ライフサイエンスコーパス: require

1 k districts in Africa, a 95% coverage may be required.

2 Randomization was not required.

3 d subsequent strict regulations are strongly required.

4 dly reducing the number of HVPG measurements required.

5 ometrically, and no fluorophore labeling was required.

6 populations and prolonged sampling times are required.

7 fespan and healthspan additional studies are required.

8 Twenty-five patients required 1 IMT and 4 needed 2 drugs.

9 Importantly, this included 20 samples that required 30-39 threshold cycles of RT-qPCR to achieve a

10 ensation may provide more power and thus may require a smaller sample size.

11 icient conversion of CO(2) to C(2+) products requires a Cu catalyst with a high density of defect sit

12 The maintenance of blood homeostasis requires a dynamic response of HSCs to stress, and dysre

13 Biomonitoring often requires a priori selection of compounds to be measured,

14 However, systematic investigation requires a quantitative analysis of FA's ability to dena

15 ees over 80 meters tall in the Amazon forest requires a reevaluation of current thinking.

16 Sustainable nanotechnology requires a scientifically based and proportionate risk g

17 Our framework requires a simulation model that can estimate quality-ad

18 ential-outcomes framework characteristically requires a well-defined hypothetical intervention.

19 cerbation in the 4 weeks after immunization, requiring a short course of systemic corticosteroids; in

20 Salmonella Here, we show that this mechanism requires aconitate decarboxylase 1 (IRG1), which synthes

21 f screening, and many false-positive results required additional, subsequent MRI scans with anesthesi

22 only for current and local currencies while requiring all participants to respond to all items.

23 The dimeric complexes on Psi RNA require an intact dimer interface within Gag.

24 besity (BMI=57+/-12 kg/m(2)), following LRM, required an increase in PEEP of 8[7, 10] cmH(2)O above t

25 increasingly critical in modern science, and requires an effort towards standardising data publicatio

26 hondrial recruitment and ligase activity but requires an intact ubiquitin-like (UBL) domain.

27 NT Adaptively navigating social interactions requires an integration of prior experiences with inform

28 er to distinguish bacterial pneumonia, which requires antibiotic therapy, from viral pneumonia, which

29 the width of a broad spectrum, and does not require any information about the phase of the received

30 coverage and sustainable resource management requires approaches that manage bodily excreta within co

31 ontrast to phosphors, no light conversion is required as the diffuser relies solely on strong broadba

32 nal programs to inform of the danger are now required, as public perception has grown that vaping is

33 soil carbonate minerals whose long-term fate requires assessment through field trials.

34 use of death from a single infectious agent, requiring at least 6 months of multidrug treatment to ac

35 emical design of multicomponent nanocrystals requires atomic-level understanding of reaction kinetics

36 axons to their postsynaptic partners, which requires axons not only to faithfully transfer action po

37 g these patterns in global vegetation models requires better mechanistic representation of water and

38 Furthermore, FICZ-induced MMP1 expression required both AHR and ARNT, demonstrating that the AHR-A

39 length AR and AR-V7 transcription activation required both PRMT5 and pICln but not MEP50.

40 Ventralization in Ankmy2 knockout requires both cilia and Gli2 activation.

41 mizing the amount of computational resources required by the large water box of standard all-atom ste

42 r SAR in patients with renal dysfunction who require CABG.

43 Results indicated that PLA2 required calcium ion for both the hydrolyzing activity a

44 thesized that cocaine-memory reconsolidation requires cannabinoid type 1 receptor (CB1R) signaling ba

45 This challenging task requires care, especially in terms of statistical reliab

46 Such fast reconstructions with real data require careful calibration, adequate data redundancy fr

47 the absence of NOD-PerIg CD8(+) T cells but required CD4(+) T cells.

48 t fluorescence lifetime imaging targets that require cellular resolution and molecular specificity.

49 although 45% and 37% programs, respectively, require cessation 4 weeks prior to surgery.

