already exist.

163 Following a drug repurposing methodology, and taking advantage of a singu

164 ance of Dr Insight over several popular drug-repurposing methods to detect known cancer drugs and dru

165 These annotations help researchers find and repurpose models, accelerate model composition and enabl

166 r study indicates a therapeutic potential of repurposing MTX for the treatment of rhodopsin-associate

167 ion, structural robustness and function, and repurposing natural microcompartments using synthetic bi

168 Using our model, we created a repurposing network to identify broad scale repurposing

169 As promising alternatives to chemo agents, repurposed non-chemo drugs and dietary phytochemicals ha

170 Early drug repurposing occurred in academia and was based on serend

171 pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare

172 This study considered the repurposing of (11)C-labeled 1,5-bis(4-methoxyphenyl)-3-

173 reveal the USTC as a striking example of the repurposing of a general transcription factor complex to

174 n of this differentiation program represents repurposing of a generic stress response to gain conside

175 Our results highlight an unexpected repurposing of a master regulator of male-specific sexua

176 This finding highlights repurposing of a protein with a nuclear function to driv

177 immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is no

178 These inhibitors allow the repurposing of antibiotics that have already proven to b

179 function through the combinatorial usage and repurposing of both lineage-determining and signal-regul

180 oinflammatory pathway, but also proposes the repurposing of CDK4/6 or EZH2 inhibitors as a new therap

181 therapeutic target in advanced PC suggesting repurposing of clinically tested IKBKE inhibitors could

182 Overall, the repurposing of decitabine emerged as an intriguing optio

183 A new genome assembly reveals how repurposing of developmental pathways, gene gains and lo

184 Repurposing of dox may provide unique opportunities for

185 Thus, repurposing of drugs targeting cancer metabolism might s

186 s introduces to the field - particularly the repurposing of epigenetic targeting cancer therapeutics

187 linical and scientific community to try drug repurposing of existing antiviral agents as a quick opti

188 initiative offers a proof of concept for the repurposing of existing approaches to enable rapidly sca

189 This repurposing of existing kinase inhibitors could lay the

190 ulating clinical trials of new therapies and repurposing of existing ones to target FGF23.

191 is of enzymatic pathways de novo, but rather repurposing of existing ones.

192 Repurposing of FDA-approved drugs that can eradicate the

193 g as non-narcotic analgesics, supporting the repurposing of fingolimod for chronic pain treatment and

194 for a number of CDKi's, offering avenues for repurposing of highly potent molecules as probes for pre

195 ug strategies targeting NQO1 may promote the repurposing of idebenone for additional disorders.SIGNIF

196 Herein, we describe the repurposing of imidazotetrazines (such as temozolomide,

197 fungal infection and highlight the metabolic repurposing of immune cells as a potential therapeutic s

198 Repurposing of ketamine for treating TRD provided a new

199 Thus, the repurposing of KLF5 for novel regulatory activity in OAC

200 Thus, repurposing of known drugs could substantially accelerat

201 We identified potential targets for repurposing of licensed medications: using Mendelian ran

202 r setting, and provide the rationale for the repurposing of mitochondrial inhibitors to treat AA canc

203 Our findings demonstrate a functional repurposing of NMDAR in the surveillance of tissue fitne

204 we describe the rationale that underpins the repurposing of PfA-M1 inhibitors as novel APN inhibitors

205 ghts the role of tinkering by exaptation-the repurposing of pre-existing functions for new roles-in t

206 Repurposing of sirolimus plus nintedanib might provide t

207 iding a rationale for investigation into the repurposing of statins to treat preterm labor in women.

208 We did not identify genetic support for the repurposing of statins, ezetimibe, or mipomersen for AD

209 ion of mitochondrial structure and function, repurposing of the electron transport chain to superoxid

210 hemistry as a means of facilitating rational repurposing of the existing medicines for treating COVID

211 nts with co-incident IBD and SpA and for the repurposing of therapeutics from one disease to the othe

212 a novel strategy for the rational design or repurposing of therapeutics to selectively cross-target

213 effects, adverse reactions, and the present repurposing of these ancient drugs.

214 Repurposing of thiazolidinediones or identification of n

215 e congression, defining for the first time a repurposing of this endocytic interaction mechanism duri

216 ation of new drug development programmes and repurposing of trials to prevent, treat or reduce advers

217 Paralympic Games Athletes' Village that was repurposed on active design principles, on adult physica

218 repurposing network to identify broad scale repurposing opportunities between drug types.

219 ormed to identify potential side effects and repurposing opportunities, with findings investigated in

220 chiatric diseases, and identify several drug-repurposing opportunities.

221 ing sites, required for cGAS activation, are repurposed or become inaccessible, and cGAS dimerization

222 & HIPEC and to identify targets for existing repurposed or novel treatment strategies.

223 However, the processes by which evolution repurposes or re-engineers host and pathogen proteins to

224 m for Evasins and discusses the potential of repurposing or engineering Evasins as therapeutic anti-i

225 Our results suggest that repurposing p110beta inhibitors to treat cognitive and b

226 Our in vivo data suggest the opportunity to repurpose p38 MAPK inhibitors for adjunct host directed

227 immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7

228 hibitor resistance during cancer therapy and repurposing PARP inhibitors for the treatment of non-onc

229 vast majority of expansion, 79%, occurred on repurposed pasture lands, and 20% was from the conversio

230 Together, these repurposing periods have led to advances in the treatmen

231 Efforts to repurpose PGMs for the detection of any analyte at the p

232 gy for which there are no effective novel or repurposed pharmacotherapeutics to prevent disease progr

233 Here, we show that a number of repurposed Phase 2-approved small molecules are capable

234 hat warrants future translational efforts to repurpose phenformin for the treatment of cutaneous squa

