ライフサイエンスコーパス: restart

1 homologous recombination and DNA replication restart.

2 anding of primosomal assembly in replication restart.

3 to stalled forks to facilitate repriming and restart.

4 of PTEN with Rad51 in promoting stalled fork restart.

5 poly (ADP-ribose) polymerase/RECQ1-regulated restart.

6 ication stress by promoting replication fork restart.

7 CD2, followed by FAN1 nuclease-mediated fork restart.

8 anded DNA break repair, and replication fork restart.

9 mventing the need for replication repair and restart.

10 of diverse replication forks to replication restart.

11 aberrations as well as defective replication restart.

12 ifferent pathways to promote fork repair and restart.

13 eckpoint activation and faithful replication restart.

14 replication forks to facilitate replication restart.

15 ication forks to promote their stability and restart.

16 ame time repressing stalled replication fork restart.

17 g DSB repair and repressing replication fork restart.

18 are required for efficient replication fork restart.

19 omologous recombination and replication fork restart.

20 and STN1 depletion has little effect on fork restart.

21 that depends on RPA-mediated DNA replication restart.

22 t the expense of lesion-skipping replication restart.

23 ed ART affects outcomes once these drugs are restarted.

24 ork regression when stalled forks need to be restarted.

25 stroke and mortality in comparison with not restarting.

26 ntegrity and poising cells for translational restart, a process that has significant clinical implica

27 ) to be specifically required for cell cycle restart after DNA damage in G1.

28 lays a novel role in genome-wide replication restart after hydroxyurea (HU)-induced replication fork

29 of reversed replication fork processing and restart after prolonged genotoxic stress.

30 ased and the ability of replication forks to restart after replicative stress is restored.

31 As cancer surgery restarts after the first COVID-19 wave, health care prov

32 wise Mutual Information and Random Walk with restart algorithm (namely IDHI-MIRW).

33 ted and optimized using the Random Walk with Restart algorithm in a protein-protein interaction netwo

34 ally, IDHI-MIRW implemented random walk with restart algorithm on the lncRNA-disease heterogeneous ne

35 tasets, then implements the random walk with restart algorithm on these similarity networks for extra

36 thod by integrating network random walk with restart algorithm, gene set enrichment analysis, and hyp

37 on stress, including slowed replication fork restart, although DNA replication checkpoints are functi

38 Pif1 DNA helicase, Pfh1, promotes efficient restart and also suppresses TS.

39 interaction likely promotes replication fork restart and gap avoidance.

40 n in EXD2(-/-) cells restores efficient fork restart and genome stability.

41 ays a major role in HDR-mediated replication restart and in suppressing new origin firing.

42 apsed replication forks by facilitating fork restart and limiting inappropriate recombination that co

43 lly associated with fork repair, replication restart and recombination, establishing new forks with t

44 ty necessary for its function in replication restart and that its SET domain is essential for recover

45 observations have implications for both fork restart and the division of labor during leading-strand

46 CtIP cooperates with FANCD2 to promote fork restart and the suppression of new origin firing.

47 Stalled replication forks can be restarted and repaired by RAD51-mediated homologous reco

48 shortened, and pipes experience regular flow restarting and draining.

49 th unscheduled replication fork stalling and restart, and suppresses tumorigenesis, at least partiall

50 s were associated with higher probability of restarting antibiotics (OR, 1.62; 95% CI, 1.01-2.61; P =

51 s were associated with higher probability of restarting antibiotics (OR, 1.62; 95% CI, 1.01-2.61; p=0

52 o had 2 negative D-dimer results and did not restart anticoagulant therapy, rates of recurrent VTE we

53 icularly important when planning to start or restart anticoagulation after an intracerebral hemorrhag

54 n 10 (5%) patients at 30 days, 5 of whom had restarted anticoagulation before the event.

55 how to bridge; and 6) outline the process of restarting anticoagulation post-procedure.