50 levels between control and disease-does not require choosing a differential expression threshold and

51 that K. pneumoniae host-to-host transmission requires close contact and generally occurs through the

52 ell over a year at mg/day dosing and may not require cold chain storage for global health and develop

53 ptor (CAR)-modified T cells, to solid tumors requires combinatorial strategies to overcome immune sup

54 g capacity and inefficient drug release, and require complex modification processes.

55 Our system does not require complex nanofabrication.

56 to cellular organization and genome function require comprehensive understanding of the interactome n

57 Our findings require confirmation in other populations, but they sugg

58 However, reaching full potential will require conscious adjustments to the skillsets and mind

59 orecasting storm impacts on these ecosystems requires consideration of risk factors associated with s

60 temperature trends and particularly the NAWH requires considering both atmospheric and oceanic mechan

61 Maintaining energy homeostasis requires coordinating physiology and behavior both on an

62 ts presented frequently severe complications requiring critical care that induced significant short-

63 , however, is limited because they typically require dedicated structural features in the enzyme, suc

64 lls reveal that LD targeting of these motifs requires deeply inserted tryptophans that have lower fre

65 Understanding evolution requires detailed knowledge of genotype-phenotype maps;

66 network organisation and conscious cognition requires direct investigations into neuropsychologically

67 disassembly, and degradation by ClpC1, which requires disordered ends in its protein substrates.

68 ions to be written into target sites without requiring double-strand breaks or donor templates.

69 PTB has multiple appalling sequelae, which require due attention and appropriate treatment in sympt

70 Together, these co-receptors are required during embryogenesis to mediate proper HH signa

71 Tissue morphogenesis requires dynamic intercellular contacts that are subsequ

72 Approximately one third of patients require early admission after LT.

73 or conventional oil and gas reservoirs would require empirical parameters to be calibrated at various

74 pening venues for clinical intervention that require enhanced or reduced production of neutrophils.

75 ecently been proposed, but such a goal would require equitable translation to country-level contribut

76 le of Legionella pneumophila bacteria, which requires ERGIC-derived membrane.

77 to a large number of target structures, but requires excess quantities of suitably protected and act

78 ted by conventional biochemical assays which require expensive reagents, is time-consuming and more o

79 changes, including regulation of mRNAs that require extensive uridine insertion/deletion (U-indel) e

80 The mAb h5B3.1 blocks the required F conformational change needed to facilitate me

81 on in C. elegans, and find that this process requires factors involved in mutant mRNA decay, as in ze

82 ; [IQR: 8,720-11,400], a 94% reduction), and required fewer days spraying than the equivalent ULV str

83 nd used.SIGNIFICANCE STATEMENT Everyday life requires flexibility in switching between several rules.

84 ydroxyprostaglandin dehydrogenase, an enzyme required for 15-Oxo-ETE synthesis, was predominantly exp

85 Intensive care unit admission was required for 27 patients (8.8%) during delivery.

86 ur results indicate that TCP14 and TCP15 are required for an efficient elongation response to auxin,

87 tates the increase in nucleic acid synthesis required for anabolic cell growth and proliferation.

88 es, but little is known about the mechanisms required for assembly membrane proteins.

89 also targets Rcr3 paralog Pip1, which is not required for Avr2 recognition but contributes to basal r

90 We showed that SnRK2.8 was required for AvrPtoB virulence functions, including faci

91 ties are down-regulated by acylation but are required for biofilm formation, thus providing a defined

92 nally, BMPR1, a type I BMP receptor normally required for BMP-mediated patterning of the embryo, is d

93 ied near RA target genes already known to be required for body axis and limb formation, thus validati

94 Interestingly, MNT was required for cell proliferation even in the absence of M

95 ng raw sequencing data, with additional time required for data analysis and mining.

96 the composite Phactr1/PP1 surface, which are required for efficient dephosphorylation.

97 paran sulfate, we show that this activity is required for efficient infection by SBV.

98 ivating proteins, GBF1, is a cellular factor required for enterovirus replication.