235 A repurposed plastic lid breath shield, 513 cm(2), was sli

236 ch to explore the potential side effects and repurposing potential of antihypertensive drugs, which a

237 s an antiviral drug target and highlight the repurposing potential of telaprevir to treat EV-D68 infe

238 sposable element RNA-protein interactions to repurpose powerful antiviral chromatin silencing machine

239 dy lays the groundwork for future efforts to repurpose prazole-based compounds as antivirals that are

240 ponse prediction applications including drug repurposing, precision oncology, and new drug developmen

241 Repurposing/repositioning of approved drugs offers a rel

242 However, efforts to repurpose ribosomes are limited by the lack of complete

243 We argue that this can be determined by repurposing samples that are already being collected as

244 complementarity to an exogenous target, the repurposed scaRNA:tracrRNA-FnoCas9 machinery can also di

245 rvations (e.g. Viagra) or experimental-based repurposing screens, which are costly, time-consuming, a

246 Additionally, repurposing serotonin agonists to inhibit CpxA may repre

247 Drug repurposing signifies an appealing approach to enhance t

248 s support the translation of combinations of repurposed small molecule-based toxin inhibitors as broa

249 d new medicines to chordoma patients, a drug repurposing strategy represents an attractive approach.

250 creening by applying a robust in silico drug repurposing strategy.

251 hlighting potential new therapeutic and drug repurposing targets.

252 Here, we explore this concept by repurposing TCR, CD25 and PD1, three major players of th

253 ions, we uncover novel opportunities of drug repurposing that may benefit cancer treatment through ac

254 We use these insights to repurpose the Ehrlich pathway and synthesize an array of

255 In conclusion, neoplastic cells repurpose the endogenous neuron to microglia signalling

256 In this study, we repurpose the engineered peroxidase APEX2 as the first g

257 sfully engineer INS-1E, a beta-cell line, to repurpose the insulin secretion machinery, which enables

258 ases (GSD-Ib and G6PC3 deficiency) led us to repurpose the widely used antidiabetic drug empagliflozi

259 We repurposed the FDA-approved bile acid sequestrant choles

260 To combat VRE, we have repurposed the FDA-approved carbonic anhydrase drug acet

261 of prenyltransferases from marine algae that repurposes the terpene cyclase structural fold for the N

262 Our study raises the possibility of repurposing the antipsychotic drug chlorpromazine for tr

263 ptibility of the organism to amoxicillin, by repurposing the beta-lactamase inhibitor, relebactam, in

264 Repurposing the clinical Cu chelator tetrathiomolybdate

265 These data indicate that repurposing the FDA-approved leukemia drug, nilotinib, m

266 We investigated the potential of repurposing the FDA-approved spironolactone (SP), as one

267 Furthermore, repurposing the iron-dependent repressor YtgR underscore

268 ific design challenges than is accessible by repurposing the limited number of naturally occurring NT

269 s of extensive purpose-unknown compounds and repurposing the novel therapeutic properties of FDA-appr

270 ening platform of cancer drugs in a quest to repurpose them for ADPKD.

271 cterial microcompartments hinders efforts to repurpose them for non-native functions.

272 We propose to repurpose this AI to test ecological hypotheses that hav

273 How to repurpose this model to incorporate these "human factors

274 fect of dofetilide raises the possibility of repurposing this antiarrhythmic drug for the treatment o

275 DMD provides new therapeutic indications for repurposing this safe drug to counteract inflammation, w

276 ce to human disease, how this model might be repurposed to be more reflective of the human condition

277 (eEndoV), an inosine-cleaving enzyme, can be repurposed to bind and isolate A-to-I edited transcripts

278 way, these sensor-rich devices can easily be repurposed to collect rich and extensive records of thei

279 capacity of uL18 ribosomal proteins has been repurposed to create factors that facilitate the splicin

280 ially available cation exchange resin can be repurposed to extract heavy metal cations from water sam

281 a terminal uridylyl transferase (TUTase) was repurposed to generate clickable sgRNA of choice by site

282 EDNR antagonists can be repurposed to improve drug delivery in VEGFA-secreting t

283 vidence that early limb-based processes were repurposed to map touch on a tool.

284 We conclude that nimodipine could be repurposed to offer substantial clinical benefit in MS.

285 common scaffolds and have been successfully repurposed to produce a suite of practical protein-based

286 ude that the proteins of the kinetochore are repurposed to sculpt developing synapses and dendrites a

287 r results suggest that Thapsigargin could be repurposed to tackle S. aureus host cell infection in co

288 ally plausible candidate drugs that could be repurposed to target calcification.

289 ndings suggest that FECH inhibitors could be repurposed to treat retinal neovascularization.

290 type addicted to CDK4/6 activation, could be repurposed to treat SCCOHT.

291 lar neoplasms, and suggests R(+)-propranolol repurposing to numerous indications ranging from vascula

292 ponsive materials while enabling their rapid repurposing toward new sequence targets.

293 ine a mechanism exploited by C. difficile to repurpose toxic heme within the inflamed gut as a shield

294 hare features found in toxins of the TAS and repurposed transcriptional data to identify which ones p

295 We repurpose type I variants of class 1 CRISPR-Cas systems

296 ction provides valuable information for drug repurposing, understanding of side effects as well as ex

297 ent, in that lineage-specific factors can be repurposed upon injury to initiate morphogenesis; howeve

298 e demonstrate a rational design strategy for repurposing venoms into promising antimicrobials.

299 egnancy-acceptable antiviral compounds is to repurpose well-known and widely used FDA-approved drugs.

300 Polar growth in Agrobacterium pirates and repurposes well-known bacterial cell cycle proteins, suc