56 Failure to stabilize and restart arrested forks results in fork collapse and geno

57 ve evolved complex mechanisms to process and restart arrested forks through the coordinated action of

58 larly for studies using higher thresholds to restart ART and longer ATI durations.

59 The other 17 restarted ART because of a confirmed recording of 1000 o

60 work points to replication fork reversal and restart as a central mechanism to ensuring high-fidelity

61 eria plays a key role in DNA replication and restart as a loader protein for the recruitment of repli

62 tive helicase at oriC and during replication restart at stalled replication forks.

63 he implementation of the L-BFGS algorithm is restarted at every segment.

64 igatran was held 1 to 2 doses before PVI and restarted at the conclusion of the procedure or as soon

65 atients requiring a drug hold, treatment was restarted at the original dose in 73 (92%) patients.

66 governed by a short element upstream of the restart AUG, designated "termination upstream ribosomal

67 n two catalysis-based assays, we demonstrate restarting autonomously stalled reactions, enabling accu

68 GreA restarts backtracked RNA polymerase and hence promotes t

69 temporary blinatumomab discontinuation; all restarted blinatumomab successfully.

70 restore broken ends of the DNA double helix, restart broken DNA replication forks, and cross over chr

71 etition in a scenario where no teams travel (restart bubble) reduces the typical effects of travel an

72 By contrast BLM restarted, but did not protect, replication forks in a m

73 A, the pools were normalized and cell growth restarted, but only after SAMHD1 had reappeared.

74 adation of collapsed forks or to replication restart by a mechanism involving strand invasion.

75 We also show RAD51 promotes replication restart by both strand exchange-dependent and strand exc

76 tiple pathways that initiate DNA replication restart by recognizing and remodeling abandoned replicat

77 on completion while suppressing excessive RF restart by recombination-dependent replication (RDR) and

78 The dynamic exchange can be restarted by addition of potassium ions that competitive

79 lled replication forks can be stabilized and restarted by homologous recombination (HR), which also r

80 the consequences of replication with a fork restarted by homologous recombination in fission yeast.

81 function is not without risk as replication restarted by homologous recombination is prone to templa

82 superior guest 4,4'-dimethylazobenzene, then restarted by irradiation.

83 in BRCA1 mutant cells arise by a replication restart-bypass mechanism terminated by end joining or by

84 structure breaks (broken fork), replication restart can proceed either by homologous recombination o

85 A few eventually restarted cell division and propagated to form derivativ

86 e timely completion of genome duplication by restarting collapsed replication forks.

87 rbed DNA replication and protect, repair and restart damaged forks.

88 nce of RTF2 at stalled forks results in fork restart defects, hyperactivation of the DNA damage signa

89 ocks, prioritize genes with random walk with restart, detect enriched subnetworks and test the signif

90 ow-up for >/=3 years after stopping DMT; not restarting DMT for >/=3 months after discontinuation.

91 leted cells exhibited a decreased ability to restart DNA replication following fork stalling in compa

92 WAPL-dependent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survi

93 here was a decreased ability to subsequently restart DNA synthesis, which is normally dependent upon

94 igin firing while promoting replication fork restart/DNA repair.

95 ent DNA duplication by repriming replication restart downstream of replicase stalling lesions and str

96 ng ELL as an essential player for RNA Pol II restart during cellular DNA damage response opens the wa

97 tion was a teschovirus translational 2A stop-restart element designed to direct the separate expressi

98 to proofread errors of transcription and to restart elongation via stimulation of RNA hydrolysis by

99 ictions relaxed and some economic activities restarted, especially in China and several European coun

100 We also imaged PriC replication restart factor and observe Rep-replisome association is

101 cation-stress signaling and replication-fork restart factors.

102 r proteins that are required for replication restart following fork replication stalling.

103 causes a decrease in genome-wide replication restart following fork stalling similar to that observed

104 ed by polyubiquitinated PCNA to promote fork restart following replication arrest.