99 4 are essential during gametogenesis and are required for ER-localized phospholipid metabolism in veg

100 idin A, an additional ketoreductase RslO8 is required for formation of the main products rishirilide

101 ehensive, high-quality reference genomes are required for functional characterization and taxonomic a

102 s according to biological characteristics is required for further BTMs validation and appropriate PIM

103 ive HDACi, and new protein synthesis was not required for gene suppression by HDACi.

104 toporphyrin IX in order to form heme that is required for growth stimulation and survival in vivo Con

105 Farnesylation at the C-terminus is required for hGBP1's activity against microbial pathogen

106 n allosteric conformational changes in PCSK9 required for high-affinity binding to LDL particles.

107 We identified 11 cellular pathways required for HIV-1 reactivation as druggable targets.

108 wed that ROS targeted by NAC was selectively required for IgG but not for IgM production.

109 f view, and new I(2)-IR ligands are urgently required for improving their pharmacological characteriz

110 and CD4+ CAR T cell cytotoxicity but was not required for in vitro or in vivo leukemia clearance.

111 To identify host factors required for infection by SARS-CoV-2 and seasonal corona

112 e in the expression of many of the key genes required for intracellular accommodation of arbuscular m

113 oxin exposure; as well as to elucidate genes required for iron acquisition and a functional type 9 se

114 ontribute to erythrocyte homeostasis and are required for iron recycling.

115 pleckstrin homology (PH) domain of P-Rex1 is required for its activation in cells.

116 n signal (NLS) that binds to importin and is required for its function during cytokinesis.

117 dillo-repeat region 6 to 9 (ARM6-9) of KAP3, required for its nuclear translocation, is also necessar

118 R-Cas9 screen in human SV589 cells for genes required for LDL-derived cholesterol to reach the ER.

119 can-retaining peptide fragments would not be required for localization.

120 The EACBE is required for long-distance regulation of the Ealpha on t

121 ailing the histologic-molecular correlations required for looking into, and making sense of, the tiss

122 acute myeloid leukemia (AML), and ALKBH5 is required for maintaining leukemia stem cell (LSC) functi

123 Ammonia was also required for MeIQ formation, but ammonia was produced by

124 ng protein that regulates translation and is required for normal cognition.

125 VPS4A function was also required for normal endosomal morphology and IST1 locali

126 Here, we show that the MA region is required for nuclear import of Gag through the TNPO3 pat

127 ct orchestration of their cross-talk that is required for optimal anti-tumour immunity.

128 ided new insights into the chemical features required for optimal interaction at the binding site.

129 HopO1-1 is required for P. syringae to spread locally to neighborin

130 Replication-dependent histones (RDH) are required for packaging of newly synthetized DNA into nuc

131 er, fixation and permeabilization procedures required for phosphoflow often affect cell surface epito

132 lower PI3,5P2, indicating that Fig4 is also required for PI3,5P2 production.

133 t the MHC-II antigen presentation pathway is required for PIV-mediated protection against C. burnetii

134 ts in vivo or in cellulo indicate that it is required for Pnr- and Srp-dependent gene expression, sug

135 nalysis we show that intact SA-signalling is required for potato defences against the necrotrophic fu

136 act SA signalling, and not JA signalling, is required for potato defences against the necrotrophic pa

137 expressed upon IS maturation, and OVCH2 was required for processing of the sperm surface protein ADA

138 L-Tryptophan is an essential amino acid required for protein synthesis.

139 iMCD patients, but additional therapies are required for refractory cases.

140 idation-related functions of ATG16L1 are not required for restricting inclusion development.

141 To determine if Pou3f4 is normally required for SGN peripheral axon extension into the sens

142 ides-lipoprotein-borne Hh pathway inhibitors required for Smo destabilization.

143 of the sperm surface protein ADAM3, which is required for sperm fertilizing ability.