105 foci and, secondly, during replication fork restart following replication fork stalling.

106 e triggered by head-on collision between the restarted fork and RNA Polymerase III transcription.

107 The restarted fork is susceptible to further collapse causin

108 cific barrier in fission yeast, leading to a restarted fork within approximately 60 min, which is onl

109 We propose that the error-prone nature of restarted forks contributes to the generation of GCRs an

110 t through the observation that recombination-restarted forks have a considerably high propensity to e

111 Def1 also enhanced transcription restart from TFIIS-induced cleavage in a pol II transcri

112 negative effects in ppGpp degrees cells when restart function priB was knocked out, causing loss of v

113 lude replication fork-stabilization and fork-restart functions.

114 me organism causing the initial bacteremia), restarting gram-negative-directed antibiotic therapy due

115 transforming event, such as a mutation, can restart growth of a tiny, growth-restricted metastasis;

116 undetectable size until a transforming event restarts growth.

117 hanisms by which PriC drives DNA replication restart have remained poorly defined due to the limited

118 iscontinuing HC and fewer symptoms when they restarted HC could we conclude that HC may protect women

119 ed SMARCAL1 promotes stalled fork repair and restart; however, unregulated SMARCAL1 contributes to fo

120 omen randomized to DCART were recommended to restart if a subsequent pregnancy occurred or for clinic

121 dimer test results were negative and was not restarted if results were still negative after 1 month.

122 trial Doppler was performed and transfusions restarted immediately in the case of reversion to abnorm

123 PriA orchestrates replication restart in bacteria by unwinding the lagging-strand arm

124 Transcription is known to restart in bulk by telophase, but whether de novo transc

125 mplicated in replication fork processing and restart in response to replication stress.

126 ciates in mitosis, and its accumulation must restart in the next cell cycle.

127 replication and does not support replication restart in vitro.

128 thesis, mimicking the process of replication restart in vivo These results demonstrate that RPA binds

129 ur when treatment with the MEK inhibitor was restarted in 2 of the patients.

130 Treatment was restarted in 57 of 61 patients with MR, and 55 patients

131 l programs that define cell identity must be restarted in each cell cycle(2-5) but how this is accomp

132 talled, remodelled, processed, protected and restarted in response to specific types of stress.

133 re, the nature of the cues required for this restarting in oilseed rape (Brassica napus) seed has bee

134 We demonstrate that CME can be 'restarted' in mitotic cells despite high membrane tensio

135 efore, and 30 minutes after interrupting and restarting intra-aortic balloon pump.

136 rocirculation were unchanged by stopping and restarting intra-aortic balloon pump.

137 that the rate-limiting steps of replication restart involve the synthesis and activation of the new

138 However, replication restart is relatively slow and, therefore, replication t

139 However, its exact role in replication restart is unclear.

140 Surprisingly, in our system fork restart is unnecessary for maintaining cell viability.

141 ew technique in which we stall the motor and restart it after increasing waiting periods, we show tha

142 s entry process at a specific stage and then restart it rapidly with a non-invasive stimulus.

143 This restarted L-BFGS algorithm balances the computational ef

144 The restarted L-BFGS algorithm proposed here is both stable

145 ets discovered by GWAS have the potential to restart largely stalled psychiatric drug development pip

146 hermore, once stopped, such assays cannot be restarted, limiting the dynamic range to two orders of m

147 wal; all transaminase elevations resolved on restarting lopinavir.

148 on and binding to the lesions, a replication restart mechanism has not been identified.

149 such, bacteria have evolved DNA replication restart mechanisms that function to reload replisomes on

150 away from the oocyte lowers oocyte cGMP and restarts meiosis.