144 is finding highlights that current densities required for spin-orbit torque switching of Cr(2) Ge(2)

145 The initiation of MSCI is required for stage progression, which enables crossover

146 cular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and cogni

147 tive allele (Sac1(ts)), we show that Sac1 is required for structural integrity of the Drosophila reti

148 The genes required for survival and proliferation in blood have no

149 out two orders of magnitude lower than those required for switching nonlayered metallic ferromagnets

150 We have previously shown that TBX1 is required for systemic lymphatic vessel development in pr

151 structural components of this matrix and are required for the assembly and architecture of biofilms p

152 Bcl6 is required for the development of T follicular helper cell

153 ion in HCT116 and HeLa cells, whereas it was required for the dissociation of cohesin from chromatin

154 Thus, Coq10 is required for the function of Q(6) in respiration and as

155 PQM-1 is required for the longevity of insulin signaling mutants,

156 Time-lapse microscopy showed that HuR was required for the promotion of cell motility in migrating

157 sults indicate that the endosomal pathway is required for the signaling cascade initiated by BDNF and

158 y for ZNF165 transcriptional activity and is required for TNBC tumor growth in vivo using an orthotop

159 The endosomal sorting complexes required for transport (ESCRTs) mediate diverse membrane

160 The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes membran

161 ic helix and its amphipathic properties were required for virus restriction.

162 remaining ~0.5% in anode reversibility will require fresh approaches, perhaps borrowed from other fi

163 These target product profiles will require further discussion and ongoing revisions as the

164 her effects of daily or weekly dosing differ requires further study.

165 th findings of pulmonary infection and those requiring further inpatient treatment were calculated, a

166 cture (e.g., AB | AB, ABC | ABC), the latter requiring greater computational power to be processed.

167 Cell differentiation and proliferation require Hedgehog (HH) signaling and aberrant HH signalin

168 of biomass-derived sugars into biofuel will require high yields, high volumetric productivities and

169 Addition to wine required high doses (25-32 g/L) for protein removal and

170 ining these particle characteristics, but it requires high particle concentrations in order to produc

171 These studies define BPIFB3 as a required host factor for both DENV and ZIKV replication

172 ich binds covalently to hRpn13 and UCHL5, to require hRpn13 Pru and not UCHL5 for cytotoxicity.

173 f the pathogenic strategies of microbes that require human (and/or mammalian) hosts, including herpes

174 ent and the outcome of the most severe forms requiring ICU admission.

175 marked contrast to the minimal phototoxicity required in live-cell experiments.

176 t Cre lines, we show that Fgf8 and Fgf17 are required in the presomitic mesoderm, whereas Fgf18 is re

177 in the presomitic mesoderm, whereas Fgf18 is required in the somites.

178 resistance provided by these mechanisms are required in this area to avoid future control failures.

179 ge-related diseases is still in its infancy, requiring in-depth characterization of the molecular lan

180 However, doing so will require intensive interdisciplinary collaboration and in

181 h ST-segment-elevation myocardial infarction requiring inter-hospital transfers for primary percutane

182 infection was noted in 74 (37.6%) patients, requiring intubation.

183 neuECG is voltage calibrated and does not require invasive procedures to impale electrodes in nerv

184 Adults requiring invasive mechanical ventilation via endotrache

185 the first example of a bacterial kinase that requires IP6 for its activation, and may aid future work

186 isturbed flow-induced endothelial activation required IRAK-1.

187 ate that cytokinin-induced protein synthesis requires isoforms of the ribosomal protein L4 encoded by

188 SIGNIFICANCE STATEMENT Achieving one's goals requires knowing what to do and when.

189 P half-widths were also fast, but absolutely required Kv3.3 subunits for fast repolarization (half-wi

190 ypothyroidism are nonspecific, the diagnosis requires laboratory testing.

191 methylbenzaldehyde functionalized substrates required longer irradiation times and resulted in lower

192 Biotrophic growth requires maintaining metabolic homeostasis while suppres

193 Twenty-two patients required mechanical ventilation; at last follow-up, 16 w

194 The required metabolic changes are also no less complex than

195 resonance imaging only in radiation therapy require methods for predicting the computed tomography n

196 Copper is a required micronutrient for bacteria and an essential cof

197 In addition, the reaction requires mild reaction conditions and easily accessible

198 ady-to-use workflows to run complex analyses requiring minimal intervention by users.