151 The pump can be restarted multiple times simply by re-illumination.

152 Sometimes restarting natalizumab treatment may be the best option

153 After restarting NNRTI-based ART (n = 90), virologic suppressi

154 RFWD3 is necessary for replication fork restart, normal repair kinetics during replication stres

155 ng oral anticoagulant were equally likely to restart OAC (58.0% versus 60.7%), had similar use of ant

156 Nearly 40% of patients did not restart OAC postprocedure, exposing patients to risk for

157 sis in patients with atrial fibrillation who restarted OAC showed a decreased HR of 0.258 (95% CI, 0.

158 tituted translesion synthesis (TLS)-mediated restart of a eukaryotic replisome following collision wi

159 ions: it binds chromatin and coordinates the restart of aphidicolin (APH)-stalled replication forks i

160 mplete genome duplication via the repair and restart of blocked replication forks also challenges via

161 ermediates in DNA recombination, repair, and restart of blocked replication.

162 ckout of the gene by CRISPR/Cas9 compromised restart of collapsed forks and led to DNA damage in cell

163 omes, preservation of the genetic integrity, restart of collapsed replication forks and telomere main

164 for accurate repair of damaged chromosomes, restart of collapsed replication forks, and telomere mai

165 SMARCAL1 promotes the repair and restart of damaged replication forks.

166 PriA protein serves as an initiator for the restart of DNA replication on stalled replication forks

167 observations implicate PrimPol in promoting restart of DNA synthesis downstream of, but closely coup

168 The median duration from IMDC to restart of ICI treatment was 49 days (IQR, 23-136 days).

169 e, which sets the stage for the orchestrated restart of life.

170 of the PriA SF2 DNA helicase, which governs restart of prematurely terminated replication processes

171 restart or homologous recombination-mediated restart of replication downstream of the lesion, and byp

172 plication, C-strand fill-in, and genome-wide restart of replication following fork stalling.

173 ns of Metnase in NHEJ repair and accelerated restart of replication forks.

174 merase inappropriately binds to and inhibits restart of reversed replication forks within telomeres,

175 In bacteria, the restart of stalled DNA replication forks requires the DN

176 crucial for DNA replication fork repair and restart of stalled forks in human is Metnase (also known

177 onarily conserved physiological response for restart of stalled forks.

178 Rad50-Nbs1) complex that plays a role in the restart of stalled replication forks and enhanced resect

179 replication, defects in the protection, and restart of stalled replication forks are major causes of

180 gly, the S495A mutant demonstrated increased restart of stalled replication forks compared with wt Me

181 The protection and efficient restart of stalled replication forks is critical for the

182 The restart of stalled replication forks is critical for the

183 pair of double-strand breaks, as well as the restart of stalled replication forks through homologous

184 stress, FANCD2 and BLM cooperate to promote restart of stalled replication forks while suppressing f

185 to suggest that lamin A/C has a role in the restart of stalled replication forks, a prerequisite for

186 MUS81 plays important cellular roles in the restart of stalled replication forks, the resolution of

187 des inactivation of checkpoint signaling and restart of stalled replication forks.

188 with the DNA helicase RECQ1, which promotes restart of stalled replication forks.

189 a capability that could be important for the restart of stalled replication forks.

190 oth DNA double-strand break (DSB) repair and restart of stalled replication forks.

191 ng telomere replication fork progression and restart of stalled telomere replication forks.

192 permits initiation of HR-mediated repair and restart of stressed forks.

193 replication stress response by mediating the restart of temporarily stalled replication forks thereby

194 ture rise in the Northern Hemisphere and the restart of the Atlantic meridional overturning circulati

195 Specifically, new roles for BRCA1 in the restart of transcription after UV damage and in preventi

196 venting the arrival of polymerase II and the restart of transcription.

197 trimestrial Doppler follow-up and immediate restart of transfusions in the case of reversion.

198 ed, and resulted in an altered velocity upon restart of translocation downstream of Chi.

199 The ending and restarting of school terms had a major effect in attenua

200 cularly, we apply downward random walks with restart on the GO directed acyclic graph, along with the

201 ed with 3HP experienced side effects--9 were restarted on 3HP, 18 switched treatment regimens, and 13

202 ent arm of the SYCAMORE study, 11 (92%) were restarted on adalimumab after withdrawal of the IMP for

203 s [D] in at least 1 eye) during phase 2 were restarted on atropine 0.01% for a further 24 months (pha

204 respectively, who progressed in phase 2 were restarted on atropine 0.01%.

205 Two subjects were restarted on ERT because of poor gene marking and immune

206 orticosteroids could be tapered, stopped, or restarted on the basis of disease activity.

207 There the synthesis of DHFR mRNA restarts on the arrival of RNA polymerase II and CSB and

208 of uncontrolled outbreaks that would require restarting OPV.

209 at Mcm10 may have a role in replication fork restart or DNA repair.

210 he damage and origin-independent replication restart or homologous recombination-mediated restart of

211 her treatment should be augmented, switched, restarted, or discontinued.

212 We hypothesized that restarting oral anticoagulant treatment was associated w

213 ectively) in the recombination-mediated fork restart pathway.

214 cG-catalyzed replication fork remodeling and restart pathways in vivo.

215 be overcome by lesion bypass or replication restart pathways, leaving repair for a later time.

216 plication forks in bacterial DNA replication restart pathways.

217 Cells and viruses possess several known 'restart' pathways to overcome lesions during DNA replica

218 Our method involves a random walk with restarts, performed on an initial network with multiple

219 gene set, based on a second random walk with restarts, performed on the above subnetwork.

220 results in a slightly-defective replication restart, persistence of under-replicated regions and chr

221 ent visits; half of these participants later restarted PrEP.

222 t tools to make the decision of stopping and restarting PrEP that considers the complex relationship

223 matic outcomes after starting, stopping, and restarting PrEP, and we review the implications of PrEP

224 oxynucleotide synthesis and replication fork restart, prevention of double-stranded DNA break formati

225 edication, increased dose, recommendation to restart preventive medication) than in the UC group (58%

226 riC/SSB complex formation in DNA replication restart, PriC variants that cannot bind SSB are non-func

227 eplication stalls and forks disassemble, the restart primosome is required to reload the replicative

228 taining reversible quiescence so cells could restart proliferation after switching p21 off.

229 ART was restarted promptly.

230 ficiency in helicase activity of replication restart protein PriA leads to a considerable loss of via

231 PriC, a key Escherichia coli DNA replication restart protein, and the single-stranded DNA-binding pro

232 It is often unnecessary to restart psychiatric medications upon which a patient has

233 k DNA and coordinates subsequent replication restart reactions have remained unclear due to the deart

234 problem is resolved by cellular "replication restart" reactions that recognize the structures of prem

235 ein blocks the first step of DNA replication restart, reloading of the replicative DnaB helicase onto

236 , but the details of how uncoupled forks are restarted remain uncertain.

237 ke, during which metabolism of the embryo is restarted, remain enigmatic.

238 In such circumstances, failure to restart replication could result in incomplete genome du

239 Failure to restart replication forks stalled at genomic regions tha

240 combination is deployed in such instances to restart replication, it is unclear how a stalled fork tr

241 synthesis unless recombination intervenes to restart replication.

242 lled replication forks to promote repair and restart replication.

243 ruitment of RPA and RAD51 to repair DSBs and restart replication.

244 loading of the helicase DnaB onto the DNA to restart replication.

245 ing support for a DDK role in stabilizing or restarting replication forks under S phase checkpoint co

246 Homologous recombination also stabilizes and restarts replication forks without a DSB.

247 e rescued by homologous recombination, which restarts replication.

248 Remarkably, replication restart requires the concerted histone H3 chaperone acti

249 ng (MeRIP-Seq) data using a Random Walk with Restart (RWR) algorithm and then builds a consensus m6A-

250 lf-organizing map (SOM) and random walk with restart (RWR) algorithms to separate the progenitors fro

251 The analysis, using a random-walk with restart (RWR) method, is adapted to the setting of WES b

252 , hypergeometrics test and random walks with restart (RWR) were used to predict additional essential

253 On restarting SD after DD treatment, a possible carryover e

254 Then, translation elongation was restarted simultaneously to synchronize the translation.

255 In this case, the inability to restart stalled forks is likely to account for the letha

256 itated by the SCFDia2 complex is critical to restart stalled replication forks during checkpoint reco

257 tly, hSSB1-depleted cells fail to repair and restart stalled replication forks.

258 ocess is the cells' ability to stabilize and restart stalled replication forks.

259 ynthesis during normal replication and/or to restart stalled replication from downstream ssDNA.

260 Rep helicase, whose primary role is to help restart stalled replication, serves as a model for Super

261 These cells were defective for restarting stalled replication forks and repairing break

262 n strand from MRE11-mediated degradation and restarted stressed replication forks in a manner additiv

263 nces of IF2-1 and IF2-2/3 on the replication restart system depending on (p)ppGpp levels, each having

264 To restart the cycle, LeuE11 toggles back to the ferric iro

265 ack to its lowest energy open state ready to restart the cycle.

266 itu normothermic regional perfusion (NRP) or restarting the heart in the donor's body may interrupt t

267 1-induced miR-146a prevents death in mice by restarting the production of type I interferon.

268 ays between doses might be acceptable before restarting the sequence of injections.

269 C2 pollen tubes could frequently recover and restart their speedy elongation, resulting in a repetiti

270 empt can safely re-establish remission after restarting their TKI therapy.

271 of MMR is a practical and safe criterion for restarting therapy in patients with CML with prolonged C

272 apy (eg, to identify a threshold above which restarting therapy should be considered).

273 At the time of restarting therapy, median difference of free light chai

274 apsing patients regained MMR and MR4.5 after restarting therapy.

275 n be mimicked by preventing replication fork restart through depletion of RECQ1 or PARG.

276 ere we show that Rad53 regulates replication restart through the checkpoint-dependent transcriptional

277 a 5'-to-3' polarity and promote replication restart, thus preventing aberrant processing of unresolv

278 wever, more than 50% of patients relapse and restart TKI, subsequently suffering unknown toxicity.

279 Of the 3 patients with recurrence, 2 had restarted TNF-alpha blocker therapy, 1 of whom died.

280 s to S. pombe Rtf2) must be removed for fork restart to be optimal.

281 ven when repaired, if transcription does not restart to reestablish cellular metabolism.

282 reassemble these gene promoters and thus to restart transcription after UV irradiation.

283 , sequestered by HelD, or upon HelD release, restart transcription.

284 Unexpectedly, the DNA-bound RNAP often restarts transcription, usually in reverse direction, th

285 Findings from the RESTART trial suggest that starting antiplatelet therapy

286 We did subgroup analyses of the RESTART trial to explore whether these brain imaging fea

287 Urea injection was stopped and restarted twice.

288 ndonuclease is required for replication fork restart under replication stress elicited by exogenous t

289 t activation during HR-dependent replication restart using a site-specific replication fork-arrest sy

290 RESTART was a prospective, randomised, open-label, blind

291 ed replication fork stalling, as replication-restart was impaired in both SMI#9-pretreated and RAD6B-

292 ction when the intra-aortic balloon pump was restarted was observed in the seven patients whose pulmo

293 s tight regulation: too little inhibits fork restart, whereas too much causes fork degradation.

294 the BLM helicase to promote replication fork restart while suppressing new origin firing.

295 g protein (CtIP) to promote replication fork restart while suppressing new origin firing.

296 and promote MRE11 exonuclease-dependent fork restart while suppressing the firing of new replication

297 disease progression, which ultimately could restart with similar aggressive behavior.

298 e stress and allows for the RNA synthesis to restart with the original rate.

299 Treatment was restarted with intravenous steroids and immunoglobulins,

300 This restart, with no new travel by teams, provided a natural