199 Cellular function requires molecular motors to transport cargoes to their

200 echanisms are noted, but a full picture will require more investigation.

201 g in mixtures, or site-specific methods that require multiple steps, introduction of mutations, or us

202 The production of soy protein-based foods requires multiple-step, intensive processing and storage

203 ing that IRAK-1 activation by disturbed flow required Nck1 in vitro and in vivo, showing endothelial

204 Global demand for phosphorus (P) requires new agronomic practices to address sustainabili

205 This algorithm requires no a priori specification of frequency bands.

206 Tumor cells require nominal increases in protein synthesis in order

207 Scc1 is expressed but neither required nor sufficient for cohesion, and its function r

208 Long-lasting, consolidated memories require not only positive biological processes that faci

209 ed upon Myc/beta-catenin activation and were required not only for the ensuing proliferative response

210 nsisted of (i) technical efficacy; primary - requiring one treatment, and secondary - requiring two t

211 atally, is maintained through adulthood, and requires ongoing type I IFN signaling to maintain it.

212 es not reimburse for home infusion; patients requiring outpatient parenteral antimicrobial therapy mu

213 Prevention of early RSV will require passive protection via maternal immunization in

214 namically unstable at ambient conditions and require peculiar synthetic approaches.

215 cover that Polycomb-mediated gene repression requires PRC1 catalytic activity.

216 Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol cont

217 The method does not require prior knowledge of reference genomes and produce

218 who are hospitalized for serious infections requiring prolonged intravenous antibiotics may face bar

219 erate by a different mechanism that does not require protein splicing.

220 The incidence of anastomotic leakage requiring reintervention or reoperation was 23.3% after

221 G-statistic method for BSA-Seq data analysis require relatively high sequencing coverage to detect si

222 ling kinetics to developing new therapeutics requires reliable kinetic assays and an analysis framewo

223 mer frequently induces a V-pattern esotropia requiring reoperation.

224 Seven eyes (10.6%) required repeat intervention for IOP control with median

225 gulation, probably less than 10% of patients require reperfusion by thrombolysis or interventional tr

226 n-fixed and paraffin-embedded (FFPE) tissues requires reversal of chemical crosslinking and the remov

227 Moreover, the method does not require sample treatment or washing steps.

228 quantitative detection ability and typically requires separate manual operations.

229 a phage T4 topoisomerase subunit gene (gp60) requires several recoding signals.

230 ever, many of the automated algorithms still require significant manual interventions or have yet to

231 low-up, patients treated with mite allergoid required significantly fewer AR and asthma prescriptions

232 on, but flies starved after training did not require sleep to form memories.

233 in many countries but for many people would require some combination of higher income, nutritional a

234 atients with sporadic cancer, these patients require specialised life-long care, with implications fo

235 mer research programs because these programs require students to relocate or be available full time,

236 ddition to grape juice prior to fermentation required substantially lower doses of GSP (5 g/L) to pre

237 f individuals with the highest risk that may require supportive treatment.

238 Twelve required surgical revision.

239 tumor with enhanced cytolytic potential and requires T cell migration from lymph nodes for therapeut

240 optimal reward structure selection (task 2) required taking into account future performance.

241 Moreover, TtAgo does not require targets to contain any specific protospacer-adja

242 t discrimination, which has been proposed to require temporoammonic input to differentiate between se

243 reduce cardiovascular risk in CKD, but this requires testing in prospective randomised trials.

244 However, the demonstrated approaches still require that the object is trapped at the high-light-int

245 In the Anthropocene, this requires that conservation planning explicitly includes

246 However, existing strategies typically require the complete encapsulation of nanostructures, wh

247 However, as conditions such as starvation require the organism to be awake and active(4), the abil

248 Many of these reduction steps require the presence of a catalyst to activate the reduc

249 acute respiratory distress syndrome did not require the presence of bilateral infiltrates.

250 ic cells using different mechanisms, but all require the presence of cholesterol to pierce lipid bila

251 This reaction does not require the use of stoichiometric activating reagents, a

252 We show that isothiocyanate formation requires the action of BT2158 and either BT2156 or BT215

253 s4, an epigenetic mark for active genes, but requires the CoREST repressor to act on nucleosome subst

254 in space and time of radioactive sources and requires the estimation of the amount of energy emitted

255 Proteolytic activity of Ddi1 requires the HDD domain and is stimulated by the UBL dom

256 Successful prevention of food allergy requires the identification of the factors adversely aff

257 r of distinct ClpP1 and ClpP2 rings and also requires the presence of activator peptides, such as ben

258 brate Hh pathway is that signal transduction requires the primary cilium (PC) where major pathway com

259 inpatients with moderate to severe UC often requires the use of immunomodulator and/or biologic ther

260 in the diagnosis of skin lesions while still requiring the user to critically consider other possible

261 s without any amplification step (e.g., PCR) required, thus simplifying the operation further.

262 previous reports had low channel counts and required time-consuming manual assembly.

263 nimal materials in gelatin-based products is required to address religious and cultural concerns, bec

264 idating the genetic basis of these traits is required to assess models of evolution and to develop su

265 Further investigations are required to assess the effect of differential barorecept

266 translational beta-catenin activation and is required to complete EGA.

267 is molecule generation, where the machine is required to design high-quality, drug-like molecules wit

268 ing methods; additional modifications appear required to differentiate GES-, IMP-, and SPM-producing

269 ed blood spots (DBS) though more research is required to evaluate mercury (Hg) speciation in DBS and

270 An estimation of the times required to form the loops of typical sizes seen in Hi-C

271 dress production and environmental goals are required to identify promising sustainable intensificati

272 was reduced (SLOW condition), the pull-force required to induce a step was less than when the visual

273 alistic host-microbiota relationship that is required to maintain homeostasis and prevent disease.

274 th the lysosomal protease cathepsin D and is required to maintain proper cathepsin D levels in oligod

275 (6)A methylation-mediated SOCS1 induction is required to maintain the negative feedback control of ma

276 We show that glycolysis is required to maintain the plasma membrane potential and t

277 dy-state, since sustained Btnl expression is required to maintain the signature TCR.Vgamma7(+) IEL ph

278 two electrons from the coordinated amide are required to occupy a 3c-4e sigma* orbital which is too h

279 Awardees were required to participate in a cross-site evaluation that

280 e remarkable ring expansion reaction that is required to produce the distinct carbon scaffold of colc

281 We estimate that the neutral density required to produce the observed pickup ion fluxes is si

282 Th17 cells were required to promote depressive-like behaviors by AI-2, a

283 More work is required to pull slowly ejecting proteins out of the exi

284 A second, cooperating genetic hit is often required to push these hyperplastic cells to malignancy

285 and structural barriers to HIV care will be required to reach national targets of the ending the HIV

286 CrI(3) but quantum rescaling corrections are required to reproduce its thermal properties.

287 UniRule rules and the code required to run the rules, are publicly available for re

288 Additionally, a food signal is required to turn on TRA-1 expression in the intestine, a

289 Further work is required to understand the intrapulmonary pharmacokineti

290 Prospective studies are required to validate biomarkers.

291 dynamics in spatially extended environments, requiring tools that can bridge the gap between intracel

292 y - requiring one treatment, and secondary - requiring two treatments (ii) complication and mortality

293 However, clustering requires upfront algorithm and hyperparameter selection,

294 disease caused by infection with SARS-CoV-2, requires urgent development of therapeutic interventions

295 Solving the V2F challenge requires us to identify causative genetic variants, rele

296 By refining where and when these genes are required using different Cre lines, we show that Fgf8 an

297 ere acute respiratory syndrome coronavirus 2 requiring venovenous extracorporeal membrane oxygenation

298 Correction of axial motion artefacts usually requires volumetric imaging resulting in slower rates of

299 ngs suggest that migratory behavior does not require widespread modifications of brain structure, but

300 To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded va